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You searched for +publisher:"Manipal University" +contributor:("Bhalla, Upinder Singh"). Showing records 1 – 2 of 2 total matches.

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1. Parthasarathy K. Neural mechanisms of stereo olfaction;.

Degree: Biological Sciences, 2014, Manipal University

Rodents primarily rely on odor information for navigation. As air-borne odor molecules constantly drift away from the source, they form a non-uniform and a fluctuating concentration gradient. To navigate in such a dynamically changing odor environment, the animal needs to extract instantaneous information about aspects of odor gradients. This is achieved by bilateral odor sampling that has been demonstrated in many species. In principle, bilateral comparison strategy could provide the animal with the knowledge of fast changing odor environment. The key assumptions for bilateral comparison are Symmetry: bilateral equivalence at all levels of the olfactory processing and Laterality: bilateral distinction of the information. Absence of any one of these prerequisites might upset the efficiency of odor localization behavior. In this study, we have checked for the extent of these attributes in early olfactory processing in the rat. We first established behavioral readouts of precisely controlled bilateral odorant stimuli. We found that rats could rapidly and accurately report the direction of a wide range of odor gradients, presented in a random sequence. Then, we measured the nasal airflow and found that the air flow was symmetric over long periods. Further, our study suggests that sampling from the two nostrils in the behavioral task were highly lateralized. Finally, we observed strong lateralization of odor elicited responses from both the receptor epithelium and the glomerular layer of the olfactory bulb. Taken together, these results suggest that the olfactory system is symmetric and the bilateral information flow is lateralized. Therefore, this forms the basis for a simple, single-sniff bilateral comparison mechanism to determine odor direction.

Summary p. 93-96 and References included

Advisors/Committee Members: Bhalla, Upinder Singh.

Subjects/Keywords: Biological Sciences; Olfaction and Behavior; Odor; Neurobiology

Page 1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

K, P. (2014). Neural mechanisms of stereo olfaction;. (Thesis). Manipal University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/17073

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

K, Parthasarathy. “Neural mechanisms of stereo olfaction;.” 2014. Thesis, Manipal University. Accessed April 24, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/17073.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

K, Parthasarathy. “Neural mechanisms of stereo olfaction;.” 2014. Web. 24 Apr 2019.

Vancouver:

K P. Neural mechanisms of stereo olfaction;. [Internet] [Thesis]. Manipal University; 2014. [cited 2019 Apr 24]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17073.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

K P. Neural mechanisms of stereo olfaction;. [Thesis]. Manipal University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17073

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Jain, Pragati. Spatiotemporal modeling of neuronal protein synthesis in synaptic plasticity;.

Degree: Biological Sciences, 2014, Manipal University

Synaptic plasticity, the ability of synapses to undergo changes in their strength, forms the basis for memory formation. Transcription and translation is required to establish such long term changes at synapses. In this thesis, I present results from my studies about how these complex processes are newlineorchestrated to produce diverse cellular responses. We have developed a biochemical model of plasticity-triggered protein synthesis. This model was constrained by reproducing experimental data. We have shown that protein synthesis is high in a narrow range of calcium levels and is gated by BDNF. We found that these properties prevent newlinerunaway activation of the pathway. Despite several positive feedback loops in the model, we have also shown that bistability is unlikely to arise. It is known that different kinds of inputs lead to synthesis of different subsets of mRNA and proteins but the mechanism is unclear. We built a model of key regulatory pathways that control neuronal mRNA synthesis, based on published experimental data. We found that this network newlinedecodes a wide range of temporal stimuli implicated in synaptic plasticity, and generates distinct combinations of mRNA transcripts in response. To explore how this differentially synthesized mRNA is delivered from the nucleus, our model can be incorporated with rate of mRNA transport. We designed an experiment to measure the speed and distance of its transport. We conducted preliminary experiments where we observed BDNF and PKM-zeta mRNA after inducing plasticity in a hippocampal slice, by using fluorescent in situ hybridization (FISH). newlineOur simulation study coupled with experiments provides a framework to study the regulation of differential protein synthesis during transport and at the synapse.

Summary p. 156-159 and References included

Advisors/Committee Members: Bhalla, Upinder Singh.

Subjects/Keywords: Biological Sciences

Page 1

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jain, P. (2014). Spatiotemporal modeling of neuronal protein synthesis in synaptic plasticity;. (Thesis). Manipal University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/17081

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Jain, Pragati. “Spatiotemporal modeling of neuronal protein synthesis in synaptic plasticity;.” 2014. Thesis, Manipal University. Accessed April 24, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/17081.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Jain, Pragati. “Spatiotemporal modeling of neuronal protein synthesis in synaptic plasticity;.” 2014. Web. 24 Apr 2019.

Vancouver:

Jain P. Spatiotemporal modeling of neuronal protein synthesis in synaptic plasticity;. [Internet] [Thesis]. Manipal University; 2014. [cited 2019 Apr 24]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17081.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jain P. Spatiotemporal modeling of neuronal protein synthesis in synaptic plasticity;. [Thesis]. Manipal University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17081

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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