+publisher:"Georgia Tech" +contributor:("James C. Powers")

Georgia Tech

1. Whitley, Ronald Jay. An investigation of chymotrypsin A[gamma]inhibition with peptide aldehydes and related analogs ; II Inhibition of elastase by tetrapeptide chloromethyl ketones.

Degree: PhD, Chemistry, 1975, Georgia Tech

URL: http://hdl.handle.net/1853/25989

Subjects/Keywords: Enzyme inhibitors; Chymotrypsin

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APA (6^th Edition):

Whitley, R. J. (1975). An investigation of chymotrypsin A[gamma]inhibition with peptide aldehydes and related analogs ; II Inhibition of elastase by tetrapeptide chloromethyl ketones. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/25989

Chicago Manual of Style (16^th Edition):

Whitley, Ronald Jay. “An investigation of chymotrypsin A[gamma]inhibition with peptide aldehydes and related analogs ; II Inhibition of elastase by tetrapeptide chloromethyl ketones.” 1975. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/25989.

MLA Handbook (7^th Edition):

Whitley, Ronald Jay. “An investigation of chymotrypsin A[gamma]inhibition with peptide aldehydes and related analogs ; II Inhibition of elastase by tetrapeptide chloromethyl ketones.” 1975. Web. 05 Mar 2021.

Vancouver:

Whitley RJ. An investigation of chymotrypsin A[gamma]inhibition with peptide aldehydes and related analogs ; II Inhibition of elastase by tetrapeptide chloromethyl ketones. [Internet] [Doctoral dissertation]. Georgia Tech; 1975. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/25989.

Council of Science Editors:

Whitley RJ. An investigation of chymotrypsin A[gamma]inhibition with peptide aldehydes and related analogs ; II Inhibition of elastase by tetrapeptide chloromethyl ketones. [Doctoral Dissertation]. Georgia Tech; 1975. Available from: http://hdl.handle.net/1853/25989

Georgia Tech

2. Dotse, Anthony Kwabla. Design, synthesis and evaluation of novel inhibitors of cysteine proteases, metalloproteases and the proteasome, a unique high molecular weight proteolytic enzyme.

Degree: PhD, Chemistry, 1997, Georgia Tech

URL: http://hdl.handle.net/1853/29979

Subjects/Keywords: Proteolytic enzymes; Protoeolytic enzyme inhibitors; Asymmetric synthesis

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APA (6^th Edition):

Dotse, A. K. (1997). Design, synthesis and evaluation of novel inhibitors of cysteine proteases, metalloproteases and the proteasome, a unique high molecular weight proteolytic enzyme. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/29979

Chicago Manual of Style (16^th Edition):

Dotse, Anthony Kwabla. “Design, synthesis and evaluation of novel inhibitors of cysteine proteases, metalloproteases and the proteasome, a unique high molecular weight proteolytic enzyme.” 1997. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/29979.

MLA Handbook (7^th Edition):

Dotse, Anthony Kwabla. “Design, synthesis and evaluation of novel inhibitors of cysteine proteases, metalloproteases and the proteasome, a unique high molecular weight proteolytic enzyme.” 1997. Web. 05 Mar 2021.

Vancouver:

Dotse AK. Design, synthesis and evaluation of novel inhibitors of cysteine proteases, metalloproteases and the proteasome, a unique high molecular weight proteolytic enzyme. [Internet] [Doctoral dissertation]. Georgia Tech; 1997. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/29979.

Council of Science Editors:

Dotse AK. Design, synthesis and evaluation of novel inhibitors of cysteine proteases, metalloproteases and the proteasome, a unique high molecular weight proteolytic enzyme. [Doctoral Dissertation]. Georgia Tech; 1997. Available from: http://hdl.handle.net/1853/29979

Georgia Tech

3. Krauser, Joel Anderson. Design, synthesis and evaluation of novel inhibitors and fluorogenic substrates for cysteine proteases and metallo proteases.

