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You searched for +publisher:"Leiden University" +contributor:("Supervisor: M.J. Schalij Co-Supervisors: D.A. Pijnappels"). Showing records 1 – 2 of 2 total matches.

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Leiden University

1. Engels, M.C. Cellular modifications and interventions for the damaged heart.

Degree: 2016, Leiden University

The aim of this thesis was to explore cellular modification processes associated with heart disease, as well as harnessing its potential for treatment and prevention of detrimental electrophysiological consequences of heart disease. For regenerative cell replacement therapies, optimal differentiation strategies can give rise to efficient generation of mature cardiomyocytes. Insuline-like growth factor (IGF) was found to selectively expand early mesodermal cardiac precursor cell populations in an embryonic stem cell model. Timed exposure of differentiating stem cells to IGF can significantly increase the efficiency of cardiac differentiation. In addition to cell replacement therapy, scar substrate can be modified in order to alter its electrophysiological properties. Fusion of fibroblastic scar cells with surrounding cardiomyocytes reduced pro-arrhtyhmic features through several mechanisms, including more negative mean diastolic potential, enhanced outward Kv current and increased connexin43 expression. Remodelled ventricular tissue is characterized by fibrosis and connexin43 downregulation. This creates an arrhythmogenic substrate, as it gives rise to action potential duration (APD) alternans. Organization of discrete areas of APD alternans is associated with stable reentry formation. By optogenetic modification of cardiomyocytes, re-entry could be effectively terminated by brief light stimuli. Cellular modification is a promising treatment strategy for heart disease. Advisors/Committee Members: Supervisor: M.J. Schalij Co-Supervisors: D.A. Pijnappels, A.A.F. de Vries.

Subjects/Keywords: Regenerative medicine; Cardiomyocyte embryonic stem cells; Fibrosis arrhythmia; Optogenetics differentiation; Regenerative medicine; Cardiomyocyte embryonic stem cells; Fibrosis arrhythmia; Optogenetics differentiation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Engels, M. C. (2016). Cellular modifications and interventions for the damaged heart. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/39392

Chicago Manual of Style (16th Edition):

Engels, M C. “Cellular modifications and interventions for the damaged heart.” 2016. Doctoral Dissertation, Leiden University. Accessed December 09, 2019. http://hdl.handle.net/1887/39392.

MLA Handbook (7th Edition):

Engels, M C. “Cellular modifications and interventions for the damaged heart.” 2016. Web. 09 Dec 2019.

Vancouver:

Engels MC. Cellular modifications and interventions for the damaged heart. [Internet] [Doctoral dissertation]. Leiden University; 2016. [cited 2019 Dec 09]. Available from: http://hdl.handle.net/1887/39392.

Council of Science Editors:

Engels MC. Cellular modifications and interventions for the damaged heart. [Doctoral Dissertation]. Leiden University; 2016. Available from: http://hdl.handle.net/1887/39392


Leiden University

2. Bingen, B.O. Molecular and cellular determinants of cardiac tachyarrhythmias: from trigger to therapy.

Degree: 2016, Leiden University

Cardiac tachyarrhythmias are a vast contributor to morbidity and mortality worldwide. Still, the mechanisms underlying these arrhythmias are incompletely understood. As a result, many of the treatment options available for these arrhythmias rely on sole alleviation of symptoms or prevention of complications secondary to the arrhythmia, or are associated with non-trivial adverse effects. An increased understanding of the mechanisms underlying cardiac tachyarrhythmias as well as the means to reverse them is a critical prerequisite if we are to shift towards more specific, more effective and less harmful arrhythmia treatment. Therefore, the research described in this thesis investigates the molecular and cellular determinants of cardiac tachyarrhythmias in ex vivo and in vitro models of cardiac hypertropfy/fibrosis, ventricular fibrillation and atrial fibrillation using state of the art electrophysiological and genetic tools. Advisors/Committee Members: Supervisor: M.J. Schalij Co-Supervisors: D.A. Pijnappels, A.A.F. de Vries.

Subjects/Keywords: Arrhythmia; Atrial fibrillation; Ventricular fibrillation; Defibrillation; Optogenetics; Arrhythmia; Atrial fibrillation; Ventricular fibrillation; Defibrillation; Optogenetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bingen, B. O. (2016). Molecular and cellular determinants of cardiac tachyarrhythmias: from trigger to therapy. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/43389

Chicago Manual of Style (16th Edition):

Bingen, B O. “Molecular and cellular determinants of cardiac tachyarrhythmias: from trigger to therapy.” 2016. Doctoral Dissertation, Leiden University. Accessed December 09, 2019. http://hdl.handle.net/1887/43389.

MLA Handbook (7th Edition):

Bingen, B O. “Molecular and cellular determinants of cardiac tachyarrhythmias: from trigger to therapy.” 2016. Web. 09 Dec 2019.

Vancouver:

Bingen BO. Molecular and cellular determinants of cardiac tachyarrhythmias: from trigger to therapy. [Internet] [Doctoral dissertation]. Leiden University; 2016. [cited 2019 Dec 09]. Available from: http://hdl.handle.net/1887/43389.

Council of Science Editors:

Bingen BO. Molecular and cellular determinants of cardiac tachyarrhythmias: from trigger to therapy. [Doctoral Dissertation]. Leiden University; 2016. Available from: http://hdl.handle.net/1887/43389

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