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You searched for +publisher:"Georgia Tech" +contributor:("Todd C. McDevitt"). Showing records 1 – 3 of 3 total matches.

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1. Ngangan, Alyssa V. Bioactive factors secreted by differentiating embryonic stem cells.

Degree: PhD, Biomedical Engineering, 2011, Georgia Tech

Current therapeutic strategies to stimulate endogenous angiogenic processes within injured tissue areas are typically based on introducing exogenous pro-angiogenic molecules or cell populations. Stem cell transplantation for angiogenic therapy aims to deliver populations of cells that secrete angiogenic factors and/or engraft in the new branching vasculature within the damaged tissue. Utilizing stem or progenitor cells has been shown to induce a rather robust angiogenic response despite minimal repopulation of the host vasculature, suggesting that stem cells may provide paracrine factors that transiently induce endogenous angiogenesis of tissues undergoing regeneration. Early differentiating embryonic stem cell (ESC) aggregates, referred to as embryoid bodies (EBs), can undergo vasculogenic differentiation, and also produce extracellular matrix and growth factors that induce proliferation, differentiation, and tissue morphogenesis. Taken together, the ESC extracellular environment may be an effective means by which to manipulate cell behavior. Thus, the objective of this project was to harness morphogens derived from ESCs undergoing differentiation and analyze their bioactive potential. To examine the expression of extracellular factors within EBs, gene expression arrays in conjunction with a variety of analytical tools were utilized to gain an understanding of the importance of extracellular factors in ESC differentiation. Furthermore, the soluble fraction of secreted factors contained within EB-conditioned media was compared to the matrix-associated factors produced by EBs, which led to the development of novel ESC-derived matrices via mechanical acellularization methods. Acellular embryonic stem cell-derived matrices demonstrated the retention of bioactive factors that impacted aspects of angiogenesis. In conclusion, extracellular factors were modulated in response to the progression of EB differentiation and can further be harnessed via acellularization techniques, in order to deliver bioactive ESC-secreted factors in a cell-free manner. Advisors/Committee Members: Dr. Todd C. McDevitt (Committee Chair), Dr. Andres J. Garcia (Committee Member), Dr. Robert E. Guldberg (Committee Member), Dr. Thomas Barker (Committee Member), Dr. Young-sup Yoon (Committee Member).

Subjects/Keywords: Angiogenesis; Extracellular matrix; Growth factors; Embryonic stem cells; Stem cells; Stem cells Research; Embryonic stem cells Research; Neovascularization

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APA (6th Edition):

Ngangan, A. V. (2011). Bioactive factors secreted by differentiating embryonic stem cells. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/44913

Chicago Manual of Style (16th Edition):

Ngangan, Alyssa V. “Bioactive factors secreted by differentiating embryonic stem cells.” 2011. Doctoral Dissertation, Georgia Tech. Accessed September 18, 2020. http://hdl.handle.net/1853/44913.

MLA Handbook (7th Edition):

Ngangan, Alyssa V. “Bioactive factors secreted by differentiating embryonic stem cells.” 2011. Web. 18 Sep 2020.

Vancouver:

Ngangan AV. Bioactive factors secreted by differentiating embryonic stem cells. [Internet] [Doctoral dissertation]. Georgia Tech; 2011. [cited 2020 Sep 18]. Available from: http://hdl.handle.net/1853/44913.

Council of Science Editors:

Ngangan AV. Bioactive factors secreted by differentiating embryonic stem cells. [Doctoral Dissertation]. Georgia Tech; 2011. Available from: http://hdl.handle.net/1853/44913


Georgia Tech

2. Zhong, Yinghui. Development and Characterization of Anti-Inflammatory Coatings for Implanted Neural Probes.

Degree: PhD, Biomedical Engineering, 2006, Georgia Tech

Stable single-unit recordings from the nervous system using microelectrode arrays can have significant implications for the treatment of a wide variety of sensory and movement disorders. However, the long-term performance of the implanted neural electrodes is compromised by the formation of glial scar around these devices, which is a typical consequence of the inflammatory tissue reaction to implantation-induced injury in the CNS. The glial scar is inhibitory to neurons and forms a barrier between the electrode and neurons in the surrounding brain tissue. Therefore, to maintain long-term recording stability, reactive gliosis and other inflammatory processes around the electrode need to be minimized. This work has succeeded in the development of neural electrode coatings that are capable of sustained release of anti-inflammatory agents while not adversely affecting the electrical performance of the electrodes. The effects of coating methods, initial drug loadings on release kinetics were investigated to optimize the coatings. The physical properties of the coatings and the bioactivity of released anti-inflammatory agents were characterized. The effect of the coatings on the electrical property of the electrodes was tested. Two candidate anti-inflammatory agents were screened by evaluating their anti-inflammatory potency in vitro. Finally, neural electrodes coated with the anti-inflammatory coatings were implanted into rat brains to assess the anti-inflammatory potential of the coatings in vivo. This work represents a promising approach to attenuate astroglial scar around the implanted silicon neural electrodes, and may provide a promising strategy to improve the long-term recording stability of silicon neural electrodes. Advisors/Committee Members: Ravi V. Bellamkonda (Committee Chair), Julia E. Babensee (Committee Member), Michelle C. LaPlaca (Committee Member), Robert J. McKeon (Committee Member), Todd C. McDevitt (Committee Member).

