+publisher:"NSYSU" +contributor:("Yu-Liang Yang")

NSYSU

1. Wang, Yu-Ting. Anti-microbial Components from Marine-derived Streptomyces spp. Against Candida albicansis.

Degree: Master, Marine Biotechnology and Resources, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0809114-180628

► Marine actinobacteria was considered as potential sources of bioactive compounds. Many natural products research pioneers found lots of bioactive secondary metabolites with novel skeletons from… (more)

Subjects/Keywords: Anti-microbial Activity; Molecular Networking; Marinebacteria; Streptomyces spp.; Candida albicans

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Y. (2014). Anti-microbial Components from Marine-derived Streptomyces spp. Against Candida albicansis. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0809114-180628

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Yu-Ting. “Anti-microbial Components from Marine-derived Streptomyces spp. Against Candida albicansis.” 2014. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0809114-180628.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Yu-Ting. “Anti-microbial Components from Marine-derived Streptomyces spp. Against Candida albicansis.” 2014. Web. 23 Jan 2021.

Vancouver:

Wang Y. Anti-microbial Components from Marine-derived Streptomyces spp. Against Candida albicansis. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0809114-180628.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Y. Anti-microbial Components from Marine-derived Streptomyces spp. Against Candida albicansis. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0809114-180628

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

2. Hung, Er-mao. Studies on the Chemical Constituents of the Marine bacterium, Microbulbifer variabilis and Marine Fungus, Nemania maritima and Their Biological Activities.

Degree: Master, Marine Biotechnology and Resources, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720114-111443

► Marine organisms are regarded as an immense resource of diverse natural products for drug discovery and development, such as trabectedin from tunicate, marinisporolide A1 form… (more)

▼ Marine organisms are regarded as an immense resource of diverse natural products for drug discovery and development, such as trabectedin from tunicate, marinisporolide A1 form Marinispora sp. and so on. In our lab, we got symbiotic marine bacteria C-01 from Cerviconia sp, C-03 and C-07 from Palythoa sp., and C-05 from Npphates sp., respectively, in Wan-Li Tong, Pingtung County. Based on 16S rRNA gene sequencing analysis, they all were identified as Microbulbifer variabilis We compared with four Microbulbifer strains by HPLC-PDA-MS fractionations and the mass spectral molecular networking to explore relationship of secondary metabolites. We further explored the bioactive components from the C-03 by chromatographic methods. Till now, one new diketopiperazine 8, as well as ten 1~7, and 9~11, six nucleotides 12~17, one pyridine 18 one pyrrolidine 19, one benzoic acid 20 and, one phenazine 21, have been isolated from the ethyl acetate extract of M. variabilis C-03. We also explored marine fungus with Nemania maritima, belonging to genus Nemania. This fungus was isolated from the mangrove dead wood. We cultured N. maritima with PDA agar, and extracted the fungus with ethyl acetate. The extracts were subjected to traditional silica column chromatography and high performance liquid chromatography to give four compounds, including adenosine (22) barceloneic acid A (23), barceloneic acid B (24) and ergosterol peroxide (25). All the chemical structures were characterized by spectroscopic methods (UV, IR, NMR, and ESI-MS). We test three kind of bioactive test about anti-bacterial, anti-virus (hepatitis C virus and dengue virus). Compound 21 showed significant anti-microbial activity against to Staphyloccocus aureus and Bacillus cereus with the same minimum inhibitory concentration (MIC) value of 8 Î¼g/mL. In addition, the antiviral test revealed that against hepatitis C virus with SI (CC50/EC50) value of 21 was 4.06. The SI values of 5, 6, 10, 12 and 13 against dengue virus were 5.89ã7.41ã8.92ã13.33, and 8.19, respectively. In addition, the compounds of 24 and 25 did not find the relevant reports in past literature about anti-virus activity. Anti-bacterial and anti-virus (hepatitis C virus) have not significant inhibitory effect, but we find compound of 24 and 25 exerted inhibitory effect against dengue virusâs with SI (CC50/EC50) values of 4.67 and 9.52, respectively. Advisors/Committee Members: Chih-Chuang Liaw (committee member), Jyh-horng Sheu (chair), Liang%20Yang%22%29&pagesize-30">Yu-Liang Yang (chair).

