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You searched for +publisher:"NSYSU" +contributor:("Yaw-Bin Huang"). One record found.

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NSYSU

1. Chen, Chun-Yu. The role of betulinic acid in modulation of membrane microdomains and TGF-β signaling.

Degree: Master, Biological Sciences, 2015, NSYSU

Betulinic acid (BetA) is a phytochemical triterpenoid acid from bark extracts and is cytotoxic to cancer cells and tumors. The specific subcellular receptors that are bound or deactivated by BetA have not been extensively investigated or identified. The goal of this study is to investigate the effect of BetA in transforming growth factor β (TGF-β) signaling. TGF-β is a key modulator in regulating cell proliferation and migration, it also involved in the process of cancer development and progression. TGF-β regulates tumor cell proliferation and invasion through a variety of Smad-dependent and -independent pathways. In most of cells, TGF-β receptors were located predominantly in lipid raft/caveolae microdomains, determined using sucrose density gradient ultracentrifugation and Western blot. BetA induces translocation of TGF-β receptors from lipid raft/caveolae to non-caveolae microdomains without changing total level of TGF-β receptors. Distribution of TGF-β receptors between lipid raft/caveolae- and clathrin-mediated endocytosis has been found to regulate TGF-β responsiveness. Most notably, BetA-induced TGF-β receptors translocation is rapid and correlate with the TGF-β-induced signaling. Here, we provide for the first the time evidence that BetA enhanced TGF-β signaling is associated with translocation of TGF-β receptors out of lipid raft/caveolae microdomains and a dramatic increase in the ability of TGF-β to stimulate Smad2 phosphorylation. Moreover, BetA-induced redistribution of TGF-β receptors also enhances TGF-β -induced PAI-1 reporter gene activation and growth inhibition in Mv1Lu cells. These results implicated that anticancer activities of BetA may be due, in part to the enhancing of TGF-β receptor signaling in non-caveolae microdomains in plasma membrane. Advisors/Committee Members: Jenq-Lin Yang (chair), Yaw-Bin Huang (chair), Chen, Chun-Lin (committee member).

Subjects/Keywords: cholesterol; TGF-beta; caveolae; lipid-raft; Betulinic acid

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chen, C. (2015). The role of betulinic acid in modulation of membrane microdomains and TGF-β signaling. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0624115-165153

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Chen, Chun-Yu. “The role of betulinic acid in modulation of membrane microdomains and TGF-β signaling.” 2015. Thesis, NSYSU. Accessed April 19, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0624115-165153.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Chen, Chun-Yu. “The role of betulinic acid in modulation of membrane microdomains and TGF-β signaling.” 2015. Web. 19 Apr 2021.

Vancouver:

Chen C. The role of betulinic acid in modulation of membrane microdomains and TGF-β signaling. [Internet] [Thesis]. NSYSU; 2015. [cited 2021 Apr 19]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0624115-165153.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen C. The role of betulinic acid in modulation of membrane microdomains and TGF-β signaling. [Thesis]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0624115-165153

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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