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You searched for +publisher:"Freie Universität Berlin" +contributor:("Prof. Dr. med. T. Kombos"). Showing records 1 – 2 of 2 total matches.

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Freie Universität Berlin

1. Störtländer, Björn Klaus. A 12-month follow-up of patients with lumbar spinal stenosis after implantation of an interspinous fixation device.

Degree: 2012, Freie Universität Berlin

Background Microsurgical Decompression is the standard surgical technique used in the treatment of lumbar spinal stenosis. In cases of low-grade spondylolisthesis (Meyerding Grade I) and facet joint arthrosis existing simultaneously, we think the additional implantation of an interspinous fixation device is a useful supplement. By its biomechanical properties such an implant allows a dynamic stabilisation of the minor instability rather increased by decompression, relieves pressure on the facet joints, and restores neuroforaminal width. Furthermore the invasiveness of this procedure is much lower than by rigid spondylodesis (e. g. PLIF). In the present study the effectiveness of operative treatment of the above-mentioned pathological complex by decompression and implantation of the interspinous fixation device “LE U” (ARCA-MEDICA GmbH, Wurmlingen, Germany) was investigated. Methods In the Neurosurgical Department of the Unfallkrankenhaus Berlin (Germany) 48 patients received this operative treatment in the period from September 21st, 2005 up to November 31st, 2007. The follow-up rate was 88% (42 of 48 patients) at one year. The patients were assessed clinically and radiographically. Results At 6 and 12 months follow-up, there was a significant improvement of low back pain and the sciatia measured by Visual-Analogue-Scale. Looking at a calculated recovery rate, at 6 months follow-up, there were 20/42 patients (48%) with an excellent clinical outcome in terms of back pain and the sciatia. Twelve months after surgery, 15/42 patients (36%) showed an excellent outcome in relation to back pain and 21/42 patients (50%) showed an excellent outcome in relation to sciatia. No differences were found between female and male patients, but there were between patients older than 55 years and younger patients, as well as between patients with a normal weight and overweight patients. The interspinous implant was dislocated in one of the 42 patients. Conclusion The study demonstrates that lumbar decompression and interspinous fixation with the “Le U” is an effective treatment in patients with degenerative spinal stenosis and low-grade spondylolisthesis and facet joint arthrosis. The implantation of an interspinous fixation device without simultaneous lumbar decompression is not a rational treatment option from the point of view of the author. Advisors/Committee Members: m (gender), Prof. Dr. med. U. Meier (firstReferee), Priv.-Doz. Dr. med. O. Süss (furtherReferee), Prof. Dr. med. T. Kombos (furtherReferee).

Subjects/Keywords: lumbar spinal stenosis; interspinous fixation; Le U; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Störtländer, B. K. (2012). A 12-month follow-up of patients with lumbar spinal stenosis after implantation of an interspinous fixation device. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9140

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Störtländer, Björn Klaus. “A 12-month follow-up of patients with lumbar spinal stenosis after implantation of an interspinous fixation device.” 2012. Thesis, Freie Universität Berlin. Accessed December 05, 2019. http://dx.doi.org/10.17169/refubium-9140.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Störtländer, Björn Klaus. “A 12-month follow-up of patients with lumbar spinal stenosis after implantation of an interspinous fixation device.” 2012. Web. 05 Dec 2019.

