+publisher:"NSYSU" +contributor:("Cho, Chung-Lung")

NSYSU

1. Tseng , Shih-Ya. Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model.

Degree: PhD, Biological Sciences, 2017, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714

► Critical limb ischemia (CLI) is an advanced form of peripheral artery disease in which the narrowing arteries limit blood supply to the lower extremities with… (more)

▼ Critical limb ischemia (CLI) is an advanced form of peripheral artery disease in which the narrowing arteries limit blood supply to the lower extremities with resultant of resting pain and eventually, tissue loss. At present time, it is likely that proangiogenic stem cell therapy is anticipated as a promising therapeutic strategy in patients with CLI. However, a potential limitation of autologous cell therapy is that the insufficient number of stem cells were available the patients who may also suffer other problems. Therefore, how to generate enough autologous stem cells in vitro for future implantation application has become a major issue. Cilostazol is used as a vasodilating and anti-platelet aggregation drug clinically by increasing intracellular levels of cAMP. Our recent works and other reports have suggested that cilostazol may promote angiogenesis. Unfortunately, the effects of cilostazol on growth and differentiation of human early endothelial progenitor cells (EPCs) remain mostly unclear. In the current work, we explored the novel angiogenic effects of cilostazol on EPCs by using both in vitro and in vivo models. We found that human early EPCs treated with cilostazol significantly increase colony-forming units and enhanced differentiation of EPCs toward endothelial lineage. It was not only stimulated proliferation, migration, anti-apoptosis effect but also in vitro vascular tube formation through activation of SDF-1Î± /CXCR4/PI3K/Akt signaling pathway. In addition, Matrigel plug assay and mouse hind limb ischemia model also demonstrated that administration of a concomitant therapy with cilostazol and EPCs-treated mice were in vessel maturation higher, capillary significantly density and blood flow recovery, in comparison with either treatment alone. These results indicated that co-administration of cilostazol reinforced the autocrine effect of transplanted human early EPCs to provide a synergistic effect in angiogenesis through activation of SDF-1 Î±/CXCR4/PI3K/Akt signaling pathway. In clinical Implication, cilostazol plus EPCs treatment may be beneficial in improving EPC transplantation efficacy and enhancing vascular re-endothelialization in patients with critical limb ischemia. Advisors/Committee Members: Wang, Hay-Yan (chair), Wang, Yang-Kao (chair), Lung%22%29&pagesize-30">Cho, Chung-Lung (committee member), Chen, Chun-Lin (chair), Chao, Ting-Hsing (committee member), Li, Yi-Heng (chair).

Subjects/Keywords: Peripheral artery disease; Critical limb ischemia; Angiogenesis; Cilostazol; SDF-1Î±; Endothelial progenitor cells

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APA (6^th Edition):

Tseng , S. (2017). Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714

Chicago Manual of Style (16^th Edition):

Tseng , Shih-Ya. “Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model.” 2017. Doctoral Dissertation, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714.

MLA Handbook (7^th Edition):

Tseng , Shih-Ya. “Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model.” 2017. Web. 08 Mar 2021.

Vancouver:

Tseng S. Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model. [Internet] [Doctoral dissertation]. NSYSU; 2017. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714.

Council of Science Editors:

Tseng S. Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model. [Doctoral Dissertation]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714

NSYSU

2. Chen, Chien-ming. A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock.

Degree: PhD, Biological Sciences, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0111114-133314

► OSTC, a Homo sapiens OSTC/DC2 protein, belongs to a new subunit of mammalian oligosaccharyltransferase (OST). OST transfers the high-mannose sugars to nascent polypeptides during N-linked… (more)

Subjects/Keywords: oligosaccharyltransferase; polyclonal antibody; gene knockdown; heat shock; glycosylation; glycoprotein

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APA (6^th Edition):

Chen, C. (2014). A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0111114-133314

Chicago Manual of Style (16^th Edition):

Chen, Chien-ming. “A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock.” 2014. Doctoral Dissertation, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0111114-133314.

