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1. van Geffen, Ankie. Complex platelet phenotyping: integrative assessment of platelet activity in haemostasis and thrombosis.

Degree: 2018, NARCIS

For my dissertation, I researched the complex mechanisms underlying thrombosis. Using the flow chamber model (a perfusion model that simulates thrombosis formation in a blood vessel), I measured thrombus formation in flowing blood by examining various vessel wall components and markers for platelet activation and blood clotting over time (kinetics). In healthy people, individual differences in the parameters for thrombus formation were discovered that could be partially explained by variations in and among genes. By measuring the kinetics of thrombus and fibrin formation, a new stimulation mechanism of the intrinsic coagulation pathway through tissue factor was discovered. In the blood of mice with hyperlipidaemia, thrombus formation was significantly higher, caused in particular by elevated platelet cholesterol. Advisors/Committee Members: Heemskerk, Johan, M.E.J., Kuipers, de Laat, B., Biochemie, RS: CARIM - R1 - Thrombosis and haemostasis.

Subjects/Keywords: flow chamber; platelets; coagulation; thrombus formation; kinetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

van Geffen, A. (2018). Complex platelet phenotyping: integrative assessment of platelet activity in haemostasis and thrombosis. (Doctoral Dissertation). NARCIS. Retrieved from https://cris.maastrichtuniversity.nl/en/publications/5072d274-5807-48b4-b7cc-30b8aa2889c2 ; urn:nbn:nl:ui:27-5072d274-5807-48b4-b7cc-30b8aa2889c2 ; 5072d274-5807-48b4-b7cc-30b8aa2889c2 ; urn:nbn:nl:ui:27-5072d274-5807-48b4-b7cc-30b8aa2889c2 ; https://cris.maastrichtuniversity.nl/en/publications/5072d274-5807-48b4-b7cc-30b8aa2889c2

Chicago Manual of Style (16th Edition):

van Geffen, Ankie. “Complex platelet phenotyping: integrative assessment of platelet activity in haemostasis and thrombosis.” 2018. Doctoral Dissertation, NARCIS. Accessed October 30, 2020. https://cris.maastrichtuniversity.nl/en/publications/5072d274-5807-48b4-b7cc-30b8aa2889c2 ; urn:nbn:nl:ui:27-5072d274-5807-48b4-b7cc-30b8aa2889c2 ; 5072d274-5807-48b4-b7cc-30b8aa2889c2 ; urn:nbn:nl:ui:27-5072d274-5807-48b4-b7cc-30b8aa2889c2 ; https://cris.maastrichtuniversity.nl/en/publications/5072d274-5807-48b4-b7cc-30b8aa2889c2.

MLA Handbook (7th Edition):

van Geffen, Ankie. “Complex platelet phenotyping: integrative assessment of platelet activity in haemostasis and thrombosis.” 2018. Web. 30 Oct 2020.

Vancouver:

van Geffen A. Complex platelet phenotyping: integrative assessment of platelet activity in haemostasis and thrombosis. [Internet] [Doctoral dissertation]. NARCIS; 2018. [cited 2020 Oct 30]. Available from: https://cris.maastrichtuniversity.nl/en/publications/5072d274-5807-48b4-b7cc-30b8aa2889c2 ; urn:nbn:nl:ui:27-5072d274-5807-48b4-b7cc-30b8aa2889c2 ; 5072d274-5807-48b4-b7cc-30b8aa2889c2 ; urn:nbn:nl:ui:27-5072d274-5807-48b4-b7cc-30b8aa2889c2 ; https://cris.maastrichtuniversity.nl/en/publications/5072d274-5807-48b4-b7cc-30b8aa2889c2.

Council of Science Editors:

van Geffen A. Complex platelet phenotyping: integrative assessment of platelet activity in haemostasis and thrombosis. [Doctoral Dissertation]. NARCIS; 2018. Available from: https://cris.maastrichtuniversity.nl/en/publications/5072d274-5807-48b4-b7cc-30b8aa2889c2 ; urn:nbn:nl:ui:27-5072d274-5807-48b4-b7cc-30b8aa2889c2 ; 5072d274-5807-48b4-b7cc-30b8aa2889c2 ; urn:nbn:nl:ui:27-5072d274-5807-48b4-b7cc-30b8aa2889c2 ; https://cris.maastrichtuniversity.nl/en/publications/5072d274-5807-48b4-b7cc-30b8aa2889c2

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