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You searched for +publisher:"Michigan Technological University" +contributor:("Keat Ghee Ong"). Showing records 1 – 2 of 2 total matches.

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Michigan Technological University

1. Nelson, Brad. A Smart Implantable Bone Fixation Plate Providing Actuation and Load Monitoring for Orthopedic Fracture Healing.

Degree: PhD, Department of Biomedical Engineering, 2019, Michigan Technological University

Fracture non-union occurs in roughly 5-10% of all fracture cases, and current interventions are both time-consuming and costly. There is therefore significant incentive to develop new tools to improve fracture healing outcomes. Several studies have shown that low-magnitude, high-frequency (LMHF) mechanical loading can promote faster healing and reduce the risk of refracture in critical-size long bone fractures. This is typically done using whole-body vibration, which may result in undesirable systemic effects on the rest of the body. This work discusses an implantable piezoelectric fixation plate that can both apply LMHF loading directly to the fracture site using flexible scheduling and indirectly monitor the progress of healing by using the increasing stiffness of the fracture callus. The design and performance of the piezoelectric bone plate show that the device can apply the target treatment and has the sensitivity to be used to observe the progress of healing. An accompanying telemetry system using BLE communication is also introduced which has a footprint of suitable size to be used in rodent studies and can provide the power necessary for piezoelectric actuation. These results pave the way for future studies regarding the efficacy and optimization of LMHF treatments in fracture healing models. Advisors/Committee Members: Keat Ghee Ong.

Subjects/Keywords: Fracture healing; fixation plate; lmhf; piezoelectric; Biomedical Devices and Instrumentation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Nelson, B. (2019). A Smart Implantable Bone Fixation Plate Providing Actuation and Load Monitoring for Orthopedic Fracture Healing. (Doctoral Dissertation). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/898

Chicago Manual of Style (16th Edition):

Nelson, Brad. “A Smart Implantable Bone Fixation Plate Providing Actuation and Load Monitoring for Orthopedic Fracture Healing.” 2019. Doctoral Dissertation, Michigan Technological University. Accessed November 29, 2020. https://digitalcommons.mtu.edu/etdr/898.

MLA Handbook (7th Edition):

Nelson, Brad. “A Smart Implantable Bone Fixation Plate Providing Actuation and Load Monitoring for Orthopedic Fracture Healing.” 2019. Web. 29 Nov 2020.

Vancouver:

Nelson B. A Smart Implantable Bone Fixation Plate Providing Actuation and Load Monitoring for Orthopedic Fracture Healing. [Internet] [Doctoral dissertation]. Michigan Technological University; 2019. [cited 2020 Nov 29]. Available from: https://digitalcommons.mtu.edu/etdr/898.

Council of Science Editors:

Nelson B. A Smart Implantable Bone Fixation Plate Providing Actuation and Load Monitoring for Orthopedic Fracture Healing. [Doctoral Dissertation]. Michigan Technological University; 2019. Available from: https://digitalcommons.mtu.edu/etdr/898


Michigan Technological University

2. Karipott, Salil Sidharthan. MAGNETOSTRICTIVE BONE FIXATION DEVICE FOR CONTROLLING LOCAL MECHANICAL STIMULI TO BONE FRACTURE SITES.

Degree: PhD, Department of Biomedical Engineering, 2019, Michigan Technological University

Several studies have shown the impact of mechanical environments on fracture healing. Studies on the low magnitude, high frequency (LMHF) mechanical stimulations (tens of micro-strains and tens of Hz) have demonstrated improved bone regeneration, especially for bone fractures that do not heal properly and developed into delayed unions or non-unions. This type of treatment is often provided as whole-body vibrations with the patient standing on a vibrating platform. While several studies have shown the useful application of LMHF mechanical stimuli in improving bone density but currently available technologies have limited application in fractured bones. The goal of this project is to develop a bone fracture fixation device that utilizes an integrated actuator based on a magnetostrictive material which changes in physical dimension from tens of nanometers to a few microns depending on the strength of an externally applied magnetic field. The strain produced by the magnetostrictive actuator transferred through the fracture fixation device acts directly on the fracture defect region, resulting in localized loading. The electromagnetic driving system for the magnetostrictive actuator remains outside the body and produces wireless mechanical actuations. This externally controlled mechanical loading can help in investigating the effect of various types of mechanical stimulus on bone healing. Specifically, this project will focus on osteogenesis in critically-sized segmental bone defects in rats, an established animal model in bone regeneration studies. The focus of this project is to (1) develop a device that can generate variable mechanical loads on segmental bone defects in rats and (2) to conduct an in vivo study assessing the effects of augmented mechanical loading on osteogenesis. Advisors/Committee Members: Keat Ghee Ong.

Subjects/Keywords: Biomechanics and Biotransport; Biomedical Devices and Instrumentation; Biomedical Engineering and Bioengineering; Other Biomedical Engineering and Bioengineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Karipott, S. S. (2019). MAGNETOSTRICTIVE BONE FIXATION DEVICE FOR CONTROLLING LOCAL MECHANICAL STIMULI TO BONE FRACTURE SITES. (Doctoral Dissertation). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/907

Chicago Manual of Style (16th Edition):

Karipott, Salil Sidharthan. “MAGNETOSTRICTIVE BONE FIXATION DEVICE FOR CONTROLLING LOCAL MECHANICAL STIMULI TO BONE FRACTURE SITES.” 2019. Doctoral Dissertation, Michigan Technological University. Accessed November 29, 2020. https://digitalcommons.mtu.edu/etdr/907.

MLA Handbook (7th Edition):

Karipott, Salil Sidharthan. “MAGNETOSTRICTIVE BONE FIXATION DEVICE FOR CONTROLLING LOCAL MECHANICAL STIMULI TO BONE FRACTURE SITES.” 2019. Web. 29 Nov 2020.

Vancouver:

Karipott SS. MAGNETOSTRICTIVE BONE FIXATION DEVICE FOR CONTROLLING LOCAL MECHANICAL STIMULI TO BONE FRACTURE SITES. [Internet] [Doctoral dissertation]. Michigan Technological University; 2019. [cited 2020 Nov 29]. Available from: https://digitalcommons.mtu.edu/etdr/907.

Council of Science Editors:

Karipott SS. MAGNETOSTRICTIVE BONE FIXATION DEVICE FOR CONTROLLING LOCAL MECHANICAL STIMULI TO BONE FRACTURE SITES. [Doctoral Dissertation]. Michigan Technological University; 2019. Available from: https://digitalcommons.mtu.edu/etdr/907

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