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You searched for +publisher:"NSYSU" +contributor:("Hui-Min David Wang"). Showing records 1 – 3 of 3 total matches.

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NSYSU

1. Chen, Li-Chai. Anti-inflammatory, analgesic and wound healing effects of the marine natural products.

Degree: PhD, Marine Biotechnology and Resources, 2016, NSYSU

Part I Recent research indicated that the compounds from the crinoids inhibit the activation of the transcription factor nuclear factor-κB (NF-κB). However, to date, no study has been conducted to explore the bioactivity of anti-inflammatory and analgesic from the crinoid. Here we report the anti-inflammatory properties of comaparvin from the crinoid Comanthus bennetti based on in vivo experiments. Comaparvin isolated from crinoids significantly decreased the expression of inducible nitric oxide synthase (iNOS) protein and mRNA in lipopolysaccharide (LPS)-stimulated macrophage cells. Moreover, our results showed that treatment with comaparvin significantly inhibited mechanical allodynia, thermal hyperalgesia and weight-bearing deficits in rats with carrageenan-induced inflammation. Comaparvin also attenuated leukocyte infiltration and iNOS protein expression in carrageenan- induced inflamed paws. These results suggest that comaparvin is a potential anti-inflammatory therapeutic agent against inflammatory pain. Part II Burn injury is one of the most devastating injuries. This injury, even only local effect, may lead to long-term intense inflammation, tissue damage, infections, and increased mortality. Today, most of the drugs used in burn injuries mainly focus on the anti-microbial activity, and the course of burn injuries is not effectively improved by any topical agent yet. In the present study, we investigated the skin regenerative activity of C-phycocyanin (C-PC) through both in vitro and in vivo models, and the result showed C-PC did not enhance significantly the migration of EA.hy926 cells. Moreover, our results showed that C-PC enhanced the wound healing rate on burn wound but not on excision wounds in normal rats. Also, this ingredient did not improve the healing process of burn or excision wounds in diabetic rats as well. This result proposes that C-PC, through different mechanisms, might involve in skin regeneration in normal rats. Advisors/Committee Members: Jih-Jung Chen (chair), Zhi-Hong Wen (committee member), Chun-Lin Chen (chair), Hui-Min David Wang (chair), Ping-Jyun Sung (chair), Li-Yu Chang (chair), Yao-Chang Chen (chair).

Subjects/Keywords: comaparvin; Comanthus bennetti; crinoids; inducible nitric oxide synthase; C-phycocyanin; wound healing

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APA (6th Edition):

Chen, L. (2016). Anti-inflammatory, analgesic and wound healing effects of the marine natural products. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0027116-204442

Chicago Manual of Style (16th Edition):

Chen, Li-Chai. “Anti-inflammatory, analgesic and wound healing effects of the marine natural products.” 2016. Doctoral Dissertation, NSYSU. Accessed May 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0027116-204442.

MLA Handbook (7th Edition):

Chen, Li-Chai. “Anti-inflammatory, analgesic and wound healing effects of the marine natural products.” 2016. Web. 08 May 2021.

Vancouver:

Chen L. Anti-inflammatory, analgesic and wound healing effects of the marine natural products. [Internet] [Doctoral dissertation]. NSYSU; 2016. [cited 2021 May 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0027116-204442.

Council of Science Editors:

Chen L. Anti-inflammatory, analgesic and wound healing effects of the marine natural products. [Doctoral Dissertation]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0027116-204442


NSYSU

2. Kao, Chien-Jen. The neuroprotective effects of modifying soft coral-derived compound.

Degree: PhD, Marine Biotechnology and Resources, 2018, NSYSU

Previous studies have demonstrated that the marine compound austrasulfone, isolated from the soft coral Cladiella australis, exerts a neuroprotective effect. The intermediate product in the synthesis of austrasulfone, dihydroaustrasulfone alcohol, attenuates inflammatory responses. The present study uses in vitro and in vivo methods to investigate the neuroprotective effects of dihydroaustrasulfone alcohol-modified 1-tosylpentan-3-one (1T3O). Results from in vitro experiments show that 1T3O effectively inhibits 6-hydroxydopamine (6-OHDA)-induced activation of both p38 mitogen-activated protein kinase (MAPK) and caspase-3 in SH-SY5Y cells; and enhances nuclear factor erythroid 2ârelated factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression via phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling. Hoechst staining and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining results reveal that 1T3O significantly inhibits 6-OHDA-induced apoptosis. Moverover, the addition of an Akt or HO-1inhibitor decreases the protective effect of 1T3O. Thus, we hypothesize that the anti-apoptotic activity of 1T3O in neuronal cells is mediated through the regulation of the Akt and HO-1 signaling pathways. In vivo experiments show that 1T3O can reverse 6-OHDA-induced reduction in locomotor behavior ability in zebrafish larvae, and inhibit 6-OHDA-induced tumor necrosis factor-alpha (TNF-α) increase at the same time. According to our in vitro and in vivo results, we consider that 1T3O exerts its anti-apoptotic activities at SH-SY5Y cells after 6-OHDA challenges, probably via the regulation of anti-oxidative signaling pathways. Therefore, this compound may be a promising therapeutic agent for neurodegenerations. Advisors/Committee Members: Wen Zhi-Hong (committee member), Wu-Fu Chen (chair), San-Nan Yang (chair), Chien-Chih Chiu (chair), Hui-Min David Wang (chair), Wu, Chang-Yi (chair).

Subjects/Keywords: 1-tosylpentan-3-one; SH-SY5Y cells; zebrafish; 6-OHDA-induced apoptosis; marine compounds; neuroprotection

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APA (6th Edition):

Kao, C. (2018). The neuroprotective effects of modifying soft coral-derived compound. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0504118-094049

Chicago Manual of Style (16th Edition):

Kao, Chien-Jen. “The neuroprotective effects of modifying soft coral-derived compound.” 2018. Doctoral Dissertation, NSYSU. Accessed May 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0504118-094049.

MLA Handbook (7th Edition):

Kao, Chien-Jen. “The neuroprotective effects of modifying soft coral-derived compound.” 2018. Web. 08 May 2021.

Vancouver:

Kao C. The neuroprotective effects of modifying soft coral-derived compound. [Internet] [Doctoral dissertation]. NSYSU; 2018. [cited 2021 May 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0504118-094049.

Council of Science Editors:

Kao C. The neuroprotective effects of modifying soft coral-derived compound. [Doctoral Dissertation]. NSYSU; 2018. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0504118-094049


NSYSU

3. Wang, Yi-Chen. The effects of anti-inflammatory marine-derived compound on atherosclerosis.

Degree: PhD, Marine Biotechnology and Resources, 2017, NSYSU

Atherosclerosis is an inflammatory disease that can be treated with medications in the clinic. Nonetheless, some anti-atherosclerotic drugs, such as simvastatin, used in clinically have several side effects. Recently, several unique marine compounds have reported to have various bioactivities. One of our previous studies revealed that dihydroaustrasulfone alcohol (WA-25), a synthetic precursor of the marine compound (austrasulfone), has anti-atherosclerotic effects in vivo. However, the detailed mechanisms remain unclear. Therefore, to clarify the mechanisms by which WA-25 exerts anti-atherosclerotic activity, we used RAW 264.7 macrophages as an in vitro model to evaluate the effects of WA-25. In lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, WA-25 significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). In contrast, simvastatin increased the COX-2 expression compared to that with WA-25. In addition, WA-25 inhibited foam cell formation and up-regulated the lysosomal and cyclic adenosine monophosphate (cAMP) signaling pathway. Moreover, transforming growth factor β1 (TGF-β1) was up-regulated by WA-25 and simvastatin in LPS-induced RAW 264.7 cells, and the promising anti-atherosclerotic effects of WA-25 were disrupted by blockade of TGF- β1 signaling. In addition, WA-25 might act by increasing lipolysis than by alteration of lipid export. Taken together, these data demonstrate that WA-25 may have potential as an anti-atherosclerotic drug with an anti-inflammatory effect. Advisors/Committee Members: Chien-Chih Chiu (chair), Zhi-Hong Wen (committee member), Chang-Yi Wu (chair), Chieh-Yu Pan (chair), Jue-Liang Hsu (chair), Chi-I Chang (chair), Hui-Min David Wang (chair), Wang-Ta Liu (chair), Li-Yu Chang (chair).

Subjects/Keywords: RAW 264.7 macrophages; lipid droplets; anti-inflammatory; marine compound; atherosclerosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wang, Y. (2017). The effects of anti-inflammatory marine-derived compound on atherosclerosis. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0522117-000509

Chicago Manual of Style (16th Edition):

Wang, Yi-Chen. “The effects of anti-inflammatory marine-derived compound on atherosclerosis.” 2017. Doctoral Dissertation, NSYSU. Accessed May 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0522117-000509.

MLA Handbook (7th Edition):

Wang, Yi-Chen. “The effects of anti-inflammatory marine-derived compound on atherosclerosis.” 2017. Web. 08 May 2021.

Vancouver:

Wang Y. The effects of anti-inflammatory marine-derived compound on atherosclerosis. [Internet] [Doctoral dissertation]. NSYSU; 2017. [cited 2021 May 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0522117-000509.

Council of Science Editors:

Wang Y. The effects of anti-inflammatory marine-derived compound on atherosclerosis. [Doctoral Dissertation]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0522117-000509

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