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You searched for +publisher:"NSYSU" +contributor:("Tseng Chao-Neng"). One record found.

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NSYSU

1. Chen, Chien-ming. A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock.

Degree: PhD, Biological Sciences, 2014, NSYSU

OSTC, a Homo sapiens OSTC/DC2 protein, belongs to a new subunit of mammalian oligosaccharyltransferase (OST). OST transfers the high-mannose sugars to nascent polypeptides during N-linked glycosylation in the lumen of the rough endoplasmic reticulum. In this study, we used synthetic peptides (RMKLPGYLMG) as an antigen to develop a polyclonal antibody against OSTC/DC2. After heat treatment of Balb/c mice, OSTC/DC2 showed up-regulated in some tissues of brain, and peaked at the 12th hour of recover stage. Furthermore, OSTC/DC2 was also up-regulated in cell lines during heat-shock treatment. The strikingly immediate up-regulation of OSTC/DC2 in response to heat shock is only seen in the cortex, suggesting that OSTC/DC2 may have unique functions in neurons. In addition, OSTC/DC2 induction is synchronous to increased expression of HSP70 and activation of AKT after heat shock, supporting the notion that OSTC/DC2 may play a significant role in heat shock response. Advisors/Committee Members: Liu, Jong-Kang (chair), Tseng Chao-Neng (chair), Liu, Wangta (chair), Cho, Chung-Lung (committee member), Chao, David (chair).

Subjects/Keywords: oligosaccharyltransferase; polyclonal antibody; gene knockdown; heat shock; glycosylation; glycoprotein

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APA (6th Edition):

Chen, C. (2014). A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0111114-133314

Chicago Manual of Style (16th Edition):

Chen, Chien-ming. “A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock.” 2014. Doctoral Dissertation, NSYSU. Accessed January 17, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0111114-133314.

MLA Handbook (7th Edition):

Chen, Chien-ming. “A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock.” 2014. Web. 17 Jan 2021.

Vancouver:

Chen C. A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock. [Internet] [Doctoral dissertation]. NSYSU; 2014. [cited 2021 Jan 17]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0111114-133314.

Council of Science Editors:

Chen C. A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock. [Doctoral Dissertation]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0111114-133314

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