Degree: PhD, Chemistry, 2001, Georgia Tech

URL: http://hdl.handle.net/1853/30003

Subjects/Keywords: Protease inhibitors; Cysteine proteinases

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APA (6^th Edition):

Krauser, J. A. (2001). Design, synthesis and evaluation of novel inhibitors and fluorogenic substrates for cysteine proteases and metallo proteases. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/30003

Chicago Manual of Style (16^th Edition):

Krauser, Joel Anderson. “Design, synthesis and evaluation of novel inhibitors and fluorogenic substrates for cysteine proteases and metallo proteases.” 2001. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/30003.

MLA Handbook (7^th Edition):

Krauser, Joel Anderson. “Design, synthesis and evaluation of novel inhibitors and fluorogenic substrates for cysteine proteases and metallo proteases.” 2001. Web. 05 Mar 2021.

Vancouver:

Krauser JA. Design, synthesis and evaluation of novel inhibitors and fluorogenic substrates for cysteine proteases and metallo proteases. [Internet] [Doctoral dissertation]. Georgia Tech; 2001. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/30003.

Council of Science Editors:

Krauser JA. Design, synthesis and evaluation of novel inhibitors and fluorogenic substrates for cysteine proteases and metallo proteases. [Doctoral Dissertation]. Georgia Tech; 2001. Available from: http://hdl.handle.net/1853/30003

Georgia Tech

4. Kerrigan, John Edward. I Uses of enol ethers in asymmetric synthesis : II Isocoumarin mechanism-based inhibitors of serine proteases.

Degree: PhD, Chemistry, 1991, Georgia Tech

URL: http://hdl.handle.net/1853/30004

Subjects/Keywords: Proteinase Inhibitors; Ethers

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APA (6^th Edition):

Kerrigan, J. E. (1991). I Uses of enol ethers in asymmetric synthesis : II Isocoumarin mechanism-based inhibitors of serine proteases. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/30004

Chicago Manual of Style (16^th Edition):

Kerrigan, John Edward. “I Uses of enol ethers in asymmetric synthesis : II Isocoumarin mechanism-based inhibitors of serine proteases.” 1991. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/30004.

MLA Handbook (7^th Edition):

Kerrigan, John Edward. “I Uses of enol ethers in asymmetric synthesis : II Isocoumarin mechanism-based inhibitors of serine proteases.” 1991. Web. 05 Mar 2021.

Vancouver:

Kerrigan JE. I Uses of enol ethers in asymmetric synthesis : II Isocoumarin mechanism-based inhibitors of serine proteases. [Internet] [Doctoral dissertation]. Georgia Tech; 1991. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/30004.

Council of Science Editors:

Kerrigan JE. I Uses of enol ethers in asymmetric synthesis : II Isocoumarin mechanism-based inhibitors of serine proteases. [Doctoral Dissertation]. Georgia Tech; 1991. Available from: http://hdl.handle.net/1853/30004

Georgia Tech

5. Lauro, Andrea Marie. The design and synthesis of novel serine proteinase inhibitors.

Degree: PhD, Chemistry, 1989, Georgia Tech

URL: http://hdl.handle.net/1853/30032

Subjects/Keywords: Proteinase; Chemical inhibitors; Chemistry

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APA (6^th Edition):

Lauro, A. M. (1989). The design and synthesis of novel serine proteinase inhibitors. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/30032

Chicago Manual of Style (16^th Edition):

Lauro, Andrea Marie. “The design and synthesis of novel serine proteinase inhibitors.” 1989. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/30032.

MLA Handbook (7^th Edition):

Lauro, Andrea Marie. “The design and synthesis of novel serine proteinase inhibitors.” 1989. Web. 05 Mar 2021.

Vancouver:

Lauro AM. The design and synthesis of novel serine proteinase inhibitors. [Internet] [Doctoral dissertation]. Georgia Tech; 1989. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/30032.

