Open Access Theses and Dissertations

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You searched for +publisher:"NSYSU" +contributor:("Chen-Chi M. Ma"). Showing records 1 – 2 of 2 total matches.

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NSYSU

1. Pan, Lunh-hsuan. Microfluidic-based optical biochip system for the detection of VEGF, PSA, and CTCs in early prostate cancer diagnosis.

Degree: Master, Institute of Medical Science and Technology, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715116-174442 

Prostate Cancer (PCa) is the third most common cancer in men in Europe, North America, and some parts of Africa. The PCa could be diagnosed by digital rectal inspection, computed tomography (CT) scan, magnetic resonance imaging (MRI), and biomarkers assay in clinical examination. To date, the prostate-specific antigen (PSA) is the best serum marker available for clinical detection of PCa, and serum values above 4.0 ng/mL are considered abnormal. Furthermore, the vascular endothelial growth factor (VEGF) also plays an important role in the progressed cancers. The VEGF is also overexpressed in patients who suffered PCa and the serum values above 100 pg/mL are considered abnormal. Most assays for PSA and VEGF detection are based on conventional immunodetection methods, including the enzyme-linked immunosorbent assay (ELISA) and electrochemical immunoassays. ELISA involves sequential binding of two antibodies to each specific antigen epitope and repeated washing steps to measure the concentration of target antigen; this makes it prone to error, relatively time-consuming, and expensive. In addition, cancer progression is comprised of both primary tumor growth and secondary metastasis, tumor cells are shed into the circulation system in few numbers since early stages of cancer formation, tumor cells can survive and through microenvironment interactions in the pathogenesis of cancer metastasis proceed to metastasis. Thus, there is an urgent need to develop the simultaneous multi-markers and circulating tumor cells (CTCs) assay for the early and accurate detection of PCa. In this study, we developed different biochip multiplexed microfluidic-based optical biosensor, which can be used to rapidly and accurately detect the concentrations of PSA (0.5-50 ng/mL), VEGF (0.5-50 ng/mL) and CTCs (300 cell/mL) simultaneously. In this design, gold nanorods were used to label with anti-PSA, anti-VEGF and ssDNA as bio-recognizers to capture PSA, VEGF, and PC3 cells for sensitive optical bio-sensing. Our data showed that the biochips can effectively detect the concentrations of PSA, VEGF, and CTCs in the human blood for early diagnosis of PCa with high sensitivity, specificity, accuracy, low-cost, and faster rate. Advisors/Committee Members: Chen-Chi M. Ma (chair), Hung-Wei Yang (committee member), See-Tong Pang (chair).

Subjects/Keywords: vascular endothelial growth factor; prostate-specific antigen; circulating tumor cells; optical biosensor; prostate cancer; microfluidic device

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Pan, L. (2016). Microfluidic-based optical biochip system for the detection of VEGF, PSA, and CTCs in early prostate cancer diagnosis. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715116-174442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Pan, Lunh-hsuan. “Microfluidic-based optical biochip system for the detection of VEGF, PSA, and CTCs in early prostate cancer diagnosis.” 2016. Thesis, NSYSU. Accessed January 15, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715116-174442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Pan, Lunh-hsuan. “Microfluidic-based optical biochip system for the detection of VEGF, PSA, and CTCs in early prostate cancer diagnosis.” 2016. Web. 15 Jan 2021.

Vancouver:

Pan L. Microfluidic-based optical biochip system for the detection of VEGF, PSA, and CTCs in early prostate cancer diagnosis. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Jan 15]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715116-174442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pan L. Microfluidic-based optical biochip system for the detection of VEGF, PSA, and CTCs in early prostate cancer diagnosis. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0715116-174442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


NSYSU

2. Liao, Jing-fong. Flexible and Rapidly-Dissolvable Microneedle Patches for Transdermal Delivery and Stability Enhancement of DNA Vaccine.

Degree: Master, Institute of Medical Science and Technology, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0529116-155910 

This study developed a flexible and rapidly-dissolvable microneedle (MN) patch for transdermal delivery and stability enhancement of DNA vaccine. The MN patch is made by polyvinyl alcohol (PVA) with the properties of rapid dissolution, biocompatibility and film-forming. Besides, the vaccine encapsulated in MN would be rapidly released after insertion of the MN patch to the skin. We were able to encapsulate 22.4 μg of PCV2 plasmid DNA vaccine in MNs per patch with a loading rate of 87.8 wt % when casting the PCV2 plasmid DNA vaccination the PDMS mode surface. We also done the stability study, the activity of vaccine encapsulated in MNs can be maintained exceed 111 days without any damage at 37 â of storage. The ex vivo study demonstrated that the MNs have excellent mechanical strength to puncture the stratum corneum and needles can be dissolved within 10 minutes to release the vaccine in epidermis then the hole can be quickly healed within 40 minutes to avoid the infection risk. The Animals studies showed that the induced antibody titers via MN patch administration were about 10-time higher than intramuscular (IM) administration after 3 weeks of vaccination. The results confirmed that the MNs can induce high antibody concentration in body to induce the strongest immune responses after immunization. Advisors/Committee Members: Hung-Wei Yang (committee member), Jin-Ching Lee (chair), Chen-Chi M. Ma (chair).

Subjects/Keywords: Transcutaneous immunization; Dissolving microneedle; DNA vaccine; Flexible patches; Polyvinyl alcohol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Liao, J. (2016). Flexible and Rapidly-Dissolvable Microneedle Patches for Transdermal Delivery and Stability Enhancement of DNA Vaccine. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0529116-155910

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Liao, Jing-fong. “Flexible and Rapidly-Dissolvable Microneedle Patches for Transdermal Delivery and Stability Enhancement of DNA Vaccine.” 2016. Thesis, NSYSU. Accessed January 15, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0529116-155910.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Liao, Jing-fong. “Flexible and Rapidly-Dissolvable Microneedle Patches for Transdermal Delivery and Stability Enhancement of DNA Vaccine.” 2016. Web. 15 Jan 2021.

Vancouver:

Liao J. Flexible and Rapidly-Dissolvable Microneedle Patches for Transdermal Delivery and Stability Enhancement of DNA Vaccine. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Jan 15]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0529116-155910.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liao J. Flexible and Rapidly-Dissolvable Microneedle Patches for Transdermal Delivery and Stability Enhancement of DNA Vaccine. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0529116-155910

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.