MLA Handbook (7^th Edition):

Chen, Chien-ming. “A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock.” 2014. Web. 08 Mar 2021.

Vancouver:

Chen C. A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock. [Internet] [Doctoral dissertation]. NSYSU; 2014. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0111114-133314.

Council of Science Editors:

Chen C. A study of OSTC/DC2, a novel subunit of oligosaccharyltransferase, after heat shock. [Doctoral Dissertation]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0111114-133314

NSYSU

3. Ming Yen, Liang. The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas.

Degree: Master, Biological Sciences, 2011, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128

► X-ray repair cross complementing Group 1 (XRCC1) protein plays an important role in base excision repair. Single nucleotide polymorphisms (SNPs) in XRCC1 gene may affect… (more)

▼ X-ray repair cross complementing Group 1 (XRCC1) protein plays an important role in base excision repair. Single nucleotide polymorphisms (SNPs) in XRCC1 gene may affect DNA repairing ability, genetic susceptibility, and prognosis to oral and pharyngeal squamous cell cancer (OPSCC). This study was carried out to evaluate the association of three XRCC1 SNPs with the risk and prognosis of OPSCC. A total of 509 OPSCC cases and 678 cancer-free controls were recruited to detect the genotypes of XRCC1 by PCR-RFLP. Then, 447 case patients with surgical treatment and safety margins were included in the survival analysis. No association was observed for XRCC1 194 and the risk of OPSCC. As compared with the wild Arg/Arg genotype, the combined genotypes of 280 Arg/His and His/His were with decreased risk (AOR=0.73, 95% CI, 0.52-1.03, p = 0.069) of OPSCC and with a significantly decreased risk (AOR=0.67, 95% CI, 0.47-0.97, p = 0.035) of oral cavity. As compared with the Arg/Arg genotype of XRCC1 399, the Gln/Gln genotype was with the increased risk of OPSCC (AOR=2.06, 95%CI: 1.21-3.51, p = 0.008) and oral cavity cancer (AOR=1.89, 95%CI: 1.08-3.33, p = 0.026). We defined the âputative high risk haplotypesâ as âArg-Arg-Gln and Trp-Arg-Glnâ. The AOR were 1.29 (95% CI, 1.04-1.60, p = 0.020) for the âputative high risk haplotypesâ as compared with other haplotypes for OPSCC. Then, two putative high risk haplotypes were combined into âputative high risk diplotypesâ. The AOR for the âhigh risk diplotypesâ were 1.98 (95% CI, 1.18-3.33, p = 0.010) as compared with other diplotypes for OPSCC. No association between XRCC1 polymorphisms and clinicopathological outcomes, except XRCC1 280. Those carriers of XRCC1 280His allele (combined Arg/His and His/His genotypes) were associated with late onset (≥50 yrs) of oral cavity cancers. No association between genetic variants in XRCC1 and disease-specific survival except XRCC1 399. Patients with 399 Arg/Gln and Gln/Gln genotypes showed a significant better survival as compared to Arg/Arg genotype carriers (AHR 0.41 95% CI: 0.18-0.93), especially for those patients younger than 50 years (p = 0.012), in pathological stage III or IV (p = 0.044), and without postoperative radiotherapy (p = 0.012). In summary, XRCC1 280 Arg/His and His/His genotypes were associated with decreased risk of oral cavity cancer. 399 Gln/Gln genotype was associated with increased risk of OPSCC and oral cavity cancer. The putative âhigh risk haplotypes and diplotypesâ were with increased risk of OPSCC. However, 399 Arg/Gln and Gln/Gln genotypes were prognostic factors, especially for those with young age, aggressive tumor stage, and without postoperative radiotherapy for oro and hypopharynx patients. These findings suggest that XRCC1 polymorphisms may play a role in the development and prognosis of OPSCC. Advisors/Committee Members: Shiue, Yow-Ling (chair), Lung%22%29&pagesize-30">Cho, Chung-Lung (chair), Cheng, Jiin-Tsuey (committee member), Luo-Ping Ger (committee member).

