Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for +publisher:"Georgia Tech" +contributor:("Dr. Wendy L. Kelly"). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters

1. Hofmekler, Jonathan. Investigating the effect of membrane anchoring on photoinduced electron transfer pyrazoline based fluorescent probes.

Degree: MS, Chemistry and Biochemistry, 2011, Georgia Tech

Fluorescence microscopy is a powerful analytical tool for visualizing biological processes at the subcellular level. In this regard, 1,3,5-triarylpyrazoline based fluorescent probes which act as "turn-on" probes, have been extensively researched. These probes achieve their fluorescence "turn-on" response by inhibition of fluorescence quenching by acceptor-excited photoinduced electron transfer upon binding of an analyte. It has been recently shown that some fluorescent probes used in biological research form colloids composed of nanoparticles, due to their hydrophobic character. This hydrophobic character can also lead to partitioning of the probe into cellular membranes. Colloid formation and membrane partitioning may affect the probes' photophysical properties such as absorption and emission wavelength and quantum yields. Recently, a series of 1,3,5-triarylpyrazolines synthesized in our group by M. T. Morgan, showed no formation of aggregates in aqueous buffer. Surprisingly, these probes increased their fluorescence intensity in the presence of liposomes. The photoinduced electron transfer process is greatly affected by the polarity of the medium in which the probe is used. In this study, the effect of membrane proximity on the photoinduced electron transfer process for pyrazoline based "turn-on" probes has been investigated. A series of water soluble 1,3,5-triarylpyrazolines have been synthesized in which a N,N-dialkylaniline moiety acts as an electron donor and a proton acceptor and an alkylated sulfonamide moiety acts as a molecular anchor for interaction with neutral and anionic liposomes. Advisors/Committee Members: Prof. Christoph J. Fahrni (Committee Chair), Dr. Adegboyega K. Oyelere (Committee Member), Dr. Wendy L. Kelly (Committee Member).

Subjects/Keywords: Pyrazoline; Liposomes; Photoinduced electron transfer; Fluorescence; Fluorescent probes; Fluorescence microscopy; Transition metals; Metal ions

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hofmekler, J. (2011). Investigating the effect of membrane anchoring on photoinduced electron transfer pyrazoline based fluorescent probes. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/42896

Chicago Manual of Style (16th Edition):

Hofmekler, Jonathan. “Investigating the effect of membrane anchoring on photoinduced electron transfer pyrazoline based fluorescent probes.” 2011. Masters Thesis, Georgia Tech. Accessed October 23, 2020. http://hdl.handle.net/1853/42896.

MLA Handbook (7th Edition):

Hofmekler, Jonathan. “Investigating the effect of membrane anchoring on photoinduced electron transfer pyrazoline based fluorescent probes.” 2011. Web. 23 Oct 2020.

Vancouver:

Hofmekler J. Investigating the effect of membrane anchoring on photoinduced electron transfer pyrazoline based fluorescent probes. [Internet] [Masters thesis]. Georgia Tech; 2011. [cited 2020 Oct 23]. Available from: http://hdl.handle.net/1853/42896.

Council of Science Editors:

Hofmekler J. Investigating the effect of membrane anchoring on photoinduced electron transfer pyrazoline based fluorescent probes. [Masters Thesis]. Georgia Tech; 2011. Available from: http://hdl.handle.net/1853/42896

.