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You searched for +publisher:"NSYSU" +contributor:("Wang, Hay-Yan"). Showing records 1 – 3 of 3 total matches.

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NSYSU

1. Wang , Hong-Jyun. Rapid in situ gelation by blue light-irradiation for combination therapy in brain tumor.

Degree: Master, Institute of Medical Science and Technology, 2018, NSYSU

About 40,000 people are diagnosed with primary brain tumors in the United States each year, an estimated 15,000 have glioblastoma multiforme (GBM), still associated with poor prognosis with 14.6 months of median survival after surgical resection combined with chemotherapy and radiation. Preventing tumor from post-surgical recurrence is a significant clinical challenge since current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells, such as Gliadel® . To overcome this drawback, we develop a blue light-crosslinking hydrogel which can be rapidly gelled in situ and tightly adhere on the tissues for controlled chemotherapy, radiotherapy, and enhanced laser interstitial thermal therapy (LITT) to inhibit residual tumor cells from post-surgical recurrence. The principle goals are to i) determine the prevailing factors that affect efficient encapsulation of chemotherapeutic drugs (i.e., Epirubicin) and radio-sensitizer (i.e., Cisplatin) within hydrogels, ii) demonstrate efficiency of gelation, LITT enhancement, in vitro drug release, iii) evaluate the efficiency in human cancer cells and in vivo tumor model. Thus, we used gelatin, a highly biocompatible material which derived from collagen, as hydrogel scaffold to encapsulate small molecule drug (Epirubicin and Cisplatin). Our results have demonstrated that this multi-treatment system can effectively prevent tumor recurrence and significantly prolong the medium survival of gliosarcoma-bearing (MBR-614 or U87-MGFL) mice to above 65 days compared with the control group (36 days). We believe this synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence. Advisors/Committee Members: Hung-Wei Yang (committee member), Wang, Hay-Yan (chair), Wei, Kuo-Chen (chair).

Subjects/Keywords: Hydrogel; Brain tumor; Drug delivery; Combination therapy; Photothermal therapy; Gelatin methylacrylate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wang , H. (2018). Rapid in situ gelation by blue light-irradiation for combination therapy in brain tumor. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728118-203208

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Wang , Hong-Jyun. “Rapid in situ gelation by blue light-irradiation for combination therapy in brain tumor.” 2018. Thesis, NSYSU. Accessed March 05, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728118-203208.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Wang , Hong-Jyun. “Rapid in situ gelation by blue light-irradiation for combination therapy in brain tumor.” 2018. Web. 05 Mar 2021.

Vancouver:

Wang H. Rapid in situ gelation by blue light-irradiation for combination therapy in brain tumor. [Internet] [Thesis]. NSYSU; 2018. [cited 2021 Mar 05]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728118-203208.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang H. Rapid in situ gelation by blue light-irradiation for combination therapy in brain tumor. [Thesis]. NSYSU; 2018. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728118-203208

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


NSYSU

2. Chen , Pei-Hsien. Detection of pancreas cancer markers CEA and CA19-9 antigen by AlGaN/GaN high electron mobility transistor biosensor.

Degree: Master, Physics, 2017, NSYSU

AlGaN / GaN high electron mobility transistors (HEMTs) have the advantages of high electron mobility, high sensitivity, and high efficiency. Therefore, HEMTs are suitable for the detection of biomolecules with very little charge and can utilize HEMTs to develop biosensor. The aim of this study is to investigate the application of AlGaN / GaN HEMT in the detection of biomolecules, and to make rapid screening, small size and convenient biosensor. AlGaN/GaN HEMT hetero structure interface form a two-dimensional electron gas (2DEG). The bio-molecules bind on the HEMT surface will change the electron concentration of 2DEG. When biomolecules bind with the AlGaN/GaN HEMT, the electron concentration in the 2DEG structure will change. We use LabVIEW software to measure the immediate current and the conductance change. In this study, CEA and CA19-9 antigen cancer tumor markers are detected to increase the reliability of the biosensor. Two sensing areas are respectively modified with different antibodies. When the liquid within two antigens flows through the sensing areas, and can be detected separately. Advisors/Committee Members: Cheng, K.H. (chair), chao-kuei Lee (chair), Wang, Hay-Yan (chair), Li-Wei Tu (committee member), Ying Sun (chair).

