+publisher:"Freie Universität Berlin" +contributor:("n")

Freie Universität Berlin

1. Lorenz, Maren. Does hearing impairment lead to decreased speech performance in elderly adults?.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10217

► Objective: The purpose of this study was (a) to study hearing loss prevalence among older adults compared to young adults, (b) to examine their speech… (more)

▼ Objective: The purpose of this study was (a) to study hearing loss prevalence among older adults compared to young adults, (b) to examine their speech and cognitive ability and (c) to analyse possible correlations between hearing ability and speech performance, (d) to detect further influences on speech performance in older adults. Study design: Clinical research. Methods: 747 older adults (age > 60 years) were examined. Hearing ability was measured by pure tone average of frequencies 0,5-4 kHz in the better ear. Grades of hearing impairment were defined according to WHO-criteria. Speech performance was measured by semantic and phonematic fluency and Boston Naming Test. The relationship between hearing loss and speech performance was assessed by means of correlation analysis and a linear regression model. In addition, cognitive performance (Trail Making Test A, Word list (out of CERAD-NAB), Multiple Choice-Vocabulary-Intelligence-Test - MWT), years of education, depression score (CES-D) and social activity were recorded. Results: 558 participants (74,4 %) showed normal hearing ability. Slight hearing impairment was detected in 19,5 %, moderate 5,4 %, severe 0,4 %. In women hearing loss was correlated with (a) semantic (p=0,027/r² =0,011) and (b) phonematic fluency (p=0,004 r²=0,018). Regression analysis found Word list, years of education and Trail Making Test A to be relevant influences on semantic fluency. Semantic fluency was found to depend on age in women only. Phonematic fluency depended on Word list, years of education and Trail Making Test A in woman. In male participants, phonematic fluency depended only on Word list. Conclusions: Speech performance tends to be impaired by declining hearing ability in women, but not in men. To assess speech performance, semantic and phonematic fluency as well as Boston Naming Test were found to be useful screening methods. Further study is required to examine speech perfomance in greater detail. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: hearing impairment; speech performance; elderly adults; semantic fluency; phonematic fluency; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lorenz, M. (2014). Does hearing impairment lead to decreased speech performance in elderly adults?. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10217

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lorenz, Maren. “Does hearing impairment lead to decreased speech performance in elderly adults?.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-10217.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lorenz, Maren. “Does hearing impairment lead to decreased speech performance in elderly adults?.” 2014. Web. 20 Nov 2019.

Vancouver:

Lorenz M. Does hearing impairment lead to decreased speech performance in elderly adults?. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-10217.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lorenz M. Does hearing impairment lead to decreased speech performance in elderly adults?. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-10217

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

2. Ahlers, Eike. Subjective sleep quality in patients with adult attention deficit/ hyperactivity disorder.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12251

► Introduction: ADHD and sleep disorders are frequent co-morbid conditions although their relationship is not yet understood. In the present study subjective sleep quality was analysed… (more)

▼ Introduction: ADHD and sleep disorders are frequent co-morbid conditions although their relationship is not yet understood. In the present study subjective sleep quality was analysed in a sample of patients of an outpatient center for adult ADHD. Methods: Subjective sleep quality was assessed by validated rating scales (Pittsburgh Sleep Quality Index (PSQI), Restless Legs Syndrome - Diagnostic Index (RLS-DI), International RLS Severity Scale (IRLS), Münchner Parasomnie Screening Fragebogen (MUPS)), subjective daytime sleepiness was measured by the Epworth Sleepiness Scale (ESS). Patients were stratified according to their leading diagnosis (n = 312: ii ADHD, n = 164, suspected ADHD, n = 80, other psychiatric disorders, n = 55, no diagnosis, n = 13), ADHD-subtypes (inattentive type IT n = 85, and combined type CT n = 79, inattentive type throughout childhood and adulthood IT/ IT n = 54) and status of psychiatric co-morbidity. Results: In the ADHD-group mean PSQI score was 6.8 (± 3.3). 56.8% showed a PSQI score above cutoff (PSQI > 5). Mean ESS was 7.8 (± 4.1), 25% showing an ESS exceeding cutoff (ESS > 10). 16% of the patients of the ADHD-group fulfilled essential diagnostic criteria for RLS, mean IRLS was 13.0 (± 9.9). Parasomnias were present to a relevant degree in the ADHD-group. PSQI scores were elevated in ADHD with psychiatric co- morbidities compared to ADHD and without co-morbidities (p = 0.023). Further, essential diagnostic criteria for RLS were fulfilled more often in ADHD with co-morbidities, though significance was missed (p = 0.074). Patients with suspected ADHD and other psychiatric disorders showed substantially elevated PSQI, ESS, RLS-DI and IRLS scores and significantly more bad sleepers (PSQI > 5) compared to individuals with ADHD. Some parasomnias (REM-sleep- behaviour disorder, night eating syndrome) were also more prevalent here than in the ADHD-group. Patients with ADHD-CT showed substantially elevated IRLS scores and significantly more indications of periodic limb movements in sleep than in ADHD-IT. In patients with ADHD-IT (p = 0.073) and IT/ IT (p = 0.033) bruxism was more prevalent when psychiatric co-morbidities were present. Conclusions: Impaired sleep quality and excessive daytime sleepiness are elevated in ADHD with regard to published data from healthy patients. ADHD-subtypes show different patterns of impaired sleep. Further, there is evidence for an association of impaired sleep and co-morbid psychiatric disorders in ADHD. These findings should be considered in clinical practise and further investigated on. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: adhd; sleep quality; adult; attention deficit hyperactivity disorder; PSQI; ESS; RLS-DI; IRLS; MUPS; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ahlers, E. (2014). Subjective sleep quality in patients with adult attention deficit/ hyperactivity disorder. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12251

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ahlers, Eike. “Subjective sleep quality in patients with adult attention deficit/ hyperactivity disorder.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-12251.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ahlers, Eike. “Subjective sleep quality in patients with adult attention deficit/ hyperactivity disorder.” 2014. Web. 20 Nov 2019.

Vancouver:

Ahlers E. Subjective sleep quality in patients with adult attention deficit/ hyperactivity disorder. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-12251.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ahlers E. Subjective sleep quality in patients with adult attention deficit/ hyperactivity disorder. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-12251

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

3. Heinbokel, Timm. Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg.

Degree: 2015, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/10901

► Kontinuierliche und komplexe Veränderungen des Immunsystems mit zunehmendem Alter haben entscheidenen Einfluss auf den klinischen Erfolg von Organtransplantationen und die Qualität von Spenderorganen. Da die… (more)

▼ Kontinuierliche und komplexe Veränderungen des Immunsystems mit zunehmendem Alter haben entscheidenen Einfluss auf den klinischen Erfolg von Organtransplantationen und die Qualität von Spenderorganen. Da die Zahl der älteren Transplantatempfänger steigt und zunehmend Organe von älteren Spendern transplantiert werden, ergeben sich drängende Herausforderungen für die Transplantationsmedizin. Klinisch konnte für die Transplantation von älteren Spenderorganen eine Assoziation mit schlechterem Patienten- und Transplantatüberleben sowie häufigeren akuten Abstoßungsreaktionen und verzögerter Transplantatfunktion gezeigt werden. Um diesen klinischen Phänomenen zugrundeliegende Mechanismen zu ergründen, wurde in der vorliegenden Arbeit ein Mausmodell heterotoper, komplett vaskularisierter Herztransplantation mit MHC-disparaten jungen (acht bis zwölf Wochen) DBA/2-Empfängern und jungen oder alten (18 Monate) C57BL/6 Spendern etabliert. Von alten Spendermäusen gewonnene Herzen zeigten eine signifikant beschleunigte Transplantatabstoßung im Vergleich zu jungen Spenderherzen. Dieser Unterschied im Transplantatüberleben war begleitet von höheren Indizes in der ISHLT Abstoßungsklassifikation und verstärkter Transplantatinfiltration durch CD4+ und CD8+ T- Zellen. Das Alter des transplantierten Organs hatte weiterhin Einfluss auf Charakteristiken der systemischen Alloimmunreaktion des Empfängers, dargestellt durch erhöhte Häufigkeit von milzständigen CD8+ Effektor-T-Zellen und CD8+IFN-γ+ T-Zellen bei Transplantation von älteren Spenderorganen, zusätzlich zu erhöhten Häufigkeiten von alloreaktiven IFN-γ- und IL-6-produzierenden Splenozyten sowie ausgeprägterer alloreaktiver Proliferation von Splenozyten bei Restimulation mit donorspezifischen Antigenen. Um Effekte des Parenchyms der transplantierten Organe von denen der mitübertragenen Passagierleukozyten zu unterscheiden, wurden chimäre Spendertiere generiert durch Transplantation von Knochenmark junger syngener Tiere in alte und junge zukünftige Spendertiere sechs Wochen vor Organentnahme. Nach Transplantation dieser chimären Spenderherzen (junges Parenchym mit jungen Passagierleukozyten oder altes Parenchym mit jungen Passagierleukozyten) waren Transplantatüberleben, Abstoßungsindizes und systemische Empfängerantworten vergleichbar, was auf eine entscheidende Rolle von organständigen Passagierleukozyten bei der Vermittlung von verstärkten Immunreaktionen nach Transplantation alter Spenderorgane hindeutete. Mit Fokus auf dendritische Zellen als eine Untergruppe der Passagierleukozyten wurden nun organständige dendritische Zellen durch Vorbehandlung der Spendertiere mit liposomalen Clodronat aus den Spenderherzen depletiert. Unterschiede in Transplantatüberleben und Abstoßungsindizes waren aufgehoben nach Transplantation von Spenderherzen vorbehandelter Tiere, ebenso waren die systemischen Immunantworten unabhängig vom Alter der Spendertiere. Weiterhin konnte eine detailliertere Charakterisierung der allostimulatorischen Priming- Fähigkeiten dendritischer Zellen in-vitro zeigen, dass… Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: transplantation; aging; immunosenescence; donor age; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heinbokel, T. (2015). Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/10901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Heinbokel, Timm. “Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/10901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Heinbokel, Timm. “Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg.” 2015. Web. 20 Nov 2019.