Subjects/Keywords: Neural implant; Drug delivery; Coatings; Inflammation; Glial scar; Nervous system; Electrodes; Implants, Artificial; Foreign-body reaction; Wound healing; Neuroglia; Coatings; Controlled release preparations; Anti-inflammatory agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Zhong, Y. (2006). Development and Characterization of Anti-Inflammatory Coatings for Implanted Neural Probes. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/19760

Chicago Manual of Style (16th Edition):

Zhong, Yinghui. “Development and Characterization of Anti-Inflammatory Coatings for Implanted Neural Probes.” 2006. Doctoral Dissertation, Georgia Tech. Accessed September 18, 2020. http://hdl.handle.net/1853/19760.

MLA Handbook (7th Edition):

Zhong, Yinghui. “Development and Characterization of Anti-Inflammatory Coatings for Implanted Neural Probes.” 2006. Web. 18 Sep 2020.

Vancouver:

Zhong Y. Development and Characterization of Anti-Inflammatory Coatings for Implanted Neural Probes. [Internet] [Doctoral dissertation]. Georgia Tech; 2006. [cited 2020 Sep 18]. Available from: http://hdl.handle.net/1853/19760.

Council of Science Editors:

Zhong Y. Development and Characterization of Anti-Inflammatory Coatings for Implanted Neural Probes. [Doctoral Dissertation]. Georgia Tech; 2006. Available from: http://hdl.handle.net/1853/19760


Georgia Tech

3. Charest, Joseph Leo. Topographic and chemical patterning of cell-surface interfaces to influence cellular functions.

Degree: PhD, Mechanical Engineering, 2007, Georgia Tech

This dissertation aims to further the understanding of the complex communication that occurs as cells interact with topographical and chemical patterns on a biomaterial interface. The research accomplishes this through two aims fabricating cell substrate surface topography and chemical patterns independently using non-cleanroom approaches, and analyzing higher order cellular response to surface features. The work will impact biomaterial surface modification and fabrication which will apply to biomedical implanted devices, tissue engineering scaffolds, and biological analysis devices. The first aim seeks to apply non-traditional topographical and chemical patterning methods in order to create independent topographical and chemical patterns on cell culture substrates. Experiments use the resulting patterned substrates to quantify cellular alignment to surface topography and compare the relative influence of topographical and chemical patterns on cellular response. The combined patterning methods of imprint lithography and micro-contact printing result in a high-throughput technique applicable to a variety of materials and a range of feature sizes from nanoscale through microscale, thereby enabling future analysis of cell response to surface features. The second aim evaluates the impact of topographical and chemical features on cellular differentiation. Experiments use patterned topography overlaid with a characterized chemical model layer to evaluate the effects of topography on myoblast differentiation and alignment. Chemical patterns that independently control available cell spreading area and modulate cell-cell contact are used to investigate the impact of cell-cell contact on differentiation. Advisors/Committee Members: Dr. William P. King (Committee Chair), Dr. Andres J. Garcia (Committee Member), Dr. F. Levent Degertekin (Committee Member), Dr. Hang Lu (Committee Member), Dr. Todd C. McDevitt (Committee Member).

Subjects/Keywords: Biomaterial; Cell-surface interface; Chemical pattern; Micropattern; Nanopattern; Topography; Cells; Keratinocytes; Cell adhesion; Biomedical materials; Surface chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Charest, J. L. (2007). Topographic and chemical patterning of cell-surface interfaces to influence cellular functions. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/24621

Chicago Manual of Style (16th Edition):

Charest, Joseph Leo. “Topographic and chemical patterning of cell-surface interfaces to influence cellular functions.” 2007. Doctoral Dissertation, Georgia Tech. Accessed September 18, 2020. http://hdl.handle.net/1853/24621.

MLA Handbook (7th Edition):

Charest, Joseph Leo. “Topographic and chemical patterning of cell-surface interfaces to influence cellular functions.” 2007. Web. 18 Sep 2020.

Vancouver:

Charest JL. Topographic and chemical patterning of cell-surface interfaces to influence cellular functions. [Internet] [Doctoral dissertation]. Georgia Tech; 2007. [cited 2020 Sep 18]. Available from: http://hdl.handle.net/1853/24621.

Council of Science Editors:

Charest JL. Topographic and chemical patterning of cell-surface interfaces to influence cellular functions. [Doctoral Dissertation]. Georgia Tech; 2007. Available from: http://hdl.handle.net/1853/24621

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