+publisher:"Freie Universität Berlin" +contributor:("n")

Freie Universität Berlin

1. Behrend, Ronja. Interprofessional teaching and learning in the health professions: Student participation in the development of interprofessional education.

Degree: 2020, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-26956

► The implementation of interprofessional education into the curricula of health professional education plays a key role in preparing students for interprofessional collaboration in patient care.… (more)

▼ The implementation of interprofessional education into the curricula of health professional education plays a key role in preparing students for interprofessional collaboration in patient care. However, the development and implementation of interprofessional education in existing curricula is challenging and thus far rarely implemented in Germany. There is a need for research with regard to planning and implementing interprofessional education. Student participation has already shown positive effects for the mono-professional curriculum development. This paper examines the effects of student participation in the context of interprofessional curriculum development. In an exploratory, qualitative study (Behrend et al. 2019a), focus group discussions were conducted with students (n = 5) and faculty members (n = 5) who jointly planned and implemented interprofessional education into health professions education. The experiences and perceptions of the focus group participants were audio-recorded and transcribed. The transcripts were analyzed qualitatively according to Kuckartz (2016). The qualitative analysis showed that student participation was perceived as having a positive influence on the process and the results of interprofessional curriculum development. The students' motivation, the balance between clarity on tasks and student autonomy and a low-hierarchy team atmosphere were identified as facilitating factors for student participation. Challenges included the risk of role conflicts between faculty members and students and the risk of over demanding of the students. The statements, from students and faculty members, indicate that students develop professionally by working in interprofessional projects due to acquiring knowledge and skills, and reflecting on their attitude towards interprofessional collaboration. The students also had a motivating influence on the faculty members. They perceived the students as future ambassadors for interprofessional collaboration in the workplace. In this qualitative study, the reported experiences and perceptions of the focus group participants, provided multiple qualitative evidence for a positive, complementary effect of student participation in interprofessional curriculum development. Facilitating factors for student participation were identified, which should be actively nurtured in future interprofessional curriculum development. The participating students developed professionally and reflected on their attitude towards interprofessional collaboration. Through this, they may play an important role in improving interprofessional collaboration in their future workplaces. The results of this work extend findings on the positive effects of student participation in mono-professional curriculum development onto the interprofessional context. This may motivate other schools to involve students more actively in the development of interprofessional education. Advisors/Committee Members: female (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: Interprofessional education; Interprofessional teaching and learning; Medical education; Health professionals; Student participation; ddc:610

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APA (6^th Edition):

Behrend, R. (2020). Interprofessional teaching and learning in the health professions: Student participation in the development of interprofessional education. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-26956

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Behrend, Ronja. “Interprofessional teaching and learning in the health professions: Student participation in the development of interprofessional education.” 2020. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-26956.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Behrend, Ronja. “Interprofessional teaching and learning in the health professions: Student participation in the development of interprofessional education.” 2020. Web. 04 Mar 2021.

Vancouver:

Behrend R. Interprofessional teaching and learning in the health professions: Student participation in the development of interprofessional education. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-26956.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Behrend R. Interprofessional teaching and learning in the health professions: Student participation in the development of interprofessional education. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-26956

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

2. Stegemann, Miriam Songa. Role of genetic variants of toll like receptors (TLR) in severe malaria and analysis of the TLR ligand glykosylphosphatidylinositol (GPI).

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12339

► Genetic host factors play a critical role in susceptibility to malaria and its severity. Malaria tropica caused by Plasmodium falciparum results in over one million… (more)

▼ Genetic host factors play a critical role in susceptibility to malaria and its severity. Malaria tropica caused by Plasmodium falciparum results in over one million deaths annually. Toll-like-receptors have been shown in vitro to be involved in recognition of P. falciparum. The glycosylphosphatidylinositol anchor of P. falciparum induces signaling in host cells via TLR-2 und TLR-4. The interaction of the microbial ligand and the respective TLR results in the release of proinflammatory cytokines via the TLR/IL-2-receptor (TIR) domain. Thus, TLR may contribute as key host molecules to inflammatory responses including cytokine production and fever in malaria. In mice, P. falciparum GPI induces the symptoms of severe malaria while the effect of P. falciparum GPI on human immune cells remains unknown. In a case-control study among 870 Ghanaian children we examined the influence of TLR-2- and -4 polymorphisms in susceptibility to severe malaria. Additionally we examined the role of synthetic P. falciparum GPI in the proinflammatory immune response in in vitro stimulation assays using murine and human cell lines. TLR-2 polymorphisms frequently seen in Caucasians and Asians were completely absent in all Ghanaian children. However, we detected a rare and previously undescribed mutation (Leu658Pro) which impairs signaling via TLR-2 in vitro. On the contrary, the TLR-4 polymorphism Asp299Gly was observed at an extraordinarily higher rate than in Europeans. In healthy controls it was found in 17.6%; in severe malaria patients it occurred at a significantly higher frequency (24.1%, P < 0.05). The TLR-4 polymorphism Thr399Ile was found at similarly high rates, in 2.4% of healthy children and in 6.2% of patients with severe malaria (P = 0.02). The polymorphisms TLR-4 Asp299Gly and TLR-4 Thr399Ile conferred an 1.5- and 2.6-fold risk of severe malaria. Synthetic P. falciparum GPI did not induce cytokine production in the stimulated cells. These findings suggest an important role of TLR in malaria susceptibility in vivo and their potential influence on the progression of the disease. Especially in Africa common TLR-4 variants predispose to severe malaria. The absence of a proinflammatory immune response to stimulation with synthetic P. falciparum GPI observed here does not mean necessarily that TLR do not recognize P. falciparum GPI or that it does not play a role in the pathogenesis of malaria. This is more likely explained by structural differences between the synthetic P. falciparum GPI and natural GPI. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: Toll like receptor; severe malaria; glycosylphosphatidylinositol; Plasmodium falciparum; innate immunity; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stegemann, M. S. (2014). Role of genetic variants of toll like receptors (TLR) in severe malaria and analysis of the TLR ligand glykosylphosphatidylinositol (GPI). (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12339

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stegemann, Miriam Songa. “Role of genetic variants of toll like receptors (TLR) in severe malaria and analysis of the TLR ligand glykosylphosphatidylinositol (GPI).” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-12339.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stegemann, Miriam Songa. “Role of genetic variants of toll like receptors (TLR) in severe malaria and analysis of the TLR ligand glykosylphosphatidylinositol (GPI).” 2014. Web. 04 Mar 2021.

Vancouver:

Stegemann MS. Role of genetic variants of toll like receptors (TLR) in severe malaria and analysis of the TLR ligand glykosylphosphatidylinositol (GPI). [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-12339.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stegemann MS. Role of genetic variants of toll like receptors (TLR) in severe malaria and analysis of the TLR ligand glykosylphosphatidylinositol (GPI). [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-12339

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

3. Gerz, Christian Wolfgang. Longitudinal changes of olfactory and gustatory function in patients with multiple sclerosis.

Degree: 2016, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6050

► The aim of this study was to investigate longitudinal over four years changes of taste and smell in patients with multiple sclerosis (MS) and correlate… (more)

▼ The aim of this study was to investigate longitudinal over four years changes of taste and smell in patients with multiple sclerosis (MS) and correlate these results to the disease activity. Initially there was made a study at the Charité of Berlin evaluating their olfactory and gustatory possibilities and compared with the new results. 20 MS patients (16 with relapsing remitting MS, four with chronique progressive MS) were tested. The Threshold Discrimination Identification test was used for subjective olfactometry (Sniffin’ Sticks) and an objective olfactometry was made. The Taste Strip Test (TST) was used to evaluate gustatory function. To evaluate the neurological system the Expanded Disability Status Scale (EDSS) was used, the Becks Depression Inventory (BDI) was used to detect a depression and the Mini Mental Status Examination (MMSE) was used to check the cognition of the patients. The changes in the TST score correlated negatively with the disease progression, expressed in the changes of the EDSS score (r=-0.81). The changes of the TDI score correlated with the self estimation of smell on the Visual Analogue Scale (r=0.47). The number of relapses in this period of time correlated with the changes of the discrimination test score (r=-0.48) and the change of the discrimination score correlated with the change of the TST score (r=0.68). This might be indicative to be a sign for an affection of the central nerve system. The results of the objective olfactometry underlined parts of the results of the TDI test but some results were so different that there were made a focus on the TDI test. The patients were aware of their olfactory capacity. Olfactory and gustatory capacity might be useful parameters to estimate disease activity in MS patients. As the discrimination of smell is processed in higher central regions of the central nervous system (CNS), the results suggest that olfactory und gustatory dysfunction in MS patients occurs due to CNS damage rather than to peripheral damage of the olfactory nerve. Advisors/Committee Members: m (gender), n. n. (firstReferee), n. n. (furtherReferee).

Subjects/Keywords: multiple sclerosis; longitudinal study; olfactoy dysfunction; gustatory dysfunction; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gerz, C. W. (2016). Longitudinal changes of olfactory and gustatory function in patients with multiple sclerosis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6050

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gerz, Christian Wolfgang. “Longitudinal changes of olfactory and gustatory function in patients with multiple sclerosis.” 2016. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-6050.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gerz, Christian Wolfgang. “Longitudinal changes of olfactory and gustatory function in patients with multiple sclerosis.” 2016. Web. 04 Mar 2021.

