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You searched for +publisher:"National University of Ireland – Galway" +contributor:("Thomas, Olivier P."). Showing records 1 – 2 of 2 total matches.

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1. Firsova, Daria. Combining biological and chemical approaches in marine biodiscovery.

Degree: 2017, National University of Ireland – Galway

Marine organisms are prolific producers of novel and structurally interesting metabolites. The identification of marine natural products contributes to many scientific areas including pharmacology, chemical ecology, chemical synthesis, and others. Today various methodologies are used to select marine organisms that potentially contain bioactive metabolites. In this thesis we used two different strategies to select promising marine organisms. The first strategy is the High Throughput Screening (HTS) of Irish marine organisms’ extracts against a cancer related target. With that purpose a library of 916 marine organisms’ extracts was composed, a colorectal cancer cell line resistant towards 5-fluorouracil was prepared and the HTS of the library was conducted on this target. Through this strategy, only one known structure was elucidated among the ‘hits’. Therefore, another methodology directed towards the construction of a marine chemical library was employed which was based on a selection of marine organisms using their taxonomy. The chemical investigation of species of the genus Haliclona yielded two new and six known compounds. Next, the taxonomy based selection was improved by addition of HPLC-DAD-ELSD chemical screening. The chemical screening of 27 sponges belonging to the order Haplosclerida from the Caribbean and Poecilosclerida order from Ireland, led to the selection of two sponges: Clathria strepsitoxa and Siphonodictyon coralliphagum. In total of 12 new compounds were isolated including interesting sesquiterpene (hydro)quinones together with four known compounds. In total, eight marine organisms were chemically investigated which led to the characterization of 14 new metabolites and 11 known. Methodologies towards selection of promising marine organisms for drug discovery are discussed. Advisors/Committee Members: Thomas, Olivier P..

Subjects/Keywords: Marine natural products; High throughput screening; Colorectal cancer; Chemical screening; Sponges; Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Firsova, D. (2017). Combining biological and chemical approaches in marine biodiscovery. (Thesis). National University of Ireland – Galway. Retrieved from http://hdl.handle.net/10379/6689

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Firsova, Daria. “Combining biological and chemical approaches in marine biodiscovery.” 2017. Thesis, National University of Ireland – Galway. Accessed October 19, 2019. http://hdl.handle.net/10379/6689.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Firsova, Daria. “Combining biological and chemical approaches in marine biodiscovery.” 2017. Web. 19 Oct 2019.

Vancouver:

Firsova D. Combining biological and chemical approaches in marine biodiscovery. [Internet] [Thesis]. National University of Ireland – Galway; 2017. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/10379/6689.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Firsova D. Combining biological and chemical approaches in marine biodiscovery. [Thesis]. National University of Ireland – Galway; 2017. Available from: http://hdl.handle.net/10379/6689

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


National University of Ireland – Galway

2. Mahajan, Nipun. Identification of bioactive natural products after screening Irish marine bio-resources.

Degree: 2016, National University of Ireland – Galway

According to the “Real Map of Ireland” published by Marine Institute, Ireland, the Nation marine territory has ten times more area than its land mass. Despite the well-studied and reported biodiversity present in Irish waters, the chemo-diversity of Irish marine invertebrates has been poorly investigated. The present thesis highlights the isolation of Marine Natural Products from different types of Irish marine organisms such as sponges, lichen, macroalgae, and marine fungi. The library of 864 extracts was prepared and subjected to antioxidant High Throughput Screening. Five most promising “hit” extracts were chemically investigated that led to the isolation of 8 novels and 16 known metabolites. Pygmaniline-A (I) and Pygmaniline-B (II), discovered from the most promising hit extract of lichen Lichina pygmaea are antioxidant and immunomodulatory in nature. The synthesis of I and II was carried out in a single step reaction with more than 85% yield. An additional integrated approach of Bioactivity-Chemical guided screening of 20 sponges was carried out that resulted in the isolation of two novel metabolites. Later, both the approaches are compared for in the interest of finding novel bioactive marine natural products.

2017-10-21

Advisors/Committee Members: Thomas, Olivier P., James Hardiman Research Scholarship.

Subjects/Keywords: Marine biodiscovery; Ireland; Lichen; Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mahajan, N. (2016). Identification of bioactive natural products after screening Irish marine bio-resources. (Thesis). National University of Ireland – Galway. Retrieved from http://hdl.handle.net/10379/6093

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mahajan, Nipun. “Identification of bioactive natural products after screening Irish marine bio-resources.” 2016. Thesis, National University of Ireland – Galway. Accessed October 19, 2019. http://hdl.handle.net/10379/6093.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mahajan, Nipun. “Identification of bioactive natural products after screening Irish marine bio-resources.” 2016. Web. 19 Oct 2019.

Vancouver:

Mahajan N. Identification of bioactive natural products after screening Irish marine bio-resources. [Internet] [Thesis]. National University of Ireland – Galway; 2016. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/10379/6093.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mahajan N. Identification of bioactive natural products after screening Irish marine bio-resources. [Thesis]. National University of Ireland – Galway; 2016. Available from: http://hdl.handle.net/10379/6093

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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