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Freie Universität Berlin

1. Meißner, Simon. Pilot study on the effect of Simvastatin on concentration of Interleukin-6, Interleukin-8, Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in gingival crevicular fluid in chronic periodontitis.

Degree: 2013, Freie Universität Berlin

Interleukins (IL) IL-6 and IL-8 which are involved in acute and chronic inflammation in chronic periodontitis are increased in the gingival crevicular fluid (GCF). These cyto-kines and inflammatory mediators induce the secretion of Matrix Metalloproteinases (MMP-9) which have a degrading effect on the extracellular tissue and the surrounding bone. Simvastatin is a HMG-CoA reductase inhibitor in treating disorders of lipid metabolism and in preventing cardiovascular disease in high-risk groups. Retrospective studies and clinical in vitro and in vivo (animal) studies have demonstrated a protective effect against progression of periodontal disease, a reduction in bone breakdown and an increase of VEGF in bone resulting in increased bone apposition. The aim of this study was to demonstrate an antiinflammatory effect of simvastatin by standard therapy on chronic periodontitis. Methods 24 patients with chronic periodontitis were included in the study. 12 of whom were treated with simvastatin (treatment group) for at least 3 months, the remaining 12 patients served as controls. None of the patients received immunmodulating therapy. Patients (treatment group / controls) were matched for age, gender and periodontal status. Seven days after the periodontal status was examined and professional tooth cleaning on the first molars of each quadrant was performed, GCF samples were taken twice and quantified. Analysis of GCF was performed after homogenization using commercial sandwich enzyme immunoassays. Measures were performed twice, for statistical analysis calculated medians were used. Two samples of a healthy person served as controls. Results In 24 patients of the treatment group and controls the median age was 66 years. Medi-an duration with regard to periodontitis was 5,5 years for statin-treated patients and 7,7 years for patients without simvastatin-therapy. Both groups did not differ in gender dis-tribution, age, height, weight and periodontal treatment. Median concentrations in GCF for IL-6 and IL-8 for patients taking simvastatin were 3,08 ng / ml (Q25: 2,13 / Q75: 3,92) and 121,74 ng / ml (Q25: 94,06 / Q75: 190,82). Concentrations in patients without statin therapy were at 2,06 ng / ml (Q25: 1,84 / Q75: 3,14) for IL-6 and 132,43 ng / ml (Q25: 84,05 / Q75: 378,42) for IL-8. In the group receiving simvastatin MMP-9 amounted to a median of 27,61 ug / ml (Q25: 12,08 / Q75: 48,15), in the group without statins 28.82 g / ml (Q25: 19,43 / Q75: 46,08). Median concentrations of VEGF in the simvastatin-group were 9,91 ng / ml (Q25: 0 / Q75: 23,18), in the control group 18,36 ng / ml (Q25: 6, 25 / Q75: 22,30). In healthy controls, median IL-6 concentrations were found to be 0,41 ng / ml, in IL-8 30,5 ng / ml, in VEGF 5,40 ng / ml (Q25: 5,24 / Q50 : 5,40), in MMP-9 6,70 ug / ml (Q25: 5,89 / Q50: 6,70). Statin-treated patients did not show significant differences neither in IL-6 and IL-8 concentrations, nor in VEGF and MMP-9. Significant differences were observed regarding healthy control. No correlations regarding disease duration,… Advisors/Committee Members: [email protected] (contact), m (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: chronic periodontitis; Simvastatin; GCF; IL-6; IL-8; VEGF; MMP-9; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6th Edition):

Meißner, S. (2013). Pilot study on the effect of Simvastatin on concentration of Interleukin-6, Interleukin-8, Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in gingival crevicular fluid in chronic periodontitis. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13193

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Meißner, Simon. “Pilot study on the effect of Simvastatin on concentration of Interleukin-6, Interleukin-8, Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in gingival crevicular fluid in chronic periodontitis.” 2013. Thesis, Freie Universität Berlin. Accessed April 18, 2021. https://refubium.fu-berlin.de/handle/fub188/13193.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Meißner, Simon. “Pilot study on the effect of Simvastatin on concentration of Interleukin-6, Interleukin-8, Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in gingival crevicular fluid in chronic periodontitis.” 2013. Web. 18 Apr 2021.

Vancouver:

Meißner S. Pilot study on the effect of Simvastatin on concentration of Interleukin-6, Interleukin-8, Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in gingival crevicular fluid in chronic periodontitis. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 18]. Available from: https://refubium.fu-berlin.de/handle/fub188/13193.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Meißner S. Pilot study on the effect of Simvastatin on concentration of Interleukin-6, Interleukin-8, Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in gingival crevicular fluid in chronic periodontitis. [Thesis]. Freie Universität Berlin; 2013. Available from: https://refubium.fu-berlin.de/handle/fub188/13193

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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