Vancouver:

Gerz CW. Longitudinal changes of olfactory and gustatory function in patients with multiple sclerosis. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-6050.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gerz CW. Longitudinal changes of olfactory and gustatory function in patients with multiple sclerosis. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-6050

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

4. Richter, Stephan. Expression and clinical impact of apoptosis proteins in childhood and adult de novo acute myeloid leukemia.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8722

► Improved diagnostic methods of cyto- and molecular genetics illustrate that acute myeloid leukemias (AML) represent a heterogeneous group of different sensitivity to chemotherapy and prognosis.… (more)

▼ Improved diagnostic methods of cyto- and molecular genetics illustrate that acute myeloid leukemias (AML) represent a heterogeneous group of different sensitivity to chemotherapy and prognosis. The differential expression of apoptosis-associated proteins plays a major role in this regard. In this study, a selection of pro-and antiapoptotic proteins of the inhibitors of apoptosis proteins (IAP) family (XIAP, cIAP1, survivin) and other apoptosis- associated proteins (caspase -3, Bcl -2, Bcl -xL , Bax) were examined for their level of expression and prognostic significance in 137 cryopreserved AML samples of children and adults. 62 of the 92 examined adult patients were treated according the AMLCG-92-study-protocol. All examined children (n=45) were treated according the protocol of the AMLBFM-93 study. The expression levels were examined by immunoblot or flowcytometry. Matching the antiapoptotic effect of XIAP, high expression of XIAP, in both AML of childhood and adulthood, was associated with a lower overall survival: adults [9 months (n=21) vs 19 months (n=41), p<0,05]; children [30 months (n=10) vs. 41 months (n=34), p=0,02]. In addition, a high XIAP expression correlated with intermediate / poor karyotype in AML of adult [mean relative optical density (mROD) 3563; n=69 vs mROD 184; n=5; p=0.011). In AML of childhood a high expression of XIAP (mROD 2509 ± 503, n=30, p<0.002) and Bcl-XL (mROD 2615 ± 439, p<0.001) correlated with intermediate / poor karyotype. Furthermore, XIAP expression correlated with myelomonocytic French–American–British (FAB) subtypes M4/M5 (p=0.05) and expression of monocytic markers (CD 14, CD 36; p < 0.05; CD 4, HLA-DR; p < 0.01) in AML blasts of adults. For the antiapototic protein survivin, a shorter overall survival [27 Monate (n=10) vs. 41 Monate (n=34); p < 0.026] was associated with high expression levels for AML in children. Comparing expression in view of age specific differences, different expression levels were shown for XIAP (p < 0.05). Matching the antiapoptotic function of XIAP the higher expression was detected in the unfavorable group of adult AML. However, a higher expression of pro-apoptotic proteins Bax (p < 0.001) and procaspase-3 (p < 0.05) was detected in the adult group, too. However, a significant variability in the expression of the different IAP in primary AML was apparent in this study, indicating a differential regulation of these proteins. Some IAP seem to play a prognostic role in AML and probably new prognostic groups of AML can be defined. The aim of current and future research is the identification of specific patient risk groups, risk adapted and targeted therapies for better responses and outcomes. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: leukemia; adults; children; apoptosis; proteins; IAP; expression; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Richter, S. (2014). Expression and clinical impact of apoptosis proteins in childhood and adult de novo acute myeloid leukemia. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Richter, Stephan. “Expression and clinical impact of apoptosis proteins in childhood and adult de novo acute myeloid leukemia.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-8722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Richter, Stephan. “Expression and clinical impact of apoptosis proteins in childhood and adult de novo acute myeloid leukemia.” 2014. Web. 04 Mar 2021.

Vancouver:

Richter S. Expression and clinical impact of apoptosis proteins in childhood and adult de novo acute myeloid leukemia. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-8722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Richter S. Expression and clinical impact of apoptosis proteins in childhood and adult de novo acute myeloid leukemia. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-8722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

5. Bittermann, Carina. Klinisches Outcome von Patienten nach extrakranieller-intrakranieller Bypass- Operation.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-13712

► Hintergrund und Fragestellung: Seitdem Yaşargil 1967 die erste extrakranielle- intrakranielle Bypass Operation durchgeführt hat, wird der Vorteil dieses Eingriffes für Patienten diskutiert. Das Ziel unserer… (more)

▼ Hintergrund und Fragestellung: Seitdem Yaşargil 1967 die erste extrakranielle- intrakranielle Bypass Operation durchgeführt hat, wird der Vorteil dieses Eingriffes für Patienten diskutiert. Das Ziel unserer retrospektiven Studie war einerseits, die Effektivität der Operation hinsichtlich der Veränderung von klinischen Symptomen zu evaluieren. Andererseits analysierten wir den regionalen zerebralen Blutfluss unter Verwendung von Acetazolamid stimulierten Perfusions-SPECT Untersuchungen. Methodik: Diese ein zentrische Studie wurde in der Klinik für Neurochirurgie mit zerebrovaskulärem Schwerpunkt des Vivantes Klinikums im Friedrichshain durchgeführt. Es handelt sich um eine nicht selektive Erhebung, die den Fokus auf patientenzentrierte Versorgung legt. Es erfolgte eine Analyse aller Patienten, die sich zwischen August 2008 und Juni 2011 einer extrakraniellen-intrakraniellen Bypass Operation unterzogen. Einschlusskriterien: mindestens ein symptomatischer Verschluss der A. carotis interna mittels digitaler Subtraktionsangiographie nachgewiesen und eine eingeschränkte oder aufgehobene relative zerebrovaskuläre Reservekapazität nachgewiesen mittels 99m Tc-HMPAO –SPECT. Ergebnisse: Von den ursprünglich 21 Patienten wurden vier nicht operiert und daher ausgeschlossen, da sie keine eingeschränkte oder aufgehobene Reservekapazität zeigten. 17 Patienten erfüllten alle Einschlusskriterien und wurden operiert. Die perioperative Morbidität und Letalität beliefen sich auf 11,8% (n=zwei) bzw. 0%. Alle Bypässe waren während der Nachsorge (zehn bis 46 Monate) durchgängig. Es konnte kein signifikanter Anstieg der lokalen Perfusion in zuvor minder- durchbluteten Arealen nachgewiesen werden. Jedoch zeigte sich eine signifikante Reduktion der Anzahl der Patienten, die unter transitorisch ischämischen Attacken (postoperativ vier Patienten im Vergleich zu neun Patienten präoperativ, p=0.020) oder Kopfschmerzen (postoperativ zwei Patienten im Vergleich zu sechs Patienten präoperativ, p=0.041) litten. In allen Fällen wurde eine nicht signifikante Reduktion (p>0.05) der Symptome wie Hemiparese, Aphasie oder visuelle Defizite in Frequenz und Intensität erzielt. Diskussion: Die Bypass-Operation kann als Erfolg gewertet werden, da sie eine signifikante Reduktion der Anzahl der Patienten, die unter transitorisch ischämischen Attacken oder Kopfschmerzen leiden, ermöglicht. Hinzu kommt, dass eine deutliche, wenn auch nicht signifikante Tendenz zur Besserung weiterer klinischer Symptome nachgewiesen werden konnte. Nichtsdestotrotz ließ sich mittels Perfusions-SPECT Untersuchung kein signifikanter Anstieg der Perfusion belegen. Zusammenfassend erachten wir es für sinnvoll, Bypass-Operationen im größeren Rahmen durchzuführen. Wir halten diese Technik für eine überzeugende Möglichkeit, die für die beschriebene Patientengruppe in Betracht gezogen werden sollte. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: extracranial-intracranial bypass surgery (EC-IC bypass); carotid artery stenosis; stroke; SPECT imaging; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bittermann, C. (2014). Klinisches Outcome von Patienten nach extrakranieller-intrakranieller Bypass- Operation. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bittermann, Carina. “Klinisches Outcome von Patienten nach extrakranieller-intrakranieller Bypass- Operation.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-13712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bittermann, Carina. “Klinisches Outcome von Patienten nach extrakranieller-intrakranieller Bypass- Operation.” 2014. Web. 04 Mar 2021.

Vancouver:

Bittermann C. Klinisches Outcome von Patienten nach extrakranieller-intrakranieller Bypass- Operation. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-13712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bittermann C. Klinisches Outcome von Patienten nach extrakranieller-intrakranieller Bypass- Operation. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-13712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

6. Krüger, Sabrina. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14434

► Intraoperative neuromonitoring is associated with a lower incidence of delirium, possibly by reducing extreme low BIS values. Therefore, in high-risk surgical patients, this may give… (more)

Subjects/Keywords: bispectral index; delirium; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krüger, S. (2015). Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krüger, Sabrina. “Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium.” 2015. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-14434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krüger, Sabrina. “Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium.” 2015. Web. 04 Mar 2021.

Vancouver:

Krüger S. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-14434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krüger S. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-14434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

7. Oesterwitz, Karolin. Outcome and analysis of predictors for succes.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4247

► Vasovasostomy (VVS) and tubulovasostomy (TVS) are the treatment options of first choice to restore fertility after vasectomy. Aim of this study was to determine the… (more)

Subjects/Keywords: vasectomy reversal; Vasovasostomy; tubulovasostomy; obstructive interval; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oesterwitz, K. (2014). Outcome and analysis of predictors for succes. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Oesterwitz, Karolin. “Outcome and analysis of predictors for succes.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-4247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Oesterwitz, Karolin. “Outcome and analysis of predictors for succes.” 2014. Web. 04 Mar 2021.

Vancouver:

Oesterwitz K. Outcome and analysis of predictors for succes. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-4247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Oesterwitz K. Outcome and analysis of predictors for succes. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-4247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

8. Mewes, Andrea U. J. the influence of work experience and work time arrangements.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8300

► Objective: Junior physicians have been shown to exhibit exceptionally high burnout levels. With this study, we aimed to investigate the relationship between work experience, medical… (more)

Subjects/Keywords: burnout; organization of work, physicians; shift work; workload; work experience; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mewes, A. U. J. (2014). the influence of work experience and work time arrangements. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8300

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mewes, Andrea U J. “the influence of work experience and work time arrangements.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-8300.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mewes, Andrea U J. “the influence of work experience and work time arrangements.” 2014. Web. 04 Mar 2021.

Vancouver:

Mewes AUJ. the influence of work experience and work time arrangements. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-8300.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mewes AUJ. the influence of work experience and work time arrangements. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-8300

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

9. Konietzny, Matthias Reiner. histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL).

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9652

► Recent studies on prenatal bone formation and bone development around the developing teeth are lacking. While molecular mechanisms underlying the tooth- bone-interface have been examined,… (more)

▼ Recent studies on prenatal bone formation and bone development around the developing teeth are lacking. While molecular mechanisms underlying the tooth- bone-interface have been examined, morphological contexts were given little attention. This study closely examines such morphologically substantial bone development processes of developing teeth and the neighboring bone in the fetal maxilla applying for the first time computer-based and three-dimensional methods. Our main focus lies on bone development processes and the formation of peridental and interdental bone around the developing teeth of fetuses in the bell stage (CRL 160-270 mm, approx. 18-28 WG). Five series of histological sections were microscopically examined; three were reconstructed in 3D using AnalySIS® 3D to illustrate different developmental stages of 160 mm CRL, 225 mm CRL and 270 mm CRL. We aimed at determining the histo-morphological conditions of bone development processes (apposition zones, resorption zones, and inactive zones). Distances from the dental follicles of the developing teeth to the surrounding bone in mesial, distal, palatal, and vestibular directions were measured. Possible interactions or regularities within the modifying process regarding the development of single teeth and their distance to the surrounding bone were investigated. We for the first time confirm also for the upper jaw that the developing teeth are enclosed by bone in bony crypts; they develop within the latter. The formation of interdental septa and a complete compartmentalization of the single developing teeth remain undone in a mesio-distal direction until a developmental stage of 270 mm CRL (WG 28). The developing primary canine is an exception with its bony septa being formed firstly. The surrounding bone never completely encloses the neighboring developing teeth within the investigation period; the bony septum remains open in a central position. The canine lacks a complete bony margin in a vestibular direction that cannot be counterbalanced until WG 28. Resorption processes dominate around the developing teeth. At the outward side of the bone, bone formation predominates. These processes imply a “centrifugal” bone formation with a concurrent volume increase of the developing teeth. Open questions remain with the distance measurements from the single developing teeth to the neighboring maxillary bone. The measured distances of the middle fetus are often bigger than those of the older fetus. Individual growth spurts and a possible physiological variability of the fetuses cannot be excluded in this study. However, our distance measurement results make it plausible that the distances follow a prospectively developing periodontal space. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: maxilla; crown-rump-length; crl; tooth-bone interface; tooth germ development, 3D-models; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Konietzny, M. R. (2014). histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL). (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9652

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Konietzny, Matthias Reiner. “histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL).” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-9652.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Konietzny, Matthias Reiner. “histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL).” 2014. Web. 04 Mar 2021.

Vancouver:

Konietzny MR. histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL). [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-9652.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Konietzny MR. histological and morphological studies on the fetal maxilla in Humans during the bell-stage of the dental primordia (160-270 mm SSL). [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-9652

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

10. Uhlemann, Ria. Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14068

► Neurodegenerative Pathologien, Alterungsprozesse und Zelltod gehen oft mit einer Dysfunktion des Aktinzytoskeletts einher. Ziel vorliegender Arbeit war es, den Einfluss des Aktinzytoskeletts auf den Prozess… (more)

▼ Neurodegenerative Pathologien, Alterungsprozesse und Zelltod gehen oft mit einer Dysfunktion des Aktinzytoskeletts einher. Ziel vorliegender Arbeit war es, den Einfluss des Aktinzytoskeletts auf den Prozess der Mikrogliaaktivierung näher zu erforschen und zu charakterisieren. Das Modell zur Untersuchung dieser Aktinstabilisierungsprozesse basiert auf der gelsolindefizienten Mauslinie (Gsn-/-) und dem Einsatz pharmazeutischer Interventionen mit Jasplakinolid und Cytochalasin D. Während Jasplakinolid zur Stabilisierung (Polymerisation) des Aktinfilamentes führt, resultieren Interventionen mit Cytochalsin D in einer Destabilisierung (Depolymerisation). Die Arbeit zeigt, dass gezielte Störungen des Auf- und Abbaus von Aktinfilamenten in klassisch aktivierter Mikroglia (mittels LPS) keinen Einfluss auf die Transkription von typischen „M1“ Genen haben. Unterdessen resultierten Eingriffe in die Aktinfilamentstabilität bei alternativer Aktivierung von Mikroglia (mittels IL-4) in einer deutlichen Herabregulierung der Transkriptionsrate typischer „M2“ Gene, was auf einen verminderten Transport des Transkriptionsaktivators pStat6 in den Nukleus zurückzuführen ist. Auf funktionaler Ebene führen Veränderungen der Aktindynamik zu reduzierter Freisetzung von Stickstoffmonoxid, TNF-, IL-6 und IGF-1. Als Grund für die verringerte NO-Sekretion konnte eine reduzierte iNOS- Proteinexpressionsrate im Zytoplasma und eine verminderte Aufnahme von Arginin gezeigt werden. Dagegen ist die LPS-induzierte Freisetzung von IL-1b, das dem „nicht-klassischen“ Freisetzungsmechanismus über Golgi-Apparat und ER folgt, unter Stabilisierung des Aktinzytoskeletts erhöht. Die in vitro Experimente vorliegender Arbeit zeigen, dass Störungen der Aktindynamik zu deutlich herabgesetzter Migration, Proliferation und Phagozytose von Mikrogliazellen führen. Zudem konnte bei der Gsn-/- Mauslinie eine verringerte Proliferationsrate IBA-1-expremierender Zellen nach Hirnischämie und ein verringerter Anstieg an IBA-1+ Zellen im Nucleus facialis nach Axotomie des Nervus facialis festgestellt werden. Desweiteren beweist die Arbeit, dass das intrazelluläre Calciumniveau (Basislinie und ATP-induziert) in Gsn-/- Mikroglia signifikant erhöht ist. Zusammenfassend kann festgehalten werden, dass gezielte Störungen der Aktindynamik sowohl klassische als auch alternative Mikrogliaaktivierungsprozesse abschwächen. Während alternative (IL-4 vermittelte) Mikrogliaaktivierung mit einer deutlichen Herabregulierungen auf Gentranskriptionsebene assoziiert ist, finden die klassischen (LPS vermittelten) Aktivierungsprozesse auf post-transkriptionaler Ebene statt und führen zu Beeinträchtigungen von Substrataufnahme-, Transport- und Freisetzungsmechanismen. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: microglia; polarization; inflammation; gelsolin; actin filament; neurodegeneration; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Uhlemann, R. (2015). Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Uhlemann, Ria. “Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung.” 2015. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-14068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Uhlemann, Ria. “Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung.” 2015. Web. 04 Mar 2021.

Vancouver:

Uhlemann R. Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-14068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Uhlemann R. Über die essentielle Bedeutung des Aktin-Zytoskeletts bei der Mikrogliaaktivierung. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-14068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

11. Mensah, Martin Atta. Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12184

► Einleitung: An ihren beiden Enden verfügen die menschlichen Geschlechtschromosomen über je einen identischen Sequenzabschnitt. Diese beiden pseudoautosomalen Regionen (PAR) ermöglichen den ansonsten unterschiedlichen Geschlechtschromosomen eine… (more)

▼ Einleitung: An ihren beiden Enden verfügen die menschlichen Geschlechtschromosomen über je einen identischen Sequenzabschnitt. Diese beiden pseudoautosomalen Regionen (PAR) ermöglichen den ansonsten unterschiedlichen Geschlechtschromosomen eine korrekte Paarung und nachfolgende Aufteilung während der Meiose des Mannes. Die Grenze zwischen pseudoautosomaler Region 1 (PAR1) und den spezifischen gonosomalen Sequenzen entstand während der Aufspaltung der Menschenaffen. Nachdem die pseudoautosomale Region an ihrem proximalen Ende Material eingebüßt hatte, gilt sie als fortan stabil. Bei einem Screening auf Kopiezahlpolymorphismen haben wir in 15 voneinander unabhängigen Familien eine Duplikation unmittelbar proximal von PAR1 entdeckt. Obwohl diese Duplikation eine X- spezifische Sequenz beinhaltete, wurde sie ausschließlich von Vater zu Sohn vererbt. Dies ließ vermuten, dass das Duplikon auf dem Y-Chromosom positioniert ist. Handelt es sich bei der Duplikation um eine evolutionär ältere Variante von PAR1 im Sinne einer „Non-Deletion“? Methodik: Um diese Fragestellung anzugehen, wurden folgende Verfahren durchgeführt: aCGH, FISH, PCR mit Gelelektrophorese, BAC- vermittelte gezielte paired-end Hochdurchsatzsequenzierung, Sequenzierung nach Sanger, Einzelmolekülsequenzierung (PacBio) und Y-chromosomale Haplogruppenbestimmung mittels Y-STR Typisierung. Ergebnisse: Diese genomische Analyse zeigte, dass es sich nicht um eine ältere, sondern um eine jüngere bisher unbekannte Variante der PAR1 handelt. Dieser die PAR1 um 105 kbp verlängernde Polymorphismus entstand durch eine nicht-allelische homologe Rekombination zwischen dem X- und dem Y-Chromosom, welche durch den nur 548 bp langen Repeat LTR6B vermittelt wurde. Die Identifikation der reziproken Deletion auf dem X-Chromosom einer Familie und das Vorkommen der Variante in verschiedenen Y-chromosomalen Haplogruppen zeigen, dass es sich dabei um ein wiederkehrendes genomisches Rearrangement in der menschlichen Population handelt. Schlussfolgerung: Es gibt einen Längenpolymorphismus von PAR1 in der menschlichen Population. Pseudoautosomale Regionen verlieren an ihren proximalen Enden nicht nur genetisches Material, sondern können dort auch welches hinzugewinnen. Dieser neue, die gonosomale Evolution gestaltende Mechanismus könnte pseudoautosomale Regionen und folglich auch Y-Chromosomen vor einer voranschreitenden Degradation bewahren. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: sex chromosomes; Y chromosome; X chromosome; pseudoautosomal region; next generation sequencing; XG; GYG2; evolution; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mensah, M. A. (2015). Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12184

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mensah, Martin Atta. “Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population.” 2015. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-12184.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mensah, Martin Atta. “Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population.” 2015. Web. 04 Mar 2021.

Vancouver:

Mensah MA. Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-12184.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mensah MA. Längenpolymorphismus der pseudoautosomalen Region 1 in der menschlichen Population. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-12184

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

12. Gölzenleuchter, Meike. Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5954

► Einleitung: Die dynamischen Eigenschaften des adulten Methyloms wurden kürzlich im zentralen Nervensystem beschrieben. Ob äußere Reize auch die DNA- Methylierungsmuster des peripheren Nervensystems beeinflussen können,… (more)

▼ Einleitung: Die dynamischen Eigenschaften des adulten Methyloms wurden kürzlich im zentralen Nervensystem beschrieben. Ob äußere Reize auch die DNA- Methylierungsmuster des peripheren Nervensystems beeinflussen können, wurde bisher nicht untersucht. Die Hypothese der vorliegenden Arbeit war, dass eine periphere Nervenschädigung Methylierungsveränderungen der DNA im Spinalganglion L5 hervorrufen kann. Dies wurde anhand eines neuropathischen Schmerzmodells nach Spinalnervenligatur (SNL) bei Ratten untersucht. Methodik: Mittels „Reduced representation bisulfite sequencing“ (RRBS) wurden die Methylome von acht Spinalganglien (vier Kontrollen, vier SNL) 24h nach SNL analysiert. RRBS ermöglicht die genomweite Untersuchung von DNA Methylierungen mit einer Auflösungsgenauigkeit einzelner Basenpaare. Dabei wird die DNA zuerst mittels eines Restriktionsenzyms in Fragmente geschnitten, die mindestens 2 Cytosin-phosphat-Guanin-Dinukleotide (CpGs) enthalten. Die nachfolgende Behandlung mit Bisulfit führt zur Desaminierung der unmethylierten Cytosinbasen in Uracilbasen, ohne die anderen Basen zu beeinflussen. Abschließend werden die DNA Fragmente amplifiziert, sequenziert und an das Referenzgenom angeglichen. Ergebnisse: Es zeigten sich weitverbreitete, hoch signifikante (p≤10-4) Cytosin Hyper- und Hypomethylierungen in etwa 1% der durch RRBS erfassten 1.4 Millionen CpGs. Diese wurden unter dem Begriff „Dynamisch differenziell methylierte CpGs“ (dDMCs) zusammengefasst. Die epigenetische Umgestaltung erfolgte größtenteils außerhalb der sogenannten CpG Inseln. 56% der beobachteten Veränderungen befanden sich in Promoter- oder Genregionen, insbesondere in Genen der „axonalen Wegfindung“ (p<10-11). Die vorliegende Arbeit fand keine Korrelation zwischen den Methylierungs-veränderungen und der Variation der Gen Expression und reiht sich damit in die wachsende Zahl von Studien mit genomweiten Analysen ein, die für eine komplexere Interaktion zwischen Methylom und Transkriptom sprechen. Die anderen 44% der dynamisch veränderten CpG Methylierungsmuster befanden sich außerhalb von Genen. Diese intergenischen dDMCs traten in Clustern auf, wobei sich benachbarte dDMCs immer in die gleiche Richtung veränderten. Ihre Positionen wurden mit intergenischen Gewebe-spezifischen differenziell methylierten CpGs (tDMCs) von Leber, Milz, Spinalganglion L4 und Skelettmuskel, verglichen. Bemerkenswert war, dass sich die Positionen der dDMCs mit denjenigen der tDMCs deckten (p<10-15) und fast nie den invarianten Teil des Methyloms betrafen (diejenigen CpGs, die in allen Geweben identisch sind). Das intergenische Methylom lässt sich damit in zwei Teile gliedern: ein invarianter Teil – welcher zwischen unterschiedlichen Geweben und unter verschiedenen Bedingungen unverändert stabil bleibt – und ein plastischer Teil, der auf Umwelteinflüsse wie z.B. die Verletzung des Spinalnervs reagieren kann. Weiterhin wurden die benachbarten hyper- oder hypomethylierten intergenischen dDMCs zu Regionen zusammengefügt und mittels Sequenzanalyse untersucht. Die häufigsten… Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: DNA methylation; dorsal root ganglion; peripheral nervous system; pain; rat;

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gölzenleuchter, M. (2015). Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5954

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gölzenleuchter, Meike. “Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte.” 2015. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-5954.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gölzenleuchter, Meike. “Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte.” 2015. Web. 04 Mar 2021.

