Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

Sorted by: relevance · author · university · dateNew search

You searched for +publisher:"Kent State University" +contributor:("Schofield, Brett"). Showing records 1 – 2 of 2 total matches.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


Kent State University

1. Motts, Susan D. Cholinergic circuitry in auditory brainstem.

Degree: PhD, College of Arts and Sciences / School of Biomedical Sciences, 2010, Kent State University

Acetylcholine is involved in many aspects of auditory function, including plasticity, arousal, and sensory gating. While there have been many studies of acetylcholine in the ear and in the auditory cortex, there is a lack of data on cholinergic innervation of many of the auditory centers that form the ascending auditory pathways. This lack of data has hindered interpretation of physiological studies, especially those in the auditory midbrain. The experiments in this dissertation address questions about cholinergic innervation of the inferior colliculus (IC) and the medial geniculate body (MG), the major auditory centers of the midbrain and thalamus. We combined immunohistochemistry for choline acetyltransferase (ChAT), a marker of cholinergic cells, with retrograde tracers to address questions about cholinergic circuitry in guinea pigs. We found that the pontomesencephalic tegmentum (PMT) is the source of cholinergic input to the IC. The PMT comprises two cholinergic nuclei: the pedunculopontine tegmental nucleus and the laterodorsal tegmental nucleus. The PMT is best known as part of the ascending reticular activating system, which affects activation of the cerebral cortex and behavioral arousal via projections to thalamus. We demonstrated that the PMT projections to the MG are similar to PMT projections to other thalamic nuclei, both in the patterns of projections and the involvement of cholinergic and non-cholinergic projecting neurons. In addition, we found that individual PMT cholinergic cells can innervate multiple auditory nuclei, including both ICs, both MGs, or an IC and an MG. Thus, the cholinergic projections are in a position to modulate auditory functions bilaterally and at multiple levels of the auditory system (i.e. auditory midbrain and thalamus). The results reveal a much broader cholinergic innervation of auditory structures from the PMT than was previously known. This broad innervation is consistent with functions previously associated with the PMT (e.g., modulation of sensory responses during the sleep-wake cycle) as well as other functions only recently related to cholinergic systems, e.g., an essential role in some forms of neuronal plasticity. Advisors/Committee Members: Schofield, Brett R. (Committee Chair).

Subjects/Keywords: Neurosciences; pedunculopontine tegmental nucleus; laterodorsal tegmental nucleus; acetylcholine; auditory; inferior colliculus; medial geniculate body; sensory gating

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Motts, S. D. (2010). Cholinergic circuitry in auditory brainstem. (Doctoral Dissertation). Kent State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=kent1290120470

Chicago Manual of Style (16th Edition):

Motts, Susan D. “Cholinergic circuitry in auditory brainstem.” 2010. Doctoral Dissertation, Kent State University. Accessed January 19, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1290120470.

MLA Handbook (7th Edition):

Motts, Susan D. “Cholinergic circuitry in auditory brainstem.” 2010. Web. 19 Jan 2020.

Vancouver:

Motts SD. Cholinergic circuitry in auditory brainstem. [Internet] [Doctoral dissertation]. Kent State University; 2010. [cited 2020 Jan 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1290120470.

Council of Science Editors:

Motts SD. Cholinergic circuitry in auditory brainstem. [Doctoral Dissertation]. Kent State University; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1290120470

2. Beebe, Nichole L. Perineuronal nets and the inhibitory circuitry of the auditory midbrain: evidence for subtypes of GABAergic neurons.

Degree: PhD, College of Arts and Sciences / School of Biomedical Sciences, 2016, Kent State University

Perineuronal nets (PNs) are aggregates of extracellular matrix molecules that surround subsets of neurons throughout the central nervous system (Celio and Blumcke, 1994). PNs appear postnatally and often in association with the closing of periods of heightened plasticity, for example in zebra finch song nuclei around the time of song learning (Balmer et al., `09). PNs are present throughout the adult auditory system, however little information is available about subcortical PNs in general, and subcortical auditory PNs in particular (Sonntag et al., `15). Preliminary data indicates a large number of PNs in the inferior colliculus (IC), a major auditory hub. Reports of PNs in the inferior colliculus (IC) vary widely in the description of their distribution (Seeger et al., `94; Atoji et al., `97; Friauf, `00; Hilbig et al., `07), and although PNs are preferentially associated with GABAergic interneurons in other brain areas (Kosaka and Heizmann, `89; Hartig et al., `92), the neurotransmitter phenotype of IC PN-surrounded neurons has not been described. Additionally, nothing is known about the circuitry of PN-surrounded IC neurons. The likely association of PNs with GABAergic cells leads to the question of whether PN-surrounded IC cells fall into the small GABAergic (SG) or large GABAergic (LG) categories described by Ito et al. (2009). Preliminary data suggests an association with the LG group, based on an association between PNs and dense rings of terminals containing vesicular glutamate transporter 2 (VGLUT2- a marker of LG cells). There is currently no information about the projections of PN-surrounded IC neurons. As stated above, PNs are associated with interneurons in other areas, however all IC neurons are believed to have projections outside of the IC (Oliver et al., `91). An association with GABA cells makes it likely that PN-surrounded IC cells will project to either the medial geniculate body (MGB) or the contralateral IC, as these are the two main projections of IC GABA cells (Gonzalez-Hernandez et al., `96; Winer et al., `96). A larger proportion of the IC-MGB pathway is GABAergic, making this the more likely target. The lack of information about the distribution, neurotransmitter phenotype, and circuitry of PN-surrounded neurons in the IC is a major roadblock to understanding the function of PNs in hearing. Advisors/Committee Members: Schofield, Brett (Advisor).

Subjects/Keywords: Neurosciences; perineuronal nets; GABA; auditory; inferior colliculus; medial geniculate body; VGLUT2; hearing

…myself), Jesse W. Young, Jeffrey G. Mellott, and Brett R. Schofield. Brett Schofield and I… …authors are Nichole L. Foster (myself), Jeffrey G. Mellott, and Brett R. Schofield… …Brett Schofield and I designed the research and wrote the paper, and all contributing authors… 

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Beebe, N. L. (2016). Perineuronal nets and the inhibitory circuitry of the auditory midbrain: evidence for subtypes of GABAergic neurons. (Doctoral Dissertation). Kent State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=kent1468938365

Chicago Manual of Style (16th Edition):

Beebe, Nichole L. “Perineuronal nets and the inhibitory circuitry of the auditory midbrain: evidence for subtypes of GABAergic neurons.” 2016. Doctoral Dissertation, Kent State University. Accessed January 19, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1468938365.

MLA Handbook (7th Edition):

Beebe, Nichole L. “Perineuronal nets and the inhibitory circuitry of the auditory midbrain: evidence for subtypes of GABAergic neurons.” 2016. Web. 19 Jan 2020.

Vancouver:

Beebe NL. Perineuronal nets and the inhibitory circuitry of the auditory midbrain: evidence for subtypes of GABAergic neurons. [Internet] [Doctoral dissertation]. Kent State University; 2016. [cited 2020 Jan 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1468938365.

Council of Science Editors:

Beebe NL. Perineuronal nets and the inhibitory circuitry of the auditory midbrain: evidence for subtypes of GABAergic neurons. [Doctoral Dissertation]. Kent State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1468938365

.