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You searched for +publisher:"NSYSU" +contributor:("Ching-Shuang Wu"). Showing records 1 – 2 of 2 total matches.

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1. Huang, Shu-Mei. Effects of high glucose on keratinocyte functions: focusing on the impaired diabetic wound healing.

Degree: PhD, Biological Sciences, 2015, NSYSU

Diabetes mellitus is characterized by elevated plasma glucose and increased rate of skin infection. Altered immune responses have been suggested to contribute to this prevalent complication. High glucose treatment reduced human β-defensin-3 (hBD3) expression of cultured keratinocytes. This pathogenic process involved inhibition of p38MAPK signaling, an event that resulted from increased formation of advanced glycation end product and showed worse anti-Staphylococcus aureus activity. In addition, high-glucose cultivated keratinocytes expressed reduced levels of human β-defensin-2 (hBD2) and pSTAT-1. Besides the impact on keratinocyte cultured under high glucose, the suboptimal interaction between keratinocytes and inflammatory cells also contributed to impaired diabetic wound healing. High-glucose environment enhanced interleukin (IL)-8 production via EGFR-ERK pathway in a ROS-dependent manner in keratinocytes. Treating diabetic rats with neutrophil inhibitor improved the healing. On the other hands, high glucose cultivated monocytes have significantly reduced production of IL-22, a molecule that is responsible for promoting keratinocyte migration. In summary, high glucose environment impared keratinocyte function directly or indirectly that contributed to impaired diabetic wound healing, and focusing on these defects will present a therapeutic approach to promote diabetic healing. Advisors/Committee Members: Ching-Shuang Wu (chair), Lan, Cheng-Che (chair), Liu, Jong-Kang (chair), Chao, David (committee member), Chen, Gwo-Shing (chair).

Subjects/Keywords: hBD3; interleukin-8; keratinocyte; hBD2; high glucose; interleukin-22

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APA (6th Edition):

Huang, S. (2015). Effects of high glucose on keratinocyte functions: focusing on the impaired diabetic wound healing. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0823115-001730

Chicago Manual of Style (16th Edition):

Huang, Shu-Mei. “Effects of high glucose on keratinocyte functions: focusing on the impaired diabetic wound healing.” 2015. Doctoral Dissertation, NSYSU. Accessed January 25, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0823115-001730.

MLA Handbook (7th Edition):

Huang, Shu-Mei. “Effects of high glucose on keratinocyte functions: focusing on the impaired diabetic wound healing.” 2015. Web. 25 Jan 2021.

Vancouver:

Huang S. Effects of high glucose on keratinocyte functions: focusing on the impaired diabetic wound healing. [Internet] [Doctoral dissertation]. NSYSU; 2015. [cited 2021 Jan 25]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0823115-001730.

Council of Science Editors:

Huang S. Effects of high glucose on keratinocyte functions: focusing on the impaired diabetic wound healing. [Doctoral Dissertation]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0823115-001730


NSYSU

2. Chang, Tsung-ming. Prox1 suppresses growth and metastasis of hepatocellular carcinoma by downregulating Twist1.

Degree: PhD, Institute of Biomedical Sciences, 2013, NSYSU

Prospero-related homeobox 1 (Prox1) was cloned as homeobox gene which homologous to the Drosophila prospero gene. As a transcription factor, Prox1 is important for liver development and is highly expressed in adult hepatocytes. In contrast, down-regulation of Prox1 in hepatocellular carcinoma (HCC) is associated with poor differentiation, prognosis, and reduced overall survival which implying a potential tumor suppressive role of Prox1 in HCC. However, the molecular mechanisms of Prox1âs tumor suppressive function are still obscure. In this study, we find that Prox1 expression is positively associated with E-cadherin and negatively linked with Twist1 and vimentin in various HCC cell lines. Ectopic expression of Prox1 reduces Twist1 while knockdown of Prox1 increased Twist1 expression. We further identify a putative Prox1 binding site located at the -117/-111 bp of the Twist1 promoter which is critical for gene repression. Chromatin immunoprecipitation assays also demonstrate the direct binding of Prox1 to human Twist1 promoter. In addition, inhibition of Twist1 by Prox1 causes p53 up-regulation and AKT2 down-regulation. Moreover, functional assays show that wild-type p53 induction is important for the growth-inhibitory effect of Prox1 and AKT2 is involved in the inhibition of migration and invasion by Prox1. In consistence with the results of cell-based study, animal experiments demonstrate that Prox1 significantly attenuates tumor growth and lung metastasis in vivo. Collectively, we conclude that Prox1 functions as a tumor suppressor in HCC cells via inhibiting Twist1 to trigger p53-dependent senescence-like phenotype and to reduce AKT2-mediated invasion. Advisors/Committee Members: Yeou-Lih Huang (chair), Wen-Chun Hung (committee member), Ching-Shuang Wu (chair), Long-Sen Chang (chair), Kuang-hung Cheng (chair).

Subjects/Keywords: AKT2; p53; Prox1; Twist1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chang, T. (2013). Prox1 suppresses growth and metastasis of hepatocellular carcinoma by downregulating Twist1. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0110113-155844

Chicago Manual of Style (16th Edition):

Chang, Tsung-ming. “Prox1 suppresses growth and metastasis of hepatocellular carcinoma by downregulating Twist1.” 2013. Doctoral Dissertation, NSYSU. Accessed January 25, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0110113-155844.

MLA Handbook (7th Edition):

Chang, Tsung-ming. “Prox1 suppresses growth and metastasis of hepatocellular carcinoma by downregulating Twist1.” 2013. Web. 25 Jan 2021.

Vancouver:

Chang T. Prox1 suppresses growth and metastasis of hepatocellular carcinoma by downregulating Twist1. [Internet] [Doctoral dissertation]. NSYSU; 2013. [cited 2021 Jan 25]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0110113-155844.

Council of Science Editors:

Chang T. Prox1 suppresses growth and metastasis of hepatocellular carcinoma by downregulating Twist1. [Doctoral Dissertation]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0110113-155844

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