Vancouver:

Störtländer BK. A 12-month follow-up of patients with lumbar spinal stenosis after implantation of an interspinous fixation device. [Internet] [Thesis]. Freie Universität Berlin; 2012. [cited 2019 Dec 05]. Available from: http://dx.doi.org/10.17169/refubium-9140.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Störtländer BK. A 12-month follow-up of patients with lumbar spinal stenosis after implantation of an interspinous fixation device. [Thesis]. Freie Universität Berlin; 2012. Available from: http://dx.doi.org/10.17169/refubium-9140

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Freie Universität Berlin

2. Tzamalis, Georgios. The association of HPV with adenoid cyctic carcinomas of the salivary glands.

Degree: 2012, Freie Universität Berlin

Adenoid cystic carcinoma is the most common malignancy of the salivary glands, though its etiology still remains unknown. Since genetic alterations are rare, other factors such as mutations, epigenetic regulation or viral infections have been discussed. Persistent HR-HPV infection is implicated in the etiology of a number of carcinomas of the anogenital and head and neck region. The main goal of this study is the first retrospective investigation of the prevalence of oncogenic HPV in ACC and their influence, in interference with the biomarkers p16, p53, Ki-67 and EGFR on the prognosis of the disease. The cohort included 67 patients, 44 women and 23 men. Clinical data were collected from medical records and the German National Cancer Registry and tissue sections were cut from the tumor specimens for immunohistochemical analysis of p16, p53, Ki-76 and EGFR as well as for HPV genotyping. 59.75% of the tumors were located in the minor salivary glands, 25.4% in the parotid gland and 14.9% in the submandibular gland. 37.3% of the tumors were HR-HPV positive, of those were 16 HPV16, 4 HPV18, 2 HPV45, each one HPV45 and HPV56 and 2 HPV33 and HPV59 detected. In 3 patients, infection with low-risk HPV 11 was observed. In 39 patients, no HPV DNA was detected. 58,82% of the tumors of parotid gland, 32.5% of tumors of the minor salivary glands, and only 20% of the tumors of submandibular gland were positive for HR-HPV. The analysis of p16 expression showed a similar pattern and significantly correlated with HR- HPV positivity. With increasing age, proportionally more HR-HPV-and p16-positive tumors were observed. Between HPV or p16 and the biomarkers p53, Ki-67 and EGFR, no correlation was observed. The prognosis of the disease for male patients in our series was better. HR-HPV association and p16 expression seem to have a positive effect on overall survival, however not on recurrency- free survival. An increasing expression of the proliferation biomarker Ki-67 was correlated with a significantly worse overall survival. For the biomarkers EGFR and p53 no correlation with prognosis could be detected. Regarding the HPV status and p16 expression, the vast majority of recurrencies and metastases histologically examined, were identical to the primary tumor. That fact could indicate a possible causality of HPV infection for the oncogenesis. This study has been describeingthe prevalence of HPV in ACC for the first time. The findings showing the similarity of the ACC, regarding the prognostic role of HPV, to other more familiar and better studied tumor entities could facilitate a useful transfer of therapeutic strategies in the future. Advisors/Committee Members: m (gender), Priv.-Doz. Dr. rer. nat. A. Kaufmann (firstReferee), Prof. Dr. med. T. Kombos (furtherReferee), Priv.-Doz. Dr. med. B. Sedlmaier (furtherReferee).

Subjects/Keywords: adenoid cyctic carcinoma; salivary glands; HPV; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Tzamalis, G. (2012). The association of HPV with adenoid cyctic carcinomas of the salivary glands. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14007

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Tzamalis, Georgios. “The association of HPV with adenoid cyctic carcinomas of the salivary glands.” 2012. Thesis, Freie Universität Berlin. Accessed December 05, 2019. http://dx.doi.org/10.17169/refubium-14007.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Tzamalis, Georgios. “The association of HPV with adenoid cyctic carcinomas of the salivary glands.” 2012. Web. 05 Dec 2019.

Vancouver:

Tzamalis G. The association of HPV with adenoid cyctic carcinomas of the salivary glands. [Internet] [Thesis]. Freie Universität Berlin; 2012. [cited 2019 Dec 05]. Available from: http://dx.doi.org/10.17169/refubium-14007.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tzamalis G. The association of HPV with adenoid cyctic carcinomas of the salivary glands. [Thesis]. Freie Universität Berlin; 2012. Available from: http://dx.doi.org/10.17169/refubium-14007

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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