Council of Science Editors:

Lauro AM. The design and synthesis of novel serine proteinase inhibitors. [Doctoral Dissertation]. Georgia Tech; 1989. Available from: http://hdl.handle.net/1853/30032

Georgia Tech

6. Cook, Robert Richard. Thioesters of amino acids, peptides and p̲a̲r̲a̲-quanidinobenzoic acid as probes of the active sites of serine proteases and metalloproteases.

Degree: PhD, Chemistry, 1983, Georgia Tech

URL: http://hdl.handle.net/1853/30073

Subjects/Keywords: Proteolytic enzymes

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APA (6^th Edition):

Cook, R. R. (1983). Thioesters of amino acids, peptides and p̲a̲r̲a̲-quanidinobenzoic acid as probes of the active sites of serine proteases and metalloproteases. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/30073

Chicago Manual of Style (16^th Edition):

Cook, Robert Richard. “Thioesters of amino acids, peptides and p̲a̲r̲a̲-quanidinobenzoic acid as probes of the active sites of serine proteases and metalloproteases.” 1983. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/30073.

MLA Handbook (7^th Edition):

Cook, Robert Richard. “Thioesters of amino acids, peptides and p̲a̲r̲a̲-quanidinobenzoic acid as probes of the active sites of serine proteases and metalloproteases.” 1983. Web. 05 Mar 2021.

Vancouver:

Cook RR. Thioesters of amino acids, peptides and p̲a̲r̲a̲-quanidinobenzoic acid as probes of the active sites of serine proteases and metalloproteases. [Internet] [Doctoral dissertation]. Georgia Tech; 1983. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/30073.

Council of Science Editors:

Cook RR. Thioesters of amino acids, peptides and p̲a̲r̲a̲-quanidinobenzoic acid as probes of the active sites of serine proteases and metalloproteases. [Doctoral Dissertation]. Georgia Tech; 1983. Available from: http://hdl.handle.net/1853/30073

Georgia Tech

7. James, Karen Amanda Ellis. Design, synthesis, and evaluation of novel cysteine protease inhibitors.

Degree: PhD, Chemistry, 2002, Georgia Tech

URL: http://hdl.handle.net/1853/30283

Subjects/Keywords: Crysteine proteinase; Protease inhibitors

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APA (6^th Edition):

James, K. A. E. (2002). Design, synthesis, and evaluation of novel cysteine protease inhibitors. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/30283

Chicago Manual of Style (16^th Edition):

James, Karen Amanda Ellis. “Design, synthesis, and evaluation of novel cysteine protease inhibitors.” 2002. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/30283.

MLA Handbook (7^th Edition):

James, Karen Amanda Ellis. “Design, synthesis, and evaluation of novel cysteine protease inhibitors.” 2002. Web. 05 Mar 2021.

Vancouver:

James KAE. Design, synthesis, and evaluation of novel cysteine protease inhibitors. [Internet] [Doctoral dissertation]. Georgia Tech; 2002. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/30283.

Council of Science Editors:

James KAE. Design, synthesis, and evaluation of novel cysteine protease inhibitors. [Doctoral Dissertation]. Georgia Tech; 2002. Available from: http://hdl.handle.net/1853/30283

Georgia Tech

8. Gheura, Iuliana L. Design, synthesis and evaluation of AZA-peptide epoxides as inhibitors of cysteine proteases.

Degree: PhD, Chemistry, 2002, Georgia Tech

URL: http://hdl.handle.net/1853/30571

Subjects/Keywords: Protease inhibitors; Epoxy compounds; Cysteine proteinases

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APA (6^th Edition):

Gheura, I. L. (2002). Design, synthesis and evaluation of AZA-peptide epoxides as inhibitors of cysteine proteases. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/30571

Chicago Manual of Style (16^th Edition):

Gheura, Iuliana L. “Design, synthesis and evaluation of AZA-peptide epoxides as inhibitors of cysteine proteases.” 2002. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/30571.

MLA Handbook (7^th Edition):

Gheura, Iuliana L. “Design, synthesis and evaluation of AZA-peptide epoxides as inhibitors of cysteine proteases.” 2002. Web. 05 Mar 2021.

Vancouver:

Gheura IL. Design, synthesis and evaluation of AZA-peptide epoxides as inhibitors of cysteine proteases. [Internet] [Doctoral dissertation]. Georgia Tech; 2002. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/30571.

Council of Science Editors:

Gheura IL. Design, synthesis and evaluation of AZA-peptide epoxides as inhibitors of cysteine proteases. [Doctoral Dissertation]. Georgia Tech; 2002. Available from: http://hdl.handle.net/1853/30571

Georgia Tech

9. Tippett, James Thomas. The kinetics of the reaction of subtilisin BPN' with chloromethyl ketones in relation to its subsite specificity.

Degree: MS, Chemistry, 1973, Georgia Tech

URL: http://hdl.handle.net/1853/26952

Subjects/Keywords: Chemical kinetics; Enzymes Analysis

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APA (6^th Edition):

Tippett, J. T. (1973). The kinetics of the reaction of subtilisin BPN' with chloromethyl ketones in relation to its subsite specificity. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/26952

Chicago Manual of Style (16^th Edition):

Tippett, James Thomas. “The kinetics of the reaction of subtilisin BPN' with chloromethyl ketones in relation to its subsite specificity.” 1973. Masters Thesis, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/26952.

MLA Handbook (7^th Edition):

Tippett, James Thomas. “The kinetics of the reaction of subtilisin BPN' with chloromethyl ketones in relation to its subsite specificity.” 1973. Web. 05 Mar 2021.

Vancouver:

Tippett JT. The kinetics of the reaction of subtilisin BPN' with chloromethyl ketones in relation to its subsite specificity. [Internet] [Masters thesis]. Georgia Tech; 1973. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/26952.

Council of Science Editors:

Tippett JT. The kinetics of the reaction of subtilisin BPN' with chloromethyl ketones in relation to its subsite specificity. [Masters Thesis]. Georgia Tech; 1973. Available from: http://hdl.handle.net/1853/26952

Georgia Tech

10. Tuhy, Peter Mirko. I Inhibition of elastase by peptide chloromethyl ketones II Modification of chymotrypsin by an aryl cyanate reagent.

Degree: PhD, Chemistry, 1975, Georgia Tech

URL: http://hdl.handle.net/1853/27126

Subjects/Keywords: Enzymes; Enzyme inhibitors; Chymotrypsin

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APA (6^th Edition):

Tuhy, P. M. (1975). I Inhibition of elastase by peptide chloromethyl ketones II Modification of chymotrypsin by an aryl cyanate reagent. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/27126

Chicago Manual of Style (16^th Edition):

Tuhy, Peter Mirko. “I Inhibition of elastase by peptide chloromethyl ketones II Modification of chymotrypsin by an aryl cyanate reagent.” 1975. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/27126.

MLA Handbook (7^th Edition):

Tuhy, Peter Mirko. “I Inhibition of elastase by peptide chloromethyl ketones II Modification of chymotrypsin by an aryl cyanate reagent.” 1975. Web. 05 Mar 2021.

Vancouver:

Tuhy PM. I Inhibition of elastase by peptide chloromethyl ketones II Modification of chymotrypsin by an aryl cyanate reagent. [Internet] [Doctoral dissertation]. Georgia Tech; 1975. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/27126.

Council of Science Editors:

Tuhy PM. I Inhibition of elastase by peptide chloromethyl ketones II Modification of chymotrypsin by an aryl cyanate reagent. [Doctoral Dissertation]. Georgia Tech; 1975. Available from: http://hdl.handle.net/1853/27126

Georgia Tech

11. Gupton, Bernard Franklin. I Inhibition of acid proteases by peptide diazomethyl ketones ; II Investigation of serine protease activity with acyl carbazates.

