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You searched for +publisher:"Michigan State University" +contributor:("Xi, Zhiyong"). Showing records 1 – 2 of 2 total matches.

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Michigan State University

1. Lu, Peng (Of Michigan State University). Wolbachia induces resistance to dengue virus in mosquito Aedes aegypti.

Degree: 2014, Michigan State University

Thesis Ph. D. Michigan State University. Microbiology and Molecular Genetics 2014.

Transmitted by the bite of mosquitoes, dengue virus (DENV) is the most important arboviral pathogen in humans. Currently no drug therapy or vaccine is available for dengue fever, leaving vector control as the major way to protect human populations. The endosymbiotic bacterium Wolbachia has been proposed as a potential agent for vector control, because it can not only spread within mosquito populations via manipulation of mosquito reproduction but also inhibit transmission of DENV in mosquitoes. In order to develop Wolbachia-based control strategies to prevent DENV infection, we have to better understand the interactions between DENV and Wolbachia in mosquitoes. Aedes albopictus naturally carries Wolbachia infection, however, Wolbachia-mediated viral resistance was not observed in Ae. albopictus. In this study, we demonstrated that the native Wolbachia induce a resistance to DENV in Wolbachia density-dependent manner in Ae. albopictus. A decrease in Wolbachia density within the host cells results in increased dengue infection. We provide evidence that a very low Wolbachia density in mosquito tissues where DENV resides and travels could contribute to the absence of Wolbachia-mediated resistance to DENV in Ae. albopictus. We also investigated the impact of Wolbachia infection on DENV life cycle. We report here that Wolbachia is able to inhibit the intracellular accumulation of DENV in Aedes. aegypti mosquito cells. We showed that Wolbachia infection inhibits DENV binding to mosquito Aag2 cells. We then compared the DENV negative strand RNA levels in Wolbachia infected and uninfected mosquito cells. Wolbachia infection also inhibits DENV replication in mosquito Aag2 cells.To further investigate Wolbachia-DENV interactions in mosquito, we carried out microarray and real-time PCR analyses to define host cell transcriptional responses that are induced by Wolbachia infection. Our data indicates that sixteen previously identified DENV host factors were up-regulated in mosquito cells infected with Wolbachia. An RNA interference (RNAi) screen revealed eleven host factors that are associated with Wolbachia-mediated viral resistance. Our data provides several potential targets for interrupting dengue virus infection in mosquitoes.

Description based on online resource; title from PDF t.p. (viewed on Oct. 18, 2017)

Advisors/Committee Members: Xi, Zhiyong, Walker, Edward, Abramovitch, Robert B, Thiem, Suzanne M.

Subjects/Keywords: Dengue – Prevention; Wolbachia; Vector control – Biological control; Communicable diseases – Transmission – Prevention; Microbiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lu, P. (. M. S. U. (2014). Wolbachia induces resistance to dengue virus in mosquito Aedes aegypti. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:2602

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lu, Peng (Of Michigan State University). “Wolbachia induces resistance to dengue virus in mosquito Aedes aegypti.” 2014. Thesis, Michigan State University. Accessed April 23, 2019. http://etd.lib.msu.edu/islandora/object/etd:2602.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lu, Peng (Of Michigan State University). “Wolbachia induces resistance to dengue virus in mosquito Aedes aegypti.” 2014. Web. 23 Apr 2019.

Vancouver:

Lu P(MSU. Wolbachia induces resistance to dengue virus in mosquito Aedes aegypti. [Internet] [Thesis]. Michigan State University; 2014. [cited 2019 Apr 23]. Available from: http://etd.lib.msu.edu/islandora/object/etd:2602.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lu P(MSU. Wolbachia induces resistance to dengue virus in mosquito Aedes aegypti. [Thesis]. Michigan State University; 2014. Available from: http://etd.lib.msu.edu/islandora/object/etd:2602

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Michigan State University

2. Uzalili, Veronica Talumba. Biotic interactions of the commensal bacterium Elizabethkingia anophelis (Flavobacteriaceae) with Anopheles stephensi Liston and Anopheles gambiae senso stricto Giles (Diptera : culicidae).

Degree: 2015, Michigan State University

"In this study the physiological effects on mosquito fecundity of the flavobacterium Elizabethkingia anopheles living in a gut-associated commensalism with two major malaria vector species, An. Gambiae and An.stephensi, was investigated."  – Abstract.

Online resource;

Advisors/Committee Members: Uzalili, Veronica T, Walker, Edward D, Miller, Jim, Xi, Zhiyong, Chen, Shicheng K.

Subjects/Keywords: Malaria – Research; Anopheles gambiae; Vector-pathogen relationships; Biotic communities; Entomology; Microbiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Uzalili, V. T. (2015). Biotic interactions of the commensal bacterium Elizabethkingia anophelis (Flavobacteriaceae) with Anopheles stephensi Liston and Anopheles gambiae senso stricto Giles (Diptera : culicidae). (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:3504

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Uzalili, Veronica Talumba. “Biotic interactions of the commensal bacterium Elizabethkingia anophelis (Flavobacteriaceae) with Anopheles stephensi Liston and Anopheles gambiae senso stricto Giles (Diptera : culicidae).” 2015. Thesis, Michigan State University. Accessed April 23, 2019. http://etd.lib.msu.edu/islandora/object/etd:3504.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Uzalili, Veronica Talumba. “Biotic interactions of the commensal bacterium Elizabethkingia anophelis (Flavobacteriaceae) with Anopheles stephensi Liston and Anopheles gambiae senso stricto Giles (Diptera : culicidae).” 2015. Web. 23 Apr 2019.

Vancouver:

Uzalili VT. Biotic interactions of the commensal bacterium Elizabethkingia anophelis (Flavobacteriaceae) with Anopheles stephensi Liston and Anopheles gambiae senso stricto Giles (Diptera : culicidae). [Internet] [Thesis]. Michigan State University; 2015. [cited 2019 Apr 23]. Available from: http://etd.lib.msu.edu/islandora/object/etd:3504.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Uzalili VT. Biotic interactions of the commensal bacterium Elizabethkingia anophelis (Flavobacteriaceae) with Anopheles stephensi Liston and Anopheles gambiae senso stricto Giles (Diptera : culicidae). [Thesis]. Michigan State University; 2015. Available from: http://etd.lib.msu.edu/islandora/object/etd:3504

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.