+publisher:"Georgia Tech" +contributor:("Dr. Elliot Chaikof")

1. Martinez, Adam W. Design and development of an elastin mimetic stent with therapeutic delivery potential.

Degree: PhD, Biomedical Engineering, 2011, Georgia Tech

► Stenting remains a common treatment option for atherosclerotic arteries. The main drawback of early stent platforms was restenosis, which has been combated by drug eluting… (more)

Subjects/Keywords: Rat stenting; Elastin miemtic; Laser fabrication; Crosslinking; Drug delivery; Stent; Stents (Surgery); Drug-eluting stents; Drug delivery devices; Implants, Artificial

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APA (6^th Edition):

Martinez, A. W. (2011). Design and development of an elastin mimetic stent with therapeutic delivery potential. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/45926

Chicago Manual of Style (16^th Edition):

Martinez, Adam W. “Design and development of an elastin mimetic stent with therapeutic delivery potential.” 2011. Doctoral Dissertation, Georgia Tech. Accessed February 28, 2021. http://hdl.handle.net/1853/45926.

MLA Handbook (7^th Edition):

Martinez, Adam W. “Design and development of an elastin mimetic stent with therapeutic delivery potential.” 2011. Web. 28 Feb 2021.

Vancouver:

Martinez AW. Design and development of an elastin mimetic stent with therapeutic delivery potential. [Internet] [Doctoral dissertation]. Georgia Tech; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1853/45926.

Council of Science Editors:

Martinez AW. Design and development of an elastin mimetic stent with therapeutic delivery potential. [Doctoral Dissertation]. Georgia Tech; 2011. Available from: http://hdl.handle.net/1853/45926

Georgia Tech

2. Sathe, Rahul D. Design and Development of a Novel Implantable Prosthetic Vein Valve.

Degree: MS, Mechanical Engineering, 2006, Georgia Tech

URL: http://hdl.handle.net/1853/14495

► Over seven million Americans suffer from Chronic Venous Insufficiency (CVI), a painful and debilitating disease that affects the superficial and deep veins of the legs.… (more)

▼ Over seven million Americans suffer from Chronic Venous Insufficiency (CVI), a painful and debilitating disease that affects the superficial and deep veins of the legs. Problems associated with CVI include varicose veins, bleeding, ulcerations, severe swelling, deep vein thrombosis, and pulmonary embolism, which may lead to death. The presence of CVI results from damaged (incompetent) one-way vein valves in leg veins. These valves normally allow forward flow of blood to the heart, and prevent blood from pooling at the feet. However, incompetent valves allow reflux of blood, causing clinical problems. There are few effective clinical therapies for treating CVI. Vein valve transplantation is a surgical option for treatment. However, it is often difficult to find suitable donor valves. Very few prosthetic valves developed in the past have demonstrated sufficient clinical or mechanical functionality. Persistent problems include thrombus formation, leaking valves, and valves that do not open at physiologic pressure gradient. The primary objective of this research was to develop a clinically relevant functional prosthetic vein valve. The novel prosthetic valve is flexible, biocompatible, has low thrombogenecity, and is easy to manufacture. It was designed to address well-defined consumer needs and functional design requirements. The valve was required to 1) withstand 300 mmHg of backpressure with leakage less than 1.0 mL/min, 2) open with a pressure gradient less than 5 mmHg, and 3) meet criteria 1 and 2 after 500,000 cycles of operation. The valve met these design requirements in bench testing. The valve can open with a pressure gradient of 2.6 0.7 mmHg, and can withstand 300 mmHg with leakage less than 0.5 mL/min. The valve remained functional after opening and closing over 500,000 times. The valve presented in this research is operationally functional, and is a potential solution for treating venous incompetence in CVI patients. Advisors/Committee Members: Dr. David N. Ku (Committee Chair), Dr. David Rosen (Committee Member), Dr. Elliot Chaikof (Committee Member).

Subjects/Keywords: Vein valve; Deep vein thrombosis; Venous valve; Prosthetic vein valve; Chronic venous insufficiency; Implants, Artificial Design and construction; Venous valves Transplantation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sathe, R. D. (2006). Design and Development of a Novel Implantable Prosthetic Vein Valve. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/14495

Chicago Manual of Style (16^th Edition):

Sathe, Rahul D. “Design and Development of a Novel Implantable Prosthetic Vein Valve.” 2006. Masters Thesis, Georgia Tech. Accessed February 28, 2021. http://hdl.handle.net/1853/14495.

MLA Handbook (7^th Edition):

Sathe, Rahul D. “Design and Development of a Novel Implantable Prosthetic Vein Valve.” 2006. Web. 28 Feb 2021.

Vancouver:

Sathe RD. Design and Development of a Novel Implantable Prosthetic Vein Valve. [Internet] [Masters thesis]. Georgia Tech; 2006. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1853/14495.

Council of Science Editors:

Sathe RD. Design and Development of a Novel Implantable Prosthetic Vein Valve. [Masters Thesis]. Georgia Tech; 2006. Available from: http://hdl.handle.net/1853/14495

Georgia Tech

3. Farrell, Laura-Lee Amelia Catherine. Prosthetic Vein Valve: Delivery and In Vitro Evaluation.

Degree: MS, Biomedical Engineering, 2007, Georgia Tech

URL: http://hdl.handle.net/1853/14531

► Venous disease will affect 1-3% of the western world at some point in their lives, yet there are few effective treatments for the venous system… (more)

▼ Venous disease will affect 1-3% of the western world at some point in their lives, yet there are few effective treatments for the venous system [1]. One such disease is chronic venous insufficiency (CVI), a painful and debilitating illness that affects the superficial and deep vein valves of the legs. When the valves become incompetent they allow reflux and subsequent pooling of blood. Current clinical therapies are only moderately; and therefore, the need for a better solution remains. Prosthetic venous valves were constructed from a novel hydrogel biomaterial patented by Georgia Tech. The valves had flexible cusps similar to normal, anatomic venous valves. The purpose of this work was to evaluate the thrombotic potential of the GT venous valve in an in vitro study and to design a percutaneous delivery system. In vitro thrombosis model provides an appropriate intermediate step between valve development and in vivo analysis, which is necessary to determine the biocompatibility of the prosthetic device. The flow system was modified from a one-pass, flow-through thrombosis assay using whole blood [2] to mimic pulsatile physiologic conditions. Cessation of flow indicated thrombotic obstruction. Histological analysis was performed using H and E staining and Carstairs stain (specific for platelets). A group of valves were lined with Dacron to confirm the thrombotic potential of the system. All Dacron valves were occluded by thrombus connecting the polymer fibers with adherent platelets. Whole blood perfused through the GT prosthetic valves exhibited no thrombosis or platelet adherence. All GT valves were patent and competent after blood perfusion. H and E staining revealed no thrombus deposition on the GT vein valves. A percutaneous delivery system was designed after evaluating the GT valves for their compressibility and plastic deformation over time. Appropriate stents, catheters and sheaths were selected. As designed, this system will be utilized in an ovine trial of the valve. Due to the low in vitro thrombotic potential and strong history of PVA as a medical implant material, positive trial results are expected. With successful animal and human trials this valve can provide a potential intervention for the 7 million people suffering from CVI. Advisors/Committee Members: Dr. David Ku (Committee Chair), Dr. Elliot Chaikof (Committee Member), Dr. Ross Milner (Committee Member).

Subjects/Keywords: Flow system; Porcine blood; Vein; Vein valve; Venous; Venous valve; Valves; Thrombus; Thrombotic potential; Platelets; Delivery; Stent; Delivery system; Catheter; Ovine; Sheep; Blood; Deep venous thrombosis; Chronic venous insufficiency

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Farrell, L. A. C. (2007). Prosthetic Vein Valve: Delivery and In Vitro Evaluation. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/14531

Chicago Manual of Style (16^th Edition):

Farrell, Laura-Lee Amelia Catherine. “Prosthetic Vein Valve: Delivery and In Vitro Evaluation.” 2007. Masters Thesis, Georgia Tech. Accessed February 28, 2021. http://hdl.handle.net/1853/14531.

MLA Handbook (7^th Edition):

Farrell, Laura-Lee Amelia Catherine. “Prosthetic Vein Valve: Delivery and In Vitro Evaluation.” 2007. Web. 28 Feb 2021.

Vancouver:

Farrell LAC. Prosthetic Vein Valve: Delivery and In Vitro Evaluation. [Internet] [Masters thesis]. Georgia Tech; 2007. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1853/14531.

Council of Science Editors:

Farrell LAC. Prosthetic Vein Valve: Delivery and In Vitro Evaluation. [Masters Thesis]. Georgia Tech; 2007. Available from: http://hdl.handle.net/1853/14531

Georgia Tech

4. Fonseca, Michael Agapito. Polymer/Ceramic Wireless MEMS Pressure Sensors for Harsh Environments: High Temperature and Biomedical Applications.

Degree: PhD, Electrical and Computer Engineering, 2007, Georgia Tech

URL: http://hdl.handle.net/1853/19789

► This dissertation presents an investigation of miniaturized sensors, designed to wirelessly measure pressure in harsh environments such as high temperature and biomedical applications. Current wireless… (more)

▼ This dissertation presents an investigation of miniaturized sensors, designed to wirelessly measure pressure in harsh environments such as high temperature and biomedical applications. Current wireless MEMS pressure sensors are silicon-based and have limited high temperature operation, require internal power sources, or have limited packaging technology that restricts their use in harsh environments. Sensor designs in this work are based on passive LC resonant circuits to achieve wireless telemetry without the need for active circuitry or internal power sources. A cavity, which is embedded into the substrate, is bound by two pressure-deformable plates that include a parallel-plate capacitor. Deflection of the plates from applied pressure changes the capacitance, thus the resonance frequency varies and is a function of the applied pressure. The LC resonant circuit and pressure-deformable plates are fabricated into a monolithic housing that servers as the final device package (i.e. intrinsically packaged). This co-integration of device and package offers increased robustness and the ability to operate wirelessly in harsh environments. To intrinsically packaged devices, the fabrication approach relies on techniques developed for MEMS and leverage established lamination-based manufacturing processes, such as ceramic and flex-circuit packaging technologies. To demonstrate operation in high temperatures applications, LTCC and HTCC ceramic pressure sensors were fabricated and characterized, operating up to 450°C under 5 bars of pressure while HTCC devices demonstrated electrical functionality up to 600°C. To demonstrate operation in biomedical implantable applications, polymer-based and polymer-ceramic flexible designs were fabricated and characterized. Bench testing for > 300 millions pressure cycles (simulated 7 years of pulse pressure) confirmed the reduction of frequency drift for polymer-ceramic pressure sensors compared to purely polymer-based pressure sensors. Finally, LCP-based pressure sensors were delivered in vivo into canine models with mock abdominal aortic aneurysms and monitored wirelessly over 30 days. The animal results confirmed both catheter deliverability and wireless telemetry in real biomedical applications. Advisors/Committee Members: Dr. Mark G. Allen (Committee Chair), Dr. Oliver Brand (Committee Co-Chair), Dr. Andrew Peterson (Committee Member), Dr. Elliot Chaikof (Committee Member), Dr. Gregory Durgin (Committee Member), Dr. Robert Butera (Committee Member).

Subjects/Keywords: High temperature; Pressure; Sensors; MEMS; Passive; Wireless; Biomedical; Detectors; Biosensors; Extreme environments; Microelectromechanical systems; Wireless communication systems

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fonseca, M. A. (2007). Polymer/Ceramic Wireless MEMS Pressure Sensors for Harsh Environments: High Temperature and Biomedical Applications. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/19789

Chicago Manual of Style (16^th Edition):

Fonseca, Michael Agapito. “Polymer/Ceramic Wireless MEMS Pressure Sensors for Harsh Environments: High Temperature and Biomedical Applications.” 2007. Doctoral Dissertation, Georgia Tech. Accessed February 28, 2021. http://hdl.handle.net/1853/19789.

MLA Handbook (7^th Edition):

Fonseca, Michael Agapito. “Polymer/Ceramic Wireless MEMS Pressure Sensors for Harsh Environments: High Temperature and Biomedical Applications.” 2007. Web. 28 Feb 2021.

Vancouver:

Fonseca MA. Polymer/Ceramic Wireless MEMS Pressure Sensors for Harsh Environments: High Temperature and Biomedical Applications. [Internet] [Doctoral dissertation]. Georgia Tech; 2007. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1853/19789.

Council of Science Editors:

Fonseca MA. Polymer/Ceramic Wireless MEMS Pressure Sensors for Harsh Environments: High Temperature and Biomedical Applications. [Doctoral Dissertation]. Georgia Tech; 2007. Available from: http://hdl.handle.net/1853/19789

Georgia Tech

5. Rose, Stacey Loren. In Vitro Model of Vascular Healing in the Presence of Biomaterials.

Degree: PhD, Biomedical Engineering, 2006, Georgia Tech

URL: http://hdl.handle.net/1853/13955

► Coronary artery stent placement has been a significant advance in the percutaneous treatment of atherosclerotic disease, and tissue engineered vascular grafts may provide a viable… (more)

▼ Coronary artery stent placement has been a significant advance in the percutaneous treatment of atherosclerotic disease, and tissue engineered vascular grafts may provide a viable alternative to autologous segments for small diameter vessels. However, in-stent restenosis remains an important limitation, and tissue engineered grafts have poor patency and high risk of thrombus formation due to their inability to maintain a confluent, adherent, and quiescent endothelium. While animal models provide insight into the pathophysiology of these situations, elucidation of the relative importance of stent or graft components, hemodynamic factors, and molecular factors is difficult. Very little research has focused on bridging gaps in knowledge concerning blood/biomaterial interactions, blood/endothelial cell interactions, and endothelial cell/smooth muscle cell cross-talk. The work presented within this thesis will do just that. The objective of this thesis research was to elucidate the influence of biomaterial-induced activation of leukocytes on endothelial cell or smooth muscle cell phenotype, as well as endothelial cell/smooth muscle cell cross-talk in co-culture systems. Towards this goal, two complimentary in vitro endothelial cell/smooth muscle cell co-culture models with divergent smooth muscle cell phenotype were developed and characterized. Using these systems, it was found that the presence of more secretory smooth muscle cells (as would be seen in wound healing or disease) in general enhanced endothelial cell activation in response to biomaterial-pretreated monocytes, while the presence of less secretory smooth muscle cells (to model more quiescent smooth muscle cells found in uninjured healthy vessels) suppressed endothelial cell activation in response to biomaterial-pretreated monocytes (and neutrophils to a small degree). Additionally, biomaterial-pretreated monocytes and neutrophils amplified a smooth muscle cell phenotypic shift away from a more quiescent state. It is likely that the compounding effect of secretory smooth muscle cells and biomaterial-activated leukocytes are responsible for altered vascular wound healing upon implantation of stents or vascular grafts. Understanding the specific signals causing these effects, or signals delivered by contractile smooth muscle cells that limit these effects help to provide design criteria for development of devices or grafts capable of long term patency. Advisors/Committee Members: Dr. Julia Babensee (Committee Chair), Dr. Elliot Chaikof (Committee Member), Dr. Hanjoong Jo (Committee Member), Dr. Michael Sefton (Committee Member), Dr. Robert Nerem (Committee Member), Dr. Suzanne Eskin (Committee Member).

Subjects/Keywords: Biomaterials; Leukocytes; Smooth muscle cells; Endothelial cells; Stents (Surgery); Vascular endothelial growth factors; Biocompatibility; Leucocytes; Regeneration (Biology)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rose, S. L. (2006). In Vitro Model of Vascular Healing in the Presence of Biomaterials. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/13955

Chicago Manual of Style (16^th Edition):

Rose, Stacey Loren. “In Vitro Model of Vascular Healing in the Presence of Biomaterials.” 2006. Doctoral Dissertation, Georgia Tech. Accessed February 28, 2021. http://hdl.handle.net/1853/13955.

MLA Handbook (7^th Edition):

Rose, Stacey Loren. “In Vitro Model of Vascular Healing in the Presence of Biomaterials.” 2006. Web. 28 Feb 2021.

Vancouver:

Rose SL. In Vitro Model of Vascular Healing in the Presence of Biomaterials. [Internet] [Doctoral dissertation]. Georgia Tech; 2006. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1853/13955.

Council of Science Editors:

Rose SL. In Vitro Model of Vascular Healing in the Presence of Biomaterials. [Doctoral Dissertation]. Georgia Tech; 2006. Available from: http://hdl.handle.net/1853/13955

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