Subjects/Keywords: CA19-9; biosensor; CEA; AlGaN/GaN HEMT

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chen , P. (2017). Detection of pancreas cancer markers CEA and CA19-9 antigen by AlGaN/GaN high electron mobility transistor biosensor. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0408117-194004

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Chen , Pei-Hsien. “Detection of pancreas cancer markers CEA and CA19-9 antigen by AlGaN/GaN high electron mobility transistor biosensor.” 2017. Thesis, NSYSU. Accessed March 05, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0408117-194004.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Chen , Pei-Hsien. “Detection of pancreas cancer markers CEA and CA19-9 antigen by AlGaN/GaN high electron mobility transistor biosensor.” 2017. Web. 05 Mar 2021.

Vancouver:

Chen P. Detection of pancreas cancer markers CEA and CA19-9 antigen by AlGaN/GaN high electron mobility transistor biosensor. [Internet] [Thesis]. NSYSU; 2017. [cited 2021 Mar 05]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0408117-194004.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen P. Detection of pancreas cancer markers CEA and CA19-9 antigen by AlGaN/GaN high electron mobility transistor biosensor. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0408117-194004

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


NSYSU

3. Tseng , Shih-Ya. Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model.

Degree: PhD, Biological Sciences, 2017, NSYSU

Critical limb ischemia (CLI) is an advanced form of peripheral artery disease in which the narrowing arteries limit blood supply to the lower extremities with resultant of resting pain and eventually, tissue loss. At present time, it is likely that proangiogenic stem cell therapy is anticipated as a promising therapeutic strategy in patients with CLI. However, a potential limitation of autologous cell therapy is that the insufficient number of stem cells were available the patients who may also suffer other problems. Therefore, how to generate enough autologous stem cells in vitro for future implantation application has become a major issue. Cilostazol is used as a vasodilating and anti-platelet aggregation drug clinically by increasing intracellular levels of cAMP. Our recent works and other reports have suggested that cilostazol may promote angiogenesis. Unfortunately, the effects of cilostazol on growth and differentiation of human early endothelial progenitor cells (EPCs) remain mostly unclear. In the current work, we explored the novel angiogenic effects of cilostazol on EPCs by using both in vitro and in vivo models. We found that human early EPCs treated with cilostazol significantly increase colony-forming units and enhanced differentiation of EPCs toward endothelial lineage. It was not only stimulated proliferation, migration, anti-apoptosis effect but also in vitro vascular tube formation through activation of SDF-1α /CXCR4/PI3K/Akt signaling pathway. In addition, Matrigel plug assay and mouse hind limb ischemia model also demonstrated that administration of a concomitant therapy with cilostazol and EPCs-treated mice were in vessel maturation higher, capillary significantly density and blood flow recovery, in comparison with either treatment alone. These results indicated that co-administration of cilostazol reinforced the autocrine effect of transplanted human early EPCs to provide a synergistic effect in angiogenesis through activation of SDF-1 α/CXCR4/PI3K/Akt signaling pathway. In clinical Implication, cilostazol plus EPCs treatment may be beneficial in improving EPC transplantation efficacy and enhancing vascular re-endothelialization in patients with critical limb ischemia. Advisors/Committee Members: Wang, Hay-Yan (chair), Wang, Yang-Kao (chair), Cho, Chung-Lung (committee member), Chen, Chun-Lin (chair), Chao, Ting-Hsing (committee member), Li, Yi-Heng (chair).

Subjects/Keywords: Peripheral artery disease; Critical limb ischemia; Angiogenesis; Cilostazol; SDF-1α; Endothelial progenitor cells

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Tseng , S. (2017). Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714

Chicago Manual of Style (16th Edition):

Tseng , Shih-Ya. “Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model.” 2017. Doctoral Dissertation, NSYSU. Accessed March 05, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714.

MLA Handbook (7th Edition):

Tseng , Shih-Ya. “Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model.” 2017. Web. 05 Mar 2021.

Vancouver:

Tseng S. Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model. [Internet] [Doctoral dissertation]. NSYSU; 2017. [cited 2021 Mar 05]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714.

Council of Science Editors:

Tseng S. Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model. [Doctoral Dissertation]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714

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