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1.
Phillips, Ronald Lee, III.
Poly(para-phenyleneethynylene)s: probing the biological interface with biomolecular materials.
Degree: PhD, Chemistry and Biochemistry, 2008, Georgia Tech
URL: http://hdl.handle.net/1853/26555 
► The synthesis and biological sensing applications of novel water soluble poly(para-phenyleneethynylene)s (PPEs) are presented. The ease of synthesis, synthetic variability, and dramatic chromicity of PPEs…
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▼ The synthesis and biological sensing applications of novel water soluble poly(para-phenyleneethynylene)s (PPEs) are presented. The ease of synthesis, synthetic variability, and dramatic chromicity of PPEs makes them well suited for biological and sensing applications. Molecular recognition and signal transduction can be achieved by using PPEs as sensory materials. By incorporating biological functional groups (e.g. sugars), PPEs can efficiently detect the presence of toxic heavy metals, proteins, and bacteria through either fluorescence quenching or enhancement. Rapid, precise, and convenient sensory arrays for the detection of biological analytes are possible through the formation of gold nanoparticle-PPE constructs.
Advisors/Committee Members: Dr. Uwe H.F. Bunz (Committee Chair), Dr. Andrew Lyon (Committee Member), Dr. Laren Tolbert (Committee Member), Dr. Nicholas Hud (Committee Member), Dr. Sherry Michele Owen (Committee Member).
Subjects/Keywords: Polymer; Biosensor; Nanoparticle; Fluorescence; Bacteria; Assays; Biological interfaces; Biomolecules; Biosensors; Chemical detectors; Conjugated polymers
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APA (6th Edition):
Phillips, Ronald Lee, I. (2008). Poly(para-phenyleneethynylene)s: probing the biological interface with biomolecular materials. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/26555
Chicago Manual of Style (16th Edition):
Phillips, Ronald Lee, III. “Poly(para-phenyleneethynylene)s: probing the biological interface with biomolecular materials.” 2008. Doctoral Dissertation, Georgia Tech. Accessed March 06, 2021.
http://hdl.handle.net/1853/26555.
MLA Handbook (7th Edition):
Phillips, Ronald Lee, III. “Poly(para-phenyleneethynylene)s: probing the biological interface with biomolecular materials.” 2008. Web. 06 Mar 2021.
Vancouver:
Phillips, Ronald Lee I. Poly(para-phenyleneethynylene)s: probing the biological interface with biomolecular materials. [Internet] [Doctoral dissertation]. Georgia Tech; 2008. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1853/26555.
Council of Science Editors:
Phillips, Ronald Lee I. Poly(para-phenyleneethynylene)s: probing the biological interface with biomolecular materials. [Doctoral Dissertation]. Georgia Tech; 2008. Available from: http://hdl.handle.net/1853/26555
Georgia Tech
2.
Heintz, Eva Liang-Huang.
Surface Biological Modification and Cellular Interactions of Magnetic Spinel Ferrite Nanoparticles.
Degree: PhD, Chemistry and Biochemistry, 2004, Georgia Tech
URL: http://hdl.handle.net/1853/4944
► Surface Biological Modification and Cellular Interactions of Magnetic Spinel Nanoparticles Eva Liang-Huang Heintz 191 Pages Directed by Dr. Z. John Zhang The interest in magnetic…
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▼ Surface Biological Modification and Cellular Interactions of Magnetic Spinel Nanoparticles
Eva Liang-Huang Heintz
191 Pages
Directed by
Dr. Z. John Zhang
The interest in magnetic nanoparticles is multi-dimensional. Fundamentally, it is important to be able to control their magnetic properties and to correlate to specific applications. In biology, magnetic nanoparticles offer promising potential as magnetic carriers or chaperones for magnetic localization and manipulation of therapeutic reagents.
The synthesis of superparamagnetic CoFe2-xSmxO4 nanoparticles and the tunability of their magnetic properties by size and composition variations are discussed. An increase in size of CoSm0.19Fe1.81O4 nanoparticles produced an increase in blocking temperature and saturation magnetization, but a non-linear coercitivity response was observed with change in size. By varying the composition, the saturation magnetization of CoFe2-xSmxO4 decreased dramatically while the coercitivity increased when compared to native cobalt spinel ferrite (CoFe2O4) nanoparticles. These results demonstrate how the magnetic properties of cobalt spinel ferrite nanoparticles can be tailored to specific applications.
Surface modifications of cobalt spinel ferrite nanoparticles facilitated the conjugation of oligonucleotides. Using a transfection reagent, CoFe2O4 ??igonucleotide conjugates were delivered into mammalian cells. Post transfection, synchronized movement of cells in response to an external magnetic field was observed. This demonstrated the possibility of magnetic manipulation and localization of therapeutic reagents coupled to CoFe2O4 magnetic nanoparticles.
Results from this thesis demonstrate the potential role of magnetic spinel nanoparticles in cell biology and will facilitate the progress towards in vivo testing.
Advisors/Committee Members: Dr. Z. John Zhang (Committee Chair), Dr. Christopher Jones (Committee Member), Dr. Jiri Janata (Committee Member), Dr. L. Andrew Lyon (Committee Member), Dr. Laren Tolbert (Committee Member).
Subjects/Keywords: Magnetic nanoparticles; Spinel ferrite; Transfection; Magnetic manipulation; Samarium; Surface modification
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APA (6th Edition):
Heintz, E. L. (2004). Surface Biological Modification and Cellular Interactions of Magnetic Spinel Ferrite Nanoparticles. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/4944
Chicago Manual of Style (16th Edition):
Heintz, Eva Liang-Huang. “Surface Biological Modification and Cellular Interactions of Magnetic Spinel Ferrite Nanoparticles.” 2004. Doctoral Dissertation, Georgia Tech. Accessed March 06, 2021.
http://hdl.handle.net/1853/4944.
MLA Handbook (7th Edition):
Heintz, Eva Liang-Huang. “Surface Biological Modification and Cellular Interactions of Magnetic Spinel Ferrite Nanoparticles.” 2004. Web. 06 Mar 2021.
Vancouver:
Heintz EL. Surface Biological Modification and Cellular Interactions of Magnetic Spinel Ferrite Nanoparticles. [Internet] [Doctoral dissertation]. Georgia Tech; 2004. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1853/4944.
Council of Science Editors:
Heintz EL. Surface Biological Modification and Cellular Interactions of Magnetic Spinel Ferrite Nanoparticles. [Doctoral Dissertation]. Georgia Tech; 2004. Available from: http://hdl.handle.net/1853/4944
Georgia Tech
3.
Sanii, Laurie Shireen.
Application of Spectroscopy to Protein Characterization.
Degree: PhD, Chemistry and Biochemistry, 2005, Georgia Tech
URL: http://hdl.handle.net/1853/7641
► There are two contributions of this thesis. The first contribution, described in chapters one through six, involves studing the relationship between the protein packing structure…
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▼ There are two contributions of this thesis. The first contribution, described in chapters one through six, involves studing the relationship between the protein packing structure of bacteriorhodopsin (bR) and its function as a proton pump. In 2002, a novel crystallization method published by Bowie and Farham resulted in an unusual antiparallel monomeric packing structure of bicelle bacteriorhodopsin (bcbR) crystals, the spectroscopic properties of which had not been studied. In this thesis, these bicelle bR crystals are investigated to better understand how the changes in the protein tertiary structure affect the function. Specifically: Does the retinal Schiff base retain its ability to isomerize in this unusual protein packing structure of bR? How is the hydration of its binding pocket affected? Does the protein retain the ability to undergo the photocycle and pump protons? If so, how are the rates of the deprotonation/reprotonation of the Schiff base affected by the antiparallel monomer packing structure of the protein? Is Asp85 still the proton acceptor during the deprotonation process of the photocycle? The second contribution of the thesis, described in chapter seven, describes the surface attachment and growth of the biofilm formed by the pathogenic bacterium Streptococcus pneumoniae using attenuated total reflection/Fourier transform infrared spectroscopy (ATR/FTIR). This organism was chosen for its clinical significance; it is one of the organisms suspected in forming biofilms in individuals who develop otitis media, one of the most common causes of ear infections of childhood. In contrast to previous ATR/FTIR experiments examining the formation of biofilms on surfaces, this method is unique in that it combines two techniques - ATR/FTIR and Epifluorescence microscopy which when used together allow for the simultaneous monitoring of the IR spectrum of the S. pneumoniae biofilm as it develops and as provides a method for quantifying total and viable cell counts at various stages during the development.
Advisors/Committee Members: Dr. Mostafa El-Sayed (Committee Chair), Charles Liotta (Committee Member), Dr. John Zhang (Committee Member), Dr. Laren Tolbert (Committee Member), Dr. Mohan Srinivasarao (Committee Member).
Subjects/Keywords: Bacteriorhodopsin; Bicelle; Crystals; Raman; FTIR; Raman spectroscopy; Spectrum analysis; Bacteriorhodopsin; Crystals; Fourier transform infrared spectroscopy; Proteins Analysis
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APA (6th Edition):
Sanii, L. S. (2005). Application of Spectroscopy to Protein Characterization. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/7641
Chicago Manual of Style (16th Edition):
Sanii, Laurie Shireen. “Application of Spectroscopy to Protein Characterization.” 2005. Doctoral Dissertation, Georgia Tech. Accessed March 06, 2021.
http://hdl.handle.net/1853/7641.
MLA Handbook (7th Edition):
Sanii, Laurie Shireen. “Application of Spectroscopy to Protein Characterization.” 2005. Web. 06 Mar 2021.
Vancouver:
Sanii LS. Application of Spectroscopy to Protein Characterization. [Internet] [Doctoral dissertation]. Georgia Tech; 2005. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1853/7641.
Council of Science Editors:
Sanii LS. Application of Spectroscopy to Protein Characterization. [Doctoral Dissertation]. Georgia Tech; 2005. Available from: http://hdl.handle.net/1853/7641
Georgia Tech
4.
Shotwell, Sandra Leigh.
Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers.
Degree: PhD, Chemistry and Biochemistry, 2006, Georgia Tech
URL: http://hdl.handle.net/1853/10449
► In the first part of this thesis, the synthesis, characterization and investigation of ortho-phenyleneethynylenes containing heterocycles, are presented. These compounds display changes in absorption and…
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▼ In the first part of this thesis, the synthesis, characterization and investigation of ortho-phenyleneethynylenes containing heterocycles, are presented. These compounds display changes in absorption and emission spectra varying with their functionalization and size. These compounds also have the ability to coordinate with metals. The synthesis of coordination compounds and their crystallographic data are reported. The synthesis and characterization of tetraethynyl thiophene compounds containing pyridines are also presented. These compounds exhibit differences in absorption and emission spectra upon exposure to various metal salts. The final topic to be discussed is the synthesis and characterization of diphenyl amine polymers. These polymers could in principle be used in NLO applications or light emitting devices.
Advisors/Committee Members: Dr. Uwe Bunz (Committee Chair), Dr. Anselm Griffin (Committee Member), Dr. David Collard (Committee Member), Dr. Joseph Perry (Committee Member), Dr. Laren Tolbert (Committee Member).
Subjects/Keywords: Polymers; Thiophenes Synthesis; Pyridinium compounds Synthesis; Ligands; Diphenylamine Synthesis; Oligomers
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APA (6th Edition):
Shotwell, S. L. (2006). Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/10449
Chicago Manual of Style (16th Edition):
Shotwell, Sandra Leigh. “Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers.” 2006. Doctoral Dissertation, Georgia Tech. Accessed March 06, 2021.
http://hdl.handle.net/1853/10449.
MLA Handbook (7th Edition):
Shotwell, Sandra Leigh. “Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers.” 2006. Web. 06 Mar 2021.
Vancouver:
Shotwell SL. Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers. [Internet] [Doctoral dissertation]. Georgia Tech; 2006. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1853/10449.
Council of Science Editors:
Shotwell SL. Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers. [Doctoral Dissertation]. Georgia Tech; 2006. Available from: http://hdl.handle.net/1853/10449
Georgia Tech
5.
Singh, Lovejeet.
Effect of Nanoscale Confinement on the Physical Properties of Polymer Thin Films.
Degree: PhD, Chemical Engineering, 2004, Georgia Tech
URL: http://hdl.handle.net/1853/4822
► The behavior of polymeric systems confined into thin films is a situation that has numerous practical consequences. One particular application in which the properties of…
(more)
▼ The behavior of polymeric systems confined into thin films is a situation that has numerous practical consequences. One particular application in which the properties of thin polymer films is becoming crucially important is in the design, formulation, and processing of photoresists for semiconductor microlithography. As devices continue to be scaled down into the nano-regime, the microelectronics industry will ultimately rely upon a molecular understanding of materials for process development. The majority of these devices are now confined in planar geometries; thus, thin films have played an ever-increasing role in manufacturing of modern electronic devices. This movement towards thinner resist films creates larger surface to volume ratios, and hence thin films can exhibit thermodynamic, structural, and dynamic properties that are different from those of the bulk material. It is thus extremely important to understand the properties of polymers when confined in such geometries for various applications including resists for lithographic patterning. In present work, the influence of a variety of factors including film thickness, molecular weight, and substrate interactions on the polymer thin film physical properties such as the glass transition temperature, coefficient of thermal expansion, dissolution rate, and diffusion coefficient was studied in detail using a combination of experimental characterization and molecular modeling simulation techniques.
Advisors/Committee Members: Dr. Clifford L. Henderson (Committee Chair), Dr. Peter J. Ludovice (Committee Co-Chair), Dr. Carson J. Meredith (Committee Member), Dr. Laren Tolbert (Committee Member), Dr. William J. Koros (Committee Member).
Subjects/Keywords: Diffusion coefficient; Glass transition temperature; Polymer thin films; Thin films; Polymers; Glass transition temperature; Diffusion
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APA ·
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MLA ·
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APA (6th Edition):
Singh, L. (2004). Effect of Nanoscale Confinement on the Physical Properties of Polymer Thin Films. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/4822
Chicago Manual of Style (16th Edition):
Singh, Lovejeet. “Effect of Nanoscale Confinement on the Physical Properties of Polymer Thin Films.” 2004. Doctoral Dissertation, Georgia Tech. Accessed March 06, 2021.
http://hdl.handle.net/1853/4822.
MLA Handbook (7th Edition):
Singh, Lovejeet. “Effect of Nanoscale Confinement on the Physical Properties of Polymer Thin Films.” 2004. Web. 06 Mar 2021.
Vancouver:
Singh L. Effect of Nanoscale Confinement on the Physical Properties of Polymer Thin Films. [Internet] [Doctoral dissertation]. Georgia Tech; 2004. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1853/4822.
Council of Science Editors:
Singh L. Effect of Nanoscale Confinement on the Physical Properties of Polymer Thin Films. [Doctoral Dissertation]. Georgia Tech; 2004. Available from: http://hdl.handle.net/1853/4822
. 
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