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You searched for +publisher:"Mississippi State University" +contributor:("Debbie J. Beard"). Showing records 1 – 2 of 2 total matches.

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Mississippi State University

1. Wilson, David L. Human carbonic anhydrase II: preparation, metal-substitution, activity, and inhibition.

Degree: PhD, Chemistry, 2015, Mississippi State University

This report details the activities and inhibition of metal-substituted human carbonic anhydrase II (M-HCA-II). The traditional activities (hydrolysis of CO2 and <I>para</I>-nitrophenol acetate) in addition to new activities (oxidation of 2-aminophenol, disproportionation of H2O2, and disproportionation of superoxide) were investigated. Values reported for the relative hydrolytic activities of M-HCA-IIs are reported here for the first time, ranging from 47.5 % (plus or minus 0.6) to 86 % (plus or minus 4) for the hydrolysis of CO2 and from 0.299 % (plus or minus 0.012) to 4.72 % (plus or minus 0.015) for the hydrolysis of <I>para</I>-nitrophenol acetate. With respect to new activities, only the oxidation of 2-aminophenol was observed. Turnover was observed for Fe-HCA-II (kcat/KM = 3.6 plus or minus 1.3 mM-1 s-1) and Cu-HCA-II (kcat/KM = 8 plus or minus 2 mM-1 s-1). Inhibition of Zn-, (di-substituted) Cu2-, and Cu/Zn-HCA-II hydrolysis of CO2 and <I>para</I>-nitrophenol acetate by sulfanilamide, coumarin, and <I>ortho</I>-coumaric acid were investigated. Sulfanilamide was shown to inhibit: Zn-HCA-II, Cu2-HCA-II, and Cu/Zn-HCA-II - (with CO2) KM = 8.9 plus or minus 1.1 microM, 11 plus or minus 2 microM, 8.8 plus or minus 1.4 microM and (with p-nitrophenyl acetate) KM = 8.4 plus or minus 1.0 microM, (none), 8.4 plus or minus 1.4 microM, respectively. No inhibition was observed for coumarin or <I>ortho</I>-coumaric acid or its derivatives for any CAs studied. Advisors/Committee Members: Joseph P. Emerson (chair), Edwin A. Lewis (committee member), Todd E. Mlsna (committee member), Nicholas C. Fitzkee (committee member), Debbie J. Beard (committee member).

Subjects/Keywords: human carbonic anhydrase II; HCA-II; metal-substitution; copper; cobalt; manganese; iron; nickel; sulfanilamide; coumarin; kinetics; 2-aminophenol; catalase; superoxide dismutase; peroxidase

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wilson, D. L. (2015). Human carbonic anhydrase II: preparation, metal-substitution, activity, and inhibition. (Doctoral Dissertation). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-06222015-164959/ ;

Chicago Manual of Style (16th Edition):

Wilson, David L. “Human carbonic anhydrase II: preparation, metal-substitution, activity, and inhibition.” 2015. Doctoral Dissertation, Mississippi State University. Accessed April 16, 2021. http://sun.library.msstate.edu/ETD-db/theses/available/etd-06222015-164959/ ;.

MLA Handbook (7th Edition):

Wilson, David L. “Human carbonic anhydrase II: preparation, metal-substitution, activity, and inhibition.” 2015. Web. 16 Apr 2021.

Vancouver:

Wilson DL. Human carbonic anhydrase II: preparation, metal-substitution, activity, and inhibition. [Internet] [Doctoral dissertation]. Mississippi State University; 2015. [cited 2021 Apr 16]. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-06222015-164959/ ;.

Council of Science Editors:

Wilson DL. Human carbonic anhydrase II: preparation, metal-substitution, activity, and inhibition. [Doctoral Dissertation]. Mississippi State University; 2015. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-06222015-164959/ ;


Mississippi State University

2. Box, Hannah Killian. The development of next generation, unsymmetrical CCC-NHC pincer ligand architectures and metalation to form unsymmetrical CCCNHC pincer Ta complexes.

Degree: PhD, Chemistry, 2015, Mississippi State University

The impact of <i>N</i>-heterocyclic carbenes (NHC) as ligands for transition metal catalysis has been rigorously investigated since their isolation by Arduengo in 1991. NHCs have become abundant in late-transition metal chemistry. This is attributed to NHCs being stronger sigma-donors than even the strongest phosphine analogues, thus constructing a transition metal-NHC complex with improved stability, catalytic reactivity, and selectivity. Additionally, pincer ligands have become recognized as an important class of ligands for transition metal complexes. The unique steric and electronic tunability of pincer ligands has resulted in pincer-transition metal complexes being exploited as catalysts for a multitude of transformations. Both ligand classes, NHC and pincer, have been reported as stable organometallic catalysts that demonstrate high catalytic activity. The combination of these two ligand systems by incorporation of NHCs into pincer ligands has attracted considerable attention. NHC pincer systems have been reported as stable organometallic catalysts that demonstrate high catalytic activity. The expansion of CCC-NHC ligand precursor methodologies and application of the newly reported methodologies in order to diversify CCC-NHC ligand architectures is reported. Extension of the amine elimination methodology yielded unsymmetrical CCCNHC Ta pincer complexes. Studies on the manipulation of the previously reported symmetrical CCC-NHC pincer Ta complexs coordination sphere to synthesize a rare Ta diimido complex with unique reactivity towards advantageous proton sources and oxidative amination of aminoalkenes are also expanded upon. These next generation catalysts developed from these architectures may prove useful in catalyzing a broad array of transformations not previously accessible through the four standard NHC containing pincer ligand architectures. Advisors/Committee Members: Keith T. Mead (chair), Andrzej Sygula (committee member), Joseph P. Emerson (committee member), Todd E. Mlsna (committee member), Debbie J. Beard (committee member).

Subjects/Keywords: Unsymmetrical CCCNHC; Ta complexes; Oxidative Amination

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Box, H. K. (2015). The development of next generation, unsymmetrical CCC-NHC pincer ligand architectures and metalation to form unsymmetrical CCCNHC pincer Ta complexes. (Doctoral Dissertation). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-04282015-140641/ ;

Chicago Manual of Style (16th Edition):

Box, Hannah Killian. “The development of next generation, unsymmetrical CCC-NHC pincer ligand architectures and metalation to form unsymmetrical CCCNHC pincer Ta complexes.” 2015. Doctoral Dissertation, Mississippi State University. Accessed April 16, 2021. http://sun.library.msstate.edu/ETD-db/theses/available/etd-04282015-140641/ ;.

MLA Handbook (7th Edition):

Box, Hannah Killian. “The development of next generation, unsymmetrical CCC-NHC pincer ligand architectures and metalation to form unsymmetrical CCCNHC pincer Ta complexes.” 2015. Web. 16 Apr 2021.

Vancouver:

Box HK. The development of next generation, unsymmetrical CCC-NHC pincer ligand architectures and metalation to form unsymmetrical CCCNHC pincer Ta complexes. [Internet] [Doctoral dissertation]. Mississippi State University; 2015. [cited 2021 Apr 16]. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-04282015-140641/ ;.

Council of Science Editors:

Box HK. The development of next generation, unsymmetrical CCC-NHC pincer ligand architectures and metalation to form unsymmetrical CCCNHC pincer Ta complexes. [Doctoral Dissertation]. Mississippi State University; 2015. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-04282015-140641/ ;

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