Degree: MS, Chemistry, 1976, Georgia Tech

URL: http://hdl.handle.net/1853/27399

Subjects/Keywords: Proteolytic enzymes

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APA (6^th Edition):

Gupton, B. F. (1976). I Inhibition of acid proteases by peptide diazomethyl ketones ; II Investigation of serine protease activity with acyl carbazates. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/27399

Chicago Manual of Style (16^th Edition):

Gupton, Bernard Franklin. “I Inhibition of acid proteases by peptide diazomethyl ketones ; II Investigation of serine protease activity with acyl carbazates.” 1976. Masters Thesis, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/27399.

MLA Handbook (7^th Edition):

Gupton, Bernard Franklin. “I Inhibition of acid proteases by peptide diazomethyl ketones ; II Investigation of serine protease activity with acyl carbazates.” 1976. Web. 05 Mar 2021.

Vancouver:

Gupton BF. I Inhibition of acid proteases by peptide diazomethyl ketones ; II Investigation of serine protease activity with acyl carbazates. [Internet] [Masters thesis]. Georgia Tech; 1976. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/27399.

Council of Science Editors:

Gupton BF. I Inhibition of acid proteases by peptide diazomethyl ketones ; II Investigation of serine protease activity with acyl carbazates. [Masters Thesis]. Georgia Tech; 1976. Available from: http://hdl.handle.net/1853/27399

Georgia Tech

12. Ekici, Ozlem Dogan. Design, synthesis, and evaluation of novel irreversible inhibitors for caspases.

Degree: PhD, Chemistry and Biochemistry, 2003, Georgia Tech

URL: http://hdl.handle.net/1853/5333

Subjects/Keywords: Proteolytic enzymes; Enzymes Synthesis; Enzyme kinetics; Enzyme inhibitors

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APA (6^th Edition):

Ekici, O. D. (2003). Design, synthesis, and evaluation of novel irreversible inhibitors for caspases. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/5333

Chicago Manual of Style (16^th Edition):

Ekici, Ozlem Dogan. “Design, synthesis, and evaluation of novel irreversible inhibitors for caspases.” 2003. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/5333.

MLA Handbook (7^th Edition):

Ekici, Ozlem Dogan. “Design, synthesis, and evaluation of novel irreversible inhibitors for caspases.” 2003. Web. 05 Mar 2021.

Vancouver:

Ekici OD. Design, synthesis, and evaluation of novel irreversible inhibitors for caspases. [Internet] [Doctoral dissertation]. Georgia Tech; 2003. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/5333.

Council of Science Editors:

Ekici OD. Design, synthesis, and evaluation of novel irreversible inhibitors for caspases. [Doctoral Dissertation]. Georgia Tech; 2003. Available from: http://hdl.handle.net/1853/5333

Georgia Tech

13. Rukamp, Brian John. Design, synthesis, and evaluation of novel thiobenzyl ester substrates and aza-peptide inhibitors for serine and cysteine proteases.

Degree: PhD, Chemistry and Biochemistry, 2003, Georgia Tech

URL: http://hdl.handle.net/1853/5371

Subjects/Keywords: Protease inhibitors; Serine proteinases; Cysteine proteinases; Serine proteinases; Protease inhibitors; Cysteine proteinases

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APA (6^th Edition):

Rukamp, B. J. (2003). Design, synthesis, and evaluation of novel thiobenzyl ester substrates and aza-peptide inhibitors for serine and cysteine proteases. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/5371

Chicago Manual of Style (16^th Edition):

Rukamp, Brian John. “Design, synthesis, and evaluation of novel thiobenzyl ester substrates and aza-peptide inhibitors for serine and cysteine proteases.” 2003. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/5371.

MLA Handbook (7^th Edition):

Rukamp, Brian John. “Design, synthesis, and evaluation of novel thiobenzyl ester substrates and aza-peptide inhibitors for serine and cysteine proteases.” 2003. Web. 05 Mar 2021.

Vancouver:

Rukamp BJ. Design, synthesis, and evaluation of novel thiobenzyl ester substrates and aza-peptide inhibitors for serine and cysteine proteases. [Internet] [Doctoral dissertation]. Georgia Tech; 2003. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/5371.

