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Freie Universität Berlin

1. Rückriegel, Stefan Mark. Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors.

Degree: 2010, Freie Universität Berlin

Motor and cognitive function losses resemble handicaps in pediatric posterior fossa tumor survivors. Several factors determine type and extent of impairment. We quantified loss of fine motor function and its association with ataxia and intelligence, as well as damage to white matter tracts in patients with and without adjuvant treatment. For this purpose, 25 medulloblastoma (MB) and 16 cerebellar pilocytic astrocytoma (PA) patients were assessed at least 1 year after completion of therapy using functional tests. 17 MB patients and 13 PA patients were examined employing MR diffusion tensor imaging. To validate fine motor assessment 187 healthy subjects were examined employing a digitizing graphic tablet. Kinematic parameters (speed, automation, variability, and pressure) of different movement complexity levels were investigated. Degree of ataxia was quantified using the International Cooperative Ataxia Rating Scale and cognition was determined using the Wechsler Intelligence Scale. Kinematic parameters of low and high complexity tasks as well as ataxia and IQ of MB patients were strongly impaired. Fine motor impairment was weaker in PA patients, but still evident in the complex task of writing. Voxel-based analysis of MR diffusion tensor imaging derived maps of fractional anisotropy using tract-based spatial statistics (part of FSL) revealed various clusters of significantly decreased cerebellar and supratentorial fractional anisotropy in both patient groups. Amount of clusters of significantly decreased fractional anisotropy was higher in MB patients. These studies underline the significance of long-term effects of posterior-fossa tumors and their therapy. Future concepts of treatment and rehabilitation have to consider these effects. Advisors/Committee Members: [email protected] (contact), m (gender), Priv.-Doz. Dr. med. P. Hernáiz Driever (firstReferee), Prof. Dr. med. R.-D. Kortmann, Prof. Dr. med. M. Frühwald (furtherReferee).

Subjects/Keywords: medulloblastoma; pilocytic astrocytoma; sequelae; diffusion tensor imaging; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rückriegel, S. M. (2010). Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11848

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Rückriegel, Stefan Mark. “Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors.” 2010. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-11848.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Rückriegel, Stefan Mark. “Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors.” 2010. Web. 09 Mar 2021.

Vancouver:

Rückriegel SM. Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-11848.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rückriegel SM. Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-11848

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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