+publisher:"NSYSU" +contributor:("Luo-Ping Ger")

NSYSU

1. Chiu, Yi-Ten. Association of Genetic Polymorphisms of Inflammatory Related Cytokines with the Risk of Oral Precancer Lesions and Oral Cancer.

Degree: Master, Institute of Biomedical Sciences, 2008, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716108-184529

► Clinical and epidemiological studies support a strong association between chronic inflammation and cancer. Inflammatory related cytokines, such as IL-1Î±, IL-1RN, IL-1Î², IL-4, IL-6, IL-8, IL-10,… (more)

▼ Clinical and epidemiological studies support a strong association between chronic inflammation and cancer. Inflammatory related cytokines, such as IL-1Î±, IL-1RN, IL-1Î², IL-4, IL-6, IL-8, IL-10, TNF-Î± and TGFÎ²-1, might play important role in carcinogenesis of oral squamous cell carcinoma (OSCC). Two case-control studies were carried out to evaluate the association of 16 various polymorphisms of 9 inflammatory-related genes with the risk for OSCC and the risk for betel quid (BQ)-related oral precancer lesions (OPL) and BQ-related OSCC. Then the association between various IL-1B C-511T/T-31C haplotypes with plasma levels of IL-1Î² was evaluated. One case-contol study included 363 OSCC case patients and 487 healthy controls as well as the other case-control study included 227 BQ-related OSCC cases, 116 BQ-related OPL patients and 209 BQ-related controls. All subjects were recruited and genotyped by use of the PCR-RFLP techniques or TaqMan real-time PCR method from November 2003 and May 2007 at Kaohsiung Veterans General Hospital. Then, 9 OSCC case patients, 9 OPL patients, and 9 controls were selected and matched on sex, age as well as the quantity of BQ-chewing, alcohol drinking, and cigarette smoking for evaluation of plasma levels of IL-1Î² by use of ELISA. In the single locus analysis, the variant genotype of RP1RP2 or RP2RP2 (VS. RP1RP1) of IL-4 intron 3 VNTR (AOR = 0.67, 95% CI = 0.45-0.99; AOR = 0.65, 95% CI = 0.45-0.95), TA or AA (VS. TT) genotype of IL-8 T-251A (AOR = 1.55, 95% CI = 1.05-2.30; AOR = 2.50, 95% CI = 1.46-4.27), TT (VS. CC) genotype of IL-8 C+781T (AOR = 2.01; 95% CI = 1.11-3.63), and GA combined with AA (VS. GG) genotype of TNFA G-308A (AOR = 0.40; 95% CI = 0.25-0.66) were associated with risk of OSCC, as compare with those genotypes of healthy controls. However, CC (VS. TT) genotype of IL-10 T-819C (AOR = 0.24, 95% CI = 0.08-0.74) and CC (VS. AA) genotype of IL-10 A-592C (AOR = 0.25, 95% CI = 0.08-0.79) were significantly associated with reduced risk of BQ-related OPL, as compared with those genotypes of BQ controls. In addition, the variant genotype of 2/2 or 1/2 (VS. 1/1) of IL-1RN intron2 VNTR (AOR = 0.11, 95% CI = 0.01-0.97; AOR = 0.48, 95% CI = 0.27-0.87), TC (VS TT) genotype of IL-1B T-31C (AOR = 1.82, 95% CI = 1.14-2.92), AA (VS. TT) genotype of IL-8 T-251A (AOR = 1.92, 95% CI = 1.01-3.66), GG (VS. TT) genotype of IL-8 T+396G (AOR = 2.18; 95% CI = 1.12-4.21), and GA combined with AA (VS. GG) genotype of TNFA G-308A (AOR = 0.46, 95% CI = 0.27-0.79) were significantly related with risk of BQ-related OSCC, as compared with BQ controls. Moreover, CC (VS. TT) genotype of IL-10 T-819C (AOR = 3.33, 95% CI = 1.07-10.42) was associated with increased risk of BQ-related OSCC, as compared with those genotypes of BQ-related OPL. In the haplotype analysis, -590C/RP2 (VS. -590T/RP1) haplotype of IL-4 (AOR = 0.69; 95% CI = 0.49-0.98) and -251A/+781T (VS. -251T/+781C) haplotype of IL-8 (AOR = 1.57, 95% CI = 1.19-2.06) were related with risk of OSCC, as compared with those haplotypes of healthy… Advisors/Committee Members: Angela Chen (chair), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member), Pei-Jung Lu (chair).

Subjects/Keywords: cytokine; oral precancer lesions; betel quid

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chiu, Y. (2008). Association of Genetic Polymorphisms of Inflammatory Related Cytokines with the Risk of Oral Precancer Lesions and Oral Cancer. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716108-184529

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chiu, Yi-Ten. “Association of Genetic Polymorphisms of Inflammatory Related Cytokines with the Risk of Oral Precancer Lesions and Oral Cancer.” 2008. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716108-184529.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chiu, Yi-Ten. “Association of Genetic Polymorphisms of Inflammatory Related Cytokines with the Risk of Oral Precancer Lesions and Oral Cancer.” 2008. Web. 08 Mar 2021.

Vancouver:

Chiu Y. Association of Genetic Polymorphisms of Inflammatory Related Cytokines with the Risk of Oral Precancer Lesions and Oral Cancer. [Internet] [Thesis]. NSYSU; 2008. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716108-184529.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chiu Y. Association of Genetic Polymorphisms of Inflammatory Related Cytokines with the Risk of Oral Precancer Lesions and Oral Cancer. [Thesis]. NSYSU; 2008. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716108-184529

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

2. Wang, Cheng-ching. Association of Polymorphisms of Oxidant-related Genes, Plasma Total Antioxidant Capacity, and Dietary Antioxidant Intakes with the Risk of Oral Squamous Cell Carcinoma.

Degree: Master, Institute of Biomedical Sciences, 2008, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0905108-034445

► Background: Oxidative stress, generating from betel quid (BQ) chewing, cigarette smoking, and alcohol drinking; regulating by antioxidant-oxidant enzymes and dietary antioxidants seems to play a… (more)

▼ Background: Oxidative stress, generating from betel quid (BQ) chewing, cigarette smoking, and alcohol drinking; regulating by antioxidant-oxidant enzymes and dietary antioxidants seems to play a role in oral carcinogenesis. Objective: We aimed to examine the association between antioxidant-oxidant gene polymorphisms (CYBA, MnSOD, MPO, GPX1 and CAT), oral habits, and dietary antioxidants with the risk of oral squamous cell carcinoma (OSCC). Design: A total of 381 pathologically proved primary OSCC cases and 598 healthy controls matched for age and sex were recruited between July 2003 and February 2008 in the hospital-based case-control study. Another 200 cancer-free controls frequency matched to 200 case patients on sex, age (Â±5 years), and pack-years of betel quid chewing. All subjects were interviewed to collect the data on socio-demographic variables, histories of BQ-chewing, tobacco smoking, alcohol drinking, and dietary antioxidant intake. Then, TaqMan assay were used to identify the genotype of functional or common allele tagging SNPs of each gene. The plasma total antioxidant capacities were measured by colorimetric assay. Results: Higher intakes of vitamin C, vitamin E and lycopene together with gene polymorphisms (SOD2, GPX1, and CYBA) were associated with a decreased risk for OSCC in a trend-related manner. The risk of OSCC associated with CYBA genotype was modified by alcohol (Pinteraction = 0.04). Significant interactions were observed between BQ-chewing and SOD2 V16A (Pinteraction = 0.001), MPO G-463A (Pinteraction = 0.006) and CAT C3261T (Pinteraction = 0.002). GPx1 polymorphism interact with vitamin C and lutein/zeaxanthin to modify the risk of OSCC, respectively (Pinteraction = 0.023 and 0.006). In the combined analysis, a preventive relation appeared with subjects with seven âat risk genotypeâ (AOR, 0.62; 95% CI, 0.36-1.04) and those with three to six ones (AOR, 0.55; 95% CI, 0.33-0.94) compared with 8-9 ones in a trend-related manner (Ptrend = 0.042). It showed an interaction effect between BQ-chewing and the combination of antioxidant-oxidant gene polymorphisms with OSCC risk (Pinteraction = 0.001). The dose-dependent protective effect was related to the decreased numbers of âat risk genotypesâ in lower intake of vitamin E (AOR, 0.54; 95% CI, 0.27-1.11 for 7 âat risk genotypeâ; AOR, 0.44; 95% CI, 0.21-0.90 for 3-6 âat risk genotypeâ; Ptrend = 0.035), and in higher intake of vitamin C (AOR, 0.33; 95% CI, 0.13-0.82 for 7 âat risk genotypeâ; AOR, 0.31; 95% CI, 0.12-0.73 for 3-6 âat risk genotypeâ; Ptrend = 0.047) and lycopene (AOR, 0.48; 95% CI, 0.20-1.14 for 7 âat risk genotypeâ; AOR, 0.38; 95% CI, 0.16-0.93 for 3-6 âat risk genotypeâ; Ptrend = 0.049). In stratification of the numbers of âat risk genotypesâ of XRCC1 (XRCC1 R194W, R180H and R399B) for two groups (0-1 and 2-3 âat risk genotypeâ of XRCC1), the decreased risk of OSCC was observed with the decreasing number of âat risk genotypeâ in the antioxidant-oxidant genes (AOR, 0.34; 95% CI, 0.14-1.83 for 7 âat risk genotypeâ; AOR, 0.31; 95% CI,… Advisors/Committee Members: Li-yu Tsai (chair), Pei-jung Lu (chair), ping%20Ger%22%29&pagesize-30">Luo-ping Ger (committee member), Shiue YL (chair).

Subjects/Keywords: GPX1; MPO; MnSOD; CAT; CYBA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, C. (2008). Association of Polymorphisms of Oxidant-related Genes, Plasma Total Antioxidant Capacity, and Dietary Antioxidant Intakes with the Risk of Oral Squamous Cell Carcinoma. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0905108-034445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Cheng-ching. “Association of Polymorphisms of Oxidant-related Genes, Plasma Total Antioxidant Capacity, and Dietary Antioxidant Intakes with the Risk of Oral Squamous Cell Carcinoma.” 2008. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0905108-034445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Cheng-ching. “Association of Polymorphisms of Oxidant-related Genes, Plasma Total Antioxidant Capacity, and Dietary Antioxidant Intakes with the Risk of Oral Squamous Cell Carcinoma.” 2008. Web. 08 Mar 2021.

Vancouver:

Wang C. Association of Polymorphisms of Oxidant-related Genes, Plasma Total Antioxidant Capacity, and Dietary Antioxidant Intakes with the Risk of Oral Squamous Cell Carcinoma. [Internet] [Thesis]. NSYSU; 2008. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0905108-034445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang C. Association of Polymorphisms of Oxidant-related Genes, Plasma Total Antioxidant Capacity, and Dietary Antioxidant Intakes with the Risk of Oral Squamous Cell Carcinoma. [Thesis]. NSYSU; 2008. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0905108-034445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

3. Hsieh, I-chien. Association of Oct4, Sox2, and Nanog Expression with Development and Prognosis in Oral Tongue Squamous Cell Carcinoma and Buccal Mucosal Squamous Cell Carcinoma.

Degree: Master, Biological Sciences, 2013, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0811113-155550

► In Taiwan, oral cancer is the 4th leading cause of cancer death for males and the top common cancer in young adult males. The most… (more)

▼ In Taiwan, oral cancer is the 4th leading cause of cancer death for males and the top common cancer in young adult males. The most common subsites of oral cancer are the tongue and buccal mucosa in Taiwan. Cancer stem cells (CSCs) have been implicated in tumorigenesis and prognosis. Reprogramming factors employed to induce pluripotent stem cells are associated with CSCs formation. The purpose of this study was to investigate the relationship of the protein expression levels of three reprogramming factors, Octamer-binding Protein 4 (Oct4), Sex-determining Region Y (SRY)-related Box 2 (Sox2), and Nanog, with the tumorigenesis, clinicopathological outcomes and survival in oral tongue SCC and buccal mucosal SCC. Expression levels of Oct4, Sox2, and Nanog were evaluated by immunohistochemistry using tissue microarray slides. We compare the expression levels of the Oct4, Sox2, Nanog-N, and Nanog-C in normal, tumor adjacent normal, and tumor tissues by subsites of oral tongue and buccal mucosa. The expression levels of both Oct4 and Sox2 in oral tongue SCC and buccal mucosal SCC were significantly lower than those in the tumor adjacent normal tissue or normal tissue, except that for Oct4 in buccal mucosal SCC. However, the expression level of Nanog-C in oral tongue SCC and buccal mucosal SCC was significantly higher than those in the tumor adjacent normal tissue and normal tissue. Our IHC results showed that the median expression levels of Oct4, Sox2, Nanog-N, and Nanog-C were 40, 2.50, 0, and 90 in 248 oral tongue SCC specimens, respectively. In addition, the median expression levels of Oct4, Sox2, Nanog-N, and Nanog-C were 73.75, 4.75, 0, and 63.75 in 188 buccal mucosal SCC specimens, respectively. The expression levels of Oct4, Sox2, and Nanog-C gradually decreased when tumor progressed from early stage and advanced stage (AJCC pathological stage, T stage, or N stage). After adjustment of clinicopathologic outcomes, our results showed a significant association between the elevated Sox2 expression and prolonged disease-specific survival in oral tongue SCC. In conclusion, Oct4, Sox2, and Nanog-C could be biomarkers for tumorigenesis in both oral tongue SCC and buccal mucosal SCC, except for Oct4 in buccal mucosal SCC. Additionally, Sox2 might be a prognostic biomarker for oral tongue SCC. Advisors/Committee Members: Chung-Lung Cho (chair), Jiin-Tsuey Cheng (committee member), Tseng, Hui-hwa (chair), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member).

Subjects/Keywords: Nanog; Sox2; Oct4; Buccal mucosal SCC; Oral tongue SCC; Cancer stem cell; Tissue microarry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hsieh, I. (2013). Association of Oct4, Sox2, and Nanog Expression with Development and Prognosis in Oral Tongue Squamous Cell Carcinoma and Buccal Mucosal Squamous Cell Carcinoma. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0811113-155550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hsieh, I-chien. “Association of Oct4, Sox2, and Nanog Expression with Development and Prognosis in Oral Tongue Squamous Cell Carcinoma and Buccal Mucosal Squamous Cell Carcinoma.” 2013. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0811113-155550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hsieh, I-chien. “Association of Oct4, Sox2, and Nanog Expression with Development and Prognosis in Oral Tongue Squamous Cell Carcinoma and Buccal Mucosal Squamous Cell Carcinoma.” 2013. Web. 08 Mar 2021.

Vancouver:

Hsieh I. Association of Oct4, Sox2, and Nanog Expression with Development and Prognosis in Oral Tongue Squamous Cell Carcinoma and Buccal Mucosal Squamous Cell Carcinoma. [Internet] [Thesis]. NSYSU; 2013. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0811113-155550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hsieh I. Association of Oct4, Sox2, and Nanog Expression with Development and Prognosis in Oral Tongue Squamous Cell Carcinoma and Buccal Mucosal Squamous Cell Carcinoma. [Thesis]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0811113-155550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

4. You, Jun-Jie. Next Generation Sequencing for Comprehensive Analysis of MicroRNA Profiles in Oral Cancer.

Degree: Master, Institute of Biomedical Sciences, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728114-162835

► MicroRNAs (miRNAs) are a class of small endogenous single-stranded non-protein coding RNAs, about 21-24 nucleotides in length. Dysfunctional miRNAs play important role during oral squamous… (more)

▼ MicroRNAs (miRNAs) are a class of small endogenous single-stranded non-protein coding RNAs, about 21-24 nucleotides in length. Dysfunctional miRNAs play important role during oral squamous cell carcinoma (OSCC) progression, and contribute to modulate cell proliferation, apoptosis, migration, invasion and cell cycle by silencing protein-coding genes. However, the detailed mechanisms and biological functions of miRNAs in OSCC have yet to be fully elucidated. In this study, we performed the expression profile of human small RNAs in OSCC tissues and the corresponding adjacent normal tissues of two OSCC patients by Next generation sequencing approach. According to the profiles, we identified 45 miRNAs were significantly upregulated (fold change > 2) and 17 miRNAs downregulated (fold change < 0.5) in OSCC, respectively. Among them, the expression levels of miR-196b were further evaluated in 69 paired OSCC tissue samples using the stem-loop real-time polymerase chain reaction. Our results showed that miR-196b significantly overexpressed in OSCC tissues, as compared to the corresponding adjacent normal tissue samples (64 out of 69; 92.7%, p < 0.001). Analysis of the methylation status indicated the frequent hypomethylation of the CpG islands upstream of miR-196b in OSCC tissues compared with adjacent normal tissues (32 out of 69; 46.3 %), and the methylation status correlated inversely with miR-196b expression levels. Furthermore, the methylation status of miR-196b promoter was correlated with the poor disease-specific survival of OSCC patients (p = 0.035). Functional analysis showed that miR-196b could facilitate migration and invasion in OSCC cell lines, suppression of miR-196b by transfection with anti-miR-196b abrogated in vitro migration and invasion in OSCC cell lines. Together, our findings indicate that miR-196b plays a crucial oncogenic role in promoting cell migration and invasion during OSCC progression and thus may serve as a potential prognosis marker or therapeutic target for OSCC. Advisors/Committee Members: Pei-Jung Lu (chair), Kuo-Wang Tsai (committee member), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member), Y. L. Shiue (chair).

Subjects/Keywords: next generation sequencing; oral cancer; methylation; microRNA; miR-196b

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

You, J. (2014). Next Generation Sequencing for Comprehensive Analysis of MicroRNA Profiles in Oral Cancer. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728114-162835

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

You, Jun-Jie. “Next Generation Sequencing for Comprehensive Analysis of MicroRNA Profiles in Oral Cancer.” 2014. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728114-162835.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

You, Jun-Jie. “Next Generation Sequencing for Comprehensive Analysis of MicroRNA Profiles in Oral Cancer.” 2014. Web. 08 Mar 2021.

Vancouver:

You J. Next Generation Sequencing for Comprehensive Analysis of MicroRNA Profiles in Oral Cancer. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728114-162835.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

You J. Next Generation Sequencing for Comprehensive Analysis of MicroRNA Profiles in Oral Cancer. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728114-162835

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

5. Li, Yi-jing. LC3, P62, P65, and EGFR Protein Expressions are Associated with Tumor Transformation and Poor Prognosis in Oral Squamous Cell Carcinoma.

Degree: Master, Biological Sciences, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621116-000801

► Oral cancer, a common type of head and neck cancer, is the sixth most common malignant tumors in the world. Tongue, buccal mucosa, and lip… (more)

▼ Oral cancer, a common type of head and neck cancer, is the sixth most common malignant tumors in the world. Tongue, buccal mucosa, and lip are the top three most common subsites of oral cavity. Autophagy plays an important role on tumor growth and progression in many cancers. Upregulation of autophagy in cancer can be either prosurvival or prodeath for tumor cells. The associations of expression levels of LC3, p62, p65, and EGFR with the tumorigenesis, clinicopathologic outcomes, and survival for three primary subsites of oral cancer were investigated. A total of 498 oral squamous cell carcinoma (OSCC) patients were recruited, including 181 buccal mucosal SCC (BMSCC), 244 tongue SCC (TSCC), and 73 lip SCC (LSCC) patients. In addition, another 76 sleep apnea patients for uvula excision were also recruited as controls. The expression levels of LC3, p62, p65 in the nuclear, p65 in the cytoplasm , EGFR in the Membrane (EGFR-M) and EGFR in the cytoplasm (EGFR-C) in three kinds of tissues, including normal, tumor, and corresponding tumor adjacent normal (TAN) were evaluated by immunohistochemistry using tissue microarray. An increased expression of LC3, p62, p65-C, EGFR-M, and EGFR-C was found in OSCC tissues and three subsites as compared to those in TAN and normal tissues (all p<0.001). However, p65-N expression was found significantly decreased in OSCC (all p<0.002), except in LSCC (p=0.119). In BMSCC patients, the higher expression of p62 was associated with poor cell differentiation (p=0.015) and lymph node metastasis (p=0.033). However, the expression of EGFR in N0 was higher than that in lymph node metastasis (p=0.031). In TSCC patients, the higher expressions of LC3 (p=0.045), p62 (p=0.040), and p65-C (p<0.001) were associated with poor cell differentiation. Moreover, higher expressions of EGFR-C are associated with advanced AJCC pathological stage (p<0.001), higher T classification (p=0.003), and lymph node metastasis patients (p=0.013). In LSCC patients, an increased expression of p62 was associated with poor cell differentiation (p=0.003) and p65-C expression was higher in older patients (>50 yrs, p=0.009). In OSCC patients, expression levels of LC3, p65-N, and p65-C were significantly different between three subsites (p<0.001). An increased expression of p62 (p=0.001) and p65-C p<0.001) was found in those with poor cell differentiation. The expressions of EGFR-C was accordingly associated in advanced AJCC pathological stage (p<0.001) and high T classification (p=0.006). An increased expression of p65-C (p=0.012) and EGFR-C (p=0.012) but a reduced expression of EGFR-M (p=0.019) were found in those with lymph node metastasis. Finally, the univariate and multivariate analysis of survival showed that a higher expression level of p62 was associated with a poor disease-specific survival (DSS) and disease-free survival (DFS) of OSCC patients, especially DSS for BMSCC patients) and DFS for LSCC. The LC3, p62, p65, and EGFR could be biomarkers for tumorigenesis in OSCC, including three primary subsites. Moreover, p62 is… Advisors/Committee Members: Chih-Wen Shu (chair), Ching-Mei Hsu (chair), Jiin-Tsuey Cheng (committee member), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member).

Subjects/Keywords: autophagy-related protein; immunohistochemistry; tumorigenesis; survival; Oral squamous cell carcinoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, Y. (2016). LC3, P62, P65, and EGFR Protein Expressions are Associated with Tumor Transformation and Poor Prognosis in Oral Squamous Cell Carcinoma. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621116-000801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Yi-jing. “LC3, P62, P65, and EGFR Protein Expressions are Associated with Tumor Transformation and Poor Prognosis in Oral Squamous Cell Carcinoma.” 2016. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621116-000801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Yi-jing. “LC3, P62, P65, and EGFR Protein Expressions are Associated with Tumor Transformation and Poor Prognosis in Oral Squamous Cell Carcinoma.” 2016. Web. 08 Mar 2021.

Vancouver:

Li Y. LC3, P62, P65, and EGFR Protein Expressions are Associated with Tumor Transformation and Poor Prognosis in Oral Squamous Cell Carcinoma. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621116-000801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li Y. LC3, P62, P65, and EGFR Protein Expressions are Associated with Tumor Transformation and Poor Prognosis in Oral Squamous Cell Carcinoma. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621116-000801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

6. Chen, Hung-chih. The Association of 5-methylation, 5-hydroxymethylation and Epigenetic Modifiersâ Expression with the Development and Prognosis of Tongue Squamous Cell Carcinoma.

Degree: Master, Biological Sciences, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0605114-225021

► ããBackgrounds: In Taiwan, oral cancer is the 4th leading cause of cancer death for males and the top common cancer in young adult males. Tongue… (more)

▼ ããBackgrounds: In Taiwan, oral cancer is the 4th leading cause of cancer death for males and the top common cancer in young adult males. Tongue squamous cell carcinoma (SCC) is one of the most common oral cancers and generally associated with poor prognosis. DNA methylation at the 5 position of cytosine (5mC) is a well-known epigenetic feature of cancer. In addition, 5-hydroxymethylcytosine (5hmc), an intermediator of gene demethylation, is reduced in cancer, including oral cancer. Recent evidences suggest that a group of enzymes of the ten-eleven translocation proteins (TET) can further convert 5mC to 5hmC in an Î±-ketoglutarate (Î±-KG) dependent oxidation reaction. In addition, isocitrate dehydrogenase (IDH) can catalyze the interconversion of isocitrate to Î±-KG, which is the cofactor to catalyze 5mC to 5hmC. ã ããMethods: The purpose of this study was to investigate the relationship of the levels of 5mc, 5hmc, TET1, TET2, IDH1 and IDH2 with the tumorigenesis and survival in 248 surgically resected tongue SCC tissues by immunohistochemistry using tissue microarray slides. ã ããResults: We found that expression levels of 5mc, 5hmc, TET1(N) , TET2(N) and IDH2 proteins in tongue SCC tissues were significantly reduced (all p < 0.001) as compared to the corresponding tumor adjacent normal tissues (CTAN), except for the increase of IDH1, TET1(C) , TET2(C) (p= 0.01, p < 0.001, p=0.036, respectively). Among tongue SCC tissues, decreased expression of 5mc was associated with female gender, and increased expression of IDH1 was associated with low-grade (well) differentiation (p= 0.027). In addition, the global hypomethylation was associated with the poor disease-specific survival in tongue SCC patients (p= 0.048), especially for patients in female gender (p =0 .028), with small tumor size (T1-T2, p=0.004), without nodal metastasis (N0, p =0 .049), and ever received post-operative radiotherapy (p=0.005). For female patients, those with high levels of 5hmc (p =0.015) and IDH1 expression (p =0 .021) had significantly better disease-free survival. Finally, high level of TET2(C) expression was correlated with the poor disease-specific survival for patients with female gender (p =0 .021), late pathologic stage (III-IV, p =0 .047), or ever received post-operative radiotherapy (p=0.025). ã ããConclusions: 5mc, 5hmc, TET1, TET2, IDH1 and IDH2 may be biomarkers for development of tongue SCC. Additionally, 5mc might be the independent prognostic biomarkers for tongue SCC. Advisors/Committee Members: Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member), Tseng, Hui-hwa (chair), Jiin-Tsuey Chen (committee member), Kuo-wang Tsai (chair).

Subjects/Keywords: 5hmc; TET; tissue microarray; IDH; tongue squamous cell carcinoma; immunohistochemistry; 5mc; survival

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, H. (2014). The Association of 5-methylation, 5-hydroxymethylation and Epigenetic Modifiersâ Expression with the Development and Prognosis of Tongue Squamous Cell Carcinoma. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0605114-225021

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Hung-chih. “The Association of 5-methylation, 5-hydroxymethylation and Epigenetic Modifiersâ Expression with the Development and Prognosis of Tongue Squamous Cell Carcinoma.” 2014. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0605114-225021.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Hung-chih. “The Association of 5-methylation, 5-hydroxymethylation and Epigenetic Modifiersâ Expression with the Development and Prognosis of Tongue Squamous Cell Carcinoma.” 2014. Web. 08 Mar 2021.

Vancouver:

Chen H. The Association of 5-methylation, 5-hydroxymethylation and Epigenetic Modifiersâ Expression with the Development and Prognosis of Tongue Squamous Cell Carcinoma. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0605114-225021.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen H. The Association of 5-methylation, 5-hydroxymethylation and Epigenetic Modifiersâ Expression with the Development and Prognosis of Tongue Squamous Cell Carcinoma. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0605114-225021

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

7. Li, Guan-cheng. Association of 5-methylcytosine, 5-hydroxymethylcytosine and Epigenetic Modifiersâ Expression with the Development and Prognosis of Invasive Mammary Ductal Carcinoma.

Degree: Master, Institute of Biomedical Sciences, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729114-151722

► Breast cancer is the most common cancer in Taiwanese women. DNA methylation at the 5-position of cytosine (5mC) represents an important epigenetic modification involved in… (more)

▼ Breast cancer is the most common cancer in Taiwanese women. DNA methylation at the 5-position of cytosine (5mC) represents an important epigenetic modification involved in tissue differentiation and is frequently altered in cancer. Recent evidence suggests that 5mC can be converted to 5-hydroxymethylcytosine (5hmC) in mammalian DNA by The ten-eleven-translocation (TET) and isocitrate dehydrogenase (IDH) enzymes. The purpose of this study was to identify whether the expression of 5mC and 5hmC were correlated with the tumorigenesis, clinicopathological features, and survival of invasive ductal carcinoma (IDC) patients. The impact of epigenetic modifiers, such as TET1, TET2, IDH1, and IDH2 on 5mC, 5hmC, tumorigenesis, and prognosis in IDC were also investigated. The expression levels of 5mC, 5hmC, TET1, TET2, IDH1, and IDH2 were evaluated by immunohistochemistry in 20 breast fibrosis tissues, 309 tumor adjacent normal (TAN), and 309 IDC, using tissue microarray slides. Our data showed a significant reduction of 5mC and 5hmC levels in IDC tissues as compared to TAN tissues and breast fibrosis tissues. In IDC tissues, only moderate reduction of 5mC was observed as compared to 5hmC obvious losses. In addition, lower level of 5mC was correlated with poor differentiation of tumor. The low levels of 5hmC was significantly associated with shorter disease-specific survival (p = 0.016) and disease-free survival (p = 0.008) in IDC patients. We also found that the low levels of 5mC expression was significantly associated with poor DSS for those with luminal B, and the decreased 5hmC expression was significantly associated with poor DSS for those with Her 2 overexpression. All TET1-n, TET2-n, IDH1, and IDH2 were significantly down-regulated in IDC. The multivariate linear regression model showed that TET1-n was an independent predictor for 5hmC. Furthermore, a low expression level of IDH1 was correlated with the advance stage of disease and lymph node metastasis. A low level of TET2-n was correlated with the advanced pN stage and poor differentiation of tumor. In conclusion, the decreased expression of 5mC, 5hmC, TET1-n, TET2-n, IDH1, and IDH2 were involved in the tumorigenesis of IDC. The higher levels of their expression might be the favorable prognosis markers for IDC, particularly for 5hmC in survival. Advisors/Committee Members: Kuo-Wang Tsai (committee member), Y. L. Shiue (chair), Pei-Jung Lu (chair), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member).

Subjects/Keywords: breast cancer; epigenetic modification; 5-methylcytosine; 5-hydroxymethylcytosine; epigenetic modifiers; immunohistochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, G. (2014). Association of 5-methylcytosine, 5-hydroxymethylcytosine and Epigenetic Modifiersâ Expression with the Development and Prognosis of Invasive Mammary Ductal Carcinoma. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729114-151722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Guan-cheng. “Association of 5-methylcytosine, 5-hydroxymethylcytosine and Epigenetic Modifiersâ Expression with the Development and Prognosis of Invasive Mammary Ductal Carcinoma.” 2014. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729114-151722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Guan-cheng. “Association of 5-methylcytosine, 5-hydroxymethylcytosine and Epigenetic Modifiersâ Expression with the Development and Prognosis of Invasive Mammary Ductal Carcinoma.” 2014. Web. 08 Mar 2021.

Vancouver:

Li G. Association of 5-methylcytosine, 5-hydroxymethylcytosine and Epigenetic Modifiersâ Expression with the Development and Prognosis of Invasive Mammary Ductal Carcinoma. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729114-151722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li G. Association of 5-methylcytosine, 5-hydroxymethylcytosine and Epigenetic Modifiersâ Expression with the Development and Prognosis of Invasive Mammary Ductal Carcinoma. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729114-151722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

8. Wang, Tsung-han. Long non-coding RNAs Expression Profiles in Human Oral Squamous Cell Carcinoma and Its Clinical Significances.

Degree: Master, Institute of Biomedical Sciences, 2015, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803115-095752

► Long non-coding RNAs (LncRNAs) are more than 200 nucleotides in length; however, they lack protein transcription ability. The biological function of lncRNAs could regulate cell… (more)

▼ Long non-coding RNAs (LncRNAs) are more than 200 nucleotides in length; however, they lack protein transcription ability. The biological function of lncRNAs could regulate cell growth, apoptosis, and metastasis in human cancer. However, the mechanism and biological function of lncRNAs remain unknown in oral squamous cell carcinoma (OSCC). In this study, we performed the transcriptome profiles of human OSCC tissues and corresponding adjacent normal tissues from two patients by Next Generation Sequencing (NGS) approach. According to our data, we identified 19 lncRNAs were upregulated (fold change > 2) and 20 lncRNAs downregulated (fold change < -2) in OSCC compared to corresponding adjacent normal tissues. Because our laboratory is interested in DNA methylation associated genes, downregulated lncRNAs are priority to further study. Therefore, we used the quantitative real-time polymerase chain reaction (RT-PCR) to examine the expression levels of lncRNA candidates, revealing that the expression levels of ATP13A4-AS1, IL20RB-AS1, LINC00265, LINC00478, LINC00568, MAST4-AS1, MIR600HG and SOX21-AS1 significantly decreased in OSCC tissues. We further assessed the impact of these lncRNAs on clinical outcomes, showing that low expression levels of LINC00265 well correlated with late pathologic stage (P value=0.013) and large tumor size (P value=0.006). Interestingly, Kaplan-Meier curves revealed that low expression level of SOX21-AS1 (SOX21 antisense RNA 1) was significantly associated with a shorter survival (log rank p value= 0.016) (crude hazard ratio 0.19, 95%CI 0.04-0.86, p=0.031). Multivariate analysis revealed that low expression levels of SOX21-AS1 significantly associated with a shorter survival (adjusted hazard ratio 0.19, 95%CI 0.04-0.87, p=0.032). In addition, the expression levels of SOX21-AS1 could be restored in oral cancer cells with 5-aza-2'-deoxycytidine (5-aza-dc) treatment. We further analyzed the methylation status of three individual CpG islands of SOX-21-AS1 using combined bisulfite restriction assay (COBRA) and revealed that hypermethylated promoter regions of SOX-21-AS1 were frequently observed in OSCC (CpG1: 65 out of 85, 76.5%; CpG2: 52 out of 85, 61.2%; CpG3: 49 out of 85; 57.6%). Hypermethylation of SOX21-AS1 promoter was significantly correlation with moderate or poor cell differentiation of OSCC. In vitro methylation assay showed that SOX21-AS1 transactivation activity could be significantly repressed with a hypermethylated promoter. Taking together, these results indicated that abnormal DNA hypermethylation might result in SOX21-AS1 repression in OSCC. We also identified 12 putative transcription factors (AP2alpha, CEBPA, CEBPB, GATA-1, NF-1, NF-kB, NR3C1, RelA, SP1, TEAD2, WT1, YY1) using bioinformatics approach. However, the detailed roles of them still need more experiments to confirm in the future. Concluding, our study revealed that DNA hypermethylation may result in silencing SOX21-AS1 expression in OSCC. Low SOX21-AS1 expression could be provided as a good independent prognostic biomarker… Advisors/Committee Members: ping%20Ger%22%29&pagesize-30">Luo-ping Ger (committee member), Y. L. Shiue (chair), Pei-feng Liu (chair), Kuo-wang Tsai (chair).

Subjects/Keywords: lncRNA; oral cancer; SOX21-AS1; next generation sequencing; methylation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, T. (2015). Long non-coding RNAs Expression Profiles in Human Oral Squamous Cell Carcinoma and Its Clinical Significances. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803115-095752

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Tsung-han. “Long non-coding RNAs Expression Profiles in Human Oral Squamous Cell Carcinoma and Its Clinical Significances.” 2015. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803115-095752.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Tsung-han. “Long non-coding RNAs Expression Profiles in Human Oral Squamous Cell Carcinoma and Its Clinical Significances.” 2015. Web. 08 Mar 2021.

Vancouver:

Wang T. Long non-coding RNAs Expression Profiles in Human Oral Squamous Cell Carcinoma and Its Clinical Significances. [Internet] [Thesis]. NSYSU; 2015. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803115-095752.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang T. Long non-coding RNAs Expression Profiles in Human Oral Squamous Cell Carcinoma and Its Clinical Significances. [Thesis]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803115-095752

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

9. Weng, Ta-Jung. The Impact of Collagens Related Proteinsâ Expression on the Tumorigenesis and Prognosis of Buccal Mucosal Squamous Cell Carcinoma.

Degree: Master, Institute of Biomedical Sciences, 2015, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806115-133110

► Oral cancer is one of the top ten most common cancers worldwide. Oral squamous cell carcinoma (SCC) is the most common type of oral cancer.… (more)

▼ Oral cancer is one of the top ten most common cancers worldwide. Oral squamous cell carcinoma (SCC) is the most common type of oral cancer. Although it can be controlled by surgical excision and radiotherapy, metastasis to the lymph nodes and distant organs, may lead to treatment failure and patient death. Recently, our next-generation sequencing assay identified 8 collagen-related genesâ expression (COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, COL6A1, and COL11A1) involved in tumorigenesis and progression of oral SCC. The purpose of this study was to validate the association of the mRNA and protein expression of 8 collagen-related genes with the development and prognosis of oral SCC. The mRNA expression levels of 8 collagen-related proteins were assayed by real-time PCR in N-T paired tissues of 23 buccal mucosal SCC and 11 tongue SCC patients. The protein expression levels of 8 collagen-related proteins were examined by immunohistochemistry (IHC) in tissue microarray slides of 484 oral SCC patients, including 176 buccal mucosal, 246 tongue, and 62 lip patients. The mRNA and protein expression levels of 8 collagen-related proteins were significantly increased in tumor tissues as compared to the paired tumor adjacent normal tissue, except mRNA and protein expression of COL5A2 in buccal mucosal SCC. Our IHC results showed that the median expression levels of COL1Î±1, COL1Î±2, COL4Î±1, COL5Î±1, COL5Î±2, COL6Î±1, and COL11Î±1 were 4, 2, 2, 4, 3, 3, and 3 in 176 buccal mucosal SCC specimens, respectively. In addition, the median expression levels of COL5Î±1 and COL5Î±2 were 5 and 2, 2 and 3, as well as 4 and 2 in 246 tongue SCC specimens, 62 lip SCC specimens, and 484 oral SCC speicements, respectively. In buccal mucosal SCC, we found that a higher level of COL1Î±1 was correlated with higher grade of cell differentiation. However, higher level of COL1Î±2 was correlated with small size of tumor and higher level of COL5Î±2 was correlated with absence of lymph node invasion. In oral SCC, the increased expression of COL5Î±1 was correlated with higher grade of cell differentiation (especially for buccal mucosal SCC), late stage of disease (except for lip SCC), and involvement of lymph node (except for lip SCC). However, the increased expression of COL5Î±2 was correlated with lower grade of cell differentiation (especially for buccal mucosal SCC). After adjustment of clinicopathologic outcomes, tongue SCC patients with the elevated COL5Î±1 expression had worse disease-specific survival (adjusted hazard ratio [AHR] 1.96, 95%CI 1.27-3.01, p=0.002) and disease-free survival ([AHR] 1.96, 95%CI 1.28-3.01, p=0.002). However, buccal mucosal SCC patients with increased COL5Î±2 expression had better disease-specific survival ([AHR] 0.49, 95%CI 0.29-0.84, p=0.009). In conclusion, COL1Î±1, COL1Î±2, COL4Î±1, COL5Î±1, COL5Î±2, COL6Î±1, and COL11Î±1 could be biomarkers for tumorigenesis in oral SCC, especially for buccal mucosal SCC. Additionally, COL5Î±1 and COL5Î±2 might be prognostic biomarkers for oral SCC, especially for buccal… Advisors/Committee Members: Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member), Y. L. Shiue (chair), Kuo-Wang Tsai (chair).

Subjects/Keywords: immunohistochemistry; prognosis; tumorigenesis; collagen; buccal mucosal squamous cell carcinoma; Oral squamous cell carcinoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Weng, T. (2015). The Impact of Collagens Related Proteinsâ Expression on the Tumorigenesis and Prognosis of Buccal Mucosal Squamous Cell Carcinoma. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806115-133110

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Weng, Ta-Jung. “The Impact of Collagens Related Proteinsâ Expression on the Tumorigenesis and Prognosis of Buccal Mucosal Squamous Cell Carcinoma.” 2015. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806115-133110.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Weng, Ta-Jung. “The Impact of Collagens Related Proteinsâ Expression on the Tumorigenesis and Prognosis of Buccal Mucosal Squamous Cell Carcinoma.” 2015. Web. 08 Mar 2021.

Vancouver:

Weng T. The Impact of Collagens Related Proteinsâ Expression on the Tumorigenesis and Prognosis of Buccal Mucosal Squamous Cell Carcinoma. [Internet] [Thesis]. NSYSU; 2015. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806115-133110.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Weng T. The Impact of Collagens Related Proteinsâ Expression on the Tumorigenesis and Prognosis of Buccal Mucosal Squamous Cell Carcinoma. [Thesis]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806115-133110

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

10. Sie, Huei-Cin. The association of GBP5, GBP6, and DDX60 expressions with the development and prognosis of oral cancer.

Degree: Master, Biological Sciences, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0029116-230311

► Backgrounds: Oral cancer is one of the most common cancers worldwide and the fourth leading cause of cancer death among males in Taiwan. Interferons (IFNs)… (more)

▼ Backgrounds: Oral cancer is one of the most common cancers worldwide and the fourth leading cause of cancer death among males in Taiwan. Interferons (IFNs) including Type I IFNs (IFN-Î±/Î²) and type II IFNs (IFN-Î³) are well-known potent cytokine in host defenses against infection with viral and microbial pathogens. However, they have been proven in malignant transformation of tumor cells. Guanylate binding protein (GBP) 5 and GBP6 belong to the guanosine triphosphatase (GTPase) superfamily, which plays an important role in cell proliferation, differentiation, signal transduction, and intracellular protein transportation. In addition, GBP expression is mostly induced by IFN-Î³. On the other hand, DDX60, a subtype of DEXD/H Box Helicase, is required for RIG-I- or MDA5-dependent type I interferon production. DDX60 belongs to a DEAD box RNA helicase involving in most cellular processes, such as essential for cancer development. However, roles of GBP5, GBP6 and DDX60 in cancer especially for oral squamous cell carcinoma (OSCC) were not identified so far. The purpose of this study was to investigate the association of the expression levels of GBP5, GBP6 and DDX60 with tumorigenesis, clinicopathologic outcomes, and survival of patients with OSCC and three primary subsites. Methods: Our preliminary data from next generation sequencing (NGS) indicated that in two pairs of OSCC and corresponding tumor adjacent normal (CTAN) tissues, the gene expressions of GBP5 and DDX60 in OSCC tissue were significant higher than that in CTAN tissue but the GBP6 gene expression in OSCC tissue was significant decreased than that in CTAN tissue. Gene expressions of GBP5, GBP6 and DDX60 were further confirmed by real-time polymerase chain reaction (RT-PCR) using 23 pairs of mucosa squamous cell carcinoma (BMSCC) and CTAN tissues as well as 14 pairs of tongue squamous cell carcinoma (TSCC) and CTAN tissues. In the study, expression levels of GBP5, GBP6 and DDX60 were examined by immunohistochemistry with tissue microarray slides of 494 OSCC patients including 180 buccal mucosal SCC (BMSCC), 241 tongues SCC (TSCC), and 73 lip SCC (LSCC) patients. Results: The expression results of GBP5, GBP6 and DDX60 assayed by NGS, RT-PCR and immunohistochemical staining were quite consistent. GBP5 and DDX60 expressions (all p <0.05) significantly increased, whereas GBP6 (p <0.001) expression decreased in tumor tissues compared to that in CTAN tissues, indicating that GBP5 and DDX60 might be oncoproteins, but GBP6 was a tumor suppressor. Among OSCC tissues of 494 patients, the higher GBP5 expression was associated with older age over 50 yrs. (>50 yrs.; p=0.019) and well differentiation (p=0.036), whereas decreased GBP6 expression was associated with poor differentiation (p<0.001). Among BMSCC tissues of 180 patients, the GBP5 expression was positively associated with older age (>50 yrs.; p=0.021), although GBP6 expression was negatively associated with poor differentiation (p=0.039). Among TSCC tissues of 241 patients, the loss of GBP6 expression was associated… Advisors/Committee Members: Pei-Feng Liu (chair), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member), Jiin-Tsuey Cheng (committee member), Ting-Ying Fu (chair).

Subjects/Keywords: GBP5; oral squamous cell carcinoma; prognosis; tumor development; DDX60; GBP6

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sie, H. (2016). The association of GBP5, GBP6, and DDX60 expressions with the development and prognosis of oral cancer. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0029116-230311

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sie, Huei-Cin. “The association of GBP5, GBP6, and DDX60 expressions with the development and prognosis of oral cancer.” 2016. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0029116-230311.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sie, Huei-Cin. “The association of GBP5, GBP6, and DDX60 expressions with the development and prognosis of oral cancer.” 2016. Web. 08 Mar 2021.

Vancouver:

Sie H. The association of GBP5, GBP6, and DDX60 expressions with the development and prognosis of oral cancer. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0029116-230311.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sie H. The association of GBP5, GBP6, and DDX60 expressions with the development and prognosis of oral cancer. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0029116-230311

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

11. Wang, Yuan-Bang. The Association of XRCC1 Polymorphisms with the Risk of Oral Precancerous Lesions.

Degree: Master, Biological Sciences, 2012, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0812112-212338

► Betel quidï¼BQï¼chewing is recognized as a major risk factor for oral precancerous lesionsï¼OPLsï¼in Taiwan. The compositions of Betel quid could cause DNA damage. X-ray repair… (more)

Subjects/Keywords: Betel quid; XRCC1; oral precancerous lesions; leukoplakia; oral submucous fibrosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Y. (2012). The Association of XRCC1 Polymorphisms with the Risk of Oral Precancerous Lesions. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0812112-212338

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Yuan-Bang. “The Association of XRCC1 Polymorphisms with the Risk of Oral Precancerous Lesions.” 2012. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0812112-212338.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Yuan-Bang. “The Association of XRCC1 Polymorphisms with the Risk of Oral Precancerous Lesions.” 2012. Web. 08 Mar 2021.

Vancouver:

Wang Y. The Association of XRCC1 Polymorphisms with the Risk of Oral Precancerous Lesions. [Internet] [Thesis]. NSYSU; 2012. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0812112-212338.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Y. The Association of XRCC1 Polymorphisms with the Risk of Oral Precancerous Lesions. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0812112-212338

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

12. Ming Yen, Liang. The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas.

Degree: Master, Biological Sciences, 2011, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128

► X-ray repair cross complementing Group 1 (XRCC1) protein plays an important role in base excision repair. Single nucleotide polymorphisms (SNPs) in XRCC1 gene may affect… (more)

▼ X-ray repair cross complementing Group 1 (XRCC1) protein plays an important role in base excision repair. Single nucleotide polymorphisms (SNPs) in XRCC1 gene may affect DNA repairing ability, genetic susceptibility, and prognosis to oral and pharyngeal squamous cell cancer (OPSCC). This study was carried out to evaluate the association of three XRCC1 SNPs with the risk and prognosis of OPSCC. A total of 509 OPSCC cases and 678 cancer-free controls were recruited to detect the genotypes of XRCC1 by PCR-RFLP. Then, 447 case patients with surgical treatment and safety margins were included in the survival analysis. No association was observed for XRCC1 194 and the risk of OPSCC. As compared with the wild Arg/Arg genotype, the combined genotypes of 280 Arg/His and His/His were with decreased risk (AOR=0.73, 95% CI, 0.52-1.03, p = 0.069) of OPSCC and with a significantly decreased risk (AOR=0.67, 95% CI, 0.47-0.97, p = 0.035) of oral cavity. As compared with the Arg/Arg genotype of XRCC1 399, the Gln/Gln genotype was with the increased risk of OPSCC (AOR=2.06, 95%CI: 1.21-3.51, p = 0.008) and oral cavity cancer (AOR=1.89, 95%CI: 1.08-3.33, p = 0.026). We defined the âputative high risk haplotypesâ as âArg-Arg-Gln and Trp-Arg-Glnâ. The AOR were 1.29 (95% CI, 1.04-1.60, p = 0.020) for the âputative high risk haplotypesâ as compared with other haplotypes for OPSCC. Then, two putative high risk haplotypes were combined into âputative high risk diplotypesâ. The AOR for the âhigh risk diplotypesâ were 1.98 (95% CI, 1.18-3.33, p = 0.010) as compared with other diplotypes for OPSCC. No association between XRCC1 polymorphisms and clinicopathological outcomes, except XRCC1 280. Those carriers of XRCC1 280His allele (combined Arg/His and His/His genotypes) were associated with late onset (≥50 yrs) of oral cavity cancers. No association between genetic variants in XRCC1 and disease-specific survival except XRCC1 399. Patients with 399 Arg/Gln and Gln/Gln genotypes showed a significant better survival as compared to Arg/Arg genotype carriers (AHR 0.41 95% CI: 0.18-0.93), especially for those patients younger than 50 years (p = 0.012), in pathological stage III or IV (p = 0.044), and without postoperative radiotherapy (p = 0.012). In summary, XRCC1 280 Arg/His and His/His genotypes were associated with decreased risk of oral cavity cancer. 399 Gln/Gln genotype was associated with increased risk of OPSCC and oral cavity cancer. The putative âhigh risk haplotypes and diplotypesâ were with increased risk of OPSCC. However, 399 Arg/Gln and Gln/Gln genotypes were prognostic factors, especially for those with young age, aggressive tumor stage, and without postoperative radiotherapy for oro and hypopharynx patients. These findings suggest that XRCC1 polymorphisms may play a role in the development and prognosis of OPSCC. Advisors/Committee Members: Shiue, Yow-Ling (chair), Cho, Chung-Lung (chair), Cheng, Jiin-Tsuey (committee member), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member).

Subjects/Keywords: prognosis; polymorphism; XRCC1; risk; OPSCC; oral cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ming Yen, L. (2011). The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ming Yen, Liang. “The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas.” 2011. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ming Yen, Liang. “The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas.” 2011. Web. 08 Mar 2021.

Vancouver:

Ming Yen L. The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas. [Internet] [Thesis]. NSYSU; 2011. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ming Yen L. The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas. [Thesis]. NSYSU; 2011. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

13. Tzeng, Yau-Jin. Next generation sequencing-based study in breast cancer.

Degree: Master, Institute of Biomedical Sciences, 2017, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0627117-110840

► Background: Breast cancer is the top one leading cause of cancer and top four cancer death for females in Taiwan. Next generation sequencing (NGS) is… (more)

▼ Background: Breast cancer is the top one leading cause of cancer and top four cancer death for females in Taiwan. Next generation sequencing (NGS) is a powerful and high-throughput technology for analyzing transcriptome profile. In this study, we like to identify differential expression genes (DEGs) in breast cancer compared to corresponding adjacent normal tissues by NGS approach. Furthermore, we will further assess whether these DEFs can be used as prognostic biomarkers for triple negative breast cancer. Methods: Using laser capture microdissection (LCM) approach, we precisely collected breast cancer tissues and adjacent normal tissues from three patients with triple negative breast cancer. The transcriptome profiles of breast cancer and corresponding adjacent normal tissue were generated using NGS approach and the DEGs were identified. We further identified metastasis-related DEGs via pathway enrichment analysis. The expression levels and clinical impacts of these metastasis-related DEGs were examined by analyzing the Cancer Genome Atlas (TCGA) database. Results: A total of 731 DEGs (fold change RPKM >4 and <0.25) were identified in triple negative breast cancer. Our data revealed that these DEGs were significantly involved in nineteen cancer-related signaling pathways by pathway enrichment analysis. Among them, 33 DEGs were significantly enriched in three metastasis-related signal transduction pathways, including PI3K-Akt signaling pathway, Rap1 signaling pathway and ECM-receptor interaction. Univariate analysis revealed that high expression levels of VEGFA and HMMR significantly correlated with poor overall survival curve (VEGFA: p=0.022 and HMMR: p=0.01), whereas high expression levels of BCL2 and IGF1R significantly associated with better overall survival curve of breast cancer(BCL2: p=0.007 and IGF1R: p=0.002). In addition, our data indicated that a high expression levels of HMMR correlated with poor pathological stage (p <0.001) and large tumor size (p<0.001). High expression levels of COL6A6 were significantly correlated with early pathological stage (p=0.003) and small tumor size (p<0.001) and high expression levels of GNG7 well associated with absence of lymph node invasion (p=0.002). Multivariate analysis revealed that high HMMR; VEGFA expression had worse overall survival (HMMR: adjust hazard ratio [AHR] 1.93, 95%CI 1.10-3.41, p=0.023 and VEGFA: [AHR] 11.60, 95%CI 1.60-84.09, p=0.015) for breast cancer. Furthermore, high BCL2 and IGF1R expression had good overall survival (BCL2: [AHR] 0.43, 95%CI 0.23-0.79, p=0.007 and IGF1R: [AHR] 0.45, 95%CI 0.25-0.8, p=0.006). In addition, the high COL6A6 expressions were significantly correlated with better disease-free survival (DFS) ([AHR] 0.37, 95%CI 0.16-0.83, p=0.016). Combined the effects of six genes risks showed a significantly correlation with worse overall survival (OS) for breast cancer patients and the degree showed a linear trend for their impact on overall survival (p for linear trend <0.001). Conclusions: We identified six differential expression… Advisors/Committee Members: Angela Chen (committee member), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (chair), Kuo-Wang Tsai (chair), Pei-Feng Liu (chair), Shiue YL (chair).

Subjects/Keywords: The Cancer Genome Atlas database; breast cancer; laser capture microdissection; pathway enrichment analysis; next generation sequencing; triple negative breast cancer; invasive ductal carcinoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tzeng, Y. (2017). Next generation sequencing-based study in breast cancer. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0627117-110840

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tzeng, Yau-Jin. “Next generation sequencing-based study in breast cancer.” 2017. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0627117-110840.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tzeng, Yau-Jin. “Next generation sequencing-based study in breast cancer.” 2017. Web. 08 Mar 2021.

Vancouver:

Tzeng Y. Next generation sequencing-based study in breast cancer. [Internet] [Thesis]. NSYSU; 2017. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0627117-110840.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tzeng Y. Next generation sequencing-based study in breast cancer. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0627117-110840

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

14. Jin, Yi-Ru. Dietary vitamin A/precursors and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaves consumption.

Degree: Master, Biological Sciences, 2005, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0722105-233128

► In 2004, lung cancer has been the leading cause of cancer death in Taiwan. Many studies demonstrate that vitamin A plays a crucial role in… (more)

▼ In 2004, lung cancer has been the leading cause of cancer death in Taiwan. Many studies demonstrate that vitamin A plays a crucial role in the prevention of lung cancer. However, few epidemiologic studies have examined the association of dietary vitamin A/precursors and lung cancer in Taiwan. Therefore, a case-control study was conducted to investigate the relationship between the consumption of local common foods that are rich in vitamin A/precursors and the risk of lung cancer. The cases were 301 newly diagnosed patients with histopathologically confirmed primary lung cancer. Two control groups were recruited: 602 hospital controls and 602 neighborhood controls. The consumption of 13 food items and vitamin supplements was estimated with the use of a structured food-frequency questionnaire in face-to-face interviews. Adjusted odds ratios (AOR) and the corresponding 95% confidence intervals (CI) were evaluated with controlling for potential confounders, using the conditional logistic regression model. It was found that reduced risk for lung cancer was associated with increased intakes of vitamin A, a-carotene, or b-carotene from various food groups except fruits. However, inverse associations were not observed for vitamin A, a-carotene, or b-carotene intake from various food items, except garland chrysanthemum and sweet potato leaves. On the other hand, retinol intake from food groups or items was not correlated with lung cancer development. Additionally, more servings of vegetables (AOR for the highest versus the lowest quartile = 0.67-0.70, 95% CI = 0.42-1.08, plinear trend = 0.04), garland chrysanthemum (AOR for the highest versus the lowest tertile = 0.58-0.74, 95% CI = 0.37-1.14, plinear trend = 0.01-0.04) and sweet potato leaves (AOR for the highest versus the lowest tertile = 0.43-0.65, 95% CI = 0.28-0.96, plinear trend £ 0.03) were associated with the reduced risk for lung cancer. In conclusion, there were protective effects of dietary intake of vitamin A, a-carotene and b-carotene. The vegetables provided higher potential protection against development of lung cancer than the fruits, especially for garland chrysanthemum and sweet potato leaves. Therefore, our findings suggest that more consumption of garland chrysanthemum and sweet potato leaves might reduce the risk of lung cancer in Taiwan. Advisors/Committee Members: Jiin-Tsuey Cheng (chair), Meei-Shyuan Lee (chair), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member).

Subjects/Keywords: garland chrysanthemum; sweet potato leaves; case-control study; vitamin A; Taiwan; lung cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jin, Y. (2005). Dietary vitamin A/precursors and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaves consumption. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0722105-233128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jin, Yi-Ru. “Dietary vitamin A/precursors and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaves consumption.” 2005. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0722105-233128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jin, Yi-Ru. “Dietary vitamin A/precursors and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaves consumption.” 2005. Web. 08 Mar 2021.

Vancouver:

Jin Y. Dietary vitamin A/precursors and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaves consumption. [Internet] [Thesis]. NSYSU; 2005. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0722105-233128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jin Y. Dietary vitamin A/precursors and lung cancer risk in Taiwan: with special reference to garland chrysanthemum and sweet potato leaves consumption. [Thesis]. NSYSU; 2005. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0722105-233128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

15. Keng, Hsiu-man. Association of Tumor Necrosis Factor a, Tumor Necrosis Factor Receptors and Interleukin-1b Genetic Polymorphisms in Palindromic Rheumatism.

Degree: Master, Biological Sciences, 2006, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607106-140016

► ABSTRACT Background: Palindromic rheumatism (PR) is the rare disease that generally occurs with multiple recurring attacks of painful inflammation affecting joints and adjacent tissues. The… (more)

Subjects/Keywords: SNP; IL-1Î²; TNFRSF1B; TNFRSF1A; Palindromic rheumatism; TNF-Î±

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keng, H. (2006). Association of Tumor Necrosis Factor a, Tumor Necrosis Factor Receptors and Interleukin-1b Genetic Polymorphisms in Palindromic Rheumatism. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607106-140016

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Keng, Hsiu-man. “Association of Tumor Necrosis Factor a, Tumor Necrosis Factor Receptors and Interleukin-1b Genetic Polymorphisms in Palindromic Rheumatism.” 2006. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607106-140016.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Keng, Hsiu-man. “Association of Tumor Necrosis Factor a, Tumor Necrosis Factor Receptors and Interleukin-1b Genetic Polymorphisms in Palindromic Rheumatism.” 2006. Web. 08 Mar 2021.

Vancouver:

Keng H. Association of Tumor Necrosis Factor a, Tumor Necrosis Factor Receptors and Interleukin-1b Genetic Polymorphisms in Palindromic Rheumatism. [Internet] [Thesis]. NSYSU; 2006. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607106-140016.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Keng H. Association of Tumor Necrosis Factor a, Tumor Necrosis Factor Receptors and Interleukin-1b Genetic Polymorphisms in Palindromic Rheumatism. [Thesis]. NSYSU; 2006. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607106-140016

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

16. Huang, Shiau-Jiuan. Detection and analysis of Anti-SARS-CoV Immunoglobulin G and associated risk factor among healthcare workers in Taiwan.

Degree: Master, Biological Sciences, 2006, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0712106-162219

► Severe acute respiratory syndrome (SARS) is an emerging infectious disease that first manifested in humans in China in November 2002 and has subsequently spread worldwide.… (more)

▼ Severe acute respiratory syndrome (SARS) is an emerging infectious disease that first manifested in humans in China in November 2002 and has subsequently spread worldwide. According to the World Health Organization, 8098 cases occurred during the outbreak, and healthcare workers accounted for 1707 (21%) of the cases. To determine the prevalence of SARS infection of healthcare workers in Taiwan, we performed a serosurvey by the recombinant protein-based enzyme-linked immunosorbent assay (ELISA) to test for immunoglobulin (Ig) G antibodies to the SARS coronavirus (SARS-CoV) among 1525 healthcare workers in 26 hospitals that admitted SARS patients in mid-May, 2003. Then, a case-control study was carried out to evaluate the risk factors of SARS infection among the healthcare workers. A total of 52 infected staffs and 78 hospital and age matched non-infected controls were recruited. The seroprevalence rate was 3.68% (58/1525) for healthcare workers. Univariate analysis showed that with the habit of drinking coffee or tea, taking care of fever patients more than 8 days, ever practice of CPR, suction of sputum, taking patientâs temperature, use of P100 mask, use of N95 mask, use of face cover, use of goggles, use of gown, removing gloves after work, working in isolation area or fever screen station were significantly protective factors. In addition, eating jujube was a risk factor for SARS infection. Then, the multivariate analysis showed that use of P100 ï¼OR: 0.056, 95%CI: 0.019-0.162, p value: <0.001ï¼and working in isolation area ï¼OR: 0.153, 95%CI: 0.029-0.810, p value: 0.027ï¼or fever screen stationï¼OR: 0.103, 95%CI: 0.011-0.963, p value: 0.046ï¼were the most important protective factors for SARS infection. These findings suggest that nosocomial infection of SARS can be prevented effectively by use of P100 and the triage screening in emergency departments. Advisors/Committee Members: Yao-Shen Chen (chair), Hsueh-Wen Chang (chair), Ping%20Ger%22%29&pagesize-30">Luo-Ping Ger (committee member).

Subjects/Keywords: severe acute respiratory syndromeãcase-control study

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Huang, S. (2006). Detection and analysis of Anti-SARS-CoV Immunoglobulin G and associated risk factor among healthcare workers in Taiwan. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0712106-162219

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Huang, Shiau-Jiuan. “Detection and analysis of Anti-SARS-CoV Immunoglobulin G and associated risk factor among healthcare workers in Taiwan.” 2006. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0712106-162219.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Huang, Shiau-Jiuan. “Detection and analysis of Anti-SARS-CoV Immunoglobulin G and associated risk factor among healthcare workers in Taiwan.” 2006. Web. 08 Mar 2021.

Vancouver:

Huang S. Detection and analysis of Anti-SARS-CoV Immunoglobulin G and associated risk factor among healthcare workers in Taiwan. [Internet] [Thesis]. NSYSU; 2006. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0712106-162219.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Huang S. Detection and analysis of Anti-SARS-CoV Immunoglobulin G and associated risk factor among healthcare workers in Taiwan. [Thesis]. NSYSU; 2006. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0712106-162219

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations