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You searched for +publisher:"Georgia Tech" +contributor:("Liu, Robert C."). Showing records 1 – 3 of 3 total matches.

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Georgia Tech

1. Chong, Kelly K. Experience dependent coding of intonations by offsets in mouse auditory cortex.

Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2019, Georgia Tech

Acoustic communication is an important aspect of many social interactions across mammalian species. The encoding of intra-species vocalizations and plasticity mechanisms engaged during the process of learning vocalizations are poorly understood. This is particularly true with regards to how sensory representations of vocalizations is transformed between primary to secondary auditory cortical areas. Moreover, learning in a natural communication paradigm engages auditory cortical plasticity mechanisms in ways that are distinct from laboratory operant training paradigms, emphasizing the importance of studying learning in social settings. Our work utilizes a natural paradigm in which mouse mothers learn the behavioral significance of pup ultrasonic vocalizations during maternal experience to study auditory cortical plasticity in a natural social context. Specifically, we aim to determine how mice learn to use acoustic features to discriminate vocalization categories. One of the acoustic features that can be used to distinguish whistle-like mouse vocalizations is their frequency trajectory or intonation, which can be modeled using a parameterized sinusoidally frequency modulated tone. We will employ a combination of in vivo head-fixed awake single unit electrophysiology and modeling of the natural mouse vocalization repertoire to explore the frequency trajectory parameter space. With this approach, we aim to study the native sensitivity of auditory cortical neurons to frequency trajectory parameters across primary and secondary auditory regions, as well as how sensitivity to these parameters changes with experience. This work will further our understanding of how the acoustic feature space is represented by the auditory cortex, and uncovers a potential mechanism by which natural sound categories are learned. Advisors/Committee Members: Liu, Robert C. (advisor), Jaeger, Dieter (committee member), Nygaard, Lynne C. (committee member), Sober, Samuel J. (committee member), Stanley, Garrett B. (committee member).

Subjects/Keywords: Neuroscience; Neural coding; Sensory; Auditory; Plasticity; Offset; Intonation; Frequency modulation; Encoding; Mouse; Cortex; Vocalization processing; Electrophysiology; Maternal; Sinusoidal frequency modulation

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APA (6th Edition):

Chong, K. K. (2019). Experience dependent coding of intonations by offsets in mouse auditory cortex. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/62628

Chicago Manual of Style (16th Edition):

Chong, Kelly K. “Experience dependent coding of intonations by offsets in mouse auditory cortex.” 2019. Doctoral Dissertation, Georgia Tech. Accessed October 24, 2020. http://hdl.handle.net/1853/62628.

MLA Handbook (7th Edition):

Chong, Kelly K. “Experience dependent coding of intonations by offsets in mouse auditory cortex.” 2019. Web. 24 Oct 2020.

Vancouver:

Chong KK. Experience dependent coding of intonations by offsets in mouse auditory cortex. [Internet] [Doctoral dissertation]. Georgia Tech; 2019. [cited 2020 Oct 24]. Available from: http://hdl.handle.net/1853/62628.

Council of Science Editors:

Chong KK. Experience dependent coding of intonations by offsets in mouse auditory cortex. [Doctoral Dissertation]. Georgia Tech; 2019. Available from: http://hdl.handle.net/1853/62628

2. Killian, Nathaniel J. Bioelectrical dynamics of the entorhinal cortex.

Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2013, Georgia Tech

The entorhinal cortex (EC) in the medial temporal lobe plays a critical role in memory formation and is implicated in several neurological diseases including temporal lobe epilepsy and Alzheimer’s disease. Despite the known importance of this brain region, little is known about the normal bioelectrical activity patterns of the EC in awake, behaving primates. In order to develop effective therapies for diseases affecting the EC, we must first understand its normal properties. To contribute to our understanding of the EC, I monitored the activity of individual neurons and populations of neurons in the EC of rhesus macaque monkeys during free-viewing of photographs using electrophysiological techniques. The results of these experiments help to explain how primates can form memories of, and navigate through, the visual world. These experiments revealed neurons in the EC that represent visual space with triangular grid receptive fields and other neurons that prefer to fire near image borders. These properties are similar to those previously described in the rodent EC, but here the neuronal responses relate to viewing of remote space as opposed to representing the physical location of the animal. The representation of visual space may be aided by another EC neuron type that was discovered, free-viewing saccade direction cells, neurons that signaled the direction of upcoming saccades. Such a signal could be used by other cells to prepare to fire according to the future gaze location. Many of these spatially-responsive neurons also represented memory for images, suggesting that they may be useful for associating items with their locations. I also examined the neuronal circuitry of recognition memory for visual stimuli in the EC, and I found that population synchronization within the gamma-band (30-140 Hz) in superficial layers of the EC was modulated by stimulus novelty, while the strength of memory formation modulated gamma-band synchronization in the deep layers and in layer III. Furthermore, the strength of connectivity in the gamma-band between different layers was correlated with the strength of memory formation, with deep to superficial power transfer being correlated with stronger memory formation and superficial to deep transfer correlated with weaker memory formation. These findings support several previous investigations of hippocampal-entorhinal connectivity in the rodent and advance our understanding of the functional circuitry of the medial temporal lobe memory system. Finally, I explored the design of a device that could be used to investigate properties of brain tissue in vitro, potentially aiding in the development of treatments for disorders of the EC and other brain structures. We designed, fabricated, and validated a novel device for long-term maintenance of thick brain slices and 3-dimensional dissociated cell cultures on a perforated multi-electrode array. To date, most electrical recordings of thick tissue preparations have been performed by manually inserting electrode arrays. This work demonstrates a… Advisors/Committee Members: Potter, Steve M. (advisor), Buffalo, Elizabeth A. (advisor), LaPlaca, Michelle C. (committee member), Liu, Robert C. (committee member), Stanley, Garrett B. (committee member).

Subjects/Keywords: Spatial representation; Primate; Medial temporal lob; Entorhinal cortex; Hippocampus; Grid cell; Border cell; Memory; Saccade; Fixation; Visual; Stimulus; Saccade-direction cell; Encoding; Recognition; Macaque; Monkey; MTL; Perfusion; Perforated microelectrode array; Neurons; Brain slice; Three-dimensional culture; MEA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Killian, N. J. (2013). Bioelectrical dynamics of the entorhinal cortex. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/52148

Chicago Manual of Style (16th Edition):

Killian, Nathaniel J. “Bioelectrical dynamics of the entorhinal cortex.” 2013. Doctoral Dissertation, Georgia Tech. Accessed October 24, 2020. http://hdl.handle.net/1853/52148.

MLA Handbook (7th Edition):

Killian, Nathaniel J. “Bioelectrical dynamics of the entorhinal cortex.” 2013. Web. 24 Oct 2020.

Vancouver:

Killian NJ. Bioelectrical dynamics of the entorhinal cortex. [Internet] [Doctoral dissertation]. Georgia Tech; 2013. [cited 2020 Oct 24]. Available from: http://hdl.handle.net/1853/52148.

Council of Science Editors:

Killian NJ. Bioelectrical dynamics of the entorhinal cortex. [Doctoral Dissertation]. Georgia Tech; 2013. Available from: http://hdl.handle.net/1853/52148

3. Lin, Frank. Experience dependent changes in the auditory cortical representation of natural sounds.

Degree: PhD, Biomedical Engineering, 2012, Georgia Tech

Vocal communication sounds are an important class of signals due to their role in social interaction, reproduction, and survival. The higher-order mechanisms by which our auditory system detects and discriminates these sounds to generate perception is still poorly understood. The auditory cortex is thought to play an important role in this process, and our current work provides new evidence that the auditory cortex changes its neural representation of sounds that are acquired in natural social contexts. We use a mouse ultrasonic communication system between pups and adult females to elucidate this. We record single neurons in the auditory cortex of awake mice, and assess the cortical differences between animals that either do (mothers) or do not (naïve virgins) recognize the pup ultrasounds as behaviorally relevant. We then evaluate the role that pup experience and the maternal physiological state play in this cortical plasticity. Finally, we develop a model to predict the responses to pup vocalizations as a way to segregate the diversity of cortical neuronal responses in the hope of more clearly assessing their roles in processing acoustic features. Our results demonstrate the detailed nature by which the core auditory cortex processes natural vocalizations, showing how it changes to represent behavioral relevance. Advisors/Committee Members: Liu, Robert C. (advisor), Butera, Robert J. (committee member), Manns, Joseph R. (committee member), Rozell, Christopher J. (committee member), Stanley, Garrett B. (committee member).

Subjects/Keywords: Electrophysiology; Neural coding; Plasticity; Neuroscience; Auditory cortex; Auditory cortex; Auditory perception; Speech perception; Hearing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lin, F. (2012). Experience dependent changes in the auditory cortical representation of natural sounds. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/49015

Chicago Manual of Style (16th Edition):

Lin, Frank. “Experience dependent changes in the auditory cortical representation of natural sounds.” 2012. Doctoral Dissertation, Georgia Tech. Accessed October 24, 2020. http://hdl.handle.net/1853/49015.

MLA Handbook (7th Edition):

Lin, Frank. “Experience dependent changes in the auditory cortical representation of natural sounds.” 2012. Web. 24 Oct 2020.

Vancouver:

Lin F. Experience dependent changes in the auditory cortical representation of natural sounds. [Internet] [Doctoral dissertation]. Georgia Tech; 2012. [cited 2020 Oct 24]. Available from: http://hdl.handle.net/1853/49015.

Council of Science Editors:

Lin F. Experience dependent changes in the auditory cortical representation of natural sounds. [Doctoral Dissertation]. Georgia Tech; 2012. Available from: http://hdl.handle.net/1853/49015

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