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You searched for +publisher:"Georgia Tech" +contributor:("Dr. David Collard"). Showing records 1 – 2 of 2 total matches.

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1. Charney, Reagan R. Coupling reactions and separations for improved synthetic processes.

Degree: PhD, Chemistry and Biochemistry, 2008, Georgia Tech

This thesis showcases a work that focused on developing processes with improved economic and environmental signatures. It illustrates the strengths of chemists and chemical engineers working together towards sustainable solutions. The joint collaboration between Drs. Liotta and Eckert allows the combination of disciplines to overcome economic and environment obstacles. This thesis depicts the application of chemical engineering and chemistry for industrial processes towards reducing cost and environmental impact. In chapter 2, a synthetic sequence yielding a pharmaceutical precursor was optimized for continuous processing. The precursor was for the pharmaceutical drug Ro 31-8959, which acts as a human immunodeficiency virus (HIV) protease inhibitor. A continuous flow reactor was designed, built and utilized successfully for the two-step reaction of the diazoketone pharmaceutical precursor, (1-benzyl-3-chloro-2-hydroxy-propyl)-carbamic acid tert-butyl ester. The best configuration for the continuous flow reactor involved a single and double coiled stainless steel reactor packed with glass beads. The yield obtained for the diazoketone was quantitative. In chapter 3, the cleavable surfactant (cleavable surfactants decompose in non-surface active ingredients upon stimulus), n-octyl thiirane oxide was synthesized, characterized and its surface activity and loss of surface activity upon heating was demonstrated. The n-octyl thiirane oxide surfactant activity was measured using a dye, Suddan III, and compared to a commercially available surfactant sodium dodecyl sulfate. In chapter 4, 5-amino-1H-tetrazole was synthesized using two novel synthetic routes starting from benign chemicals. Both routes involved Sharpless click chemistry in the first step to form the tetrazole ring. Both routes also used hydrogen transfer as the last step for the formation of the 5-amino-1H-tetrazole. These syntheses eliminated the use of highly toxic and/or explosive chemicals such as cyanamide, hydrazoic acid, and hydrazine. Finally in chapter 5, phase transfer catalysis was used as a means to improve reaction rates and yields between a siloxylated reagent (in the liquid phase) and insoluble ionic reagents (in the solid phase). The activity of commercial phase transfer catalysts like tetra-n-butylammonium bromide was compared to the activity of two novel custom-made siloxylated phase transfer catalysts. Surprisingly, the tetra-n-butylammonium resulted in superior rate constants to the custom made siloxylated phase transfer catalysts. Advisors/Committee Members: Dr. Charles Liotta (Committee Chair), Dr. Charles Eckert (Committee Co-Chair), Dr. David Collard (Committee Member), Dr. Facundo Fernandez (Committee Member), Dr. Rigoberto Hernandez (Committee Member).

Subjects/Keywords: 5-aminotetrazole; Cleavable surfactants; Siloxylated aminoacids; Continuous flow reactor; PTC; Metabolomics; Reactivity (Chemistry); Sustainable engineering; Technology transfer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Charney, R. R. (2008). Coupling reactions and separations for improved synthetic processes. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/26675

Chicago Manual of Style (16th Edition):

Charney, Reagan R. “Coupling reactions and separations for improved synthetic processes.” 2008. Doctoral Dissertation, Georgia Tech. Accessed November 19, 2019. http://hdl.handle.net/1853/26675.

MLA Handbook (7th Edition):

Charney, Reagan R. “Coupling reactions and separations for improved synthetic processes.” 2008. Web. 19 Nov 2019.

Vancouver:

Charney RR. Coupling reactions and separations for improved synthetic processes. [Internet] [Doctoral dissertation]. Georgia Tech; 2008. [cited 2019 Nov 19]. Available from: http://hdl.handle.net/1853/26675.

Council of Science Editors:

Charney RR. Coupling reactions and separations for improved synthetic processes. [Doctoral Dissertation]. Georgia Tech; 2008. Available from: http://hdl.handle.net/1853/26675


Georgia Tech

2. Shotwell, Sandra Leigh. Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers.

Degree: PhD, Chemistry and Biochemistry, 2006, Georgia Tech

In the first part of this thesis, the synthesis, characterization and investigation of ortho-phenyleneethynylenes containing heterocycles, are presented. These compounds display changes in absorption and emission spectra varying with their functionalization and size. These compounds also have the ability to coordinate with metals. The synthesis of coordination compounds and their crystallographic data are reported. The synthesis and characterization of tetraethynyl thiophene compounds containing pyridines are also presented. These compounds exhibit differences in absorption and emission spectra upon exposure to various metal salts. The final topic to be discussed is the synthesis and characterization of diphenyl amine polymers. These polymers could in principle be used in NLO applications or light emitting devices. Advisors/Committee Members: Dr. Uwe Bunz (Committee Chair), Dr. Anselm Griffin (Committee Member), Dr. David Collard (Committee Member), Dr. Joseph Perry (Committee Member), Dr. Laren Tolbert (Committee Member).

Subjects/Keywords: Polymers; Thiophenes Synthesis; Pyridinium compounds Synthesis; Ligands; Diphenylamine Synthesis; Oligomers

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Shotwell, S. L. (2006). Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/10449

Chicago Manual of Style (16th Edition):

Shotwell, Sandra Leigh. “Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers.” 2006. Doctoral Dissertation, Georgia Tech. Accessed November 19, 2019. http://hdl.handle.net/1853/10449.

MLA Handbook (7th Edition):

Shotwell, Sandra Leigh. “Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers.” 2006. Web. 19 Nov 2019.

Vancouver:

Shotwell SL. Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers. [Internet] [Doctoral dissertation]. Georgia Tech; 2006. [cited 2019 Nov 19]. Available from: http://hdl.handle.net/1853/10449.

Council of Science Editors:

Shotwell SL. Synthesis and Characterization of ortho-Phenyleneethynylenes and Diphenylamine Polymers. [Doctoral Dissertation]. Georgia Tech; 2006. Available from: http://hdl.handle.net/1853/10449

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