Subjects/Keywords: Microbulbifer variabilis; anti-microbial activity; Hepatitis C virus; Nemania maritima; mass spectral molecular networking; Dengue virus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hung, E. (2014). Studies on the Chemical Constituents of the Marine bacterium, Microbulbifer variabilis and Marine Fungus, Nemania maritima and Their Biological Activities. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720114-111443

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hung, Er-mao. “Studies on the Chemical Constituents of the Marine bacterium, Microbulbifer variabilis and Marine Fungus, Nemania maritima and Their Biological Activities.” 2014. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720114-111443.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hung, Er-mao. “Studies on the Chemical Constituents of the Marine bacterium, Microbulbifer variabilis and Marine Fungus, Nemania maritima and Their Biological Activities.” 2014. Web. 23 Jan 2021.

Vancouver:

Hung E. Studies on the Chemical Constituents of the Marine bacterium, Microbulbifer variabilis and Marine Fungus, Nemania maritima and Their Biological Activities. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720114-111443.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hung E. Studies on the Chemical Constituents of the Marine bacterium, Microbulbifer variabilis and Marine Fungus, Nemania maritima and Their Biological Activities. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720114-111443

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

3. Aqib Raza Khan, Mo. Studies on the Chemical Components of Marine-Derived Fungus, Aspergillus terreus and Their Biological Activities.

Degree: Master, Marine Biotechnology and Resources, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0801116-154952

► Abstract Marine microbes are regarded as one of the worthiest treasures for bioactive chemical Scaffolds. To search for anti-microbial secondary metabolites from marine environment, we… (more)

▼ Abstract Marine microbes are regarded as one of the worthiest treasures for bioactive chemical Scaffolds. To search for anti-microbial secondary metabolites from marine environment, we isolated a marine-derived fungus Aspergillus terreus (MB14-HBr) from the sponge Haliclona species, Collected from Dongsha Atoll, Taiwan in May 2014. The isolated fungus was further cultured in laboratory and fungal metabolites were extracted by ethyl acetate (EtOAc). Preliminary anti-microbial assay indicated that EtOAc extract of MB14-HBr could inhibit the bacterial pathogen Acinetobacter baumannii and the fungal one Candida albicans, respectively. Besides interestingly, we also discovered that the crude EtOAc extract, fraction as well as pure compounds including dihydrogeodin (A-01), butryolactone II (A-02), Butryolactone I (A-06), Terrelumamide A (A-11) and Methyl 3,4,5-trimethoxy-2-(2-nicotinamido)benzamido)benzoate (A-15) exhibited siderophore-like (iron-chelating) effects in Chrome-azurol S (CAS) assay. Due to natural iron clutching properties of sidherophores, they have impending applications in cancer chemotherapy. Acinetobacter baumannii is an opportunistic human pathogen which is easy mutant to be several clinical antibiotics and very famous due to cause of nosocomial infection in human. Moreover, three compounds, butryolactone II (A-02), Butryolactone I (A-06) and methyl 3, 5 dichloro-asterric acid (A-03) showed activity in luciferase assay, suggested that these components might block Transforming Growth Factor (TGF)-Î²-induced transcriptional responses. The objective of this study is to isolate the bioactive components from the strain Aspergillus terreus. In order to isolate bioactive components, the EtOAc extract was subjected to Sephadex LH-20 column chromatography and reversed phase high performance liquid chromatography. As a result, a total of fifteen known compounds have been isolated from this fungal extract, including dihydrogeodin (A-01) butryolactoneII (A-02), methyl 3,5 dichloro-asterrric acid (A-03), 3R-methyl-6-hydroxy-8-methoxy isocoumarin (A-04), terretonin C (A-05), butryolactone I (A-06), geodin hydrate (A-07), 6,7-dimethoxy-4-hydroxymellein (A-08), butryolactone V (A-09), asterric acid (A-10), terrein (A-12) asterrelenin (A-13), terretonin (A-14) and methyl 3,4,5-trimethoxy-2-(2-nicotinamido)benzamido)benzoate (A-15). Moreover, we isolated one are peptide named terrelumamide-A (A-11). The structures of these isolates were elucidated on the basis of 1D and 2D NMR, Mass spectrometry, as well as literature data. Key words: Aspegillus terreus, Anti-microbial activity, Acinetobacter baumannii, luciferase assay activity, MTS cell viability effect, Iron chelating effects. Advisors/Committee Members: Jyh-Horng Sheu (chair), Liang%20Yang%22%29&pagesize-30">Yu-Liang Yang (chair), Chih-Chuang Liaw (committee member), Jyh-Horng Sheu (chair).