Vancouver:

Heinbokel T. Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/10901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Heinbokel T. Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg. [Thesis]. Freie Universität Berlin; 2015. Available from: https://refubium.fu-berlin.de/handle/fub188/10901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

4. Posch, Helena. Evaluation of possible long-term effects of repeated administration of the liver-specific contrast agent gadoxetic acid on the signal intensity in predefined brain areas on unenhanced MRI.

Degree: 2018, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/13390

► The aim of this exploratory cross-sectional study with prospective design was the MRI-based evaluation of potential long-term alterations of signal intensity (SI) in predefined brain… (more)

▼ The aim of this exploratory cross-sectional study with prospective design was the MRI-based evaluation of potential long-term alterations of signal intensity (SI) in predefined brain areas after repeated administration of the linear ionic gadolinium-based contrast agent (GBCA) gadoxetic acid, used in liver-specific MRI. Participants belonging to a study group (A, n = 91) and a control group (B, n = 52) underwent unenhanced MRI examinations of the brain using a T1-weighted Spin-Echo pulse sequence at 1.5 T. Patients in the study group had previously received from 1 to 37 doses of gadoxetic acid; exclusion criteria included past exposure to other linear MRI contrast agents or more than 2 doses of macrocyclic MRI contrast agents. (Study group A was divided into 3 subgroups according to the number of previous gadoxetic-acid enhanced examinations, each with a nearly equal number of subjects: A1 < 5, A2 5 to 10, A3 > 10.) Control group B was limited to patients who had never been given GBCA of any sort. Quantitative analysis of the image data was performed. We examined the index regions dentate nucleus (DN) and globus pallidus (GP) in relation to the neutral reference regions of the middle cerebellar peduncle (MCP), the pons (P), and the thalamus (Th). The signal intensity (SI) of each of these areas was measured, and the resulting ratios (SI ratios) served as a basis for comparison between the patient groups. SI ratios for DN/MCP and DN/P were significantly different between control subjects (B) and those patients in the study group who had previously received anywhere from 11 to 37 gadoxetic acid administrations (A3). Groups of patients with fewer than 5 (A1) or fewer than 11 (A2) gadoxetic acid administrations showed no such statistically relevant differences. GT/Th ratios differed significantly between the study group in its entirety (A) and the control group (B), whereas no significant dose dependency on gadoxetic acid was found. Instead, for the GP signal intensity we detected a significant dependency on age that might have acted as a confounding factor. Results show a significant positive correlation between the number of gadoxetic acid administrations and the increase of SI in the cerebellar region of the DN in unenhanced T1-weighted MRI images. Current research indicates that this correlation might be due to long-term gadolinium retention following the repeated application of this linear ionic contrast agent. In comparison to other commercially available linear GBCAs, however, the effect of T1 shortening is considerably subtler and becomes statistically relevant only after high cumulative doses. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: gadoxetic acid; liver-specific contrast agent; GBCA; MRI; signal intensity; gadolinium; retention; CNS; brain; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Posch, H. (2018). Evaluation of possible long-term effects of repeated administration of the liver-specific contrast agent gadoxetic acid on the signal intensity in predefined brain areas on unenhanced MRI. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Posch, Helena. “Evaluation of possible long-term effects of repeated administration of the liver-specific contrast agent gadoxetic acid on the signal intensity in predefined brain areas on unenhanced MRI.” 2018. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/13390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Posch, Helena. “Evaluation of possible long-term effects of repeated administration of the liver-specific contrast agent gadoxetic acid on the signal intensity in predefined brain areas on unenhanced MRI.” 2018. Web. 20 Nov 2019.

Vancouver:

Posch H. Evaluation of possible long-term effects of repeated administration of the liver-specific contrast agent gadoxetic acid on the signal intensity in predefined brain areas on unenhanced MRI. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/13390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Posch H. Evaluation of possible long-term effects of repeated administration of the liver-specific contrast agent gadoxetic acid on the signal intensity in predefined brain areas on unenhanced MRI. [Thesis]. Freie Universität Berlin; 2018. Available from: https://refubium.fu-berlin.de/handle/fub188/13390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

5. Heim, Susanne. Survey on the relevance of a mutation of Chitotriosidase 1 concerning the outcome of patients that are in intensive care.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-7548

► Human Chitotriosidase 1 (Chit 1) is a chitinolytic enzyme whose physiological function in humans is widely unknown. A relation to the congenital immunosystem is assumed.… (more)

▼ Human Chitotriosidase 1 (Chit 1) is a chitinolytic enzyme whose physiological function in humans is widely unknown. A relation to the congenital immunosystem is assumed. Purpose of this study was to detect, whether critically ill patients’ course of disease in intensive care was altered, if a polymorphism of Chit 1 was reducing or inactivating this enzyme’s activity. Methodology: Prospective, controlled, non interventional, clinical, observational trial involving 5 anesthesiological Intensive Care Units (ICU) of the Department of Anesthesiology and Intensive Care Medicine, Charité - University Medicine Berlin. 200 critically ill patients (SAPS II ≥65) were selected (02-05/2007, 09-11/2008). Their course of disease was studied daily. After collecting this data the cohort was genotyped concerning a mutation in Chit 1-gene and divided into carriers and non-carriers of this inactivating polymorphism. Primary endpoint was the course of disease and its severity measured by validated scores (SAPS II, SOFA, TISS-28). Secondary infections and correlation with causative organisms were inspected. This study was approved by the Ethical Committee of Charité - University Medicine Berlin with study EA1/117/06. A vote of data privacy protection has been issued. Results: 129 non-carriers and 71 hetero-/homozygote carriers of a Chit 1-polymorphism were accepted. Basic characteristics and comorbidities were distributed homogeneously. On the day of admission no significant difference between groups was seen concerning SAPS II1-values [median 53 vs. 55, p = 0,178], but SOFA1 [median 8 vs. 7, p = 0,004] and TISS-281 [median 44 vs. 38, p = 0,008] showed significantly lower values for carriers of the Polymorphism. In contrast during ICU-stay SAPS II, SOFA and TISS-28 showed a significant difference concerning the severity of disease [p = 0,04749, p = 0,01361, p = 0,04889]: while in non-carriers severity of disease gradually decreased, this stayed on high levels in carriers of the polymorphism. Incidence and dynamics of SIRS and sepsis, duration of stay and mortality showed no significant difference. Concerning susceptibility for gram-negative organisms a tendency to be at risk was seen for carriers of the mutation. Conclusion: The results of this trial showed a significant difference concerning severity of disease during ICU-stay with a disadvantage for carriers of the Chit 1-polymorphism. No statistically significant difference could be proved concerning basic characteristics, infections, causative organisms, incidence and dynamics of SIRS or sepsis, duration of stay and mortality. In short: in this trial a polymorphism of Chit 1 did influence the severity of disease but not the course of stay. A causative relation could not be detected. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: Chitotriosidase 1; polymorphism; outcome; intensive care; anesthesiological Intensive Care Units; severity of disease; sepsis; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heim, S. (2015). Survey on the relevance of a mutation of Chitotriosidase 1 concerning the outcome of patients that are in intensive care. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7548

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Heim, Susanne. “Survey on the relevance of a mutation of Chitotriosidase 1 concerning the outcome of patients that are in intensive care.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-7548.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Heim, Susanne. “Survey on the relevance of a mutation of Chitotriosidase 1 concerning the outcome of patients that are in intensive care.” 2015. Web. 20 Nov 2019.

Vancouver:

Heim S. Survey on the relevance of a mutation of Chitotriosidase 1 concerning the outcome of patients that are in intensive care. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-7548.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Heim S. Survey on the relevance of a mutation of Chitotriosidase 1 concerning the outcome of patients that are in intensive care. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-7548

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

6. Züllich, Dan. Patient satisfaction and migration background.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-13527

► Background The public health-related, socio-economic and epidemiological implications of patient satisfaction and migration in the public health and health related jobs are increasingly recognized. Data… (more)

▼ Background The public health-related, socio-economic and epidemiological implications of patient satisfaction and migration in the public health and health related jobs are increasingly recognized. Data on health-related issues in children and adolescents with a migration background are yet scarce but needed for future public health planning and improvement. For further investigation on this subject we examined the association of migration background and patient satisfaction. Aim This study examines patient satisfaction and migration background and influencing factors in patients and their families treated in a paediatric clinic in Berlin to identify and study influencing variables. We were investigating among others the question, if patients and families with a migration background were less satisfied with the treatment. Methods We conducted a cross sectional study of 348 families in the Paediatric Nephrology Outpatient Department at the Charité University Children’s Hospital in Berlin. Parents answered a questionnaire containing basic socio-demographic information, a subjective categorical rating of disease severity and of communication with the medical team, and a validated patient satisfaction score. Results A migration background was present in 131 patients (38%). These families were of 20 different nationalities and spoke a total of 22 different native languages. Families came mainly coming from Turkey, the former Yugoslavia, Russia, Poland, Vietnam, Iraq, and the Lebanon. A total of 50% of migrant families had at least one parent with current unemployment, whereas the rate in non-migrant families was 22%. Patient satisfaction (on a scale from 8-40) was significantly higher in families without (32.9 + 4.6) than in those with a migration background (30.8 + 4.7; p<0.0001). In a multivariate linear regression analysis, patient satisfaction showed significant independent correlations with “trust in the doctor”, “friendliness of the doctor”, “severity of the child’s disease”, “number of medications prescribed” and “migration background”. Conclusions The Assessment of patient satisfaction is increasingly recognized as an important tool in medical decision making and may contribute to better care of chronically ill children and their families. A migration background is present in more than a third of families in our paediatric outpatient population. Migrant families were less satisfied with the provision of our outpatient care than non- migrants. Variables that showed significant independent correlations for patient satisfaction were trust in the doctor, friendliness of the doctor, severity of the child’s disease, number of medications prescribed. Further studies, planning and focus is needed to improve communication, patient satisfaction and outcome between medical staff and migrant families in the German health system. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: migration background; children; parents; patient satisfaction; health-care; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Züllich, D. (2015). Patient satisfaction and migration background. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13527

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Züllich, Dan. “Patient satisfaction and migration background.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-13527.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Züllich, Dan. “Patient satisfaction and migration background.” 2015. Web. 20 Nov 2019.