Vancouver:

Gölzenleuchter M. Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-5954.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gölzenleuchter M. Schmerz-induzierte Plastizität des DNA-Methyloms im peripheren Nervensystem der Ratte. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-5954

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

13. Ackert, Ulrike. Analysis of lung function of 26 patients with congenital diaphragmatic hernia and evaluation of prognostic indicators for pulmonary morbidity.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12539

► Congenital diaphragmatic hernia (CDH) is a rare birth defect characterized by malformation of the diaphragm and prolapse of abdominal organs into the thoracic cavity. Complicating… (more)

▼ Congenital diaphragmatic hernia (CDH) is a rare birth defect characterized by malformation of the diaphragm and prolapse of abdominal organs into the thoracic cavity. Complicating factors are pulmonary hypoplasia and pulmonary hypertension. Even after a successful operation, these patients commonly need prolonged assisted ventilation. Patients and Methods: We evaluated retrospectively the course of disease of 26 newborns with CDH, born between 1993 and 2003 and treated at the Department of Neonatology at University Hospital Charité, Berlin. In addition, data from lung function tests (infant whole-body plethysmography, tidal breathing analysis and occlusion tests), carried out at a median age of 32 days were analyzed. With the help of these data, we looked for prognostic indicators for a reduced pulmonary outcome. Results: The majority of patients with CDH had a pathological lung function. Respiratory compliance, resistance, thoracic gas volume, respiratory rate and tidal volume differed significantly from the parameters of controls. Further analysis showed an association between duration and intensity of mechanical ventilation and pulmonary outcome. An early prenatal diagnosis of CDH, a non- left-sided hernia, the use of a patch for operative repair or complications like pleural effusion and pulmonary hypertension significantly increased likelihood of abnormal results from subsequent lung function tests. And where there was an impaired pulmonary function, patients were more likely to be hospitalized longer, especially those children with an obstructive-restrictive pattern. Conclusion: Even after successful surgery, most children with a congenital diaphragmatic hernia have a reduced lung function. With certain risk factors it is more likely for these patients to develop a ventilation disorder. This underlines the necessity of a protective ventilation strategy, in order to reduce additional pulmonary sequelae due to barotrauma and oxygen toxicity. It seems sensible to perform early lung function tests on all children with CDH and to refer them to a specialist paediatric pulmonology unit for continuous follow-up. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: congenital diaphragmatic hernia; infants; lung function; prognostic indicators; neonatology; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ackert, U. (2014). Analysis of lung function of 26 patients with congenital diaphragmatic hernia and evaluation of prognostic indicators for pulmonary morbidity. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ackert, Ulrike. “Analysis of lung function of 26 patients with congenital diaphragmatic hernia and evaluation of prognostic indicators for pulmonary morbidity.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/12539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ackert, Ulrike. “Analysis of lung function of 26 patients with congenital diaphragmatic hernia and evaluation of prognostic indicators for pulmonary morbidity.” 2014. Web. 04 Mar 2021.

Vancouver:

Ackert U. Analysis of lung function of 26 patients with congenital diaphragmatic hernia and evaluation of prognostic indicators for pulmonary morbidity. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/12539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ackert U. Analysis of lung function of 26 patients with congenital diaphragmatic hernia and evaluation of prognostic indicators for pulmonary morbidity. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/12539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

14. Josek, Claudia. Retrospective survey of supra- and y-condylar fractures of the humerus in children between 01-01-2005 to 31-12-2010 with focus of disorders of peripheral blood supply, motor and sensory functions before and after surgery.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/13708

► This thesis presents a survey of supra- and y-condylar fractures of the humerus in children who were treated in the Department of Pediatric Surgery at… (more)

▼ This thesis presents a survey of supra- and y-condylar fractures of the humerus in children who were treated in the Department of Pediatric Surgery at the Virchow Campus of the Charité Universitätsmedizin Berlin between 01-01-2005 to 31-12-2010. The focus of this retrospective study is the identification of disorders of peripheral blood supply, motor and sensory functions before and after surgery. The surgeons in the Department of Pediatric Surgery of the Charité observed an increasing number of disorders of peripheral blood supply, motor and/or sensory functions. Therefore, this work relates the current treatment outcomes to similar studies and especially to a former study performed in the same Department focusing on the period from 01-04-1996 to 30-04-2001. The study includes 355 supracondylar and 16 y-condylar fractures of the humerus, which are classified according to Baumann. 49% of all cases were type Baumann I fractures, 21% Baumann II and 30% Baumann III. The age ranged from four months to 17.4 years (middle 5.9 years). The most fractures affected males (56%). Correlated fractures were identified very seldom (3%). Preoperative disorders of blood supply, motor and/ or sensory functions were found in 7% of the cases. Postoperative disorders in blood supply were not found. There was also non compartment syndrome or Volkmann contracture identified. Disorders of peripheral sensory and motor function were found 43 times (11.6%). The ulnar nerve was affected in 65% of all postoperative nervale disorders. Out of the affected 43 children, 22 (51%) were actually further examined. Only one of them had a hyperesthesia in the second thru fifth finger, another had a hypesthesia in the fifth finger. Disorders of blood supply or motor function were not found at all. Overall, the observation of the surgeons in the Department of Pediatric Surgery of the Charité was correct. There were currently indeed a higher absolute number of disorders of peripheral blood supply, motor and/ or sensory function. However, they also treated more children with fractures of the distal humerus in general. Considering this increased total number of treated distal humerus fractures the relative number of disorders of peripheral blood supply, motor and/ or sensory function decreased from 18.1% to 11.6% in comparison to the previous study. The number of preoperative disorders shows a slightly increase from 5.2 to 5.9%. The share of postoperative disorders that was found in this study ranges in the level, which is also shown in other studies (4 to 18.1%). Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: supracondylar fracture; y-condylar fracture; children; disorders motor, sensory and peripheral blood; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Josek, C. (2017). Retrospective survey of supra- and y-condylar fractures of the humerus in children between 01-01-2005 to 31-12-2010 with focus of disorders of peripheral blood supply, motor and sensory functions before and after surgery. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Josek, Claudia. “Retrospective survey of supra- and y-condylar fractures of the humerus in children between 01-01-2005 to 31-12-2010 with focus of disorders of peripheral blood supply, motor and sensory functions before and after surgery.” 2017. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/13708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Josek, Claudia. “Retrospective survey of supra- and y-condylar fractures of the humerus in children between 01-01-2005 to 31-12-2010 with focus of disorders of peripheral blood supply, motor and sensory functions before and after surgery.” 2017. Web. 04 Mar 2021.

Vancouver:

Josek C. Retrospective survey of supra- and y-condylar fractures of the humerus in children between 01-01-2005 to 31-12-2010 with focus of disorders of peripheral blood supply, motor and sensory functions before and after surgery. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/13708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Josek C. Retrospective survey of supra- and y-condylar fractures of the humerus in children between 01-01-2005 to 31-12-2010 with focus of disorders of peripheral blood supply, motor and sensory functions before and after surgery. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/13708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

15. Heinbokel, Timm. Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg.

Degree: 2015, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/10901

► Kontinuierliche und komplexe Veränderungen des Immunsystems mit zunehmendem Alter haben entscheidenen Einfluss auf den klinischen Erfolg von Organtransplantationen und die Qualität von Spenderorganen. Da die… (more)

▼ Kontinuierliche und komplexe Veränderungen des Immunsystems mit zunehmendem Alter haben entscheidenen Einfluss auf den klinischen Erfolg von Organtransplantationen und die Qualität von Spenderorganen. Da die Zahl der älteren Transplantatempfänger steigt und zunehmend Organe von älteren Spendern transplantiert werden, ergeben sich drängende Herausforderungen für die Transplantationsmedizin. Klinisch konnte für die Transplantation von älteren Spenderorganen eine Assoziation mit schlechterem Patienten- und Transplantatüberleben sowie häufigeren akuten Abstoßungsreaktionen und verzögerter Transplantatfunktion gezeigt werden. Um diesen klinischen Phänomenen zugrundeliegende Mechanismen zu ergründen, wurde in der vorliegenden Arbeit ein Mausmodell heterotoper, komplett vaskularisierter Herztransplantation mit MHC-disparaten jungen (acht bis zwölf Wochen) DBA/2-Empfängern und jungen oder alten (18 Monate) C57BL/6 Spendern etabliert. Von alten Spendermäusen gewonnene Herzen zeigten eine signifikant beschleunigte Transplantatabstoßung im Vergleich zu jungen Spenderherzen. Dieser Unterschied im Transplantatüberleben war begleitet von höheren Indizes in der ISHLT Abstoßungsklassifikation und verstärkter Transplantatinfiltration durch CD4+ und CD8+ T- Zellen. Das Alter des transplantierten Organs hatte weiterhin Einfluss auf Charakteristiken der systemischen Alloimmunreaktion des Empfängers, dargestellt durch erhöhte Häufigkeit von milzständigen CD8+ Effektor-T-Zellen und CD8+IFN-γ+ T-Zellen bei Transplantation von älteren Spenderorganen, zusätzlich zu erhöhten Häufigkeiten von alloreaktiven IFN-γ- und IL-6-produzierenden Splenozyten sowie ausgeprägterer alloreaktiver Proliferation von Splenozyten bei Restimulation mit donorspezifischen Antigenen. Um Effekte des Parenchyms der transplantierten Organe von denen der mitübertragenen Passagierleukozyten zu unterscheiden, wurden chimäre Spendertiere generiert durch Transplantation von Knochenmark junger syngener Tiere in alte und junge zukünftige Spendertiere sechs Wochen vor Organentnahme. Nach Transplantation dieser chimären Spenderherzen (junges Parenchym mit jungen Passagierleukozyten oder altes Parenchym mit jungen Passagierleukozyten) waren Transplantatüberleben, Abstoßungsindizes und systemische Empfängerantworten vergleichbar, was auf eine entscheidende Rolle von organständigen Passagierleukozyten bei der Vermittlung von verstärkten Immunreaktionen nach Transplantation alter Spenderorgane hindeutete. Mit Fokus auf dendritische Zellen als eine Untergruppe der Passagierleukozyten wurden nun organständige dendritische Zellen durch Vorbehandlung der Spendertiere mit liposomalen Clodronat aus den Spenderherzen depletiert. Unterschiede in Transplantatüberleben und Abstoßungsindizes waren aufgehoben nach Transplantation von Spenderherzen vorbehandelter Tiere, ebenso waren die systemischen Immunantworten unabhängig vom Alter der Spendertiere. Weiterhin konnte eine detailliertere Charakterisierung der allostimulatorischen Priming- Fähigkeiten dendritischer Zellen in-vitro zeigen, dass… Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: transplantation; aging; immunosenescence; donor age; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heinbokel, T. (2015). Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/10901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Heinbokel, Timm. “Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg.” 2015. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/10901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Heinbokel, Timm. “Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg.” 2015. Web. 04 Mar 2021.

Vancouver:

Heinbokel T. Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/10901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Heinbokel T. Einfluss von Immunoseneszenz und Spenderalter auf Alloimmunreaktionen und Transplantationserfolg. [Thesis]. Freie Universität Berlin; 2015. Available from: https://refubium.fu-berlin.de/handle/fub188/10901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

16. Grotjohann, Sarah. Influence of pelvic tilt on functional acetabular orientation.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/10800

► Introduction Pelvic tilt influences acetabular orientation (AO). Anteversion (AA) and inclination (AI) define anatomical acetabular orientation. Pelvic tilt determines functional acetabular orientation because of its… (more)

▼ Introduction Pelvic tilt influences acetabular orientation (AO). Anteversion (AA) and inclination (AI) define anatomical acetabular orientation. Pelvic tilt determines functional acetabular orientation because of its spatial relocation. Anterior pelvic plane is used for calculation of anatomical AO, whereas functional AO is defined by the table plane of operating table or medical imaging. The following analysis shows, if there is an influence of pelvic tilt on functional AO. Secondary was verified, if anteversion and inclination give equivalent information for correct AO. Material and methods Computed tomography – based three dimensional reconstruction of bony pelvic structures provided the basis of the following analysis. 138 pelvises were determined with the patients supine. APP was distinguished by the most ventral points of the right and left Spina iliaca anterior superior and both pubic tubercles, while the angle between APP and coronal plane defined pelvic tilt. Results Pelvic tilt supine amounted to -0,1°±5,5°. 79% of the collective showed a physiological pelvic tilt. AA amounted to 18,3°±4,5° relative to APP and 18,5°±4,6° relative to table plane. AI was 46,9°±3,7° for both reference planes. AA and pelvic tilt correlated positive relative to APP (all: p < 0, 01, r = 0,497, R2 = 0,320) and negative relative to table plane (all: p < 0, 01, r = -0,366, R2 = 0,117). 29 persons showed increased posterior or anterior pelvic tilt of -10,3°±4,5° respectively 8,5°±1,8°. These individuals showed a difference of AA between both reference planes. AA differed from 8,3°±3,1° (females) and 7,7°±3,6° (males) with extensive posterior tilt and from 6,2°±1,0° (females) and 5,4°±2,0° (males) with extensive anterior tilt. AI showed less marked differences of 2,2°±0,8° for extensive pelvic tilt. Discussion Pelvic tilt compensated for increased AO. Individuals with high anatomical AA showed high pelvic tilt, which reduced functional AA. Conversely individuals with low anatomical AA had low pelvic tilt and therefore enlarged functional AA. Pelvic tilt is considered by APP, but it is not by table plane. Hence in individuals with physiological pelvic tilt both reference planes can be used for correct AO. By contrast table plane is no reliable reference plane for correct anatomical AO in individuals with extensive pelvic tilt. Conclusion Anatomical anteversion influences pelvic tilt. Pelvic tilt has a compensating influence on functional acetabular orientation. In conclusion results of this study serve to further understand the functional anatomy of the acetabulum and demonstrate the importance of pelvic tilt for correct AO. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: pelvic tilt; acetabular orientation; anteversion; inclination (abduction); reference plane; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Grotjohann, S. (2017). Influence of pelvic tilt on functional acetabular orientation. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/10800

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grotjohann, Sarah. “Influence of pelvic tilt on functional acetabular orientation.” 2017. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/10800.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grotjohann, Sarah. “Influence of pelvic tilt on functional acetabular orientation.” 2017. Web. 04 Mar 2021.

Vancouver:

Grotjohann S. Influence of pelvic tilt on functional acetabular orientation. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/10800.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grotjohann S. Influence of pelvic tilt on functional acetabular orientation. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/10800

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

17. Schubert, Anne. analysis of maximum load capability, margin integrity and physical properties.

Degree: 2016, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11472

► Objectives: The aim was to investigate the performance of an experimental self-adhesive resin cement used as a post and core build-up material in comparison to… (more)

▼ Objectives: The aim was to investigate the performance of an experimental self-adhesive resin cement used as a post and core build-up material in comparison to two commercially available core build-up materials. Materials and methods: 40 human maxillary incisors were endodontically treated and prepared for post insertion (RelyX Fiber post). Post and core build-ups were performed using one of the four investigated materials: two build-up composites based on an etch-and-rinse adhesive approach (LuxaCore Dual – LC und Clearfil Core – CC) and one self-adhesive resin cement in two application modes (Handmix and Automix). The samples were subjected to thermo-mechanical loading (TML). Maximum load capability (Fmax) was tested in a universal testing machine. Margin integrity was evaluated using Scanning Electron Microscopy. Physical properties were additionally examined. Results: Fmax was significantly affected by the core build-up material (p<0.0005; 1-way ANOVA). CC [481 (158) N] achieved higher Fmax than LC [226 (80) N], Handmix [205 (115) N] and Automix [197 (134) N] (p<0.05; Tukey-B). The percentage of perfect continuous margin in enamel after TML differed significantly among the groups (p<0.0005; Kruskal Wallis). CC gained significantly higher percentages of perfect margin compared to the other groups. Physical properties were significantly affected by the build-up material (p<0.0005; ANOVA). CC and LC demonstrated higher flexural strength in comparison to the self-adhesive groups (p<0.05; Scheffé). Water sorption was significantly higher in the self-adhesive groups (p<0.05; Scheffé). Conclusion: Within the limitations of the present in vitro study it can be concluded that the investigated self- adhesive resin cement is not suitable as a core build-up material due to its low maximum load capability, low margin integrity and weak mechanical properties. Clinical relevance: The investigated self-adhesive resin cement cannot be recommended as a core build-up material. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: post and core build-up; self-adhesive resin cement; margin integrity; maximum load capability; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schubert, A. (2016). analysis of maximum load capability, margin integrity and physical properties. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11472

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schubert, Anne. “analysis of maximum load capability, margin integrity and physical properties.” 2016. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/11472.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schubert, Anne. “analysis of maximum load capability, margin integrity and physical properties.” 2016. Web. 04 Mar 2021.

Vancouver:

Schubert A. analysis of maximum load capability, margin integrity and physical properties. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/11472.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schubert A. analysis of maximum load capability, margin integrity and physical properties. [Thesis]. Freie Universität Berlin; 2016. Available from: https://refubium.fu-berlin.de/handle/fub188/11472

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

18. Stenzel, Fabian. Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography.

Degree: 2015, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12868

► Coronary artery disease (CAD) with its manifestations chronic ischemic heart disease and acute myocardial infarction was the leading cause of death in Germany in the… (more)

▼ Coronary artery disease (CAD) with its manifestations chronic ischemic heart disease and acute myocardial infarction was the leading cause of death in Germany in the year 2012 with 14.2% of all deaths. Invasive conventional coronary angiography (CCA) serves as the reference standard in the detection of coronary artery stenosis and in-stent restenosis (ISR). Noninvasive coronary angiography using multislice computed tomography (CTA) is a promising tool for patients with a low-to-intermediate likelihood for CAD due to its low risk of complications and high sensitivity and specificity in the detection of CAD. The aim of this work was to investigate 1. the diagnostic accuracy of the combination of myocardial perfusion imaging (CTP) and CTA compared to CTA alone for the assessment of coronary artery stents, 2. the time efficiency and agreement of perfusion parameters of two different myocardial perfusion software releases and 3. the image quality using two different bolus tracking methods for CTA image acquisition. The combination of CTA and CTP compared to CTA alone achieved a higher diagnostic accuracy in the detection of ISR on the patient level (87% vs. 71%, p < 0.001) and on the stent level (89% vs. 76%, p < 0.001; publication 1). The number of non-diagnostic stents was significantly reduced using the additional CTP information (p < 0.001). The evaluation of the two software releases for CTP analysis showed that with the new software version significantly less analysis time is required compared to the previous software version (p < 0.001). The diagnostic accuracy was not significantly different between the two software versions (publication 2; p = 0.169). In the analysis of two different bolus tracking methods for the initiation of CTA (publication 3) both a manual and a fixed threshold bolus tracking method achieved a reliable image quality. The evaluation of the image quality of the coronary arteries showed no significant differences between the two groups (p > 0.41). The present work confirms that the non-invasive coronary angiography using CT is a constantly developing and promising tool and - under certain conditions - an alternative to CCA in the diagnosis of CAD. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: computed tomography; coronary angiography; contrast media; bolus tracking; myocardial perfusion imaging; stents; coronary vessel; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stenzel, F. (2015). Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stenzel, Fabian. “Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography.” 2015. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/12868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stenzel, Fabian. “Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography.” 2015. Web. 04 Mar 2021.