Subjects/Keywords: luciferase assay activity; Acinetobacter baumannii; Anti-microbial activity; Aspegillus terreus; MTS cell viability effect; Iron chelating effects

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aqib Raza Khan, M. (2016). Studies on the Chemical Components of Marine-Derived Fungus, Aspergillus terreus and Their Biological Activities. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0801116-154952

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Aqib Raza Khan, Mo. “Studies on the Chemical Components of Marine-Derived Fungus, Aspergillus terreus and Their Biological Activities.” 2016. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0801116-154952.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Aqib Raza Khan, Mo. “Studies on the Chemical Components of Marine-Derived Fungus, Aspergillus terreus and Their Biological Activities.” 2016. Web. 23 Jan 2021.

Vancouver:

Aqib Raza Khan M. Studies on the Chemical Components of Marine-Derived Fungus, Aspergillus terreus and Their Biological Activities. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0801116-154952.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aqib Raza Khan M. Studies on the Chemical Components of Marine-Derived Fungus, Aspergillus terreus and Their Biological Activities. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0801116-154952

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

4. Cheng, Po-yi. Study on the Chemical Constituents of Marine-Derived Fungus, Fusarium solani and Their Biological Activities.; Study on the Synthesis of Vitroprocines and Its Derivatives.

Degree: Master, Marine Biotechnology and Resources, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0724116-095035

► Part 1 When searching the novel anti-microbial secondary metabolites from marine-derived fungus. We found a symbiotic fungus, Fusarium solani (FS-01), isolated from a Palythoa sp.,… (more)

Subjects/Keywords: marine fungus; Fusarium solani; Bacillus cereus; cytotoxicity; oral cancer; natural product; amino-polyketide derivatives; antibiotics; marine Vibrio sp.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cheng, P. (2016). Study on the Chemical Constituents of Marine-Derived Fungus, Fusarium solani and Their Biological Activities.; Study on the Synthesis of Vitroprocines and Its Derivatives. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0724116-095035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cheng, Po-yi. “Study on the Chemical Constituents of Marine-Derived Fungus, Fusarium solani and Their Biological Activities.; Study on the Synthesis of Vitroprocines and Its Derivatives.” 2016. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0724116-095035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cheng, Po-yi. “Study on the Chemical Constituents of Marine-Derived Fungus, Fusarium solani and Their Biological Activities.; Study on the Synthesis of Vitroprocines and Its Derivatives.” 2016. Web. 23 Jan 2021.

Vancouver:

Cheng P. Study on the Chemical Constituents of Marine-Derived Fungus, Fusarium solani and Their Biological Activities.; Study on the Synthesis of Vitroprocines and Its Derivatives. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0724116-095035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cheng P. Study on the Chemical Constituents of Marine-Derived Fungus, Fusarium solani and Their Biological Activities.; Study on the Synthesis of Vitroprocines and Its Derivatives. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0724116-095035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

5. Chen, Yi-yu. Studies on the Chemical Constituents of the Marine Derived fungi, Trichoderma atroviride and T.reesi and Their Biological Activities.

Degree: Master, Marine Biotechnology and Resources, 2015, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720115-110035

► Acinetobacter baumannii is an opportunistic pathogen, which easily develop a drug-resistant strain and is liable to spread and increase the mortality in the hospital.Therefore, to… (more)

▼ Acinetobacter baumannii is an opportunistic pathogen, which easily develop a drug-resistant strain and is liable to spread and increase the mortality in the hospital.Therefore, to develop new antibiotics to treat the patients with infection by A. baumannii became an important research object. On the other hand, marine microorganisms develop a series of specific organic-ligand systems to assist them harvest iron, zinc, and other trace metals to survive in the trace metals-insufficient seawater environments. These organic ligands are species-specific to influence the growth of other microorganisms by scavenging environmental trace metals. Such ligands can be also regarded as anti-microbial components to treat patients infected with pathogens. To search novel anti-microbial secondary metabolites from marine microorganisms, we found that two marine fungi, Trichoderma reesi (MR13-TR01) and T. atroviride (MR13-TA01), isolated from a sponge Niphates collected from Wan-Li Tong, Pingtung County, showed clearly good inhibitory effects against eight bacterial indicators and one fungal indicator, especially for A. baumannii. Both also showed the iron-chelating effect by the Chrome azurol S (CAS) assay. Through the bioactivity-guided fractionation isolation (BGFI), we isolated four new peptaibols, as well as 16 known compounds, including four peptaibols, five polyketides, two known diketopiperazines, two sesquiterpenes, one alitol, one nucleoside, and one disaccharide, from the extracts of the two marine fungi. The structures of the compounds mentioned above were elucidated by spectroscopic (UV, IR, CD, NMR, HRESI-MS) and chemical methods. In addition, eight peptaibols showed inhibitory effect against A. baumannii, especially for compound 1. And some of them also had the clear iron-chelating effect by the CAS assay. In addition to the compound 5 had a great activity for the oral cancer cell CAL 27, and the IC50 = 13.0 ug/mLã Advisors/Committee Members: Liang%20Yang%22%29&pagesize-30">Yu-Liang Yang (chair), Fang-Rong Chang (chair), Cheng-Yeh Duh (chair), Chih-Chuang Liaw (committee member), Jhy-Horng Sheu (chair).

Subjects/Keywords: Acinetobacter baumannii; Trichoderma spp.; peptaibol; mass spectral molecular networking; oral cancer; cytotoxic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, Y. (2015). Studies on the Chemical Constituents of the Marine Derived fungi, Trichoderma atroviride and T.reesi and Their Biological Activities. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720115-110035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Yi-yu. “Studies on the Chemical Constituents of the Marine Derived fungi, Trichoderma atroviride and T.reesi and Their Biological Activities.” 2015. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720115-110035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Yi-yu. “Studies on the Chemical Constituents of the Marine Derived fungi, Trichoderma atroviride and T.reesi and Their Biological Activities.” 2015. Web. 23 Jan 2021.

Vancouver:

Chen Y. Studies on the Chemical Constituents of the Marine Derived fungi, Trichoderma atroviride and T.reesi and Their Biological Activities. [Internet] [Thesis]. NSYSU; 2015. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720115-110035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen Y. Studies on the Chemical Constituents of the Marine Derived fungi, Trichoderma atroviride and T.reesi and Their Biological Activities. [Thesis]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0720115-110035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

6. Chang, Yu-Chia. Chemical Constituents and Their Bioactivities from a Formosan Gorgonian Coral Pinnigorgia sp.

Degree: PhD, Doctoral Degree Program in Marine Biotechnology, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0714116-223033

► Studies on the chemical constituents of a gorgonian coral identified as Pinnigorgia sp. have resulted in the isolation of 5 new 4,5;5,6;9,11-triseco-4(5â6),5(6â7)-diabeo-ergostane, pinnigorgiols AâE (1â5);… (more)

▼ Studies on the chemical constituents of a gorgonian coral identified as Pinnigorgia sp. have resulted in the isolation of 5 new 4,5;5,6;9,11-triseco-4(5â6),5(6â7)-diabeo-ergostane, pinnigorgiols AâE (1â5); 11 new 9,11-secosteroids, pinnisterols AâK (6â16); five new sterols, (22R)-24-methyl-5-ene-3Î²-ol-22-acetate (17), (22E,24R)- ergosta-5,22-diene-3Î²,11Î±-diol (18), (24S)-ergosta-5-ene-3Î²,11Î±-diol (19), 5Î±,6Î±- epoxy-23-demethylgorgost-8(14)-ene-3Î²,7Î±-diol (20), 5Î±,6Î±-epoxy-23-demethyl- gorgost-8-ene-3Î²,7Î±-diol (21); and six known compounds, cerevisterol (22), 23-demethylgorgost-7-ene-3,5,6-triol (23), ergosterol peroxide (24), (22R,23R,24R)-5,8-epidioxy-22,23-methylene-24-methylcholest-6-en-3-ol (25), apo-9â²-fucoxanthinone (26), and pubinernoid A (27). The structures of each metabolite were determined by spectroscopic methods, particular by the 1D and 2D NMR experiments. The configurations of metabolite 1â5 were further confirmed by comparative analysis of circular dichroism spectroscopic data. Each metabolite was screened for anti-hepatofibric and anti-inflammatory activities. Metabolites 1, 2, 4â6, 9, 10, 12, 13, and 23 were found to exhibit cytotoxicity in HSC-T6. Activation of hepatic stellate cells (HSCs) plays a major role in liver fibrosis. During liver fibrosis, extracellular matrix proteins and pro-inflammatory growth factors are overexpressed by activated HSCs. Clearance of activated HSCs by inducing apoptosis is an efficient way to treat liver fibrosis. In the anti-inflammation assay, compounds 1â6, 8, 9, 12, and 15 inhibited the production of superoxide anion and decreased the release of elastase in the human neutrophils that stimulated by formyl-L-methionyl-L-leucyl- L-phenylalanine/cytochalasin B (fMLP/CB). The metabolite 13 only caused the inhibit superoxide anion generation, while the compounds 11 and 26 only resulted in inhibition of elastase release in human neutrophils. Although numerous studies have attempted to characterize marine bioactive compounds with the aim of curing human diseases, the focus on liver diseases is very limited. Further biomedical investigation of the 9,11-secosteroids may warrant the application to be promising bioactive agents for liver disease. Advisors/Committee Members: Liang%20Yang%22%29&pagesize-30">Yu-Liang Yang (chair), Ping-Jyun Sung (committee member), Fang-Rong Chang (chair), Yang-Chang Wu (chair), Ching-Kuo Lee (chair), Chain-Shing Lin (committee member), Yueh-Hsiung Kuo (chair).

Subjects/Keywords: 9,11-secosteroid; anti-inflammatory; anti-hepatofibric; Pinnigorgia; marine drugs

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chang, Y. (2016). Chemical Constituents and Their Bioactivities from a Formosan Gorgonian Coral Pinnigorgia sp. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0714116-223033

Chicago Manual of Style (16^th Edition):

Chang, Yu-Chia. “Chemical Constituents and Their Bioactivities from a Formosan Gorgonian Coral Pinnigorgia sp.” 2016. Doctoral Dissertation, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0714116-223033.

MLA Handbook (7^th Edition):

Chang, Yu-Chia. “Chemical Constituents and Their Bioactivities from a Formosan Gorgonian Coral Pinnigorgia sp.” 2016. Web. 23 Jan 2021.

Vancouver:

Chang Y. Chemical Constituents and Their Bioactivities from a Formosan Gorgonian Coral Pinnigorgia sp. [Internet] [Doctoral dissertation]. NSYSU; 2016. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0714116-223033.

Council of Science Editors:

Chang Y. Chemical Constituents and Their Bioactivities from a Formosan Gorgonian Coral Pinnigorgia sp. [Doctoral Dissertation]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0714116-223033

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