Vancouver:

Züllich D. Patient satisfaction and migration background. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-13527.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Züllich D. Patient satisfaction and migration background. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-13527

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

7. Grotjohann, Sarah. Influence of pelvic tilt on functional acetabular orientation.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/10800

► Introduction Pelvic tilt influences acetabular orientation (AO). Anteversion (AA) and inclination (AI) define anatomical acetabular orientation. Pelvic tilt determines functional acetabular orientation because of its… (more)

▼ Introduction Pelvic tilt influences acetabular orientation (AO). Anteversion (AA) and inclination (AI) define anatomical acetabular orientation. Pelvic tilt determines functional acetabular orientation because of its spatial relocation. Anterior pelvic plane is used for calculation of anatomical AO, whereas functional AO is defined by the table plane of operating table or medical imaging. The following analysis shows, if there is an influence of pelvic tilt on functional AO. Secondary was verified, if anteversion and inclination give equivalent information for correct AO. Material and methods Computed tomography – based three dimensional reconstruction of bony pelvic structures provided the basis of the following analysis. 138 pelvises were determined with the patients supine. APP was distinguished by the most ventral points of the right and left Spina iliaca anterior superior and both pubic tubercles, while the angle between APP and coronal plane defined pelvic tilt. Results Pelvic tilt supine amounted to -0,1°±5,5°. 79% of the collective showed a physiological pelvic tilt. AA amounted to 18,3°±4,5° relative to APP and 18,5°±4,6° relative to table plane. AI was 46,9°±3,7° for both reference planes. AA and pelvic tilt correlated positive relative to APP (all: p < 0, 01, r = 0,497, R2 = 0,320) and negative relative to table plane (all: p < 0, 01, r = -0,366, R2 = 0,117). 29 persons showed increased posterior or anterior pelvic tilt of -10,3°±4,5° respectively 8,5°±1,8°. These individuals showed a difference of AA between both reference planes. AA differed from 8,3°±3,1° (females) and 7,7°±3,6° (males) with extensive posterior tilt and from 6,2°±1,0° (females) and 5,4°±2,0° (males) with extensive anterior tilt. AI showed less marked differences of 2,2°±0,8° for extensive pelvic tilt. Discussion Pelvic tilt compensated for increased AO. Individuals with high anatomical AA showed high pelvic tilt, which reduced functional AA. Conversely individuals with low anatomical AA had low pelvic tilt and therefore enlarged functional AA. Pelvic tilt is considered by APP, but it is not by table plane. Hence in individuals with physiological pelvic tilt both reference planes can be used for correct AO. By contrast table plane is no reliable reference plane for correct anatomical AO in individuals with extensive pelvic tilt. Conclusion Anatomical anteversion influences pelvic tilt. Pelvic tilt has a compensating influence on functional acetabular orientation. In conclusion results of this study serve to further understand the functional anatomy of the acetabulum and demonstrate the importance of pelvic tilt for correct AO. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: pelvic tilt; acetabular orientation; anteversion; inclination (abduction); reference plane; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Grotjohann, S. (2017). Influence of pelvic tilt on functional acetabular orientation. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/10800

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grotjohann, Sarah. “Influence of pelvic tilt on functional acetabular orientation.” 2017. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/10800.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grotjohann, Sarah. “Influence of pelvic tilt on functional acetabular orientation.” 2017. Web. 20 Nov 2019.

Vancouver:

Grotjohann S. Influence of pelvic tilt on functional acetabular orientation. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/10800.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grotjohann S. Influence of pelvic tilt on functional acetabular orientation. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/10800

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

8. Danyel, Leon Alexander. In vitro screening for intrinsic activity of potential AT2R–agonists in differentiated THP-1-macrophages.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8637

► Accumulating evidence suggests tissue-protective properties of pharmacological AT2R-stimulation in various animal models of cerebral and cerebrovascular disease. Further investigation of the neuroprotective properties of pharmacological… (more)

▼ Accumulating evidence suggests tissue-protective properties of pharmacological AT2R-stimulation in various animal models of cerebral and cerebrovascular disease. Further investigation of the neuroprotective properties of pharmacological AT2R-stimulation is hindered, because common AT2R-agonists like CGP42112 and the non-peptide agonist Compound 21 cannot penetrate the blood-brain barrier. Therefore, a new generation of blood-brain barrier- penetrating AT2R-agonists is being developed. New substances, designed through chemical alteration of established molecules, need to be reevaluated for AT2R–affinity and intrinsic activity. Common assays available, e. g. the Neurite-Outgrowth-assay are considered to be unreliable on the grounds of subjective analysis and imprecise quantification of results. Therefore, this project aimed at establishing a reliable and robust in vitro screening of potential AT2R–agonists for intrinsic activity at the AT2R based on determining interleukin 6 (IL-6) mRNA expression in THP-1-macrophages. AT2R- protein expression in THP-1-monocytes was compared with AT2R-protein expression in PMA-differentiated THP-1-macrophages using Western-Blot analysis. Effects of LPS- (50 ng/ml) and Compound 21- (1 µM) incubation on AT2R-protein-expression in THP-1-macrophages were evaluated. THP-1-macrophages were incubated with LPS (50 ng/ml), co-treated with the novel agents JS5090, L162-389 and VR0008 (1 µM each) for 6 hours and IL-6-mRNA expression determined by qPCR. AT2R-agonist Compound 21 was used for reference. AT2R- agonism was postulated if the substance in question attenuated the increase of LPS-induced IL-6-mRNA expression. The AT2R -antagonist PD123319 (10 µM) was used to confirm AT2R -specificity of observed effects. PMA-induced differentiation of THP-1 monocytes to macrophages increased expression of the AT2R-receptor-protein tenfold in Western Blot analysis (single experiment, p = 0,0002). Incubation with LPS and Compound 21 each significantly decreased AT2R-receptor-protein-expression (single experiment, p = 0,0001 and p = 0,0008 respectively). Treatment of THP-1 macrophages with JS5090, L162-389, VR0008, or Compound 21 did not result in consistent, significant effects on LPS- induced IL-6-mRNA-expression. JS5090, L162-389 and VR0008 could not be verified as AT2R-receptor agonists. Since the established AT2R-Agonist Compound 21 also did not elicit consistent effects on LPS-induced IL-6-mRNA- expression in our assay, we conclude that the tested assay was of limited validity probably due to unpredictable effects of PMA-induced differentiation and LPS-incubation of THP-1-macrophages. Future protocols should be optimized to achieve controlled and inter-experimentally consistent PMA-induced differentiation of THP-1-monocytes. In conclusion, the current IL-6-THP-1-assay has to be regarded as not suitable for the screening of potential AT2R-receptor agonists. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: Angiotensin II Type 2 receptor; THP-1; Angiotensin II; Compound 21; PD123319; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Danyel, L. A. (2018). In vitro screening for intrinsic activity of potential AT2R–agonists in differentiated THP-1-macrophages. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8637

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Danyel, Leon Alexander. “In vitro screening for intrinsic activity of potential AT2R–agonists in differentiated THP-1-macrophages.” 2018. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-8637.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Danyel, Leon Alexander. “In vitro screening for intrinsic activity of potential AT2R–agonists in differentiated THP-1-macrophages.” 2018. Web. 20 Nov 2019.

Vancouver:

Danyel LA. In vitro screening for intrinsic activity of potential AT2R–agonists in differentiated THP-1-macrophages. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-8637.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Danyel LA. In vitro screening for intrinsic activity of potential AT2R–agonists in differentiated THP-1-macrophages. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-8637

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

9. Budnick, Andrea. Health promotion for older family caregivers with special consideration of the problem of low uptake of health-promotion measures such as moderate physical activity.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8356

► Background: Due to an increasing number of (elderly) family caregivers and various burdens related to home care, this target group is predestined for health promotion… (more)

▼ Background: Due to an increasing number of (elderly) family caregivers and various burdens related to home care, this target group is predestined for health promotion such as moderate physical activity. Despite a strong need for health promotion in general, elderly caregivers are rarely reached by activity offers. This might be explained by shortcomings in existing offers such as a lack of need orientation. The aim of this cumulative doctoral thesis was to contribute to health promotion for elderly family caregivers (50 years and older) in Germany and to explore the set of problems of disuse of moderate activity offers (exercise and/or relaxation). Methods: For this purpose an assessment-instrument (ARR) was developed (Publication1) and validated (Publication 2). The ARR encompasses physical and psychological resources and risks of elderly family caregivers. Based on results of the ARR need-oriented activity offers (exercise and/or relaxation) were provided. The utilization of these activity offers was low, however, semi-standardized interviews were conducted with caregivers to analyze reasons (Publication 3). Moreover, new scales were developed and validated to assess the perceived benefits of and barriers to moderate physical activity. Stages of change for activity were assessed to analyze different levels of motivation to activity (Publication 4). Results: Factorial validity for the ARR was confirmed. Psychometric qualities allow the conclusion that the ARR is a reliable and valid instrument (N = 202). Personal perceptions more than external circumstances inhibited the use of activity offers. Moreover, the majority of caregivers had either no intention to become active (precontemplation stage: 42.7 %) or had been exercising regularly for more than six months (maintenance stage: 43.7 %). While both perceived benefits and barriers were significantly related to stages of change for activity, perceived benefits showed a stronger positive relationship. Conclusion: Thus, interventions to promote moderate physical activity for elderly family caregivers should provide individual and need- oriented activity offers. Moreover, those interventions should consider strategies that maximize the perceived benefits of activity rather than refuting the barriers. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: health promotion; family caregiver; assessment; physical activity; benefits; barriers; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Budnick, A. (2014). Health promotion for older family caregivers with special consideration of the problem of low uptake of health-promotion measures such as moderate physical activity. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Budnick, Andrea. “Health promotion for older family caregivers with special consideration of the problem of low uptake of health-promotion measures such as moderate physical activity.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-8356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Budnick, Andrea. “Health promotion for older family caregivers with special consideration of the problem of low uptake of health-promotion measures such as moderate physical activity.” 2014. Web. 20 Nov 2019.

Vancouver:

Budnick A. Health promotion for older family caregivers with special consideration of the problem of low uptake of health-promotion measures such as moderate physical activity. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-8356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Budnick A. Health promotion for older family caregivers with special consideration of the problem of low uptake of health-promotion measures such as moderate physical activity. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-8356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

10. Schubert, Anne. analysis of maximum load capability, margin integrity and physical properties.

Degree: 2016, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11472

► Objectives: The aim was to investigate the performance of an experimental self-adhesive resin cement used as a post and core build-up material in comparison to… (more)

▼ Objectives: The aim was to investigate the performance of an experimental self-adhesive resin cement used as a post and core build-up material in comparison to two commercially available core build-up materials. Materials and methods: 40 human maxillary incisors were endodontically treated and prepared for post insertion (RelyX Fiber post). Post and core build-ups were performed using one of the four investigated materials: two build-up composites based on an etch-and-rinse adhesive approach (LuxaCore Dual – LC und Clearfil Core – CC) and one self-adhesive resin cement in two application modes (Handmix and Automix). The samples were subjected to thermo-mechanical loading (TML). Maximum load capability (Fmax) was tested in a universal testing machine. Margin integrity was evaluated using Scanning Electron Microscopy. Physical properties were additionally examined. Results: Fmax was significantly affected by the core build-up material (p<0.0005; 1-way ANOVA). CC [481 (158) N] achieved higher Fmax than LC [226 (80) N], Handmix [205 (115) N] and Automix [197 (134) N] (p<0.05; Tukey-B). The percentage of perfect continuous margin in enamel after TML differed significantly among the groups (p<0.0005; Kruskal Wallis). CC gained significantly higher percentages of perfect margin compared to the other groups. Physical properties were significantly affected by the build-up material (p<0.0005; ANOVA). CC and LC demonstrated higher flexural strength in comparison to the self-adhesive groups (p<0.05; Scheffé). Water sorption was significantly higher in the self-adhesive groups (p<0.05; Scheffé). Conclusion: Within the limitations of the present in vitro study it can be concluded that the investigated self- adhesive resin cement is not suitable as a core build-up material due to its low maximum load capability, low margin integrity and weak mechanical properties. Clinical relevance: The investigated self-adhesive resin cement cannot be recommended as a core build-up material. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: post and core build-up; self-adhesive resin cement; margin integrity; maximum load capability; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schubert, A. (2016). analysis of maximum load capability, margin integrity and physical properties. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11472

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schubert, Anne. “analysis of maximum load capability, margin integrity and physical properties.” 2016. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/11472.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schubert, Anne. “analysis of maximum load capability, margin integrity and physical properties.” 2016. Web. 20 Nov 2019.

Vancouver:

Schubert A. analysis of maximum load capability, margin integrity and physical properties. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/11472.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schubert A. analysis of maximum load capability, margin integrity and physical properties. [Thesis]. Freie Universität Berlin; 2016. Available from: https://refubium.fu-berlin.de/handle/fub188/11472

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

11. Arias, Aimara. The influence of the proteasome inhibitor bortezomib on atherosclerosis in the LDL receptor-deficient mouse.

Degree: 2017, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4932

► Atherosclerosis is a progressing inflammatory disease of the large blood vessels that causes accumulation of lipids, generation of a fibrous tissue and calcifications narrowing the… (more)

Subjects/Keywords: bortezomib; proteasome inhibitor; proteasome inhibition; atherosclerosis; LDL receptor-deficient mouse; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arias, A. (2017). The influence of the proteasome inhibitor bortezomib on atherosclerosis in the LDL receptor-deficient mouse. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4932

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arias, Aimara. “The influence of the proteasome inhibitor bortezomib on atherosclerosis in the LDL receptor-deficient mouse.” 2017. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-4932.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arias, Aimara. “The influence of the proteasome inhibitor bortezomib on atherosclerosis in the LDL receptor-deficient mouse.” 2017. Web. 20 Nov 2019.

Vancouver:

Arias A. The influence of the proteasome inhibitor bortezomib on atherosclerosis in the LDL receptor-deficient mouse. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-4932.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arias A. The influence of the proteasome inhibitor bortezomib on atherosclerosis in the LDL receptor-deficient mouse. [Thesis]. Freie Universität Berlin; 2017. Available from: http://dx.doi.org/10.17169/refubium-4932

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

12. Zech, Annegret. Influence of the adjustability of opening pressure on the outcome after shunttherapy of hydrocephalus with the hydrostatic gravitation-assisted proGAV.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5138

► Background: Modern valves for the shunt-therapy of hydrocephalus reduce the risk of overdrainage but increase the risk of underdrainage. The valve system proGAV combines a… (more)

▼ Background: Modern valves for the shunt-therapy of hydrocephalus reduce the risk of overdrainage but increase the risk of underdrainage. The valve system proGAV combines a gravitational unit with an adjustable differential pressure valve for a non-invasive regulation of the opening pressure. We evaluated if over- or underdrainage can effectively be regulated by means of a proGAV adjustment. Material and methods: We analysed the data of 114 consecutive patients (63.2% male, 36.8% female) aged between 15 and 93 years (55.9 ± 17.5 years) who underwent the implantation of a shunt with proGAV because of different etiologies: idiopathic normal pressure hydrocephalus (INPH, 35.1%), posthemorrhagic hydrocephalus (postHHC, 28.1%), hypertensive/pediatric hydrocephalus (HHC, 21.1%), secondary normal pressure hydrocephalus (SNPH, 10.5%), and pseudotumour cerebri (PTC, 5.3%). 22 patients (27.1%) had been revised after complications following the implantatation of a conventional valve system. The follow-up was 30.8 ± 11.5 months. Results: For the majority of patients we initially chose an opening pressure of 5 cmH2O at the programmable unit except for the patients suffering from pseudotumour cerebri with an initial opening pressure up to 14 cmH2O. The initial opening pressure could be maintained in 53.5% of all patients during the entire observational period. In the remaining 46.5% the opening pressure was adjusted once to three times due to a primary overdrainage (11.4%) or underdrainage (35.1%). Despite of cautious adjustment settings some secondary underdrainages (n = 5) or overdrainages (n = 6) occured. All of them could be intercepted by repeated adjustments. The need for a consecutive adjustment of opening pressure was independent from patient parameters like height and weight and largely also from the hydrocephalus etiology. Radiologically 42.6% of patients showed no regression of their extended ventricles. However, the clinical results were excellent or good in 73.6% of patients, and only in 4.4% they were bad. There was no correlation between the clinical and the radiological results neither for the entire group nor for the subgroups of different hydrocephalus types. Conclusions: Similar to other valve systems the use of a proGAV valve may result in an overdrainage or functional underdrainage. These shunt complications are easy to treat by simple epicutaneous adjustments without the previously required revision surgery, particularly in overdrainages which are more dangerous as compared to underdrainage. The valve adjustment may result in a secondary under-/overdrainage, therefore in the majority of cases the opening pressure should be regulated in small steps. Because of the frequent gap between clinical and radiological results and because of the small sample sizes of subgroups we cannot conclude which patients will benefit most of this adjustable hydrostatic valve. Prospective randomized multicenter studies with large numbers of cases are meaningful and necessary. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: proGAV; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zech, A. (2014). Influence of the adjustability of opening pressure on the outcome after shunttherapy of hydrocephalus with the hydrostatic gravitation-assisted proGAV. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5138

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zech, Annegret. “Influence of the adjustability of opening pressure on the outcome after shunttherapy of hydrocephalus with the hydrostatic gravitation-assisted proGAV.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-5138.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zech, Annegret. “Influence of the adjustability of opening pressure on the outcome after shunttherapy of hydrocephalus with the hydrostatic gravitation-assisted proGAV.” 2014. Web. 20 Nov 2019.

Vancouver:

Zech A. Influence of the adjustability of opening pressure on the outcome after shunttherapy of hydrocephalus with the hydrostatic gravitation-assisted proGAV. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-5138.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zech A. Influence of the adjustability of opening pressure on the outcome after shunttherapy of hydrocephalus with the hydrostatic gravitation-assisted proGAV. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-5138

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

13. Friedrich, Stefanie. Detection of malperfusion in the hands of patients with systemic sclerosis using fluorescenceoptical imaging.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-699

► Introduction: Fluorescence optical imaging (FOI) has been used in the detection of inflamed joints in different arthritides. Due to an increase in perfusion a higher… (more)

Subjects/Keywords: systemic sclerosis; fluorescence optical imaging; digital ulcer; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Friedrich, S. (2018). Detection of malperfusion in the hands of patients with systemic sclerosis using fluorescenceoptical imaging. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-699

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Friedrich, Stefanie. “Detection of malperfusion in the hands of patients with systemic sclerosis using fluorescenceoptical imaging.” 2018. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-699.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Friedrich, Stefanie. “Detection of malperfusion in the hands of patients with systemic sclerosis using fluorescenceoptical imaging.” 2018. Web. 20 Nov 2019.

Vancouver:

Friedrich S. Detection of malperfusion in the hands of patients with systemic sclerosis using fluorescenceoptical imaging. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-699.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Friedrich S. Detection of malperfusion in the hands of patients with systemic sclerosis using fluorescenceoptical imaging. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-699

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

14. Stenzel, Fabian. Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography.

Degree: 2015, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12868

► Coronary artery disease (CAD) with its manifestations chronic ischemic heart disease and acute myocardial infarction was the leading cause of death in Germany in the… (more)

▼ Coronary artery disease (CAD) with its manifestations chronic ischemic heart disease and acute myocardial infarction was the leading cause of death in Germany in the year 2012 with 14.2% of all deaths. Invasive conventional coronary angiography (CCA) serves as the reference standard in the detection of coronary artery stenosis and in-stent restenosis (ISR). Noninvasive coronary angiography using multislice computed tomography (CTA) is a promising tool for patients with a low-to-intermediate likelihood for CAD due to its low risk of complications and high sensitivity and specificity in the detection of CAD. The aim of this work was to investigate 1. the diagnostic accuracy of the combination of myocardial perfusion imaging (CTP) and CTA compared to CTA alone for the assessment of coronary artery stents, 2. the time efficiency and agreement of perfusion parameters of two different myocardial perfusion software releases and 3. the image quality using two different bolus tracking methods for CTA image acquisition. The combination of CTA and CTP compared to CTA alone achieved a higher diagnostic accuracy in the detection of ISR on the patient level (87% vs. 71%, p < 0.001) and on the stent level (89% vs. 76%, p < 0.001; publication 1). The number of non-diagnostic stents was significantly reduced using the additional CTP information (p < 0.001). The evaluation of the two software releases for CTP analysis showed that with the new software version significantly less analysis time is required compared to the previous software version (p < 0.001). The diagnostic accuracy was not significantly different between the two software versions (publication 2; p = 0.169). In the analysis of two different bolus tracking methods for the initiation of CTA (publication 3) both a manual and a fixed threshold bolus tracking method achieved a reliable image quality. The evaluation of the image quality of the coronary arteries showed no significant differences between the two groups (p > 0.41). The present work confirms that the non-invasive coronary angiography using CT is a constantly developing and promising tool and - under certain conditions - an alternative to CCA in the diagnosis of CAD. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: computed tomography; coronary angiography; contrast media; bolus tracking; myocardial perfusion imaging; stents; coronary vessel; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Stenzel, F. (2015). Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stenzel, Fabian. “Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/12868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stenzel, Fabian. “Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography.” 2015. Web. 20 Nov 2019.

Vancouver:

Stenzel F. Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/12868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stenzel F. Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography. [Thesis]. Freie Universität Berlin; 2015. Available from: https://refubium.fu-berlin.de/handle/fub188/12868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

15. Kim, Damon. Magnetic resonance imaging features of fibrous dysplasia.

Degree: 2017, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9278

► Fibrous dysplasia (FD) is one of the most common benign tumor-like conditions of the bone. Little is known about its appearance in magnetic resonance imaging… (more)

▼ Fibrous dysplasia (FD) is one of the most common benign tumor-like conditions of the bone. Little is known about its appearance in magnetic resonance imaging (MRI). The purpose of this study was to describe the morphology of FD in MRI and to examine morphologic characteristics in MRI for differential diagnosis. 43 FD-, 10 meningioma- and 2 patients with Paget's disease were included retrospectively. Detectability of craniofacial FD (CFD) in MRI compared to CT was evaluated by means of 10 CFD, meningioma and normal bone examinations. In MRI and CT size, margin, transition zone of the lesion and local changes of bone were evaluated. Internal structure and signal change in T1w and T2w before and after contrast medium application were evaluated. Whole lesion and the ground-glass area in particular were analyzed. 43 patients with 56 lesions were included. In MRI both bone broadening and cortical thinning could be seen in >90 %, and cyst-like changes in 41 %. Evaluated parameters in CT and MRI showed slight to good consistency in Cohen's Kappa. FD was iso- hypointense in T1w (91 %) and hyperintense in T2w (79 %). Ground-glass areas showed a more homogeneous internal structure compared to the entire lesion (100 % vs. 50 % in T1w, 89 % vs. 41 % in T2w). In differentiating CFD from meningioma, hyperintensity in T2w was associated with 78 % sensitivity and 44 % specificity. For CFD, unilateral localisation, bone broadening, cortical thinning, absence of soft tissue changes and cyst-like changes were sensitive parameters, absence of soft tissue component and presence of cyst-like changes were specific parameters. In CT, ground-glass phenomenon showed 97 % sensitivity and 90 % specificity. Logistic regression analysis resulted in a significantly increased odds ratio for CFD vs. meningioma in expansile bony lesion in CT, ground-glass phenomenon in CT, absence of soft tissue changes, osseous MRI contrast enhancement and lower age. Patients with meningioma were significantly older than CFD patients. MRI is capable of reliably detecting CFD lesions compared to CT. As known from histological studies, MRI showed heterogeneous appearance of FD lesions and was highly consistent with CT for visualizing changes of bone and adjacent tissue. Ground-glass areas showed more homogeneous appearance in MRI but signal change was only unspecific. Taking into account clinical presentation, age, localization and local morphologic characteristics, FD can be diagnosed with a high probability and well differentiated from Paget's disease and intraosseous meningioma. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: fibrous dysplasia; MR imaging; ground-glass phenomenon; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, D. (2017). Magnetic resonance imaging features of fibrous dysplasia. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9278

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kim, Damon. “Magnetic resonance imaging features of fibrous dysplasia.” 2017. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-9278.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kim, Damon. “Magnetic resonance imaging features of fibrous dysplasia.” 2017. Web. 20 Nov 2019.

Vancouver:

Kim D. Magnetic resonance imaging features of fibrous dysplasia. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-9278.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim D. Magnetic resonance imaging features of fibrous dysplasia. [Thesis]. Freie Universität Berlin; 2017. Available from: http://dx.doi.org/10.17169/refubium-9278

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

16. Fürschke, Verona Siglinde. Endobronchial brachytherapy utilising high dose rate IR- 192 afterloading technique in the treatment of lung cancer.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/10931

► Introduction: Lung cancer has been the most common cause of death due to cancer among men with a quota of 24,9 % whereas it has… (more)

▼ Introduction: Lung cancer has been the most common cause of death due to cancer among men with a quota of 24,9 % whereas it has been the second frequent cause of death among women with 13,6 %. Despite latest treatment methods the five-year survival rate remains poor with 16 percent for men and 21 percent for women. The indication for therapeutic use of high- dose- rate Iridium 192 brachytherapy for patients is a central, endobronchial tumor growth into the trachea, main bronchi or lobar bronchi. The aim is to treat effectively post stenotic pneumonia and atelectasis and the symptoms dyspnea, coughing and bleeding. Methods: In this thesis 4005 patients with lung cancer are included, who have been reported during 1995 to 2006 in the Tumorzentrum Potsdam e.V. This work compares those 3658 patiens who were not treated with a HDR - brachytherapy with 347 patients, who received treatment by endobronchial HDR – brachytherapy. The data has been analyzed especially regarding gender, age, performance level, tumor localization, tumor stage and histology. In addition we examined the survival rates of patient groups. Results: Applied to the UICC-stages, the groups divides without / with endobronchial therapy in stage III in 30 / 44 % while in stage IV in 45 / 36 %. Concerning the histological result, the quota of squamous cell carcinoma has been 29 % within the group of patients without brachytherapy and 53 % for the group of patients with HDR-brachytherapy. The five-year survival rate without brachytherapy was 11,7 % and for those patients treated with endobronchial brachytherapy 3,7 %. All patients of both groups have been treated multimodal by individual therapy plans depending on the extension of the disease and additional illnesses. Of our 365 patients with endobronchial brachytherapy, 45 died due to hemoptysis, which is 13 %. Conclusion: The endobronchial HDR-brachytherapy eases effectively and rapidly symptoms of patients with central endobronchial tumor growth due to its small volume radiation dose on functional critical bronchial segments. It is an established treatment, viable without complications worth mentioning and should receive more propagation in the daily routine. Advisors/Committee Members: w (gender), N. N. (inspector), N. N. (firstReferee).

Subjects/Keywords: endobronchial brachytherapy; lung cancer; high dose rate IR-192; afterloading; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fürschke, V. S. (2017). Endobronchial brachytherapy utilising high dose rate IR- 192 afterloading technique in the treatment of lung cancer. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/10931

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fürschke, Verona Siglinde. “Endobronchial brachytherapy utilising high dose rate IR- 192 afterloading technique in the treatment of lung cancer.” 2017. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/10931.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fürschke, Verona Siglinde. “Endobronchial brachytherapy utilising high dose rate IR- 192 afterloading technique in the treatment of lung cancer.” 2017. Web. 20 Nov 2019.

Vancouver:

Fürschke VS. Endobronchial brachytherapy utilising high dose rate IR- 192 afterloading technique in the treatment of lung cancer. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/10931.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fürschke VS. Endobronchial brachytherapy utilising high dose rate IR- 192 afterloading technique in the treatment of lung cancer. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/10931

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

17. Barth-Zoubairi, Anke. The impact of social support on depression and hospital length of stay (LOS) of surgical patients.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12001

► Background: The impact of social support on hospital length of stay (LOS) of surgical patients has so far mainly been studied in the fields of… (more)

▼ Background: The impact of social support on hospital length of stay (LOS) of surgical patients has so far mainly been studied in the fields of cardiac operation or organ transplantation or utilising rather small sample groups. The acknowledgement of depression as an additional factor is rare. The present study investigates the relationships between social support, clinically significant depression and LOS of surgical patients. Sociodemographic and somatic parameters will be additionally considered in this analysis. Method: This prospective observational study took place in the context of the BRIA project (Bridging Intervention in Anaesthesiology) in the Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité–Universitätsmedizin, Berlin, Germany. A sample of 2704 patients completed before the preoperative anesthesiological examination a computerized life style screening including questionnaires assessing social support and depression. The scales ‘perceived social support’, ‘support seeking’ and ‘need for support’ of the Berlin Social Support Scales (BSSS) were used as well as the scale for Depression of the Hospital Anxiety and Depression Scale (HADS-D). Statistical analyses were performed via descriptive statistics, correlation analysis, group comparison and binary logistic regression analysis. Results: The majority of patients considered themselves to be well socially supported. Patients with clinically significant depression showed a significantly lower score concerning perceived social support (p<0.001) and support seeking (p<0.001) than patients without depression. Perceived social support (OR= 0.153 [95% CI 0.122-0.193], p<0.001) and support seeking (OR= 0.390 [95% CI 0.331-0.460], p<0.001) were significant predictors for clinically relevant depression in binary logistic regression analysis. The following factors were accounted for in the analysis: age, gender, living alone, income, education, employment, preoperative health, severity of physical comorbidities, severity of surgical procedure and surgical area. There was no association between social support and LOS. Patients with clinically significant depression had a significantly longer LOS (M= 4 days, IQR= 2-6) than patients without depression (M= 3 days, IQR= 2-5, p<0.001). In the regression model adjusted for earlier mentioned factors, depression predicts prolonged LOS (OR= 1.497 [95% CI 1.130-1.984], p<0.001). Conclusion: Social support has no direct impact on the LOS of surgical patients. However, results indicate an indirect association, as social support is significantly associated with depression, and depression has a significant association with LOS. The provision of psychotherapeutic interventions aimed at depression might positively influence LOS. Furthermore, the positive impact of social support could be strengthened and the long term outcome for surgical patients might be improved. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N (furtherReferee).

Subjects/Keywords: social support; depression; hospital length of stay; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barth-Zoubairi, A. (2017). The impact of social support on depression and hospital length of stay (LOS) of surgical patients. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Barth-Zoubairi, Anke. “The impact of social support on depression and hospital length of stay (LOS) of surgical patients.” 2017. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/12001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Barth-Zoubairi, Anke. “The impact of social support on depression and hospital length of stay (LOS) of surgical patients.” 2017. Web. 20 Nov 2019.

Vancouver:

Barth-Zoubairi A. The impact of social support on depression and hospital length of stay (LOS) of surgical patients. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/12001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Barth-Zoubairi A. The impact of social support on depression and hospital length of stay (LOS) of surgical patients. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/12001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

18. Heunisch, Fabian. The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12535

► Introduction: Asymmetric dimethylarginine is a competitive inhibitor of the NO-sythase and an important factor of the regulations of vessels. It is synthesized through posttranslational modification… (more)

▼ Introduction: Asymmetric dimethylarginine is a competitive inhibitor of the NO-sythase and an important factor of the regulations of vessels. It is synthesized through posttranslational modification of proteins and released by proteolyses into circulation. In literature patients with chronic kidney disease or dialysis had higher ADMA levels. Iodonated radiocontrast media can heavily damage the kidney, which can lead to a complete loss of kidney function. Especially patients with predamaged kidneys have a higher risk. Because of the rising usage of radiocontrast media, the importance of identification of biomarkers for the prognosis after application rises as well. The ADMA-NO-System might be taking part in the pathogenesis of a contrast induced nephropathy. So this work examines the behavior and the force of expression of ADMA to renal events. Methods: Therefore 330 patients with preexisting diabetes mellitus or renal impairment, who were undergoing a percutanous coronary angiography, were included and the levels of ADMA, creatinine and cystatin c before and 24 hours after contrast media application were measured. To determine the development creatinine was also measured 48 hours and tree months after the application. At three month follow up data about clinical relevant events were collected, too. Results: As result ADMA rises after contrast media application. But there was no relationship between ADMA and the incidence of an acute renal failure. For longer prognosis ADMA levels before and after contrast media application were predictive for dialysis and major adverse renal events (MARE). Additional patients with MARE had a significant higher increase of the ADMA levels than other patients. Diabetes mellitus, anemia, congestive heart failure and the hydration of patients emerged as important influencing factors in the assessment of ADMA. Conclusion: In conclusion the ADMA-regulation is influenced by contrast media. Patients with poorer prognosis demonstrated a different behavior by a higher increase of ADMA. For the short term outcome ADMA seems to be less relevant. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: ADMA; Asymmetric dimethylarginine; radiocontrast exposure; renal outcome; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heunisch, F. (2014). The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12535

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Heunisch, Fabian. “The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/12535.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Heunisch, Fabian. “The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study.” 2014. Web. 20 Nov 2019.

Vancouver:

Heunisch F. The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/12535.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Heunisch F. The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/12535

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

19. Konietzny, Matthias Reiner. histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL).

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9652

► Recent studies on prenatal bone formation and bone development around the developing teeth are lacking. While molecular mechanisms underlying the tooth- bone-interface have been examined,… (more)

▼ Recent studies on prenatal bone formation and bone development around the developing teeth are lacking. While molecular mechanisms underlying the tooth- bone-interface have been examined, morphological contexts were given little attention. This study closely examines such morphologically substantial bone development processes of developing teeth and the neighboring bone in the fetal maxilla applying for the first time computer-based and three-dimensional methods. Our main focus lies on bone development processes and the formation of peridental and interdental bone around the developing teeth of fetuses in the bell stage (CRL 160-270 mm, approx. 18-28 WG). Five series of histological sections were microscopically examined; three were reconstructed in 3D using AnalySIS® 3D to illustrate different developmental stages of 160 mm CRL, 225 mm CRL and 270 mm CRL. We aimed at determining the histo-morphological conditions of bone development processes (apposition zones, resorption zones, and inactive zones). Distances from the dental follicles of the developing teeth to the surrounding bone in mesial, distal, palatal, and vestibular directions were measured. Possible interactions or regularities within the modifying process regarding the development of single teeth and their distance to the surrounding bone were investigated. We for the first time confirm also for the upper jaw that the developing teeth are enclosed by bone in bony crypts; they develop within the latter. The formation of interdental septa and a complete compartmentalization of the single developing teeth remain undone in a mesio-distal direction until a developmental stage of 270 mm CRL (WG 28). The developing primary canine is an exception with its bony septa being formed firstly. The surrounding bone never completely encloses the neighboring developing teeth within the investigation period; the bony septum remains open in a central position. The canine lacks a complete bony margin in a vestibular direction that cannot be counterbalanced until WG 28. Resorption processes dominate around the developing teeth. At the outward side of the bone, bone formation predominates. These processes imply a “centrifugal” bone formation with a concurrent volume increase of the developing teeth. Open questions remain with the distance measurements from the single developing teeth to the neighboring maxillary bone. The measured distances of the middle fetus are often bigger than those of the older fetus. Individual growth spurts and a possible physiological variability of the fetuses cannot be excluded in this study. However, our distance measurement results make it plausible that the distances follow a prospectively developing periodontal space. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: maxilla; crown-rump-length; crl; tooth-bone interface; tooth germ development, 3D-models; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Konietzny, M. R. (2014). histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL). (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9652

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Konietzny, Matthias Reiner. “histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL).” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-9652.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Konietzny, Matthias Reiner. “histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL).” 2014. Web. 20 Nov 2019.

Vancouver:

Konietzny MR. histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL). [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-9652.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Konietzny MR. histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL). [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-9652

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

20. Uhlemann, Ria. Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14068

► Neurodegenerative Pathologien, Alterungsprozesse und Zelltod gehen oft mit einer Dysfunktion des Aktinzytoskeletts einher. Ziel vorliegender Arbeit war es, den Einfluss des Aktinzytoskeletts auf den Prozess… (more)

▼ Neurodegenerative Pathologien, Alterungsprozesse und Zelltod gehen oft mit einer Dysfunktion des Aktinzytoskeletts einher. Ziel vorliegender Arbeit war es, den Einfluss des Aktinzytoskeletts auf den Prozess der Mikrogliaaktivierung näher zu erforschen und zu charakterisieren. Das Modell zur Untersuchung dieser Aktinstabilisierungsprozesse basiert auf der gelsolindefizienten Mauslinie (Gsn-/-) und dem Einsatz pharmazeutischer Interventionen mit Jasplakinolid und Cytochalasin D. Während Jasplakinolid zur Stabilisierung (Polymerisation) des Aktinfilamentes führt, resultieren Interventionen mit Cytochalsin D in einer Destabilisierung (Depolymerisation). Die Arbeit zeigt, dass gezielte Störungen des Auf- und Abbaus von Aktinfilamenten in klassisch aktivierter Mikroglia (mittels LPS) keinen Einfluss auf die Transkription von typischen „M1“ Genen haben. Unterdessen resultierten Eingriffe in die Aktinfilamentstabilität bei alternativer Aktivierung von Mikroglia (mittels IL-4) in einer deutlichen Herabregulierung der Transkriptionsrate typischer „M2“ Gene, was auf einen verminderten Transport des Transkriptionsaktivators pStat6 in den Nukleus zurückzuführen ist. Auf funktionaler Ebene führen Veränderungen der Aktindynamik zu reduzierter Freisetzung von Stickstoffmonoxid, TNF-, IL-6 und IGF-1. Als Grund für die verringerte NO-Sekretion konnte eine reduzierte iNOS- Proteinexpressionsrate im Zytoplasma und eine verminderte Aufnahme von Arginin gezeigt werden. Dagegen ist die LPS-induzierte Freisetzung von IL-1b, das dem „nicht-klassischen“ Freisetzungsmechanismus über Golgi-Apparat und ER folgt, unter Stabilisierung des Aktinzytoskeletts erhöht. Die in vitro Experimente vorliegender Arbeit zeigen, dass Störungen der Aktindynamik zu deutlich herabgesetzter Migration, Proliferation und Phagozytose von Mikrogliazellen führen. Zudem konnte bei der Gsn-/- Mauslinie eine verringerte Proliferationsrate IBA-1-expremierender Zellen nach Hirnischämie und ein verringerter Anstieg an IBA-1+ Zellen im Nucleus facialis nach Axotomie des Nervus facialis festgestellt werden. Desweiteren beweist die Arbeit, dass das intrazelluläre Calciumniveau (Basislinie und ATP-induziert) in Gsn-/- Mikroglia signifikant erhöht ist. Zusammenfassend kann festgehalten werden, dass gezielte Störungen der Aktindynamik sowohl klassische als auch alternative Mikrogliaaktivierungsprozesse abschwächen. Während alternative (IL-4 vermittelte) Mikrogliaaktivierung mit einer deutlichen Herabregulierungen auf Gentranskriptionsebene assoziiert ist, finden die klassischen (LPS vermittelten) Aktivierungsprozesse auf post-transkriptionaler Ebene statt und führen zu Beeinträchtigungen von Substrataufnahme-, Transport- und Freisetzungsmechanismen. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: microglia; polarization; inflammation; gelsolin; actin filament; neurodegeneration; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Uhlemann, R. (2015). Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Uhlemann, Ria. “Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-14068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Uhlemann, Ria. “Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung.” 2015. Web. 20 Nov 2019.

Vancouver:

Uhlemann R. Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-14068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Uhlemann R. Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-14068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

21. Mensah, Martin Atta. Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12184

► Einleitung: An ihren beiden Enden verfügen die menschlichen Geschlechtschromosomen über je einen identischen Sequenzabschnitt. Diese beiden pseudoautosomalen Regionen (PAR) ermöglichen den ansonsten unterschiedlichen Geschlechtschromosomen eine… (more)

▼ Einleitung: An ihren beiden Enden verfügen die menschlichen Geschlechtschromosomen über je einen identischen Sequenzabschnitt. Diese beiden pseudoautosomalen Regionen (PAR) ermöglichen den ansonsten unterschiedlichen Geschlechtschromosomen eine korrekte Paarung und nachfolgende Aufteilung während der Meiose des Mannes. Die Grenze zwischen pseudoautosomaler Region 1 (PAR1) und den spezifischen gonosomalen Sequenzen entstand während der Aufspaltung der Menschenaffen. Nachdem die pseudoautosomale Region an ihrem proximalen Ende Material eingebüßt hatte, gilt sie als fortan stabil. Bei einem Screening auf Kopiezahlpolymorphismen haben wir in 15 voneinander unabhängigen Familien eine Duplikation unmittelbar proximal von PAR1 entdeckt. Obwohl diese Duplikation eine X- spezifische Sequenz beinhaltete, wurde sie ausschließlich von Vater zu Sohn vererbt. Dies ließ vermuten, dass das Duplikon auf dem Y-Chromosom positioniert ist. Handelt es sich bei der Duplikation um eine evolutionär ältere Variante von PAR1 im Sinne einer „Non-Deletion“? Methodik: Um diese Fragestellung anzugehen, wurden folgende Verfahren durchgeführt: aCGH, FISH, PCR mit Gelelektrophorese, BAC- vermittelte gezielte paired-end Hochdurchsatzsequenzierung, Sequenzierung nach Sanger, Einzelmolekülsequenzierung (PacBio) und Y-chromosomale Haplogruppenbestimmung mittels Y-STR Typisierung. Ergebnisse: Diese genomische Analyse zeigte, dass es sich nicht um eine ältere, sondern um eine jüngere bisher unbekannte Variante der PAR1 handelt. Dieser die PAR1 um 105 kbp verlängernde Polymorphismus entstand durch eine nicht-allelische homologe Rekombination zwischen dem X- und dem Y-Chromosom, welche durch den nur 548 bp langen Repeat LTR6B vermittelt wurde. Die Identifikation der reziproken Deletion auf dem X-Chromosom einer Familie und das Vorkommen der Variante in verschiedenen Y-chromosomalen Haplogruppen zeigen, dass es sich dabei um ein wiederkehrendes genomisches Rearrangement in der menschlichen Population handelt. Schlussfolgerung: Es gibt einen Längenpolymorphismus von PAR1 in der menschlichen Population. Pseudoautosomale Regionen verlieren an ihren proximalen Enden nicht nur genetisches Material, sondern können dort auch welches hinzugewinnen. Dieser neue, die gonosomale Evolution gestaltende Mechanismus könnte pseudoautosomale Regionen und folglich auch Y-Chromosomen vor einer voranschreitenden Degradation bewahren. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: sex chromosomes; Y chromosome; X chromosome; pseudoautosomal region; next generation sequencing; XG; GYG2; evolution; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mensah, M. A. (2015). Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12184

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mensah, Martin Atta. “Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-12184.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mensah, Martin Atta. “Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population.” 2015. Web. 20 Nov 2019.

Vancouver:

Mensah MA. Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-12184.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mensah MA. Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-12184

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

22. Brenneis, Cornelia. The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12268

► Background: Although joining patient self-help groups is recommended to patients with ankylosing spondylitis (AS) the evidence for benefits of membership is limited. Objective: To evaluate… (more)

Subjects/Keywords: ankylosing spondylitis; members of the patient organisation; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brenneis, C. (2014). The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12268

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brenneis, Cornelia. “The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/12268.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brenneis, Cornelia. “The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members.” 2014. Web. 20 Nov 2019.

Vancouver:

Brenneis C. The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/12268.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brenneis C. The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/12268

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

23. Gölzenleuchter, Meike. Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5954

► Einleitung: Die dynamischen Eigenschaften des adulten Methyloms wurden kürzlich im zentralen Nervensystem beschrieben. Ob äußere Reize auch die DNA- Methylierungsmuster des peripheren Nervensystems beeinflussen können,… (more)

▼ Einleitung: Die dynamischen Eigenschaften des adulten Methyloms wurden kürzlich im zentralen Nervensystem beschrieben. Ob äußere Reize auch die DNA- Methylierungsmuster des peripheren Nervensystems beeinflussen können, wurde bisher nicht untersucht. Die Hypothese der vorliegenden Arbeit war, dass eine periphere Nervenschädigung Methylierungsveränderungen der DNA im Spinalganglion L5 hervorrufen kann. Dies wurde anhand eines neuropathischen Schmerzmodells nach Spinalnervenligatur (SNL) bei Ratten untersucht. Methodik: Mittels „Reduced representation bisulfite sequencing“ (RRBS) wurden die Methylome von acht Spinalganglien (vier Kontrollen, vier SNL) 24h nach SNL analysiert. RRBS ermöglicht die genomweite Untersuchung von DNA Methylierungen mit einer Auflösungsgenauigkeit einzelner Basenpaare. Dabei wird die DNA zuerst mittels eines Restriktionsenzyms in Fragmente geschnitten, die mindestens 2 Cytosin-phosphat-Guanin-Dinukleotide (CpGs) enthalten. Die nachfolgende Behandlung mit Bisulfit führt zur Desaminierung der unmethylierten Cytosinbasen in Uracilbasen, ohne die anderen Basen zu beeinflussen. Abschließend werden die DNA Fragmente amplifiziert, sequenziert und an das Referenzgenom angeglichen. Ergebnisse: Es zeigten sich weitverbreitete, hoch signifikante (p≤10-4) Cytosin Hyper- und Hypomethylierungen in etwa 1% der durch RRBS erfassten 1.4 Millionen CpGs. Diese wurden unter dem Begriff „Dynamisch differenziell methylierte CpGs“ (dDMCs) zusammengefasst. Die epigenetische Umgestaltung erfolgte größtenteils außerhalb der sogenannten CpG Inseln. 56% der beobachteten Veränderungen befanden sich in Promoter- oder Genregionen, insbesondere in Genen der „axonalen Wegfindung“ (p<10-11). Die vorliegende Arbeit fand keine Korrelation zwischen den Methylierungs-veränderungen und der Variation der Gen Expression und reiht sich damit in die wachsende Zahl von Studien mit genomweiten Analysen ein, die für eine komplexere Interaktion zwischen Methylom und Transkriptom sprechen. Die anderen 44% der dynamisch veränderten CpG Methylierungsmuster befanden sich außerhalb von Genen. Diese intergenischen dDMCs traten in Clustern auf, wobei sich benachbarte dDMCs immer in die gleiche Richtung veränderten. Ihre Positionen wurden mit intergenischen Gewebe-spezifischen differenziell methylierten CpGs (tDMCs) von Leber, Milz, Spinalganglion L4 und Skelettmuskel, verglichen. Bemerkenswert war, dass sich die Positionen der dDMCs mit denjenigen der tDMCs deckten (p<10-15) und fast nie den invarianten Teil des Methyloms betrafen (diejenigen CpGs, die in allen Geweben identisch sind). Das intergenische Methylom lässt sich damit in zwei Teile gliedern: ein invarianter Teil – welcher zwischen unterschiedlichen Geweben und unter verschiedenen Bedingungen unverändert stabil bleibt – und ein plastischer Teil, der auf Umwelteinflüsse wie z.B. die Verletzung des Spinalnervs reagieren kann. Weiterhin wurden die benachbarten hyper- oder hypomethylierten intergenischen dDMCs zu Regionen zusammengefügt und mittels Sequenzanalyse untersucht. Die häufigsten… Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: DNA methylation; dorsal root ganglion; peripheral nervous system; pain; rat;

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gölzenleuchter, M. (2015). Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5954

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gölzenleuchter, Meike. “Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-5954.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gölzenleuchter, Meike. “Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte.” 2015. Web. 20 Nov 2019.

Vancouver:

Gölzenleuchter M. Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-5954.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gölzenleuchter M. Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-5954

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

24. Khalefa, Mohammad. Effects of air-polishing devices with different abrasives on bovine primary and second teeth and deciduous human teeth.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12855

► Air-polishing-devices are used by adults to remove biofilm and discoloration as an efficient alternative to conventional tooth polishing. There is hardly any data for the… (more)

▼ Air-polishing-devices are used by adults to remove biofilm and discoloration as an efficient alternative to conventional tooth polishing. There is hardly any data for the effect of air-polishing-devices on the enamel of the 1st dentition. Therefore the purpose of this in vitro study was to examine, whether air-polishing-devices are suitable for regular teeth cleaning in children and adolescents with teeth of the 1st and 2nd dentition. Crowns from lower incisors of freshly slaughtered animals (calves, cattle) were partially embedded in polyurethane casting resin and polished flat. As a comparison, human primary incisors and second primary molars were also embedded and polished flat. Before and after embedding, the teeth were kept in 0.1% thymol solution. The teeth were then separated according to type and randomly assigned to 22 groups (n=10). With the distribution of the teeth into 22 groups, each tooth type (cattle, calf and human primary) in its corresponding group was treated with a combination of air-polishing-devices (PROPHYflex 3®, Air-Flow® Handy 2+) and Abrasives (Air-Flow® Pulver Classic, ClinProTM Prophy Powder, PROPHYpearls®) or was polished with CCS® 40 or Cleanic® using a brush at low speed; exposure time: 60 seconds, air-polisher nozzle distance 5 ± 0.5 mm, maximum setting. Subsequently, various surface texture parameters (Ra, Rz, Rmax) and the maximum loss of enamel were determined by profilometry (Perthometer PCV). Statistical analysis was performed with Stata/IC 11.2 for Windows. An ANOVA F-test was used to test globally which of the variables had a significant impact on the differences in surface roughness compared to the baseline after air-polishing. Findings were considered statistically significant at p < 0.05. • Enamel, ground smooth and highly polished, was raised by application of polishing pastes (CCS® 40, Cleanic®) as well as air- polishing-devices (Air-Flow® Handy 2+, PROPHYflex® 3). • PROPHYflex 3® produced significantly rougher surfaces than Air-Flow® Handy 2+. • Roughness on permanent bovine teeth after application of air-polishing-devices or polishing pastes was significantly smaller than on calves and primary teeth. There was no significant difference in the roughness between calves and primary teeth. • The roughness produced after the application of Air-Flow® Handy 2+ and PROPHYflex® 3 was significantly greater than with CCS® 40-paste, but comparable with Cleanic®-paste. • Enamel abrasion produced by air- polishing-devices was equivalent or smaller than the effect of Cleanic®-paste. • PROPHYpearls® produced significantly greater roughness and more enamel abrasion than Air-Flow® Pulver Classic and ClinProTM Prophy Powder. Air-Flow® Handy 2+ and PROPHYflex® 3 produced roughness which is not different from the roughness produced by polishing using Cleanic®-paste. Air polishing-devices are suitable every four weeks for routine removal of plaque and discoloration among children with mixed dentition and fixed orthodontic appliances. PROPHYpearls® is too aggressive and should not be used. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: air-polishing devices; bovine primary teeth; deciduous human teeth; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Khalefa, M. (2014). Effects of air-polishing devices with different abrasives on bovine primary and second teeth and deciduous human teeth. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12855

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Khalefa, Mohammad. “Effects of air-polishing devices with different abrasives on bovine primary and second teeth and deciduous human teeth.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-12855.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Khalefa, Mohammad. “Effects of air-polishing devices with different abrasives on bovine primary and second teeth and deciduous human teeth.” 2014. Web. 20 Nov 2019.

Vancouver:

Khalefa M. Effects of air-polishing devices with different abrasives on bovine primary and second teeth and deciduous human teeth. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-12855.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Khalefa M. Effects of air-polishing devices with different abrasives on bovine primary and second teeth and deciduous human teeth. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-12855

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

25. Akdeniz, Sinan. Implikationen für die Pathogenese der progressiven knöchernen Heteroplasie.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4852

► Unsere Untersuchung von ADSCs und ihrer genotyp-spezifischen Fähigkeit zur adipogenetischen Differenzierung hat auf ein gesteigertes adipogenetisches Potential für aus paternalen E2KO-Mäusen stammende ADSCs und ein… (more)

Subjects/Keywords: progressive osseous heteroplasia; adipose-derived stromal cells; Gnas; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Akdeniz, S. (2015). Implikationen für die Pathogenese der progressiven knöchernen Heteroplasie. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4852

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Akdeniz, Sinan. “Implikationen für die Pathogenese der progressiven knöchernen Heteroplasie.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-4852.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Akdeniz, Sinan. “Implikationen für die Pathogenese der progressiven knöchernen Heteroplasie.” 2015. Web. 20 Nov 2019.

Vancouver:

Akdeniz S. Implikationen für die Pathogenese der progressiven knöchernen Heteroplasie. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-4852.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Akdeniz S. Implikationen für die Pathogenese der progressiven knöchernen Heteroplasie. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-4852

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

26. Stoedter, Mette. Regulation of selenoproteins after synthetic selenocompound exposure and during the acute phase inflammatory response.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-7943

► The view on selenium (Se) changed from a toxic substance to an essential trace element with the discovery of the 21st aminoacid selenocysteine (Sec). Se… (more)

▼ The view on selenium (Se) changed from a toxic substance to an essential trace element with the discovery of the 21st aminoacid selenocysteine (Sec). Se exerts its biological function as part of Sec-containing selenoproteins. Sec synthesis is mediated by a complex molecular machinery and depends on an optimal selenium status. Se is essential for cellular functions and energy metabolism, thyroid gland and immune system. Se research gained interest by being linked to several diseases through animal and clinical studies. Se is a supplement in the clinics to support the immune system and replenish loss of Se in critical illness. Still, the function of several selenoproteins and the underlying physiological mechanisms controlling Se metabolism are not completely understood or have not even been explored. The present work includes experimental studies on the role and regulation of Se and selenoproteins in inflammatory diseases. To this end, an endotoxin (LPS)-challenged mouse model with different Se status was analysed, and Se- containing carbamates were characterized in tumor and non-transformed cells. Using LPS-injected mice as sepsis model, our work highlighted a hierarchical distribution of the available Se for the biosyntheses of the selenoproteome. In addition, these regulatory principles acted in a sex-specific way. The secreted SePP proved as stabile Se biomarker in blood. In inflammation, SePP qualified as a hepatic negative acute phase protein whereas SepS was regulated as a positive acute phase protein. SepS is located in the ER membrane and is part of the protein quality control and therefore reduces cellular ER stress. The second part of my work based on the interesting phenomenon that humans in Se deficient areas are diagnosed more often with cancer than others. In fact, several studies indicate an anticarcinogenic effect of Se. The relevant selenoproteins and physiological mechanisms are unknown. Comparative studies with the chemical class of imidoselenocarbamates using tumor-derived and non- transformed cells showed different effects on translation of different selenoproteins. The specific modulation of the selenoproteome expressed reflects substance- and cell-specific effects of selenocarbamates on specific selenoproteins, but not a general activation of the selenoprotein biosynthesis machinery. Especially methyl-carrying selenocarbamates proved to be efficient modulators. Moreover, this substance class proved to be effective modulators of deiodinase activities without showing toxic effects. A further characterization of the interaction of selenocompounds with specific selenoproteins and their role in inflammation, cancer and the immune system is needed to provide a better insight into underlying mechanisms needed to optimize Se supplementation. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: selenium; selenoprotein; sepsis; cancer; imidoselenocarbamate; LPS; C57Bl/6; HepG2; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stoedter, M. (2015). Regulation of selenoproteins after synthetic selenocompound exposure and during the acute phase inflammatory response. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7943

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stoedter, Mette. “Regulation of selenoproteins after synthetic selenocompound exposure and during the acute phase inflammatory response.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-7943.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stoedter, Mette. “Regulation of selenoproteins after synthetic selenocompound exposure and during the acute phase inflammatory response.” 2015. Web. 20 Nov 2019.

Vancouver:

Stoedter M. Regulation of selenoproteins after synthetic selenocompound exposure and during the acute phase inflammatory response. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-7943.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stoedter M. Regulation of selenoproteins after synthetic selenocompound exposure and during the acute phase inflammatory response. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-7943

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

27. Sakellariou, Christian J. C. comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/13356

► Infections with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are associated with increased mortality. Outcome differences due to various species of ESBL-E or ESBL genotypes are not well… (more)

Subjects/Keywords: sepsis; bacteremia; gram-negative; ESBL; extended-spectrum beta-Lactamase; Escherichia coli; Klebsiella pneumoniae; genotype; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sakellariou, C. J. C. (2017). comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sakellariou, Christian J C. “comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype.” 2017. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/13356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sakellariou, Christian J C. “comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype.” 2017. Web. 20 Nov 2019.

Vancouver:

Sakellariou CJC. comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/13356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sakellariou CJC. comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/13356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

28. Krüger, Sabrina. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14434

► Intraoperative neuromonitoring is associated with a lower incidence of delirium, possibly by reducing extreme low BIS values. Therefore, in high-risk surgical patients, this may give… (more)

Subjects/Keywords: bispectral index; delirium; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krüger, S. (2015). Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krüger, Sabrina. “Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-14434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krüger, Sabrina. “Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium.” 2015. Web. 20 Nov 2019.

Vancouver:

Krüger S. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-14434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krüger S. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-14434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

29. Oesterwitz, Karolin. Outcome and analysis of predictors for succes.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4247

► Vasovasostomy (VVS) and tubulovasostomy (TVS) are the treatment options of first choice to restore fertility after vasectomy. Aim of this study was to determine the… (more)

Subjects/Keywords: vasectomy reversal; Vasovasostomy; tubulovasostomy; obstructive interval; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oesterwitz, K. (2014). Outcome and analysis of predictors for succes. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Oesterwitz, Karolin. “Outcome and analysis of predictors for succes.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-4247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Oesterwitz, Karolin. “Outcome and analysis of predictors for succes.” 2014. Web. 20 Nov 2019.

Vancouver:

Oesterwitz K. Outcome and analysis of predictors for succes. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-4247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Oesterwitz K. Outcome and analysis of predictors for succes. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-4247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

30. Wolfram, Julia. Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10286

► Background: The acquired factor XIII deficiency after major operations is correlated with perioperative blood loss and bleeding disorders. This study investigated the effect of a… (more)

▼ Background: The acquired factor XIII deficiency after major operations is correlated with perioperative blood loss and bleeding disorders. This study investigated the effect of a prophylactic factor XIII application on the perioperative blood loss and the rate of blood transfusions for alcohol dependent patients undergoing a neck dissection. Methods: In this prospective double-blind clinical study 23 alcohol dependent patients with a carcinoma, an elective neck dissection and a daily minimum consumption of 60 g of alcohol were randomized into two groups. The Fibrogammin group (n=11) was treated with 2500 U Fibrogammin® preoperatively and four times 1250 U postoperatively. The placebo group (n=12) received 0.9 % saline solution instead. The blood loss and transfused blood products were measured intraoperatively and daily up to 10 days after surgery or until the discharge from hospital. Results: In between Fibrogammin and placebo group there was no significant difference of blood loss according to the multivariate testing method (p=0.59) as well as the univariate testing method (intraoperative p=0.83; postoperative p=0.74; perioperative p=0.88). A tendency of decreased bleeding was found at 1. POD (1. POD: p=0.24). Intraoperative blood products were administered to 1 patient in the Fibrogammin (1 EK and 2 FFP) and 2 patients from the placebo group (3 EK respectively 2 EK). 1 patient in each group received a transfusion postoperatively (Fibrogammin group: 1 EK, placebo group: 3 EK). The need of transfusions did not differ within the groups (p=1.00). The length of hospital stay in the Fibrogammin group tended to be 2 days shorter (p=0.41). After the neck dissection, the factor XIII levels within the placebo group decreased significantly by 30 %. 40 % of patients from the placebo group developed an acquired factor XIII deficiency (≤ 70 %). The patients with an acquired factor XIII deficiency showed a significantly enhanced blood loss intraoperatively and at the 2nd POD (intraop: p=0.02; 2. POD: p=0.02). In the Fibrogammin group, the value remained within the range of reference. Conclusions: Within both groups the results did not show a significant reduction of perioperative blood loss or decreased need for blood transfusions after the prophylactic application of factor XIII. However, the descriptive results indicate that the detection of factor XIII levels and the selective application of factor XIII can be beneficial for alcohol-dependent patients with a high perioperative blood loss. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: factor XIII; neck dissection; alcohol dependent patients; blood loss; blood transfusion; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wolfram, J. (2018). Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wolfram, Julia. “Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions.” 2018. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-10286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wolfram, Julia. “Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions.” 2018. Web. 20 Nov 2019.

Vancouver:

Wolfram J. Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-10286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wolfram J. Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-10286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations