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You searched for +publisher:"NSYSU" +contributor:("Zhang Liyu"). One record found.

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NSYSU

1. Wu, Bao-Jueng. The molecular mechanisms of vascular malformation caused by zinc deficiency.

Degree: PhD, Marine Biotechnology and Resources, 2018, NSYSU

Zinc is an essential nutrient for all organisms because it is required as a structural and catalytic cofactor by hundreds of proteins. Zinc deficiency is associated with increased levels of lipid and protein oxidation. In addition, the oxidative stress associated with zinc deficiency leads to increased levels of DNA damage. One previous study showed zinc deficiency can cause oxidative stress in yeast. Similar studies in animal and mammalian cells also showed that zinc limitation leads to increased oxidative stress. Many studies have been shown the connection between oxidative stress and vascular diseases. However, most studies have done in adult animals under pathological conditions, and very limited information about oxidative stress and vascular development during embryogenesis. Zinc is important in several biological processes including growth and development. Recent study showed zinc transporter LIV1 (Zip6) is important for Epithelial-mesenchymal transition (EMT) during the development mediated by STAT3/Snail signalings. However, it has limited knowledge regarding to the molecular mechanism on the impact of zinc deficiency in the developing embryo due to a lack of suitable experimental models, and no report has been shown the effect of zinc deficiency in vascular development yet. Our preliminary data showed that zinc deficiency results in the defect in vascular development at intersegmental vessels (ISVs) and caudal vein plexus (CVP). In addition, vascular specific markers showed reduced or ectopic expression, suggested the impacts of zinc deficiency in vascular development. Understanding the effects of zinc deficiency in the developmental process will help us to prevent the prenatal zinc-related symptoms that might cause severe developmental malformation, such as acrodermatitis enteropathica (AE), infantile hemangioma. In addition, zinc depletion might serve as a new therapy for anti-angiogenesis related disease, such as cancer. Advisors/Committee Members: Jing-Ru Weng (chair), Wu, Chang-Yi (committee member), Wen Zhi-Hong (committee member), Zhang Liyu (chair), Chieh-Yu Pan (chair), Yao-Chang Chen (chair), Chien-Chih Chiu (chair).

Subjects/Keywords: caudal vein plexus; zinc deficiency; oxidative stress; zebrafish; vascular development; antioxidant gene; intersegmental vessels

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wu, B. (2018). The molecular mechanisms of vascular malformation caused by zinc deficiency. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0702118-143707

Chicago Manual of Style (16th Edition):

Wu, Bao-Jueng. “The molecular mechanisms of vascular malformation caused by zinc deficiency.” 2018. Doctoral Dissertation, NSYSU. Accessed May 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0702118-143707.

MLA Handbook (7th Edition):

Wu, Bao-Jueng. “The molecular mechanisms of vascular malformation caused by zinc deficiency.” 2018. Web. 08 May 2021.

Vancouver:

Wu B. The molecular mechanisms of vascular malformation caused by zinc deficiency. [Internet] [Doctoral dissertation]. NSYSU; 2018. [cited 2021 May 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0702118-143707.

Council of Science Editors:

Wu B. The molecular mechanisms of vascular malformation caused by zinc deficiency. [Doctoral Dissertation]. NSYSU; 2018. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0702118-143707

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