Vancouver:

Stenzel F. Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/12868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stenzel F. Detection of in-stent restenosis, myocardial perfusion analysis and bolus tracking with 320-row computed tomography. [Thesis]. Freie Universität Berlin; 2015. Available from: https://refubium.fu-berlin.de/handle/fub188/12868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

19. Heunisch, Fabian. The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12535

► Introduction: Asymmetric dimethylarginine is a competitive inhibitor of the NO-sythase and an important factor of the regulations of vessels. It is synthesized through posttranslational modification… (more)

▼ Introduction: Asymmetric dimethylarginine is a competitive inhibitor of the NO-sythase and an important factor of the regulations of vessels. It is synthesized through posttranslational modification of proteins and released by proteolyses into circulation. In literature patients with chronic kidney disease or dialysis had higher ADMA levels. Iodonated radiocontrast media can heavily damage the kidney, which can lead to a complete loss of kidney function. Especially patients with predamaged kidneys have a higher risk. Because of the rising usage of radiocontrast media, the importance of identification of biomarkers for the prognosis after application rises as well. The ADMA-NO-System might be taking part in the pathogenesis of a contrast induced nephropathy. So this work examines the behavior and the force of expression of ADMA to renal events. Methods: Therefore 330 patients with preexisting diabetes mellitus or renal impairment, who were undergoing a percutanous coronary angiography, were included and the levels of ADMA, creatinine and cystatin c before and 24 hours after contrast media application were measured. To determine the development creatinine was also measured 48 hours and tree months after the application. At three month follow up data about clinical relevant events were collected, too. Results: As result ADMA rises after contrast media application. But there was no relationship between ADMA and the incidence of an acute renal failure. For longer prognosis ADMA levels before and after contrast media application were predictive for dialysis and major adverse renal events (MARE). Additional patients with MARE had a significant higher increase of the ADMA levels than other patients. Diabetes mellitus, anemia, congestive heart failure and the hydration of patients emerged as important influencing factors in the assessment of ADMA. Conclusion: In conclusion the ADMA-regulation is influenced by contrast media. Patients with poorer prognosis demonstrated a different behavior by a higher increase of ADMA. For the short term outcome ADMA seems to be less relevant. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: ADMA; Asymmetric dimethylarginine; radiocontrast exposure; renal outcome; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heunisch, F. (2014). The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12535

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Heunisch, Fabian. “The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/12535.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Heunisch, Fabian. “The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study.” 2014. Web. 04 Mar 2021.

Vancouver:

Heunisch F. The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/12535.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Heunisch F. The predictive value of asymmetric dimethylaginine for the renal outcome after radiocontrast exposure - a prospective clinical study. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/12535

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

20. Brenneis, Cornelia. The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12268

► Background: Although joining patient self-help groups is recommended to patients with ankylosing spondylitis (AS) the evidence for benefits of membership is limited. Objective: To evaluate… (more)

Subjects/Keywords: ankylosing spondylitis; members of the patient organisation; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brenneis, C. (2014). The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12268

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brenneis, Cornelia. “The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/12268.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brenneis, Cornelia. “The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members.” 2014. Web. 04 Mar 2021.

Vancouver:

Brenneis C. The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/12268.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brenneis C. The current situation of patients with ankylosing spondylitis in Germany compared between members of the patient organisation DVMB (German Association of ankylosing spondylitis) and non-members. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/12268

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

21. Sakellariou, Christian J. C. comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/13356

► Infections with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are associated with increased mortality. Outcome differences due to various species of ESBL-E or ESBL genotypes are not well… (more)

Subjects/Keywords: sepsis; bacteremia; gram-negative; ESBL; extended-spectrum beta-Lactamase; Escherichia coli; Klebsiella pneumoniae; genotype; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sakellariou, C. J. C. (2017). comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sakellariou, Christian J C. “comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype.” 2017. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/13356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sakellariou, Christian J C. “comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype.” 2017. Web. 04 Mar 2021.

Vancouver:

Sakellariou CJC. comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/13356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sakellariou CJC. comparison of severity of sepsis, delay of anti-infective therapy and ESBL genotype. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/13356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

22. Jung, Sora. Influence of nutrition, lifestyle habits and sociocultural factors as well as clinical applicability.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/13161

► Background: Antioxidants represent an important protective mechanism against the destructive effects of free radicals in the human organism. These can arise due to various internal… (more)

▼ Background: Antioxidants represent an important protective mechanism against the destructive effects of free radicals in the human organism. These can arise due to various internal and external influences, such as UV and infrared radiation, chemical toxicants, infectious diseases or nicotine and alcohol abuse. The aim of this study was to investigate the impact of individual lifestyle habits, such as diet and stress factors, on the antioxidant status of the skin. Furthermore possible differences between ethnical population groups, age and social groups were examined. Materials and Methods: For this purpose the cutaneous carotenoid concentration was determined in healthy volunteers of different social and ethnical background using a mobile, miniaturized measurement device based on reflection spectroscopy. Moreover individual data on dietary and lifestyle habits was assessed. In a further step, the clinical use of a topically applied cream containing highly concentrated antioxidants was investigated for treatment and prevention of palmar plantar erythrodysesthesia in patients receiving chemotherapy with pegylated liposomal doxorubicine. Results: It was shown that especially a healthy diet, rich in fruit and vegetables, and avoidance of stress are equally important for a high antioxidant status. The antioxidant status is a multifactorial process that is influenced by stimulating, as well as reducing factors. The nutritional and stress behavior is of particular importance. Individual changes in diet and lifestyle can quickly be shown by using the above mentioned non-invasive spectroscopic mean measuring carotenoids as biomarkers. In addition to that, the measurements are well suited to provide a biofeedback about present individual lifestyle and eating habits or even motivate to a healthier lifestyle. Furthermore the clinical application of a cream containing a high concentration of antioxidants showed positive therapeutic and preventive effects against palmar plantar erythrodysesthesia. Discussion: Due to its handiness, mobility and non-invasiveness, the used spectroscopic device is a well suited tool to investigate the antioxidant status in a larger amount of subjects. Both the determination of cutaneous antioxidants by means of the described method as well as the topical application of concentrated antioxidants can be effectively used for individual health promotion and disease prevention. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: antioxidants; carotenoids; stress; nutrition; ethnic differences; traditional Korean nutrition; hand-foot syndrome; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jung, S. (2014). Influence of nutrition, lifestyle habits and sociocultural factors as well as clinical applicability. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jung, Sora. “Influence of nutrition, lifestyle habits and sociocultural factors as well as clinical applicability.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/13161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jung, Sora. “Influence of nutrition, lifestyle habits and sociocultural factors as well as clinical applicability.” 2014. Web. 04 Mar 2021.

Vancouver:

Jung S. Influence of nutrition, lifestyle habits and sociocultural factors as well as clinical applicability. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/13161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jung S. Influence of nutrition, lifestyle habits and sociocultural factors as well as clinical applicability. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/13161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

23. Siara, Kati. Value of MRI and CT in the differential diagnosis of neoplasms of adrenal glands in a high risk group.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11647

► Neoplasm of adrenal glands are frequent. In a normal population benign neoplasm dominates. For these the value of CT and MRI in diagnostics is well… (more)

▼ Neoplasm of adrenal glands are frequent. In a normal population benign neoplasm dominates. For these the value of CT and MRI in diagnostics is well examined. Both are suited to predict benignancy. However, for patient with a high risk for adrenal metastases only few data is available. This study examined whether CT and MRI are sufficiently accurate to predict benignancy in a high-risk group. A diagnostic algorithm for patients with a lung carcinoma (LuCa) and an adrenal neoplasm (AN) is derived from our data. This retrospectives study included patients with LuCa and at least one AN, if at least one MRI with chemical shift imaging (CS-MRI) and optionally an unenhanced CT (nCT) existed and if the nature of the AN was known either by histologic proof or follow-up. 51 patients with 65 AN were enrolled. In all cases a CS-MRI and in 41 a nCT was available. The signal loss in CS-MRI and the density in nCT were measured. Threshold values for assuming benignancy were fixed: in nCT a density of ≤10 HU, in CS-MRI a signal loss of >50%. For CS-MRI a sensitivity of 88.9% and a specificity of 93.6% were found (negative prediction value (NPV) 95.7%, positive prediction value (PPV) 84.2%, accuracy 92.3%. A ROC analysis confirmed that the threshold value of 50% signal loss offers a good differentiation between benign and malign neoplasm in a high- risk group. In nCT a sensitivity of 92.3% and a specificity of 78.6% were found (NPV 95.6%, PPV 66.6%, exactness 82.9%). From this data an algorithm was derived for patients with LuCa and AN. As nCT and CS-MRI are equivalent concerning the NPV, it is possible to perform nCT first. If benignancy of AN cannot be proven, a CS-MRI can provided further specificity. With this algorithm staging of LuCa patients can be non-invasively preformed with clinically sufficient accuracy. If the dignity of AN remains unclear a PET-CT and possibly histologic proof may be necessary in potentially operable patients. Our data on the performance of CS-MRI and nCT in a high-risk group is comparable with published data found in a normal population. In conclusion, the proposed diagnostic algorithm using nCT and CS-MRI for patients with a high risk for adrenal metastases can, with sufficient accuracy, predict the benignity of an adrenal neoplasm. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: neoplasm of adrenal glands; ct; mri; staging; lung carcinoma; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Siara, K. (2014). Value of MRI and CT in the differential diagnosis of neoplasms of adrenal glands in a high risk group. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11647

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Siara, Kati. “Value of MRI and CT in the differential diagnosis of neoplasms of adrenal glands in a high risk group.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/11647.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Siara, Kati. “Value of MRI and CT in the differential diagnosis of neoplasms of adrenal glands in a high risk group.” 2014. Web. 04 Mar 2021.

Vancouver:

Siara K. Value of MRI and CT in the differential diagnosis of neoplasms of adrenal glands in a high risk group. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/11647.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Siara K. Value of MRI and CT in the differential diagnosis of neoplasms of adrenal glands in a high risk group. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/11647

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

24. Börner, Constanze. The neuroprotective effect of the specific caspase-2 inhibitor TRP601 in a neonatal rat model after exposure to hyperoxia.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11539

► Oxygen contributes to the pathogenesis of neonatal brain damage, leading to neurocognitive impairment of prematurely born infants in later life (17,120). We have identified a… (more)

▼ Oxygen contributes to the pathogenesis of neonatal brain damage, leading to neurocognitive impairment of prematurely born infants in later life (17,120). We have identified a critical role for receptor-mediated neuronal apoptosis in the immature rodent brain. The contribution of the intrinsic apoptotic pathway accompanied by activation of caspase-2 under hyperoxia in the neonatal brain still remains elusive. Inhibition of caspases appears a promising strategy for neuroprotection in neonatal brain injury. 6-day-old Han Wistar rats were randomly assigned to four groups and treated as follows: (1) normoxia (21% O2) and vehicle i.p., (2) normoxia and 1mg TRP601/kg/KG i.p., (3) hyperoxia (80% O2) and vehicle i.p. (4) hyperoxia and 1 mg TRP601/kg/KG i.p. We applied a recently developed pentapeptide-based group II caspase-inhibitor (5-(2,6 -difluoro-phenoxy) -3(R,S)-(2(S)-(2(S)-(3-methoxy-carbonyl-2(S)-(3-methyl-2(S )-((quino-line-2-carbonyl)-amino) butyrylamino)pro- pionylamino)3methylbutyrylamino)propionyl-amino)-4-oxo-pentanoic-acid- methylester; TRP601). 12 or 24h after treatment, postnatal day-6 pups were killed. They were transcardially perfused with PBS and decapitated. Brains were removed and prepared for Fluoro-Jade B staining, Western blot analysis and detection of caspase-2 and -3 enzymatic activities. Data were analyzed by R Project for Statistical Computing and presented as mean±standard error. Group effects were assessed by ANOVA, followed by independent sample t-test multiple comparison. Adjusted P-values of <0.05 were considered statistically significant. We report that elevated oxygen (hyperoxia) levels trigger a marked increase in active caspase-2 expression, resulting in an initiation of the intrinsic apoptotic pathway with upregulation of key proteins, namely, cytochrome c, Apaf-1 and AIF, whereas Bid and the anti-apoptotic Bcl-2 are downregulated. These results coincide with an upregulation of caspase-3 activity and marked neurodegeneration. However, single treatment with TRP601 at the beginning of hyperoxia reversed the detrimental effects in this model. The present study reveals the involvement of caspase-2 in combination with the intrinsic apoptotic cascade in hyperoxia-induced injury to the immature central nervous system. We report for the first time that TRP601 provides strong evidence for neuroprotective action against hyperoxia-induced apoptosis influencing intrinsic caspase-dependent and also caspase-independent pathways. Our results are in line with a recently published report of a protective effect of TRP601 in other rodent models of perinatal rodent brain injury, (128) and suggest different potential molecular mechanisms that may entertain this tissue-protective effect of TRP601. TRP601 seems to be a auspicious prospect for neuroprotection in neonatology. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: Hyperoxia; caspase-inhibitor; neuroprotection; neurodegeneration; neonatal brain; rat model; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Börner, C. (2014). The neuroprotective effect of the specific caspase-2 inhibitor TRP601 in a neonatal rat model after exposure to hyperoxia. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Börner, Constanze. “The neuroprotective effect of the specific caspase-2 inhibitor TRP601 in a neonatal rat model after exposure to hyperoxia.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. https://refubium.fu-berlin.de/handle/fub188/11539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Börner, Constanze. “The neuroprotective effect of the specific caspase-2 inhibitor TRP601 in a neonatal rat model after exposure to hyperoxia.” 2014. Web. 04 Mar 2021.

Vancouver:

Börner C. The neuroprotective effect of the specific caspase-2 inhibitor TRP601 in a neonatal rat model after exposure to hyperoxia. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: https://refubium.fu-berlin.de/handle/fub188/11539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Börner C. The neuroprotective effect of the specific caspase-2 inhibitor TRP601 in a neonatal rat model after exposure to hyperoxia. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/11539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

25. Homburg, David. Evaluation der Visusleistung nach beidseitiger Implantation einer Tecnis® Symfony IOL (Modell ZXR00) im Vergleich zu einer beidseitigen Implantation einer Tecnis® Monofokal 1-Piece IOL (Modell ZCB00).

Degree: 2019, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-1827

► Purpose: Spectacle independence after cataract surgery is one of the main goals in refractive cataract surgery today. The surgeon can choose between a vast variety… (more)

▼ Purpose: Spectacle independence after cataract surgery is one of the main goals in refractive cataract surgery today. The surgeon can choose between a vast variety of intraocular lenses. One of the most recent generations of intraocular lenses is the Tecnis Symfony IOL which uses a new achromatic diffractive lens design. The purpose of this study was to evaluate this extended depth of focus (EDOF) IOL and to compare it to a monofocal intraocular lens. Methoden: This was a prospective non-randomized clinical study including 60 eyes of 30 patients undergoing cataract surgery with the implantation of the EDOF-IOL Tecnis Symfony IOL (ZXR00, Abbot Medical Optics Inc, Santa Ana, CA, USA) (EDOF group: 30 eyes of 15 patients) or the monofocal Tecnis Monofokal 1-Piece IOL (ZCB00, Abbot Medical Optics Inc, Santa Ana, CA, USA) (monofocal group: 30 eyes of 15 patients). The visual acuity in far, intermediate and near distance, the depth of focus, contrast sensitivity and glare vision unter photopic and mesopic conditions, higher-order aberrations and the quality of life (National Eye Institute Refractive Error of Life Instrument 42 Questionnaire) were evaluated during a 4-week and 3-month follow-up. Results: There was a significant better contrast sensitivity and glare vision unter photopic conditions and a significant better contrast sensitivity unter mesopic conditions for the monofocal group (p=0,041). No differences were found in the glare vision under mesopic conditions and in the ability to drive a car (p=0,485). The EDOF group showed significant better monocular and binocular intermediate and near visual acuity (p<0,001). No significant differences were found when looking at higher order aberrations between the groups (p=0,655). Concerning the questionnaire no differences were found in the categories “glare” (p=0,384) and “satisfaction” (p=0,14). However, in the category “dependence on correction” the EDOF group showed significantly better results (p=0,001). Conclusion: The EDOF IOL is a good contribution to the spectrum of intraocular lenses. It provides better intermediate and near visual acuity compared to a monofocal lens. The worse results in contrast sensitivity and glare vision seem to have a limited clinical relevance when looking at driving ability and quality of life. Advisors/Committee Members: male (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: Tecnis Symfony IOL; extended range of vision; contrast sensitivity; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Homburg, D. (2019). Evaluation der Visusleistung nach beidseitiger Implantation einer Tecnis® Symfony IOL (Modell ZXR00) im Vergleich zu einer beidseitigen Implantation einer Tecnis® Monofokal 1-Piece IOL (Modell ZCB00). (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-1827

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Homburg, David. “Evaluation der Visusleistung nach beidseitiger Implantation einer Tecnis® Symfony IOL (Modell ZXR00) im Vergleich zu einer beidseitigen Implantation einer Tecnis® Monofokal 1-Piece IOL (Modell ZCB00).” 2019. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-1827.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Homburg, David. “Evaluation der Visusleistung nach beidseitiger Implantation einer Tecnis® Symfony IOL (Modell ZXR00) im Vergleich zu einer beidseitigen Implantation einer Tecnis® Monofokal 1-Piece IOL (Modell ZCB00).” 2019. Web. 04 Mar 2021.

Vancouver:

Homburg D. Evaluation der Visusleistung nach beidseitiger Implantation einer Tecnis® Symfony IOL (Modell ZXR00) im Vergleich zu einer beidseitigen Implantation einer Tecnis® Monofokal 1-Piece IOL (Modell ZCB00). [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-1827.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Homburg D. Evaluation der Visusleistung nach beidseitiger Implantation einer Tecnis® Symfony IOL (Modell ZXR00) im Vergleich zu einer beidseitigen Implantation einer Tecnis® Monofokal 1-Piece IOL (Modell ZCB00). [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-1827

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

26. Finke, Johann Felix. Connection of osseous and muscular deficits in revision of total hip arthroplasty.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6004

► Introduction: The relationship between osseous and muscular deficit in revision of total hip replacement is unknown so far. Therefore, the aim of this study is… (more)

▼ Introduction: The relationship between osseous and muscular deficit in revision of total hip replacement is unknown so far. Therefore, the aim of this study is the evaluation of the osseous and muscular status before and after revision of total hip replacement. Methods: Prospective cohort study. 22 patients scheduled for acetabular revision using the direct lateral approach. Age 70,3 ± 10,4 years, body-mass-index 27,3 ± 3,3 kg/m2. Preoperatively, the Paprosky classification of the acetabular defect was used. In addition, preoperatively and six months postoperatively, the fatty degeneration of gluteus medius muscle was quantified using magnetic resonance tomography. Subsequently, the analysis of the osseous and muscular damage and the varianceanalysis of the muscle damage as a function of severity of the acetabular bone defect were performed. Results: The present study includes four patients with defect type 1, twelve patients with defekts type 2A, 2B and 2C and six patients with defects typ 3A and 3B according to the Paprosky classification. In the cohort, a significant increase in the muscular fatty degeneration of the gluteus medius muscle can be demonstrated (preoperatively 30%± 28,6; postoperatively 40% ± 30,7; p = 0,002). Preoperatively, patients with first revision manifest a significantly lower extend of muscle damage compared to patients with multiple revisions (fatty degeneration: first revision 20% ± 22,6; multiple revisions 45% ± 31,0; p = 0,045%). A preoperative high-grade osseous defect of the acetabulum is associated with significantly higher damage of gluteus medius muscle than low-grade osseous defects (p = 0,006). Conclusion: The present study shows that a preoperative high-grade bone damage of the acetabulum is associated with significantly higher muscle degeneration. With patients with multiple revision and/or higher osseous deficits, the possible functional deficits have to be reasoned and implants for reduction of the risk of dislocation have to be available intraoperatively. Large femoral heads, dual mobility cups and constrained liner represent possible options. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: Paprosky classification; musculus gluteus medius; revision total hip arthroplasty; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Finke, J. F. (2018). Connection of osseous and muscular deficits in revision of total hip arthroplasty. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6004

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Finke, Johann Felix. “Connection of osseous and muscular deficits in revision of total hip arthroplasty.” 2018. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-6004.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Finke, Johann Felix. “Connection of osseous and muscular deficits in revision of total hip arthroplasty.” 2018. Web. 04 Mar 2021.

Vancouver:

Finke JF. Connection of osseous and muscular deficits in revision of total hip arthroplasty. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-6004.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Finke JF. Connection of osseous and muscular deficits in revision of total hip arthroplasty. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-6004

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

27. Wolfram, Julia. Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10286

► Background: The acquired factor XIII deficiency after major operations is correlated with perioperative blood loss and bleeding disorders. This study investigated the effect of a… (more)

▼ Background: The acquired factor XIII deficiency after major operations is correlated with perioperative blood loss and bleeding disorders. This study investigated the effect of a prophylactic factor XIII application on the perioperative blood loss and the rate of blood transfusions for alcohol dependent patients undergoing a neck dissection. Methods: In this prospective double-blind clinical study 23 alcohol dependent patients with a carcinoma, an elective neck dissection and a daily minimum consumption of 60 g of alcohol were randomized into two groups. The Fibrogammin group (n=11) was treated with 2500 U Fibrogammin® preoperatively and four times 1250 U postoperatively. The placebo group (n=12) received 0.9 % saline solution instead. The blood loss and transfused blood products were measured intraoperatively and daily up to 10 days after surgery or until the discharge from hospital. Results: In between Fibrogammin and placebo group there was no significant difference of blood loss according to the multivariate testing method (p=0.59) as well as the univariate testing method (intraoperative p=0.83; postoperative p=0.74; perioperative p=0.88). A tendency of decreased bleeding was found at 1. POD (1. POD: p=0.24). Intraoperative blood products were administered to 1 patient in the Fibrogammin (1 EK and 2 FFP) and 2 patients from the placebo group (3 EK respectively 2 EK). 1 patient in each group received a transfusion postoperatively (Fibrogammin group: 1 EK, placebo group: 3 EK). The need of transfusions did not differ within the groups (p=1.00). The length of hospital stay in the Fibrogammin group tended to be 2 days shorter (p=0.41). After the neck dissection, the factor XIII levels within the placebo group decreased significantly by 30 %. 40 % of patients from the placebo group developed an acquired factor XIII deficiency (≤ 70 %). The patients with an acquired factor XIII deficiency showed a significantly enhanced blood loss intraoperatively and at the 2nd POD (intraop: p=0.02; 2. POD: p=0.02). In the Fibrogammin group, the value remained within the range of reference. Conclusions: Within both groups the results did not show a significant reduction of perioperative blood loss or decreased need for blood transfusions after the prophylactic application of factor XIII. However, the descriptive results indicate that the detection of factor XIII levels and the selective application of factor XIII can be beneficial for alcohol-dependent patients with a high perioperative blood loss. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: factor XIII; neck dissection; alcohol dependent patients; blood loss; blood transfusion; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wolfram, J. (2018). Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wolfram, Julia. “Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions.” 2018. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-10286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wolfram, Julia. “Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions.” 2018. Web. 04 Mar 2021.

Vancouver:

Wolfram J. Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-10286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wolfram J. Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-10286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

28. Lucka, Tilmann Christian. Efficacy of systemic therapies for moderate-to-severe psoriasis: a systematic review and meta-analysis of long-term treatment.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9008

► Background: Psoriasis vulgaris is a chronic disease that predominantly affects the skin. The prevalence is about 2-3 % in the European population with a variation… (more)

▼ Background: Psoriasis vulgaris is a chronic disease that predominantly affects the skin. The prevalence is about 2-3 % in the European population with a variation among different ethnic groups. So far systemic reviews focused predominantly on short-term treatment, whereas symptoms usually persist throughout life. Objective: Evaluation of effective systemic long-term treatments for moderate-to-severe psoriasis. Methods: A systematic literature research in Medline, Embase and the Cochrane Li-brary was conducted with a search strategy similar to the german Psoriasis S3 guide-line. The proportion of patients with a decrease in the Psoriasis Area Severity Index (PASI) of at least 75 % and the reduction in the Dermatology Life Quality Index (DLQI) at different points in time during therapy were gathered. Studies have been summarized in terms of study designs and survey periods. Among these appropriate studies were included in the meta-analysis. Particular attention was given to the sta-tistical approach with the handling of dropouts. Results: 33 publications reporting on 27 trials with active treatment of 6575 patients were included in the systematic review. 7 randomized controlled trials were eligible for the meta-analysis. After 24 weeks of treatment infliximab 5 mg/kg bodyweight [risk dif-ference (RD) 78%, 95% confidence interval (CI) 72–83%] and ustekinumab 90 mg (RD 77%, 95% CI 71–83%) were the most efficacious active agents. Adalimumab 40 mg (RD: 60%, 95% CI 45–74%) showed results within the range of different etanercept dosages (etanercept 50 mg once weekly: RD 62%, 95% CI, 52–72%), (etanercept 25 mg twice weekly: RD 45%, 95% CI 34–56%), (etanercept 50 mg twice weekly: RD 56%, 95% CI 49–62%) and (etanercept 50 mg twice weekly until week 12, then 25 mg twice weekly: RD 50%, 95% CI 42–57%). In studies lasting longer than 24 weeks a decrease in efficacy for inflximab, adalimumab and etanercept was observed. Conclusion: More sufficient data is needed to draw reliable conclusions in efficacy of long-term treatments beyond 24 weeks and head-to-head comparisons of different ac-tive agents are necessary. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: psoriasis; long-term; efficacy; systemic therapy; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lucka, T. C. (2014). Efficacy of systemic therapies for moderate-to-severe psoriasis: a systematic review and meta-analysis of long-term treatment. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9008

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lucka, Tilmann Christian. “Efficacy of systemic therapies for moderate-to-severe psoriasis: a systematic review and meta-analysis of long-term treatment.” 2014. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-9008.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lucka, Tilmann Christian. “Efficacy of systemic therapies for moderate-to-severe psoriasis: a systematic review and meta-analysis of long-term treatment.” 2014. Web. 04 Mar 2021.

Vancouver:

Lucka TC. Efficacy of systemic therapies for moderate-to-severe psoriasis: a systematic review and meta-analysis of long-term treatment. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-9008.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lucka TC. Efficacy of systemic therapies for moderate-to-severe psoriasis: a systematic review and meta-analysis of long-term treatment. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-9008

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

29. Busche, Marlene. Changes of immunological parameters in therapy resistant unipolar depression under lithium augmentation and their relevance to response prediction.

Degree: 2017, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10424

► Background: There is growing evidence that inflammatory processes are involved in the pathophysiology of depression. Immunmodulatory mechanisms may be part of an effective antidepressant treatment.… (more)

▼ Background: There is growing evidence that inflammatory processes are involved in the pathophysiology of depression. Immunmodulatory mechanisms may be part of an effective antidepressant treatment. Lithium augmentation (LA) is one of the treatment strategies with the best evidence concerning the efficacy for treatment resistant depression (TRD). The impact of immune parameters on lithium augmentation has not been investigated yet. The aim of this study was to explore for the first time, if immune parameters such as cytokines change under LA and if cytokines and brain-derived neurotrophic factor (BDNF) are potential predictors of response to LA. Furthermore the relationship between cytokines and BDNF as well as clinical characteristics was investigated. Methods: As a subproject of a prospective multicenter study investigating response prediction to LA in unipolar TRD (ICD10 F32.1-3 und F33.1-3) serum levels of the immune parameters interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor (GM-CSF), Interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) were measured in 95 patients, BDNF in 104 patients before and after four weeks of LA. Depression severity was assessed weekly using the Hamilton Depression Rating Scale (HAMD-17). Results: Significant changes of cytokine levels under LA could not be found. Cytokines before LA had no significant influence on the response or remission probability. BDNF before LA showed a significant effect on the response probability (Hazard Ratio (HR) 0.903, 95%KI 0.83-0.99, p=0.023) and an influence with a trend to significance to remission probability to LA (HR 0.894, 95% KI 0.8-1.00, p=0.052) – cytokines had no effect. Patients with a faster speed of onset of the depressive episode differed from patients with a slower onset of the depressive episode in terms of cytokine levels (IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ: p<0.05, TNF-α: p<0.1). BDNF was positively correlated with IL-4 (p=0.009), GM-CSF (p=0.028) and IFN-γ (p=0.042) before LA and IL-4, GM-CSF (p=0.012), IL-8 (p=0.067), IL-10 (p=0.081) and IFN- γ (p=0.057) under LA. Conclusion: This is the first clinical study investigating the influence of LA on cytokines. There was no modulating effect of LA on peripheral cytokines. The data of this study does not indicate that cytokines can predict treatment response to LA, whereas patients with low BDNF levels are related with a better response to LA. Differences in clinical characteristics of depression may correlate with immunological parameters and there may be a connection between cytokines and BDNF. These results need further evaluation. The findings contribute to the knowledge of cytokines and BDNF as a state marker in affective disorders. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: cytokines; depression; lithium augmentation, response prediction; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Busche, M. (2017). Changes of immunological parameters in therapy resistant unipolar depression under lithium augmentation and their relevance to response prediction. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10424

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Busche, Marlene. “Changes of immunological parameters in therapy resistant unipolar depression under lithium augmentation and their relevance to response prediction.” 2017. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-10424.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Busche, Marlene. “Changes of immunological parameters in therapy resistant unipolar depression under lithium augmentation and their relevance to response prediction.” 2017. Web. 04 Mar 2021.

Vancouver:

Busche M. Changes of immunological parameters in therapy resistant unipolar depression under lithium augmentation and their relevance to response prediction. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-10424.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Busche M. Changes of immunological parameters in therapy resistant unipolar depression under lithium augmentation and their relevance to response prediction. [Thesis]. Freie Universität Berlin; 2017. Available from: http://dx.doi.org/10.17169/refubium-10424

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

30. Rejmus, Robert. Spatial organization of fecal bacteria in patients with multiple sclerosis.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8560

► Abstract Introduction: Multiple sclerosis (MS) is an immune-mediated, inflammatory disease of the central nervous system. Although its etiology remains unclear, some scientific studies indicate, that… (more)

▼ Abstract Introduction: Multiple sclerosis (MS) is an immune-mediated, inflammatory disease of the central nervous system. Although its etiology remains unclear, some scientific studies indicate, that the mucosal immune system may play an important role in the regulation of autoimmunity. The purpose of this study was to evaluate the changes in the composition of the intestinal flora of patients with MS Methods: Stool samples were collected from MS outpatients (N = 54) in the MS Center of Oberhavel Kliniken in Hennigsdorf and from control persons (N = 54) attending the General Internal Medicine Outpatient Clinic of the Charité Hospital in Berlin. They were investigated with fluorescence in situ hybridization (FISH) techniques, with probes specific for six bacterial groups: Atopobium, Bacteroidaceae, Bifidobacteriae, Enterobacteriaceae, Eubacterium rectale and Faecalibacterium prausnitzii. Results: Atopobium bacteria occured significantly more often in MS patients than in controls. Concentrations of Atopobium and Bifidobacterium were significantly higher, while the concentration of Bacteroidaceae laws significantly lower in MS patients. The concentrations of Atopobium and Bifidobacteriae in MS patients reached levels, which are typically for Firmicutes and Bacteroidetes. The composition of the intestinal flora in patients with MS did not depend on the clinical form of the disease, disease activity, degree of disability, type of therapy and the place of residence. Conclusion: The structure of the fecal flora in MS patients in regards to the presence of bacterial groups corresponded to results of previous observations in other autoimmune diseases. The evidence suggests that bacterial dysbiosis of the intestinal flora could affect the immunological and metabolic characteristics of MS patients. Some factors related to the evolution of the human intestinal flora and its environmentally induced changes may suggest a connection to the known MS-typical epidemiological patterns. Advisors/Committee Members: m (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: autoimmunity; commensal bacteria; experimental autoimmune encephalomyelitis; gut commensal microflora; multiple sclerosis;

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rejmus, R. (2015). Spatial organization of fecal bacteria in patients with multiple sclerosis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8560

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rejmus, Robert. “Spatial organization of fecal bacteria in patients with multiple sclerosis.” 2015. Thesis, Freie Universität Berlin. Accessed March 04, 2021. http://dx.doi.org/10.17169/refubium-8560.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rejmus, Robert. “Spatial organization of fecal bacteria in patients with multiple sclerosis.” 2015. Web. 04 Mar 2021.

Vancouver:

Rejmus R. Spatial organization of fecal bacteria in patients with multiple sclerosis. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Mar 04]. Available from: http://dx.doi.org/10.17169/refubium-8560.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rejmus R. Spatial organization of fecal bacteria in patients with multiple sclerosis. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-8560

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations