Open Access Theses and Dissertations

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You searched for +publisher:"Georgia Tech" +contributor:("Dr. John McDonald"). Showing records 1 – 2 of 2 total matches.

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Georgia Tech

1. Scarberry, Kenneth Edward. Biomedical applications of cobalt-spinel ferrite nanoparticles for cancer cell extraction and drug delivery.

Degree: PhD, Chemistry and Biochemistry, 2009, Georgia Tech

URL: http://hdl.handle.net/1853/33951 

In this presentation it is demonstrated that the unique magnetic properties of superparamagnetic cobalt-spinel ferrite nanoparticles can be employed in several novel applications. A method to selectively capture and remove pathogens from infected organisms to improve longevity is presented. Evidence is provided to show that automated methods using modified forms of hemofiltration or peritoneal dialysis could be used to eliminate the particle/pathogen or particle/infected cell conjugates from the organism postoperatively. It is shown that disparately functionalized nanoparticles can be used in concert as drug carrier and release mechanisms. Lastly, we provide preliminary evidence to support the use of magnetic nanoparticles for controlling reaction kinetics. Advisors/Committee Members: Dr. John Zhang (Committee Chair), Dr. John McDonald (Committee Co-Chair), Dr. Adegboyega Oyelere (Committee Member), Dr. Dennis Doyle (Committee Member), Dr. Nael McCarty (Committee Member).

Subjects/Keywords: Nanotechnology; Chemiluminescence; Biochemistry; Peptide; Aptamer; HIV; Drug delivery; Cancer; Magnetic nanoparticles; Nanobiotechnology; Magnetic materials; Ferrites (Magnetic materials); Chemiluminescence Diagnostic use; Nanomedicine; Nanoparticles; Drug delivery systems; Cobalt; Spinel group

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Scarberry, K. E. (2009). Biomedical applications of cobalt-spinel ferrite nanoparticles for cancer cell extraction and drug delivery. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/33951

Chicago Manual of Style (16th Edition):

Scarberry, Kenneth Edward. “Biomedical applications of cobalt-spinel ferrite nanoparticles for cancer cell extraction and drug delivery.” 2009. Doctoral Dissertation, Georgia Tech. Accessed January 15, 2021. http://hdl.handle.net/1853/33951.

MLA Handbook (7th Edition):

Scarberry, Kenneth Edward. “Biomedical applications of cobalt-spinel ferrite nanoparticles for cancer cell extraction and drug delivery.” 2009. Web. 15 Jan 2021.

Vancouver:

Scarberry KE. Biomedical applications of cobalt-spinel ferrite nanoparticles for cancer cell extraction and drug delivery. [Internet] [Doctoral dissertation]. Georgia Tech; 2009. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1853/33951.

Council of Science Editors:

Scarberry KE. Biomedical applications of cobalt-spinel ferrite nanoparticles for cancer cell extraction and drug delivery. [Doctoral Dissertation]. Georgia Tech; 2009. Available from: http://hdl.handle.net/1853/33951


Georgia Tech

2. Elango, Navin. Evolutionary impacts of DNA methylation on vertebrate genomes.

Degree: PhD, Biology, 2008, Georgia Tech

URL: http://hdl.handle.net/1853/26691 

DNA methylation is an epigenetic modification in which a methyl group is covalently added to the DNA. In vertebrate genomes methylation occurs almost exclusively at cytosines immediately followed by a guanine (CpG dinucleotides). Two important aspects of DNA methylation have inspired several recent scientific investigations including those in this dissertation. First, methylated cytosines are hotspots of point mutation due to a methylation-dependent mutation mechanism, which has caused a deficiency of CpGs in vertebrate genomes. Second, DNA methylation in promoters is linked with transcriptional silencing of the associated genes. This dissertation presents the results of four studies in which I investigated the impacts of DNA methylation on the neutral and functional evolution of vertebrate genomes. The results of the first two studies demonstrate that DNA methylation has profound impacts on both inter- and intra-genomic neutral substitution rate variation. The third and fourth studies demonstrate that DNA methylation has played critical roles in shaping the evolution of vertebrate promoters and gene regulation. Advisors/Committee Members: Dr. Soojin Yi (Committee Chair), Dr. Eric Vigoda (Committee Member), Dr. James Thomas (Committee Member), Dr. John McDonald (Committee Member), Dr. Kirill Lobachev (Committee Member), Dr. Michael Goodisman (Committee Member).

Subjects/Keywords: Evolution; Vertebrate; Promoter; Molecular clock; Gene regulation; Vertebrates Genetic aspects; DNA Methylation; Evolution (Biology)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Elango, N. (2008). Evolutionary impacts of DNA methylation on vertebrate genomes. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/26691

Chicago Manual of Style (16th Edition):

Elango, Navin. “Evolutionary impacts of DNA methylation on vertebrate genomes.” 2008. Doctoral Dissertation, Georgia Tech. Accessed January 15, 2021. http://hdl.handle.net/1853/26691.

MLA Handbook (7th Edition):

Elango, Navin. “Evolutionary impacts of DNA methylation on vertebrate genomes.” 2008. Web. 15 Jan 2021.

Vancouver:

Elango N. Evolutionary impacts of DNA methylation on vertebrate genomes. [Internet] [Doctoral dissertation]. Georgia Tech; 2008. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1853/26691.

Council of Science Editors:

Elango N. Evolutionary impacts of DNA methylation on vertebrate genomes. [Doctoral Dissertation]. Georgia Tech; 2008. Available from: http://hdl.handle.net/1853/26691

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