Subjects/Keywords: prognosis; polymorphism; XRCC1; risk; OPSCC; oral cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ming Yen, L. (2011). The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ming Yen, Liang. “The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas.” 2011. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ming Yen, Liang. “The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas.” 2011. Web. 08 Mar 2021.

Vancouver:

Ming Yen L. The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas. [Internet] [Thesis]. NSYSU; 2011. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ming Yen L. The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas. [Thesis]. NSYSU; 2011. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

4. Liu, Shu-hui. In search of Callionymoidei (Teleostei: Perciformes) relatives and the inferred phylogeny of Glaucosomatidae.

Degree: PhD, Marine Biology, 2010, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0131110-130512

► Percomorpha is the most diverse group of Acanthomorpha, and the interrelationships among the members are unsettled. Perciformes, one order of Percomorpha, is the largest fish… (more)

▼ Percomorpha is the most diverse group of Acanthomorpha, and the interrelationships among the members are unsettled. Perciformes, one order of Percomorpha, is the largest fish order with 160 families placed in 20 suborders. The relationships among the suborders of Perciformes remain conflicting between the hypotheses of phylogenetic relationships based on different characters. Presently, major studies on relationships of higher taxa are from Japanese based on the mitogenome, and the other studies were based on nuclear gene sequences. Mok recently suggest a hypothesis of the Gobioidei, it is the sister group to a clade which includes the Callionymoidei, Dactylopteriformes, and possibly Pegasidae, based on osteological characters. Following this, a phylogenetic hypothesis of the Callionymoidei based on mitochondrial and nuclear genes was conducted, and the Taiwanese and Australian specimens of G. buergeri might be treated as different species. Morphological differentiation in the sagitta in these two groups points to the same conclusion. The Pempheridae is the sister group of the Glaucosomatidae that is demonstrated by molecular evidences. It is the same with the relationship based on the morphological characters, such as otolith and swimbladder, etc. The monophyly of Callionymoidei is not recovered in this study. The Syngnathoidei may be the closest group of Callionymidae, and the Gobiesocoidei is suggested to be closest with Draconettidae. In the application of mitogenomic information, the sequcences selected by Japanese have not been decided to be unsaturated, so I made statistical inference of the variation for mitochondrial sequences and selected nuclear genes. I have found out the variation-saturated genes and discuss the application of these sequences to phylogenetic studies derived from these datasets in this study. Advisors/Committee Members: Shao, Kwang-Tsao (chair), Mok, Hin-Kiu (committee member), Lung%22%29&pagesize-30">Cho, Chung-Lung (chair), Chang, Hsueh-Wen (chair), Tzeng, Chyng-Shyan (chair).

Subjects/Keywords: Molecular phylogeny; Callionymoidei; Saturation analysis; Glaucosomatidae

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, S. (2010). In search of Callionymoidei (Teleostei: Perciformes) relatives and the inferred phylogeny of Glaucosomatidae. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0131110-130512

Chicago Manual of Style (16^th Edition):

Liu, Shu-hui. “In search of Callionymoidei (Teleostei: Perciformes) relatives and the inferred phylogeny of Glaucosomatidae.” 2010. Doctoral Dissertation, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0131110-130512.

MLA Handbook (7^th Edition):

Liu, Shu-hui. “In search of Callionymoidei (Teleostei: Perciformes) relatives and the inferred phylogeny of Glaucosomatidae.” 2010. Web. 08 Mar 2021.

Vancouver:

Liu S. In search of Callionymoidei (Teleostei: Perciformes) relatives and the inferred phylogeny of Glaucosomatidae. [Internet] [Doctoral dissertation]. NSYSU; 2010. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0131110-130512.

Council of Science Editors:

Liu S. In search of Callionymoidei (Teleostei: Perciformes) relatives and the inferred phylogeny of Glaucosomatidae. [Doctoral Dissertation]. NSYSU; 2010. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0131110-130512

NSYSU

5. Hsu, Yung-ting. Clinicopathological Features in Oral Cavity Squamous Cells Produced by podoplanin and Its Functional Role in Head and Neck Cancer Cell Lines.

Degree: Master, Biological Sciences, 2008, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909108-102025

► Head and neck cancer (HNC) makes up 6 ï¼ of the cancer patients in the world every year. This disease usually occurs in males and… (more)

▼ Head and neck cancer (HNC) makes up 6 ï¼ of the cancer patients in the world every year. This disease usually occurs in males and the incidence is increasing year by year. According to statistical analysis, HNC has less than 50 ï¼ five-year survival rate. Therefore, the research of HNC seems imminent so that may lead to the development of new approaches of diagnosis and therapy. Recent research had shown that expression of podoplanin caused cellular proliferation, and may be associated with tumor invasion, metastasis and malignant prognosis. Podoplanin, a mucin-type transmembrane sialoglycoprotein, is highly expressed in lymphatic endothelial cells but not expressed in vascular endothelial cells. The purpose of this study was to determine the clinical and pathological significance of podoplanin in oral squamous cell carcinoma (OSCC). Therefore, we collected clinical specimen and associated patient history of OSCC. Further, we used the human cell lines of HNSCC (Fadu, Hep2) to investigate the molecular regulation of podoplanin. Podoplanin expression was analyzed by RT-PCR and Western blot assay firstly. As shown, podoplanin was found to be overexpressed in tumors compared with normal adjacent tissues. Further, immunohistochemical analysis revealed the location of podoplanin expression in OSCC tissues. The results showed that podoplanin had higher expression in T4 stage tumor section than in normal adjacent tissues of OSCC samples, or in T1 stage. Here, podoplanin was highly expressed in the OSCC tumor cell and lymphatics of stage T4 OSCC tissue. Furthermore, we found that overexpression of podoplanin in OSCC patients was associated with decreased five-years survival rate. In the univariate analysis, several factors were statistically significantly associated with disease-specific survival rate, including Tumor stage, Nodal stage, and podoplanin expression. In the subsequent multivariate analysis, only Tumor stage and Nodal stage showed a trend toward worse disease-specific survival. To further investigate the regulatory mechanism of podoplanin and its position of expression within the cell, immunofluorescence and transfection were utilized to assay. The results showed that podoplanin was expressed in the nuclear membrane of the Fadu and Hep2 cell lines, and the PI3K/AKT signaling pathway was involved. We suggest that the role of podoplanin in OSCC should be further investigated for potential future treatment. Advisors/Committee Members: Lung%22%29&pagesize-30">Cho, Chung-Lung (chair), Chao, David (committee member), Chien, Chin-Yen (chair).

Subjects/Keywords: podoplanin; oral squamous cell carcinoma (OSCC)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hsu, Y. (2008). Clinicopathological Features in Oral Cavity Squamous Cells Produced by podoplanin and Its Functional Role in Head and Neck Cancer Cell Lines. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909108-102025

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hsu, Yung-ting. “Clinicopathological Features in Oral Cavity Squamous Cells Produced by podoplanin and Its Functional Role in Head and Neck Cancer Cell Lines.” 2008. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909108-102025.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hsu, Yung-ting. “Clinicopathological Features in Oral Cavity Squamous Cells Produced by podoplanin and Its Functional Role in Head and Neck Cancer Cell Lines.” 2008. Web. 08 Mar 2021.

Vancouver:

Hsu Y. Clinicopathological Features in Oral Cavity Squamous Cells Produced by podoplanin and Its Functional Role in Head and Neck Cancer Cell Lines. [Internet] [Thesis]. NSYSU; 2008. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909108-102025.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hsu Y. Clinicopathological Features in Oral Cavity Squamous Cells Produced by podoplanin and Its Functional Role in Head and Neck Cancer Cell Lines. [Thesis]. NSYSU; 2008. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0909108-102025

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

6. Wang, Ting-ya. Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis.

Degree: Master, Biological Sciences, 2008, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845

► High mobility group box 1 (HMGB-1) protein is a non-histone chromosomal protein. As a DNA binding protein, HMGB-1 is involved in the maintenance of nucleosome… (more)

Subjects/Keywords: RNA interference (RNAi); sepsis; cytokine; High mobility group box 1 (HMGB1)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, T. (2008). Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Ting-ya. “Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis.” 2008. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Ting-ya. “Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis.” 2008. Web. 08 Mar 2021.

Vancouver:

Wang T. Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis. [Internet] [Thesis]. NSYSU; 2008. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang T. Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis. [Thesis]. NSYSU; 2008. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

7. Lee, Ju-Chien. Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress.

Degree: PhD, Biological Sciences, 2007, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450

► This research has investigated the gene expression of protein disulfide isomerase (PDI; EC 5.3.4.1) and thioredoxin (Trx) in the marine macroalga Ulva fasciata Delile in… (more)

Subjects/Keywords: Salinity stress; Oxidative stress; PDI; Polyamine; Ulva fasciata

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, J. (2007). Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450

Chicago Manual of Style (16^th Edition):

Lee, Ju-Chien. “Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress.” 2007. Doctoral Dissertation, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450.

MLA Handbook (7^th Edition):

Lee, Ju-Chien. “Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress.” 2007. Web. 08 Mar 2021.

Vancouver:

Lee J. Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress. [Internet] [Doctoral dissertation]. NSYSU; 2007. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450.

Council of Science Editors:

Lee J. Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress. [Doctoral Dissertation]. NSYSU; 2007. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450

NSYSU

8. Chung, Yueh-hua. The role and effect of bone morphogenetic protein-2 in liver fibrosis.

Degree: Master, Biological Sciences, 2007, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0827107-112806

► Bone Morphogenetic proteins (BMPs) belong to transforming growth factor beta (TGF-Î²) superfamily. They regulate cell proliferation, cell differentiation, and bone morphogenesis. Previous evidence suggests that… (more)

Subjects/Keywords: liver fibrosis; Bone morphogenetic protein-2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chung, Y. (2007). The role and effect of bone morphogenetic protein-2 in liver fibrosis. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0827107-112806

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chung, Yueh-hua. “The role and effect of bone morphogenetic protein-2 in liver fibrosis.” 2007. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0827107-112806.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chung, Yueh-hua. “The role and effect of bone morphogenetic protein-2 in liver fibrosis.” 2007. Web. 08 Mar 2021.

Vancouver:

Chung Y. The role and effect of bone morphogenetic protein-2 in liver fibrosis. [Internet] [Thesis]. NSYSU; 2007. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0827107-112806.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chung Y. The role and effect of bone morphogenetic protein-2 in liver fibrosis. [Thesis]. NSYSU; 2007. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0827107-112806

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

9. Wu, Chia-Ling. The effect of Dlk overexpression on the tumorigenicity of hepatoma cells.

Degree: Master, Biological Sciences, 2004, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904104-203607

► Dlk is a transmembrane protein that possesses six epidermal growth factor-like sequences at the extracellular domain, a single transmembrane domain and an intracellular tail. The… (more)

▼ Dlk is a transmembrane protein that possesses six epidermal growth factor-like sequences at the extracellular domain, a single transmembrane domain and an intracellular tail. The extracellular EFG-like region of Dlk can be released by action of an unknown protease that cuts the extracellular region near the cell membrane. Dlk belongs to the EGF-like homeotic protein family and has received many names: pG2, FA-1, Pref-1, SCP-1, ZOG and Dlk. All the proteins are identical or polymorphic products of a single gene. Dlk has been involved in several differentiation processes, such as adipogenesis, hematopoiesis and neuroendocrine differentiation. Dlk is also known as the preadipocyte factor-1 (Pref-1), is highly expressed in preadipocytes but is completely abolished in adipocytes. Pref-1 may function in the maintenance of the preadipocyte state and is a negative regulator of adipocyte differentiation. Dlk is expressed in tumors with neuroendocrine features, such as human neuroblastoma, rat pheochromocytoma, and a subset of Small Cell Lung Cancer (SCLC) cell lines. The Dlk expression is probably associated with some differentiation stages because the most undifferentiated cells were lacking expression of Dlk. The finding suggests that Dlk plays an important role in differentiation and tumorigenesis of several cell types. The study was designed to examine the influence of dlk overexpression on tumorigenicity of hepatoma cells. We constructed the mammalian expression vectors for full-length dlk, dlk extracellular domain, which were transfected into SK-Hep-1 cells for generation of stable clones. The transgene expressions in selected stable clones were verified by QRT-PCR and western blot analysis. Our results indicated that overexpression of extracellular domain significantly promoted the viability of SK-Hep1 cells during serum deprivation. In SCID mice, injection of full-length dlk clones led to increased tumor growth compared with the control groups. However, the migration ability was reduced in Dlk stable clones. In summary, these results suggested full-length Dlk promoted the tumor growth but reduced the migration ability of SK-Hep1 cells. Advisors/Committee Members: Lung%22%29&pagesize-30">Cho Chung-Lung (chair), Tai Ming-Hong (committee member), Cheng Jiin-Tsuey (chair), Chuang Jiin-Haur (committee member).

Subjects/Keywords: overexpression; tumorigenicity; hepatoma cells; Dlk protein

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wu, C. (2004). The effect of Dlk overexpression on the tumorigenicity of hepatoma cells. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904104-203607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wu, Chia-Ling. “The effect of Dlk overexpression on the tumorigenicity of hepatoma cells.” 2004. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904104-203607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wu, Chia-Ling. “The effect of Dlk overexpression on the tumorigenicity of hepatoma cells.” 2004. Web. 08 Mar 2021.

Vancouver:

Wu C. The effect of Dlk overexpression on the tumorigenicity of hepatoma cells. [Internet] [Thesis]. NSYSU; 2004. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904104-203607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wu C. The effect of Dlk overexpression on the tumorigenicity of hepatoma cells. [Thesis]. NSYSU; 2004. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904104-203607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

10. Lin, James. The Differential Expression of Bcl10 in the Tumor Cell Lines.

Degree: Master, Biological Sciences, 2004, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816104-155835

► Bcl10 is one of the apoptosis regulatory protein. It is located at 1p22,one site harbor tumor suppressor tumor gene. We screen Bcl10 expression in different… (more)

Subjects/Keywords: tumor suppressor tumor gene

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, J. (2004). The Differential Expression of Bcl10 in the Tumor Cell Lines. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816104-155835

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lin, James. “The Differential Expression of Bcl10 in the Tumor Cell Lines.” 2004. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816104-155835.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lin, James. “The Differential Expression of Bcl10 in the Tumor Cell Lines.” 2004. Web. 08 Mar 2021.

Vancouver:

Lin J. The Differential Expression of Bcl10 in the Tumor Cell Lines. [Internet] [Thesis]. NSYSU; 2004. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816104-155835.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin J. The Differential Expression of Bcl10 in the Tumor Cell Lines. [Thesis]. NSYSU; 2004. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816104-155835

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

11. Sy, Wei-Dih. Analysis of human Dynamin IV (Dymple) gene promoter.

Degree: Master, Biological Sciences, 2003, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904103-145445

► We first identified the transcriptional regulatory element of the human dynamin IV gene (Hdyn IV; dymple). The Hdyn IV belongs to a large GTPase family.… (more)

▼ We first identified the transcriptional regulatory element of the human dynamin IV gene (Hdyn IV; dymple). The Hdyn IV belongs to a large GTPase family. This protein has a N-terminal highly conserved tripartite GTP-binding domain, coiled-coil (CC) region, but it lacks the pleckstrin homology (PH) domain and a modestly conserved C-terminal proline rich domain (PRD). Hdyn IV gene is enriched in subcellular membrane fractions of cytoplasmic vesicles and endoplasmic reticulum, and the function of Hdyn IV gene is considered to be associated with the functions of mitochondria. The Hdyn IV is expressed as four alternative splicing variants in all eukaryotic organisms. Our question concerning why expressions of four alternative splicing variants in brain tumor tissues? To elucidate the regulatory mechanism and the transcription factors involved, we firstly determined the transcriptional start site by 5â RACE. We next cloned the 5â-flanking region of the Hdyn IV gene and determined the nucleotide sequence of 999 bases upstream from the transcription start site. The promoter has several potential binding sites for AP2, Sp1 binding protein, but it lacks TATA and CAAT boxes. Transfection studies using a series of Hdyn IV promoter luciferase constructs in HeLa cell demonstrate that the 5âflanking region has a promoter activity. Functional promoter element of the Hdyn IV gene was located within the â140~ +29 region. Deletion analyses demonstrated that the minimal promoter activity for the transcriptional element of Hdyn IV was detected in the sequence between nucleotides â110 and â100. Electorphoretic mobility shift assay demonstrated that a putative transcriptional factor bound to the â119 to â90 region. Site-directed mutagenesis analysis of this region revealed that nucleotides at positions â108 to â100 were essential for transactivation mediated by this element. To summary, the data indicated that the ââCTCCCAGCAââ (-108~ -100) sequence is capable of regulating Hdyn IV gene expression. However, the protein involved in the binding of this novel sequence requires further study. Advisors/Committee Members: Hsu, Ching-Mei (chair), Hong, Yi-Ren (committee member), Cheng, Jiin-Tsuey (chair), Lung%22%29&pagesize-30">Cho, Chung-Lung (committee member).

Subjects/Keywords: transcription factor; promoter; DynIV

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sy, W. (2003). Analysis of human Dynamin IV (Dymple) gene promoter. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904103-145445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sy, Wei-Dih. “Analysis of human Dynamin IV (Dymple) gene promoter.” 2003. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904103-145445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sy, Wei-Dih. “Analysis of human Dynamin IV (Dymple) gene promoter.” 2003. Web. 08 Mar 2021.

Vancouver:

Sy W. Analysis of human Dynamin IV (Dymple) gene promoter. [Internet] [Thesis]. NSYSU; 2003. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904103-145445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sy W. Analysis of human Dynamin IV (Dymple) gene promoter. [Thesis]. NSYSU; 2003. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904103-145445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

12. Shiue, Wen-Ming. Studies on the culture and mitochondrial rDNA sequence analysis of Antrodia camphorata mycelium.

Degree: Master, Biological Sciences, 2003, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816103-004317

► Antrodia camphorata is a Taiwan-unique fungus which grows on the walls inside the core of decayed Cinnamomum kanehirae. Antrodia camphorata provides many bioactive substance and… (more)

Subjects/Keywords: polysaccharides; mitochondrial DNA; antrodia camphorata; triterpenoids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shiue, W. (2003). Studies on the culture and mitochondrial rDNA sequence analysis of Antrodia camphorata mycelium. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816103-004317

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shiue, Wen-Ming. “Studies on the culture and mitochondrial rDNA sequence analysis of Antrodia camphorata mycelium.” 2003. Thesis, NSYSU. Accessed March 08, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816103-004317.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shiue, Wen-Ming. “Studies on the culture and mitochondrial rDNA sequence analysis of Antrodia camphorata mycelium.” 2003. Web. 08 Mar 2021.

Vancouver:

Shiue W. Studies on the culture and mitochondrial rDNA sequence analysis of Antrodia camphorata mycelium. [Internet] [Thesis]. NSYSU; 2003. [cited 2021 Mar 08]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816103-004317.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shiue W. Studies on the culture and mitochondrial rDNA sequence analysis of Antrodia camphorata mycelium. [Thesis]. NSYSU; 2003. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0816103-004317

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations