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You searched for +publisher:"Georgia Tech" +contributor:("Christoph J. Fahrni"). Showing records 1 – 2 of 2 total matches.

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Georgia Tech

1. Cody, John W., Jr. Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture.

Degree: PhD, Chemistry and Biochemistry, 2006, Georgia Tech

Copper is an essential trace element present in all living systems and is important for the function of many cellular enzymes. It ranks third in intracellular abundance behind only zinc and iron and plays a very important role as a catalytic cofactor in various cellular processes such as mitochondrial respiration, iron uptake, and the redox processes of a number of enzymes, including superoxide dismutase, lysyl oxidase, or tyrosinase. Any abnormality in copper trafficking pathways can lead to serious diseases such as Wilsons disease, Menkes syndrome and has been implicated in the neurodegenerative diseases amyotropic lateral sclerosis (ALS) and Alzheimers disease. While free copper in the cytoplasm would prove toxic, there is compelling evidence for the existence of a labile pool of copper that remains kinetically accessible. In order to investigate the existence of such a pool the development of Cu(I) selective probes is necessary. Chapter I provides the background for the role of copper in biology and elucidates the main trafficking pathways discovered to date. This chapter also provides recent developments of fluorescent sensors for selective visualization of biologically relevant metals. Chapter II discusses the exploration of a phenanthroline-based ligand for the selective detection of Cu(I). A series of derivatives incorporating chelating substituents in the 2- and 9-positions to enforce a 1:1 binding stoichiometry were synthesized and the properties of their respective Cu(I) complexes were characterized by x-ray structural analysis, and their photophysical properties were investigated by absorption and emission spectroscopy. Visible light excitation yielded metal-to-ligand charge-transfer (MLCT) excited states with luminescence lifetimes up to 155 ns. Electrochemical measurements further indicate that coordinative rearrangements are involved in nonradiative deactivation of the excited states. According to time-dependent density functional theory calculations (B3LYP/6-31G**), the major MLCT transitions are polarized along the C2 axis of the complex and originate predominantly from the dxz orbital. In chapter III, the development of a ratiometric Cu(I) sensor based on a donor-acceptor functionalized biphenyl fluorophore platform is discussed. The fluorescence emission energy for such fluorophores is highly dependent upon the interannular twist angle and this property was harnessed to provide a ratiometric sensor selective for Cu(I). Coordination of Cu(I) leads to a flattening of the biphenyl backbone and was confirmed by absorbance and emission spectroscopy as well as 2D NOESY experiments. The peak emission energy was shifted by 39 nm towards higher energy upon metal cation binding with a concomitant 7 bathochromic shift in absorption energy. The photophysical data accompanied by 1H NMR analysis confirms a well-defined 1:1 binding stoichiometry between metal and ligand. The findings from this study showed ratiometric behavior for this probe, albeit with a lowered quantum yield. While… Advisors/Committee Members: Christoph J. Fahrni (Committee Chair), James C. Powers (Committee Member), John Zhang (Committee Member), Julia Kubanek (Committee Member), Suzanne Beckham (Committee Member).

Subjects/Keywords: Donor-acceptor; Cu(I); Sensors; Charge transfer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Cody, John W., J. (2006). Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/13962

Chicago Manual of Style (16th Edition):

Cody, John W., Jr. “Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture.” 2006. Doctoral Dissertation, Georgia Tech. Accessed March 06, 2021. http://hdl.handle.net/1853/13962.

MLA Handbook (7th Edition):

Cody, John W., Jr. “Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture.” 2006. Web. 06 Mar 2021.

Vancouver:

Cody, John W. J. Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture. [Internet] [Doctoral dissertation]. Georgia Tech; 2006. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1853/13962.

Council of Science Editors:

Cody, John W. J. Design, Synthesis, and Evaluation of Metal Cation Sensors with Donor-Acceptor Architecture. [Doctoral Dissertation]. Georgia Tech; 2006. Available from: http://hdl.handle.net/1853/13962


Georgia Tech

2. Moore, Susanna. Synthesis and Pharmacology of Potential Site-Specific Therapeutic Agents for Cocaine Abuse.

Degree: PhD, Chemistry and Biochemistry, 2004, Georgia Tech

Synthesis and Pharmacology of Potential Site-Directed Therapeutic Agents for Cocaine Abuse Susanna Moore 235 Pages Directed by Dr. David M. Collard and Dr. Howard M. Deutsch Stimulants such as cocaine continue to dominate the nations illicit drug problem. An effective medication for any aspect of cocaine addiction has not been developed. Cocaine binds, although not selectively, to the dopamine transporter (DAT) and disrupts normal dopamine (DA) neurotransmission between neurons. While the dopamine hypothesis for the mechanism of action of cocaine has been widely accepted, cocaine also possesses the ability to block the uptake of serotonin at the serotonin transporter (5-HTT) and norepinephrine at the norepinephrine transporter (NET). The purpose of the work described herein is directed towards synthesizing and testing compounds selective for the DAT, leading to the identification of candidates as potential pharmacotherapies for cocaine dependence. A series of disubstituted and trisubstituted [2.2.2] and [2.2.1]bicycles were synthesized and tested for inhibitor potency in [3H]WIN 35,428 (WIN) binding at the DAT and for inhibition of [3H]DA uptake. Based on results from some of the pharmacology data new regio- and stereochemical isomers of bicyclic [2.2.1]heptanes and [2.2.2]octanes were synthesized. This will lead to further structure-activity-relationships, which will provide a better understanding of the structural requirements needed to bind at the DAT. Advisors/Committee Members: Dr. David M. Collard (Committee Co-Chair), Dr. Howard M. Deutsch (Committee Co-Chair), Dr. Christoph J. Fahrni (Committee Member), Dr. Margaret M. Schweri (Committee Member), Dr. Suzy B. Shuker (Committee Member).

Subjects/Keywords: LR5182; Cocaine habit Treatment; Dopamine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Moore, S. (2004). Synthesis and Pharmacology of Potential Site-Specific Therapeutic Agents for Cocaine Abuse. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/5010

Chicago Manual of Style (16th Edition):

Moore, Susanna. “Synthesis and Pharmacology of Potential Site-Specific Therapeutic Agents for Cocaine Abuse.” 2004. Doctoral Dissertation, Georgia Tech. Accessed March 06, 2021. http://hdl.handle.net/1853/5010.

MLA Handbook (7th Edition):

Moore, Susanna. “Synthesis and Pharmacology of Potential Site-Specific Therapeutic Agents for Cocaine Abuse.” 2004. Web. 06 Mar 2021.

Vancouver:

Moore S. Synthesis and Pharmacology of Potential Site-Specific Therapeutic Agents for Cocaine Abuse. [Internet] [Doctoral dissertation]. Georgia Tech; 2004. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1853/5010.

Council of Science Editors:

Moore S. Synthesis and Pharmacology of Potential Site-Specific Therapeutic Agents for Cocaine Abuse. [Doctoral Dissertation]. Georgia Tech; 2004. Available from: http://hdl.handle.net/1853/5010

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