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You searched for +publisher:"Old Dominion University" +contributor:("Jingdong Mao"). Showing records 1 – 2 of 2 total matches.

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1. Garcia, Consuelo. Characterization of 3-Ester and 3-Carbamate Derivatives of N-Acetyl-D-Glucosamine and Their Use in Controlled Drug Delivery.

Degree: MS, Chemistry and Biochemistry, 2017, Old Dominion University

Low molecular weight gelators (LMWGs) are a class of compounds which reversibly form a network that traps solvents to form gels. Gelation by LMWGs is driven solely by non-covalent interactions such as hydrogen bonding, π - π stacking, and hydrophobic interactions. LMWGs can be designed such that the gel-sol and sol-gel transitions happen as a response to a specific stimulus. These stimulus responsive gels or “smart” gels can be used in a wide variety of applications including tissue regeneration, biosensing, and controlled drug delivery. Among the different types of compounds that are LMWGs, carbohydrate based systems are especially interesting. Carbohydrates are abundant, renewable, biocompatible, and have numerous hydroxyl groups which can be readily functionalized. Our group has previously found that organogelators and hydrogelators can be obtained from D-glucose and D-glucosamine by selectively functionalization of the hydroxyl groups. Various C-2 acyl derivatives including esters and carbamates are found to be effective LMWGs for both water and organic solvents. In this study, the functionalization at the C-3 position of glucosamine derivative was carried out. Two types of C-3 derivatives including esters and carbamates were synthesized and characterized by 1H and 13C NMR spectroscopy and LCMS. These compounds were then analyzed for gelation properties in a series of selected solvents. Several compounds were found to be effective organogelators, the resulting gels were characterized using IR, rheology, optical microscopy, etc. The use of these gelators for controlled drug delivery was tested and it was found that the gels loaded with naproxen sodium or chloramphenicol released the drug in an acidic environment. Advisors/Committee Members: Guijun Wang, Richard Gregory, Alvin Holder, Jingdong Mao.

Subjects/Keywords: Carbohydrate chemistry; Drug release; Medicinal chemistry; Organic Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Garcia, C. (2017). Characterization of 3-Ester and 3-Carbamate Derivatives of N-Acetyl-D-Glucosamine and Their Use in Controlled Drug Delivery. (Thesis). Old Dominion University. Retrieved from 9780355386226 ; https://digitalcommons.odu.edu/chemistry_etds/16

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Garcia, Consuelo. “Characterization of 3-Ester and 3-Carbamate Derivatives of N-Acetyl-D-Glucosamine and Their Use in Controlled Drug Delivery.” 2017. Thesis, Old Dominion University. Accessed December 14, 2018. 9780355386226 ; https://digitalcommons.odu.edu/chemistry_etds/16.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Garcia, Consuelo. “Characterization of 3-Ester and 3-Carbamate Derivatives of N-Acetyl-D-Glucosamine and Their Use in Controlled Drug Delivery.” 2017. Web. 14 Dec 2018.

Vancouver:

Garcia C. Characterization of 3-Ester and 3-Carbamate Derivatives of N-Acetyl-D-Glucosamine and Their Use in Controlled Drug Delivery. [Internet] [Thesis]. Old Dominion University; 2017. [cited 2018 Dec 14]. Available from: 9780355386226 ; https://digitalcommons.odu.edu/chemistry_etds/16.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garcia C. Characterization of 3-Ester and 3-Carbamate Derivatives of N-Acetyl-D-Glucosamine and Their Use in Controlled Drug Delivery. [Thesis]. Old Dominion University; 2017. Available from: 9780355386226 ; https://digitalcommons.odu.edu/chemistry_etds/16

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. DiDonato, Nicole. Alicyclic and Aromatic Carboxylic Acids in Soil Organic Matter: An Investigation of Potential Origin and Association with Plutonium Using Advanced Analytical Techniques.

Degree: PhD, Chemistry and Biochemistry, 2017, Old Dominion University

Carboxylic acids are a defining component of soil organic matter, responsible for many of the physical and chemical properties, including metal-organic matter interactions, which govern its role as an important constituent of soils. However, there is a shortage of detailed molecular level information regarding orientation and structural arrangement of carboxylic acids within soil organic matter. This dissertation utilizes electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICRMS) as well as solid-state and multi-dimensional nuclear magnetic resonance (NMR) to investigate the molecular formula composition within several organic matter sources and the primary structures that feature carboxylic acids. Soil organic matter is evaluated in two forms: as the alkali-soluble, acid-insoluble portion of organic matter (humic acids) from a collection of sources, as well as the alkali soluble soil organic material associated with high Fe and Pu metal concentrations at a contaminated munitions facility. Two predominant carboxyl-containing molecular assemblages are found to be common in a wide variety of soil humic acids. Along with lignin-like assemblages, these are carboxyl-containing aliphatic molecules (CCAM) and condensed aromatic molecules. The proportion of these groups relative to lignin-like compounds within samples and the percent of total carboxylic acid molecular formulas among samples are found to increase with increasing humification of the soil. Since CCAM and condensed aromatic molecules have previously been shown to be generated from oxidization of lignin, this represents renewed evidence for lignin as a major source of organic matter in soils. Lignin ring-opening and radical re-polymerization reactions have been proposed to form alicyclic CCAM and condensed aromatic molecules. Detailed evaluation of the aliphatic molecules using multi-dimensional NMR confirms the presence of ring structures, replete with carboxylic acids, heteroatom substitutions in the form of alcohols and ethers, as well as a variety of methyl group substituents. Additionally, condensed aromatic carboxylic acid molecular formulas, primarily those containing nitrogen, were found composed in organic matter with elevated metal ions Pu and Fe. Carboxylic acid oxygens in combination with nitrogen in aromatic structures are suspected to be partially responsible for the high metal affinity. Nitrogen-containing hydroxamate groups were also investigated for their potential to be incorporated into stable organic matter by testing the reaction between an amine-containing hydroxamate siderophore and the biopolymer cutin. While products of this reaction could not be confirmed, carboxylic acid functional groups are identified in this thesis as key molecular components contributing to Pu and Fe metal-binding attributes of organic matter, and potentially formed during the production of condensed aromatic and alicyclic compounds as a result of radical oxidation reactions of lignin. Advisors/Committee Members: Patrick G. Hatcher, Jingdong Mao, John Donat, Cary Schafran.

Subjects/Keywords: Carboxylic acid; ESI-FTICRMS; Humic acid; Lignin; NMR; Analytical Chemistry; Geochemistry; Soil Science

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

DiDonato, N. (2017). Alicyclic and Aromatic Carboxylic Acids in Soil Organic Matter: An Investigation of Potential Origin and Association with Plutonium Using Advanced Analytical Techniques. (Doctoral Dissertation). Old Dominion University. Retrieved from 9780355039313 ; https://digitalcommons.odu.edu/chemistry_etds/14

Chicago Manual of Style (16th Edition):

DiDonato, Nicole. “Alicyclic and Aromatic Carboxylic Acids in Soil Organic Matter: An Investigation of Potential Origin and Association with Plutonium Using Advanced Analytical Techniques.” 2017. Doctoral Dissertation, Old Dominion University. Accessed December 14, 2018. 9780355039313 ; https://digitalcommons.odu.edu/chemistry_etds/14.

MLA Handbook (7th Edition):

DiDonato, Nicole. “Alicyclic and Aromatic Carboxylic Acids in Soil Organic Matter: An Investigation of Potential Origin and Association with Plutonium Using Advanced Analytical Techniques.” 2017. Web. 14 Dec 2018.

Vancouver:

DiDonato N. Alicyclic and Aromatic Carboxylic Acids in Soil Organic Matter: An Investigation of Potential Origin and Association with Plutonium Using Advanced Analytical Techniques. [Internet] [Doctoral dissertation]. Old Dominion University; 2017. [cited 2018 Dec 14]. Available from: 9780355039313 ; https://digitalcommons.odu.edu/chemistry_etds/14.

Council of Science Editors:

DiDonato N. Alicyclic and Aromatic Carboxylic Acids in Soil Organic Matter: An Investigation of Potential Origin and Association with Plutonium Using Advanced Analytical Techniques. [Doctoral Dissertation]. Old Dominion University; 2017. Available from: 9780355039313 ; https://digitalcommons.odu.edu/chemistry_etds/14

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