+publisher:"NSYSU" +contributor:("Wen, Zhi-Hong")

NSYSU

1. Li, Chi-min. The effects of compounds obtained from Formosa soft coral on carrageenan-induced inflammation in rats.

Degree: Master, Marine Biotechnology and Resources, 2011, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0830111-153126

► In recent years, studies have increasingly recognized that many natural products with biological activity have been isolated from marine organisms, while the chemical structures are… (more)

▼ In recent years, studies have increasingly recognized that many natural products with biological activity have been isolated from marine organisms, while the chemical structures are very different from those of land-based organisms. Therefore, the ocean is a natural drug source. Regarding drug screening, anti-inflammatory activity has become a key point, and many studies confirm that inflammation plays an important role in many human diseases. Many different compounds are now in the clinical evaluation stage. However, the inflammation-related diseases being closely linked, there is an urgent need to study the anti-inflammatory effects as well as screen the therapeutic drugs for research and development. In this study, we isolated and purified compounds from Formosan gorgonian (Briareum excavatum) and Formosan soft coral (Lobophytum sarcophytoides) and investigated biological activities. We confirmed that the natural compound Brei from B. excavatum and the compounds Sac-1 and Sac-2 from L. sarcophytoides produced significant inhibition of the proinflammatory proteins inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-induced murine macrophages (RAW 264.7) cell model. We examined in vivo whether the B. excavatum Brei has anti-inflammatory and antinociceptive effects by using the carrageenan-induced inflammation model. Using the paw-edema assay, we performed several important investigations such as the plantar analgesia test, mechanical hyperalgesia test (allodynia), and weight-bearing analysis of animal behavior to evaluate the degree of pain and inflammation. Our results demonstrate that the natural product Brei can reduce paw-pad swelling, thermal hyperalgesia, threshold latency, and improve the affected limb in the carrageenan-induced inflammatory model. In the histopathology analysis, we showed that Brei significantly inhibited the aggregation and infiltration of inflammation-related blood cells and improved the inflammatory status of the tissues. Therefore, the marine natural compound Brei has anti-inflammatory activity and it can be used as a therapeutic compound for acute inflammation in the near future. Advisors/Committee Members: Hong%22%29&pagesize-30">Wen Zhi-Hong (committee member), Wang Hui-Min (chair), Jean Ten-Hsuan (chair).

Subjects/Keywords: antinociceptive; anti-inflammatory; lipopolysaccharide; inducible nitric oxide synthase; cycloxygenase-2; carrageenan

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, C. (2011). The effects of compounds obtained from Formosa soft coral on carrageenan-induced inflammation in rats. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0830111-153126

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Chi-min. “The effects of compounds obtained from Formosa soft coral on carrageenan-induced inflammation in rats.” 2011. Thesis, NSYSU. Accessed April 14, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0830111-153126.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Chi-min. “The effects of compounds obtained from Formosa soft coral on carrageenan-induced inflammation in rats.” 2011. Web. 14 Apr 2021.

Vancouver:

Li C. The effects of compounds obtained from Formosa soft coral on carrageenan-induced inflammation in rats. [Internet] [Thesis]. NSYSU; 2011. [cited 2021 Apr 14]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0830111-153126.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li C. The effects of compounds obtained from Formosa soft coral on carrageenan-induced inflammation in rats. [Thesis]. NSYSU; 2011. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0830111-153126

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

2. Yang, Pei-hua. Study the mechanisms of Pentabromophenol in the modulation of TGF-Î² signaling.

Degree: Master, Biological Sciences, 2017, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715117-084334

► Pentabromophenol (PBP), a brominated flame retardant (BFR), is widely used in various consumer products. BFRs exert adverse health effects such as neurotoxic and endocrine-disrupting effects.… (more)

Subjects/Keywords: BFR; EMT; Smad; TGF-Î²; PBP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, P. (2017). Study the mechanisms of Pentabromophenol in the modulation of TGF-Î² signaling. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715117-084334

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yang, Pei-hua. “Study the mechanisms of Pentabromophenol in the modulation of TGF-Î² signaling.” 2017. Thesis, NSYSU. Accessed April 14, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715117-084334.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yang, Pei-hua. “Study the mechanisms of Pentabromophenol in the modulation of TGF-Î² signaling.” 2017. Web. 14 Apr 2021.

Vancouver:

Yang P. Study the mechanisms of Pentabromophenol in the modulation of TGF-Î² signaling. [Internet] [Thesis]. NSYSU; 2017. [cited 2021 Apr 14]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715117-084334.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yang P. Study the mechanisms of Pentabromophenol in the modulation of TGF-Î² signaling. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715117-084334

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

3. Kao, Yu-Chen. Study the effects of Dibromotyrosine Derivative in TGF-Î² responsiveness.

Degree: Master, Biological Sciences, 2017, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0718117-194840

► The Transforming growth factor Î²1 (TGF-Î²1) is belong to transforming growth factor superfamily. Many tumor lesions process are related to TGF-Î²1, such as: cell proliferation,… (more)

▼ The Transforming growth factor Î²1 (TGF-Î²1) is belong to transforming growth factor superfamily. Many tumor lesions process are related to TGF-Î²1, such as: cell proliferation, extracellular matrix secretion, cell attachment, movement, differentiation and apoptosis. TGF-Î²1 cell signaling via two protein receptors on membrane which are Type I TGF-Î² receptor (TÎ²R-I) and Type II TGF-Î² receptor (TÎ²R-II). TGF-Î² is activated that lead smad2/3 to phosphorylation, and p-Smad2/3 will transfer to nuclear than regulates the transcription of the target gene with other transcription factor. At cancer early stage, TGF-Î² will use inhibit cell proliferation and promote cell apoptosis to inhibit cancer growth, but at cancer late stage,instead, TGF-Î² will promote cancer cell growth, invasion, transfer and help it to escape the immune system attack. There are some small molecule inhibitors which can inhibit TGF-Î² cell signal transduction have great value at cancer research. Small molecule inhibitor is a powerful tool in research of signal transduction pathway interaction. In this study, we found (1â²R,5â²S,6â²S)-2-(3â²,5â²- dibromo-1â²,6â²-dihydroxy-4â²-oxocyclohex-2â²-enyl) acetonitrile (DT), a bromotyrosine derivate from Pseudoceratina sp., which inhibits the TÎ²R-I serine/threonine kinase then inhibits TGF-Î² downstream cell signaling. We use such as: luciferase activity assay, western blotting, wound healing assay, in vitro ALK5 kinase assay etc. to know the effect of DT on TGF-Î² cell signaling, and use epithelial cells to study of the inhibitory effects of DT on TGF-Î²-induced Smad signaling and epithelial-to-mesenchymal transition. We also confirmed the new ALK5 inhibitor can effectively inhibit TGF-Î² stimulate smad2/3 to phosphorylation and inhibit smad2/3 transfer to nuclear. In addition, DT also can inhibit TGF-Î² stimulate epithelial-to-mesenchymal transition and A549 cell metastasis. Our study showed DT can apply to treatment of fibrotic diseases and cancer in the future. Advisors/Committee Members: Wu, Chang-Yi (chair), Chien-Chih Chiu (chair), Hong%22%29&pagesize-30">Wen Zhi-Hong (chair), (Chen, Chun-Lin (committee member).

Subjects/Keywords: TGF-Î²; bromotyrosine derivative; small molecular inhibitors; epithelial-to-mesenchymal transition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kao, Y. (2017). Study the effects of Dibromotyrosine Derivative in TGF-Î² responsiveness. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0718117-194840

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kao, Yu-Chen. “Study the effects of Dibromotyrosine Derivative in TGF-Î² responsiveness.” 2017. Thesis, NSYSU. Accessed April 14, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0718117-194840.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kao, Yu-Chen. “Study the effects of Dibromotyrosine Derivative in TGF-Î² responsiveness.” 2017. Web. 14 Apr 2021.

