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You searched for +publisher:"Penn State University" +contributor:("Jennifer Baccon, Outside Member"). Showing records 1 – 2 of 2 total matches.

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Penn State University

1. Hsu, Paul. CARDIOLIPIN REMODELING AND MITOPHAGY: INVESTIGATING THE ROLE OF MITOCHONDRIAL QUALITY CONTROL IN DISEASE.

Degree: 2016, Penn State University

Metabolic disorders and aging-related diseases are characterized by an accumulation of dysfunctional mitochondria and a gradual decline of the aging organism. Mitophagy, the selective degradation of mitochondria, is required for clearing damaged mitochondria. A decrease in mitophagy is observed with aging and is associated with an increase in aging-related diseases, but the mechanism of this is uncertain. Cardiolipin (CL) is a mitochondria-specific phospholipid that is necessary for optimal mitochondrial function. CL remodeling is required for the maturation of CL into healthy tetra-linoleoyl CL. However, pathological remodeling by ALCAT1, an acyltransferase located at the mitochondria-associated membrane, occurs in response to oxidative stress and aging. This remodeling results in dysfunctional mitochondria with leaky electron transport chain and increased oxidative stress. However the mechanism by which CL remodeling leads to accumulation of dysfunctional mitochondria in aging-related diseases, such as cardiovascular disease, is unknown. The hypothesis is that CL remodeling associated with aging and oxidative stress reduces mitophagy, and links CL remodeling with accumulation of dysfunctional mitochondria. With a genetic model that silences CL maturation, CL remodeling is specifically required for the recognition of mitochondria by the autophagy machinery in mitophagy. The results demonstrate in an ALCAT1 knockout mouse model that blocking pathologic CL remodeling reduces vascular oxidative stress and renders mice resistant to obesity-induced hypertension. Lastly, the unexpected role of CL remodeling and mitochondrial dysfunction in cellular inflammatory response is explored. Unexpectedly, overexpression of ALCAT1 results in upregulation of type I interferon signaling secondary to mitochondrial DNA release into the cytoplasm. These data support the well-established link between oxidative stress and aging-related diseases and suggest involvement of pro-inflammatory mechanisms. Overall, the results show that pathological CL remodeling is an underlying mechanism that drives acceleration of oxidative stress and aging-related disease. Furthermore, they indicate that CL remodeling, specifically ALCAT1 inhibition, may be a druggable target to reduce the burden of oxidative stress and inflammatory response as well as aid in the clearance of dysfunctional mitochondria. Advisors/Committee Members: Yuguang Shi, Dissertation Advisor/Co-Advisor, Yuguang Shi, Committee Chair/Co-Chair, Leonard Jefferson, Committee Member, Hong-Gang Wang, Committee Member, Jennifer Baccon, Outside Member.

Subjects/Keywords: Mitophagy; Cardiolipin; Barth Syndrome; Hypertension; Type I interferon

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hsu, P. (2016). CARDIOLIPIN REMODELING AND MITOPHAGY: INVESTIGATING THE ROLE OF MITOCHONDRIAL QUALITY CONTROL IN DISEASE. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/13165pxh200

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Hsu, Paul. “CARDIOLIPIN REMODELING AND MITOPHAGY: INVESTIGATING THE ROLE OF MITOCHONDRIAL QUALITY CONTROL IN DISEASE.” 2016. Thesis, Penn State University. Accessed November 29, 2020. https://submit-etda.libraries.psu.edu/catalog/13165pxh200.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Hsu, Paul. “CARDIOLIPIN REMODELING AND MITOPHAGY: INVESTIGATING THE ROLE OF MITOCHONDRIAL QUALITY CONTROL IN DISEASE.” 2016. Web. 29 Nov 2020.

Vancouver:

Hsu P. CARDIOLIPIN REMODELING AND MITOPHAGY: INVESTIGATING THE ROLE OF MITOCHONDRIAL QUALITY CONTROL IN DISEASE. [Internet] [Thesis]. Penn State University; 2016. [cited 2020 Nov 29]. Available from: https://submit-etda.libraries.psu.edu/catalog/13165pxh200.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hsu P. CARDIOLIPIN REMODELING AND MITOPHAGY: INVESTIGATING THE ROLE OF MITOCHONDRIAL QUALITY CONTROL IN DISEASE. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/13165pxh200

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Penn State University

2. Wang, Yanli. IDENTIFICATION AND VISUALIZATION OF REGULATORY ELEMENTS AND 3D GENOME STRUCTURE.

Degree: 2017, Penn State University

The three-dimensional (3D) organization of vertebrate genomes is intricately linked to genome function, specifically gene regulation. At the DNA level, distal regulatory elements such as enhancers need to be in physical contact with their target genes. At a larger scale, topological associating domains (TADs) have been suggested to be the basic unit of genome organization. To gain a better understanding of the relationship between chromatin structure and function, we designed and implemented a widely-used online platform for visualizing the spatial organization of the genome, which is also integrated with thousands of genomic datasets such as ChIP-Seq and RNA-Seq. This system is currently visited by thousands of people each month, as it facilitate researchers to hypothesize the function of non-coding elements and disease-related variants. We employed zebrafish as a model organism to explore its cis-regulatory landscape and investigate how the structure of the vertebrate genome impact its function. Advisors/Committee Members: Feng Yue, Dissertation Advisor/Co-Advisor, James Riley Broach, Committee Chair/Co-Chair, Ross Cameron Hardison, Committee Member, James Riley Broach, Committee Member, Jennifer Baccon, Outside Member.

Subjects/Keywords: Genomcs; Genomic Structure; Hi-C; Genome Browser; Cis-Regulatory Elements; Enhancers; Promoters

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wang, Y. (2017). IDENTIFICATION AND VISUALIZATION OF REGULATORY ELEMENTS AND 3D GENOME STRUCTURE. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/14311yzw125

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Wang, Yanli. “IDENTIFICATION AND VISUALIZATION OF REGULATORY ELEMENTS AND 3D GENOME STRUCTURE.” 2017. Thesis, Penn State University. Accessed November 29, 2020. https://submit-etda.libraries.psu.edu/catalog/14311yzw125.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Wang, Yanli. “IDENTIFICATION AND VISUALIZATION OF REGULATORY ELEMENTS AND 3D GENOME STRUCTURE.” 2017. Web. 29 Nov 2020.

Vancouver:

Wang Y. IDENTIFICATION AND VISUALIZATION OF REGULATORY ELEMENTS AND 3D GENOME STRUCTURE. [Internet] [Thesis]. Penn State University; 2017. [cited 2020 Nov 29]. Available from: https://submit-etda.libraries.psu.edu/catalog/14311yzw125.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Y. IDENTIFICATION AND VISUALIZATION OF REGULATORY ELEMENTS AND 3D GENOME STRUCTURE. [Thesis]. Penn State University; 2017. Available from: https://submit-etda.libraries.psu.edu/catalog/14311yzw125

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.