Council of Science Editors:

Rukamp BJ. Design, synthesis, and evaluation of novel thiobenzyl ester substrates and aza-peptide inhibitors for serine and cysteine proteases. [Doctoral Dissertation]. Georgia Tech; 2003. Available from: http://hdl.handle.net/1853/5371

Georgia Tech

14. Rukamp, Karrie Eileen Adlington. Design and synthesis of inhibitors for serine and cysteine proteases.

Degree: PhD, Chemistry and Biochemistry, 2003, Georgia Tech

URL: http://hdl.handle.net/1853/5426

Subjects/Keywords: Protease inhibitors; Serine proteinases; Cysteine proteinases; Serine proteinases; Protease inhibitors; Cysteine proteinases

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APA (6^th Edition):

Rukamp, K. E. A. (2003). Design and synthesis of inhibitors for serine and cysteine proteases. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/5426

Chicago Manual of Style (16^th Edition):

Rukamp, Karrie Eileen Adlington. “Design and synthesis of inhibitors for serine and cysteine proteases.” 2003. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/5426.

MLA Handbook (7^th Edition):

Rukamp, Karrie Eileen Adlington. “Design and synthesis of inhibitors for serine and cysteine proteases.” 2003. Web. 05 Mar 2021.

Vancouver:

Rukamp KEA. Design and synthesis of inhibitors for serine and cysteine proteases. [Internet] [Doctoral dissertation]. Georgia Tech; 2003. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/5426.

Council of Science Editors:

Rukamp KEA. Design and synthesis of inhibitors for serine and cysteine proteases. [Doctoral Dissertation]. Georgia Tech; 2003. Available from: http://hdl.handle.net/1853/5426

Georgia Tech

15. Conwell, Christine C. Kinetic and Thermodynamic Factors Govern DNA Condensate Size and Morphology.

Degree: PhD, Chemistry and Biochemistry, 2004, Georgia Tech

URL: http://hdl.handle.net/1853/5213

► It is well known that multivalent cations can cause DNA to condense from solution to form high-density nanometer scale particles. However, several fundamental questions concerning… (more)

Subjects/Keywords: Gene delivery; Toroids; Condensation; DNA

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APA (6^th Edition):

Conwell, C. C. (2004). Kinetic and Thermodynamic Factors Govern DNA Condensate Size and Morphology. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/5213

Chicago Manual of Style (16^th Edition):

Conwell, Christine C. “Kinetic and Thermodynamic Factors Govern DNA Condensate Size and Morphology.” 2004. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/5213.

MLA Handbook (7^th Edition):

Conwell, Christine C. “Kinetic and Thermodynamic Factors Govern DNA Condensate Size and Morphology.” 2004. Web. 05 Mar 2021.

Vancouver:

Conwell CC. Kinetic and Thermodynamic Factors Govern DNA Condensate Size and Morphology. [Internet] [Doctoral dissertation]. Georgia Tech; 2004. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/5213.

Council of Science Editors:

Conwell CC. Kinetic and Thermodynamic Factors Govern DNA Condensate Size and Morphology. [Doctoral Dissertation]. Georgia Tech; 2004. Available from: http://hdl.handle.net/1853/5213

Georgia Tech

16. Gotz, Marion Gabriele. Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases.

Degree: PhD, Chemistry and Biochemistry, 2004, Georgia Tech

URL: http://hdl.handle.net/1853/8072

► Cysteine proteases are a class of proteolytic enzymes, which are involved in a series of metabolic and catabolic processes, such as protein turnover, digestion, blood… (more)

▼ Cysteine proteases are a class of proteolytic enzymes, which are involved in a series of metabolic and catabolic processes, such as protein turnover, digestion, blood coagulation, apoptosis, fertilization and cell differentiation, and the immune response system. The development of novel potent and selective inhibitors for cysteine proteases has therefore gained increasing attention among medicinal chemists. In this thesis we have reported the design, synthesis, and evaluation of several peptidyl inhibitors for clan CA and clan CD cysteine proteases. We have continued the investigation of dipeptidyl vinyl sulfones as potent and selective inhibitors for dipeptidyl peptidase I (DPPI), a lysosomal cysteine protease, which is involved in the processing of intracellular proteases, such as granzymes. We have found that DPPI tolerates negatively charged amino acid residues in the P2 position with inhibition rates of 7,600 M-1s-1. Dipeptidyl vinyl sulfones with positively charged amino acid residues at the P1 position, however, do not inhibit DPPI at all. A second project focused on the epoxidation of the double bond of the vinyl sulfone moiety of the dipeptidyl vinyl sulfones. Instead of epoxidizing the double bond, we found that an isomerization had occurred. The newly formed compounds were determined to be allyl sulfones. We tested this new class of inhibitors with clan CA proteases and obtained inhibition rates of 560 M-1s-1 for Cbz-Leu-Phe-AS-Ph with calpain I. Two new classes of compounds for the clan CD protease S. mansoni legumain were designed, synthesized, and evaluated. Aza-peptidyl epoxides were found to be potent and selective inhibitors of S. mansoni legumain with IC50’s as low as 45 nM. Aza-peptide Michael acceptors were derived from the aza-peptide epoxide design and synthesized in an analogous fashion. The aza-peptide Michael acceptors inhibited S. mansoni legumain with even lower IC50’s, as low as 10 nM. However, the aza-peptide Michael acceptors react with thioalkylating agents contained in the buffer, such as DTT. The rates of degradation were determined spectroscopically, and half-lives of 3 to 20 minutes were measured. This observation gave us insights into the enzymatic mechanism and allowed us to determine the point of attack for the legumain active site cysteine thiol. Advisors/Committee Members: Dr. James C. Powers (Committee Chair), Dr. Donald Doyle, Dr. Nicholas Hud, Dr. Niren Murthy, and Dr. Suzanne Shuker (Committee Members).

Subjects/Keywords: Allyl sulfone; Aza-peptide; Biosynthesis; Cysteine protease; Cysteine proteinases; Irreversible inhibitors; Protease inhibitors; Sulphones; Vinyl sulfone

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APA (6^th Edition):

Gotz, M. G. (2004). Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/8072

Chicago Manual of Style (16^th Edition):

Gotz, Marion Gabriele. “Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases.” 2004. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/8072.

MLA Handbook (7^th Edition):

Gotz, Marion Gabriele. “Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases.” 2004. Web. 05 Mar 2021.

Vancouver:

Gotz MG. Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases. [Internet] [Doctoral dissertation]. Georgia Tech; 2004. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/8072.

Council of Science Editors:

Gotz MG. Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases. [Doctoral Dissertation]. Georgia Tech; 2004. Available from: http://hdl.handle.net/1853/8072

Georgia Tech

17. Cody, John W., Jr. Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture.

Degree: PhD, Chemistry and Biochemistry, 2006, Georgia Tech

URL: http://hdl.handle.net/1853/13962

► Copper is an essential trace element present in all living systems and is important for the function of many cellular enzymes. It ranks third in… (more)

▼ Copper is an essential trace element present in all living systems and is important for the function of many cellular enzymes. It ranks third in intracellular abundance behind only zinc and iron and plays a very important role as a catalytic cofactor in various cellular processes such as mitochondrial respiration, iron uptake, and the redox processes of a number of enzymes, including superoxide dismutase, lysyl oxidase, or tyrosinase. Any abnormality in copper trafficking pathways can lead to serious diseases such as Wilsons disease, Menkes syndrome and has been implicated in the neurodegenerative diseases amyotropic lateral sclerosis (ALS) and Alzheimers disease. While free copper in the cytoplasm would prove toxic, there is compelling evidence for the existence of a labile pool of copper that remains kinetically accessible. In order to investigate the existence of such a pool the development of Cu(I) selective probes is necessary. Chapter I provides the background for the role of copper in biology and elucidates the main trafficking pathways discovered to date. This chapter also provides recent developments of fluorescent sensors for selective visualization of biologically relevant metals. Chapter II discusses the exploration of a phenanthroline-based ligand for the selective detection of Cu(I). A series of derivatives incorporating chelating substituents in the 2- and 9-positions to enforce a 1:1 binding stoichiometry were synthesized and the properties of their respective Cu(I) complexes were characterized by x-ray structural analysis, and their photophysical properties were investigated by absorption and emission spectroscopy. Visible light excitation yielded metal-to-ligand charge-transfer (MLCT) excited states with luminescence lifetimes up to 155 ns. Electrochemical measurements further indicate that coordinative rearrangements are involved in nonradiative deactivation of the excited states. According to time-dependent density functional theory calculations (B3LYP/6-31G**), the major MLCT transitions are polarized along the C2 axis of the complex and originate predominantly from the dxz orbital. In chapter III, the development of a ratiometric Cu(I) sensor based on a donor-acceptor functionalized biphenyl fluorophore platform is discussed. The fluorescence emission energy for such fluorophores is highly dependent upon the interannular twist angle and this property was harnessed to provide a ratiometric sensor selective for Cu(I). Coordination of Cu(I) leads to a flattening of the biphenyl backbone and was confirmed by absorbance and emission spectroscopy as well as 2D NOESY experiments. The peak emission energy was shifted by 39 nm towards higher energy upon metal cation binding with a concomitant 7 bathochromic shift in absorption energy. The photophysical data accompanied by 1H NMR analysis confirms a well-defined 1:1 binding stoichiometry between metal and ligand. The findings from this study showed ratiometric behavior for this probe, albeit with a lowered quantum yield. While… Advisors/Committee Members: Christoph J. Fahrni (Committee Chair), James C. Powers (Committee Member), John Zhang (Committee Member), Julia Kubanek (Committee Member), Suzanne Beckham (Committee Member).

Subjects/Keywords: Donor-acceptor; Cu(I); Sensors; Charge transfer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cody, John W., J. (2006). Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/13962

Chicago Manual of Style (16^th Edition):

Cody, John W., Jr. “Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture.” 2006. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/13962.

MLA Handbook (7^th Edition):

Cody, John W., Jr. “Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture.” 2006. Web. 05 Mar 2021.

Vancouver:

Cody, John W. J. Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture. [Internet] [Doctoral dissertation]. Georgia Tech; 2006. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/13962.

Council of Science Editors:

Cody, John W. J. Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture. [Doctoral Dissertation]. Georgia Tech; 2006. Available from: http://hdl.handle.net/1853/13962

Georgia Tech

18. Foster, Michael Scott. Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation.

Degree: PhD, Chemistry and Biochemistry, 2008, Georgia Tech

URL: http://hdl.handle.net/1853/31816

► Novel, rationally-designed acrylate analogs of various known dipeptide substrates were found to be mechanism-based inactivators of the enzyme peptidylglycine alpha-amidating monooxygenase (PAM, EC 1.14.17.3). This… (more)

Subjects/Keywords: Molecular modeling; Stereochemistry; Molecules Models; Peptides; Chemical structure; Peptide hormones; Neuropeptides

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Foster, M. S. (2008). Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/31816

Chicago Manual of Style (16^th Edition):

Foster, Michael Scott. “Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation.” 2008. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021. http://hdl.handle.net/1853/31816.

MLA Handbook (7^th Edition):

Foster, Michael Scott. “Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation.” 2008. Web. 05 Mar 2021.

Vancouver:

Foster MS. Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation. [Internet] [Doctoral dissertation]. Georgia Tech; 2008. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1853/31816.

Council of Science Editors:

Foster MS. Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation. [Doctoral Dissertation]. Georgia Tech; 2008. Available from: http://hdl.handle.net/1853/31816

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