Vancouver:

Kao Y. Study the effects of Dibromotyrosine Derivative in TGF-Î² responsiveness. [Internet] [Thesis]. NSYSU; 2017. [cited 2021 Apr 14]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0718117-194840.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kao Y. Study the effects of Dibromotyrosine Derivative in TGF-Î² responsiveness. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0718117-194840

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

4. Liu, Yu-Ting. The Surface Recognition on the VLPs of Dragon Grouper Nervous Necrosis Virus by its Antibodies.

Degree: Master, Marine Biotechnology and Resources, 2011, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909111-114035

► Grouper in Taiwan is of high value, but nervous necrosis virus infection causes 100% mortality. Our laboratory had developed a good expression system to produce… (more)

Subjects/Keywords: grouper nervous necrosis virus; monoclone antibody; virus-like particles; hybridoma; ascites

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, Y. (2011). The Surface Recognition on the VLPs of Dragon Grouper Nervous Necrosis Virus by its Antibodies. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909111-114035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Yu-Ting. “The Surface Recognition on the VLPs of Dragon Grouper Nervous Necrosis Virus by its Antibodies.” 2011. Thesis, NSYSU. Accessed April 14, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909111-114035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Yu-Ting. “The Surface Recognition on the VLPs of Dragon Grouper Nervous Necrosis Virus by its Antibodies.” 2011. Web. 14 Apr 2021.

Vancouver:

Liu Y. The Surface Recognition on the VLPs of Dragon Grouper Nervous Necrosis Virus by its Antibodies. [Internet] [Thesis]. NSYSU; 2011. [cited 2021 Apr 14]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909111-114035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu Y. The Surface Recognition on the VLPs of Dragon Grouper Nervous Necrosis Virus by its Antibodies. [Thesis]. NSYSU; 2011. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909111-114035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

5. Tsui, Kuan-Hao. Effects of dehydroepiandrosterone supplementation on clinical outcomes and cumulus cells gene expression in women with poor ovarian response.

Degree: PhD, Biological Sciences, 2015, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0613115-115441

► The aim of the study was to investigate the effects of dehydroepiandrosterone (DHEA) supplementation on IVF (In vitro fertilization) outcomes and the gene expression of… (more)

▼ The aim of the study was to investigate the effects of dehydroepiandrosterone (DHEA) supplementation on IVF (In vitro fertilization) outcomes and the gene expression of cumulus cells (CCs) in patients with poor ovarian response (POR). This was a prospective self-controlled study, including ten patients with POR. All women received DHEA supplementation (30 mg, t.i.d.) for around 3 months before starting the a new IVF cycle. Biochemical, ultrasound parameters and treatment outcomes were determined before and after DHEA therapy. Moreover, CCs were isolated to examine the gene expression level of nine genes, including Hyaluronan synthase (HAS2), Versican (VCAN), Thrombospondin 1 (THBS1), Runt-related transcription factor 2 (RUNX2), Chromobox homolog 3 (CBX3), Tripartite motif-containing 28 (TRIM28), B-cell lymphoma 2 (BCL2), BCL2-associated X protein (BAX), Ankyrin repeat domain 57 (ANKRD57), Syndecan 4 (SDC4), Activated leukocyte cell adhesion molecule (ALCAM), Gremlin 1 (GREM1), Prostaglandin-endoperoxide synthase 1 (PTGS1), Prostaglandin-endoperoxide synthase 2 (PTGS2), Sprouty homolog 4 (SPRY4), Coagulation factor II receptor-like 1 (F2RL1), Ribosomal protein S6 kinase, polypeptide 2 (RPS6KA2), solute carrier family 38, member 2 (SLC38A2), YTH domain familyï¼member 2 (YTHDF2), Cytochrome oxidase 17 (COX17), E3 ubiquitin protein ligase (UBR3), Krueppel-like factor 4 (KLF4), prostaglandin E receptor 2 (PTGER2), exostoses 1 (EXT1) by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). It showed significant changes in day 3 follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC) and Anti-MÃ¼llerian Hormone (AMH) (p < 0.0001, < 0.0001, < 0.05 and < 0.001, respectively), as well as number of oocytes retrieved, fertilized oocytes, day 3 embryos, transferred embryos (p < 0.0001, < 0.0001, < 0.05 and < 0.001, respectively) after DHEA therapy. In addition, the gene expression levels of extracellular matrix (ECM), including HAS2, VCAN, THBS1, showed significant increase after DHEA treatment. Although the gene expression levels of BCL2 and BAX, which are apoptotic genes, showed decrease; however, BCL2/BAX ratio elevated significantly, suggested that DHEA may play a role in anti-apoptosis. The study demonstrated that DHEA shows benefit for artificial reproductive outcomes and upregulates the gene expression of CCs in POR patients. Advisors/Committee Members: Chen Chun-Lin (chair), Hong%22%29&pagesize-30">Wen Zhi-Hong (chair), Cheng Jiin-Tsuey (committee member), Chang Shiuh-Young (chair), Wang Peng-Hui (chair).

Subjects/Keywords: DHEA; cumulus cells; Dehydroepiandrosterone; diminished ovarian reserve

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tsui, K. (2015). Effects of dehydroepiandrosterone supplementation on clinical outcomes and cumulus cells gene expression in women with poor ovarian response. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0613115-115441

Chicago Manual of Style (16^th Edition):

Tsui, Kuan-Hao. “Effects of dehydroepiandrosterone supplementation on clinical outcomes and cumulus cells gene expression in women with poor ovarian response.” 2015. Doctoral Dissertation, NSYSU. Accessed April 14, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0613115-115441.

MLA Handbook (7^th Edition):

Tsui, Kuan-Hao. “Effects of dehydroepiandrosterone supplementation on clinical outcomes and cumulus cells gene expression in women with poor ovarian response.” 2015. Web. 14 Apr 2021.

Vancouver:

Tsui K. Effects of dehydroepiandrosterone supplementation on clinical outcomes and cumulus cells gene expression in women with poor ovarian response. [Internet] [Doctoral dissertation]. NSYSU; 2015. [cited 2021 Apr 14]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0613115-115441.

Council of Science Editors:

Tsui K. Effects of dehydroepiandrosterone supplementation on clinical outcomes and cumulus cells gene expression in women with poor ovarian response. [Doctoral Dissertation]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0613115-115441

NSYSU

6. Kao, Chien-Jen. The neuroprotective effects of modifying soft coral-derived compound.

Degree: PhD, Marine Biotechnology and Resources, 2018, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0504118-094049

► Previous studies have demonstrated that the marine compound austrasulfone, isolated from the soft coral Cladiella australis, exerts a neuroprotective effect. The intermediate product in the… (more)

Subjects/Keywords: 1-tosylpentan-3-one; SH-SY5Y cells; zebrafish; 6-OHDA-induced apoptosis; marine compounds; neuroprotection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kao, C. (2018). The neuroprotective effects of modifying soft coral-derived compound. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0504118-094049

Chicago Manual of Style (16^th Edition):

Kao, Chien-Jen. “The neuroprotective effects of modifying soft coral-derived compound.” 2018. Doctoral Dissertation, NSYSU. Accessed April 14, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0504118-094049.

MLA Handbook (7^th Edition):

Kao, Chien-Jen. “The neuroprotective effects of modifying soft coral-derived compound.” 2018. Web. 14 Apr 2021.

Vancouver:

Kao C. The neuroprotective effects of modifying soft coral-derived compound. [Internet] [Doctoral dissertation]. NSYSU; 2018. [cited 2021 Apr 14]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0504118-094049.

Council of Science Editors:

Kao C. The neuroprotective effects of modifying soft coral-derived compound. [Doctoral Dissertation]. NSYSU; 2018. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0504118-094049

NSYSU

7. Wu, Bao-Jueng. The molecular mechanisms of vascular malformation caused by zinc deficiency.

Degree: PhD, Marine Biotechnology and Resources, 2018, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0702118-143707

► Zinc is an essential nutrient for all organisms because it is required as a structural and catalytic cofactor by hundreds of proteins. Zinc deficiency is… (more)

▼ Zinc is an essential nutrient for all organisms because it is required as a structural and catalytic cofactor by hundreds of proteins. Zinc deficiency is associated with increased levels of lipid and protein oxidation. In addition, the oxidative stress associated with zinc deficiency leads to increased levels of DNA damage. One previous study showed zinc deficiency can cause oxidative stress in yeast. Similar studies in animal and mammalian cells also showed that zinc limitation leads to increased oxidative stress. Many studies have been shown the connection between oxidative stress and vascular diseases. However, most studies have done in adult animals under pathological conditions, and very limited information about oxidative stress and vascular development during embryogenesis. Zinc is important in several biological processes including growth and development. Recent study showed zinc transporter LIV1 (Zip6) is important for Epithelial-mesenchymal transition (EMT) during the development mediated by STAT3/Snail signalings. However, it has limited knowledge regarding to the molecular mechanism on the impact of zinc deficiency in the developing embryo due to a lack of suitable experimental models, and no report has been shown the effect of zinc deficiency in vascular development yet. Our preliminary data showed that zinc deficiency results in the defect in vascular development at intersegmental vessels (ISVs) and caudal vein plexus (CVP). In addition, vascular specific markers showed reduced or ectopic expression, suggested the impacts of zinc deficiency in vascular development. Understanding the effects of zinc deficiency in the developmental process will help us to prevent the prenatal zinc-related symptoms that might cause severe developmental malformation, such as acrodermatitis enteropathica (AE), infantile hemangioma. In addition, zinc depletion might serve as a new therapy for anti-angiogenesis related disease, such as cancer. Advisors/Committee Members: Jing-Ru Weng (chair), Wu, Chang-Yi (committee member), Hong%22%29&pagesize-30">Wen Zhi-Hong (committee member), Zhang Liyu (chair), Chieh-Yu Pan (chair), Yao-Chang Chen (chair), Chien-Chih Chiu (chair).

Subjects/Keywords: caudal vein plexus; zinc deficiency; oxidative stress; zebrafish; vascular development; antioxidant gene; intersegmental vessels

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APA (6^th Edition):

Wu, B. (2018). The molecular mechanisms of vascular malformation caused by zinc deficiency. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0702118-143707

Chicago Manual of Style (16^th Edition):

Wu, Bao-Jueng. “The molecular mechanisms of vascular malformation caused by zinc deficiency.” 2018. Doctoral Dissertation, NSYSU. Accessed April 14, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0702118-143707.

MLA Handbook (7^th Edition):

Wu, Bao-Jueng. “The molecular mechanisms of vascular malformation caused by zinc deficiency.” 2018. Web. 14 Apr 2021.

Vancouver:

Wu B. The molecular mechanisms of vascular malformation caused by zinc deficiency. [Internet] [Doctoral dissertation]. NSYSU; 2018. [cited 2021 Apr 14]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0702118-143707.

Council of Science Editors:

Wu B. The molecular mechanisms of vascular malformation caused by zinc deficiency. [Doctoral Dissertation]. NSYSU; 2018. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0702118-143707

NSYSU

8. Wang, Chih-chiang. The renal-protective effects of active substances from marine photosynthetic bacteria.

Degree: PhD, Marine Biotechnology and Resources, 2017, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0506117-163948

► Chronic kidney disease (CKD) is a major burden worldwide. Oxidative stress and chronic inflammation play pivotal roles in CKD, especially CKD caused by diabetic nephropathy… (more)

▼ Chronic kidney disease (CKD) is a major burden worldwide. Oxidative stress and chronic inflammation play pivotal roles in CKD, especially CKD caused by diabetic nephropathy (DN). End-stage renal disease that needs treatment through hemodialysis is most commonly caused via DN. Antioxidants have been shown to be beneficial against DN. However, antioxidants are rarely used in clinical practice, probably due to the extremely high doses needed to achieve therapeutic effects. Therefore, possible side effects and cost limit the use of antioxidants for therapeutic purposes. Recently, a novel compound LCG that displays anti-inflammatory activity was extracted from transformant Rhodobacter sphaeroides. LCG showed less toxicity and more potent anti-oxidative activity than lycopene, an antioxidant widely used as a nutritional supplement. Microbial carotenoids have many advantages over plant carotenoids. Carotenoid extraction from microorganisms is more effective and less expensive process. Fermentation is independent of the weather situation. The mutant strain displayed a 3.5-fold increase in carotenoid content, relative to the wild type. The components of LCG were discovered via nuclear magnetic resonance (NMR) studies, these include spheroidenone, methoxyneurosporene, Î¾-carotene, and neurosporene. Interestingly, no irritation response was seen on hamster skins after 30 days of treatment with 0.2% LCG, demonstrating that LCG has good biocompatibility. LCG reduced reactive oxygen species and epithelialâmesenchymal transition markers in H2O2-treated HK2 cells. Using a diabetic mouse model, orally administered LCG (200mg/kg) significantly reduced proteinuria, lowered blood sugar, and reduced insulin resistance after 24 hours. LycogenTM reduced apoptosis in diabetic mice measured via the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay from biopsies of renal tissue. A reduction in apoptosis can attenuate nephron loss and decrease proteinuria. LCG reduced phosphorylation of p38, which is probably how LCG presents an anti-inflammatory effect and reduces EMT. Due to less toxicity and more potent anti-oxidative activity than lycopene, LCG is a potential target for further investigation to confirm the benefits of high dose antioxidants treatment in DN. Advisors/Committee Members: Wang, Hui-Min (chair), Pan, Chieh-Yu (chair), Chang, Chi-I (chair), Liu, Wang-ta (chair), Lin, Hsiu-Chin (chair), Hsu, Jue-Liang (chair), Chang, Li-Yu (chair), Hong%22%29&pagesize-30">Wen, Zhi-Hong (committee member), Chen, Chun-Lin (chair).

Subjects/Keywords: diabetic nephropathy; oxidative stress; LCG; chronic kidney disease; antioxidants

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, C. (2017). The renal-protective effects of active substances from marine photosynthetic bacteria. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0506117-163948

Chicago Manual of Style (16^th Edition):

Wang, Chih-chiang. “The renal-protective effects of active substances from marine photosynthetic bacteria.” 2017. Doctoral Dissertation, NSYSU. Accessed April 14, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0506117-163948.

MLA Handbook (7^th Edition):

Wang, Chih-chiang. “The renal-protective effects of active substances from marine photosynthetic bacteria.” 2017. Web. 14 Apr 2021.

Vancouver:

Wang C. The renal-protective effects of active substances from marine photosynthetic bacteria. [Internet] [Doctoral dissertation]. NSYSU; 2017. [cited 2021 Apr 14]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0506117-163948.

Council of Science Editors:

Wang C. The renal-protective effects of active substances from marine photosynthetic bacteria. [Doctoral Dissertation]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0506117-163948

NSYSU

9. Lo, I-wen. Cytotoxic Constituents from Soft Coral Clavularia viridis.

Degree: Master, Marine Biotechnology and Resources, 2006, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829106-135710

► Seven new steroids, GN70-153E (1), GN70-153F (2), GN70-153I (3), GN70-272F (4), GN70-272I (5), GN70-272L (6), and GN70-272L (7), were isolated from the Formosan soft coral… (more)

Subjects/Keywords: Clavularia viridis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lo, I. (2006). Cytotoxic Constituents from Soft Coral Clavularia viridis. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829106-135710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lo, I-wen. “Cytotoxic Constituents from Soft Coral Clavularia viridis.” 2006. Thesis, NSYSU. Accessed April 14, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829106-135710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lo, I-wen. “Cytotoxic Constituents from Soft Coral Clavularia viridis.” 2006. Web. 14 Apr 2021.

Vancouver:

Lo I. Cytotoxic Constituents from Soft Coral Clavularia viridis. [Internet] [Thesis]. NSYSU; 2006. [cited 2021 Apr 14]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829106-135710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lo I. Cytotoxic Constituents from Soft Coral Clavularia viridis. [Thesis]. NSYSU; 2006. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829106-135710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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