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You searched for +publisher:"Governors State University" +contributor:("Patty Fu-Giles, Ph.D."). Showing records 1 – 2 of 2 total matches.

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1. Bikki, Sree Divya. Interaction Between Humic Acid and DNA.

Degree: MS, Analytical Chemistry, 2012, Governors State University

Humic acid (HA) are widely dispersed, naturally occurring biopolymers most commonly found in soil, drinking water, and plants. Humic acid is soluble in alkali and insoluble in an acidic medium or water. In the present study the interaction of Humic acid with DNA is determined by the calculation of the binding constant of humic acid with CT-DNA and the quenching phenomenon of humic acid in the presence of DNA is also studied using Stern Volmer Relationship. Advisors/Committee Members: Patty Fu-Giles, Ph.D., Walter Henne, Jr., Ph.D., Karen D'Arcy, Ph.D..

Subjects/Keywords: Analytical Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bikki, S. D. (2012). Interaction Between Humic Acid and DNA. (Thesis). Governors State University. Retrieved from http://opus.govst.edu/theses/1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Bikki, Sree Divya. “Interaction Between Humic Acid and DNA.” 2012. Thesis, Governors State University. Accessed February 21, 2019. http://opus.govst.edu/theses/1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Bikki, Sree Divya. “Interaction Between Humic Acid and DNA.” 2012. Web. 21 Feb 2019.

Vancouver:

Bikki SD. Interaction Between Humic Acid and DNA. [Internet] [Thesis]. Governors State University; 2012. [cited 2019 Feb 21]. Available from: http://opus.govst.edu/theses/1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bikki SD. Interaction Between Humic Acid and DNA. [Thesis]. Governors State University; 2012. Available from: http://opus.govst.edu/theses/1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Corcoran, David A. Developing Novel Nanoparticulated Imaging System using Luminescence Enhancement of Eu(III) and TB(III) by Single-Strand DNA Encapsulation.

Degree: MS, Analytical Chemistry, 2011, Governors State University

Non-toxic biosensors are encountering an increase in attention for use in understanding the fate of cells and as a diagnostic tool. Development and incorporation of suitable fluorophores into biological molecules is the key for monitoring proteins in vivo research. This study investigated the enhanced emission of Eu (III) and Tb (III) upon binding to the four DNA bases and their respective nucleotides, found the best ratio for effective energy transfer, and developing nanoparticles to deliver the biosensor into the cells. It is well known that Eu (III) and Tb (III) exhibit very distinctive photo-characteristics. The luminescence of these two lanthanides is weak due to low absorption cross sections. Conversely, the emission of both trivalent ions, upon irradiation, in aqueous solution, is strong when bound to complex ligand systems. The luminescent enhancement is the result of energy transfer (EnT) and the binding with single-stranded DNA, making these ions perfect candidates for luminescent probes (1). The emission lanthanides theory by G.A. Crosby establishes that the intramolecular energy transfer in a lanthanide complex is when the lowest triplet state energy level of the complex equals or lies above the resonance level of the lanthanide (2) To overcome the inherently low absorption of lanthanide ions, researchers have developed sensitizing fluorophores that upon excitation, transfer energy to the lanthanide (3) (4). One problem with luminescence in an aqueous solution is that another pathway is available for deactivation of the excited state of the lanthanide, in the form of vibrational energy transfer to water molecules (1). Early research shows that quenching of luminescence is minimized by using ligands which tended to encapsulate the lanthanide ion (1). Longer emission lifetimes and greater quantum yield intensities can be accomplished by either chelation by ligands (5)or encapsulation of the lanthanides. We ascertained the maximum enhancement for the lanthanide ions occurred through the interaction with the base guanine or its nucleotide guanosine 5’-monophosphate disodium salt. The research initially pursued the encapsulation of the lanthanide ions by single-strand oligonucleotides as a biosensor. However, an alternative delivery method based on inverse micelles and liposomes was developed and it proved to be economical and simple to encapsulate and deliver the biosensor into the cells. The creation of a double emulsion, or water-oil-water system, and the encapsulation (using palmitic acid as surfactant) of the water soluble biosensors were successful. This thesis determined the particle size achieved of 75nm, for both lanthanides had fallen into the nanoemulsions range. Their small size permits the nanoparticles to be injected intravenously(6). The in vitro toxicity of the nanoparticles, with both luminescence biosensors, was assessed by BCA assay. Results supported… Advisors/Committee Members: Patty Fu-Giles, Ph.D., Phyllis Klingensmith, Ph.D., Karen D'Arcy, Ph.D..

Subjects/Keywords: Analytical Chemistry

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Corcoran, D. A. (2011). Developing Novel Nanoparticulated Imaging System using Luminescence Enhancement of Eu(III) and TB(III) by Single-Strand DNA Encapsulation. (Thesis). Governors State University. Retrieved from http://opus.govst.edu/theses/15

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Corcoran, David A. “Developing Novel Nanoparticulated Imaging System using Luminescence Enhancement of Eu(III) and TB(III) by Single-Strand DNA Encapsulation.” 2011. Thesis, Governors State University. Accessed February 21, 2019. http://opus.govst.edu/theses/15.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Corcoran, David A. “Developing Novel Nanoparticulated Imaging System using Luminescence Enhancement of Eu(III) and TB(III) by Single-Strand DNA Encapsulation.” 2011. Web. 21 Feb 2019.

Vancouver:

Corcoran DA. Developing Novel Nanoparticulated Imaging System using Luminescence Enhancement of Eu(III) and TB(III) by Single-Strand DNA Encapsulation. [Internet] [Thesis]. Governors State University; 2011. [cited 2019 Feb 21]. Available from: http://opus.govst.edu/theses/15.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Corcoran DA. Developing Novel Nanoparticulated Imaging System using Luminescence Enhancement of Eu(III) and TB(III) by Single-Strand DNA Encapsulation. [Thesis]. Governors State University; 2011. Available from: http://opus.govst.edu/theses/15

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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