Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for +publisher:"Freie Universität Berlin" +contributor:("Prof. Dr. C. Vogelmeier"). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


Freie Universität Berlin

1. Hübner, Ralf-Harto. Endobronchial valve treatment in patients with severe lung emphysema.

Degree: 2018, Freie Universität Berlin

According to the World Health Organization (WHO) chronic obstructive pulmonary disease (COPD) became the 4th most leading cause of death among all diseases worldwide. Long-term cigarette smoking is the main cause of COPD responsible for over 90% of all cases, that permanent smoking cessation remains the most effective therapy. Another new treatment option includes endoscopic lung volume reduction (ELVR), which has developed from surgical lung volume reduction (LVRS) with the goal of reducing hyperinflated lobes without exposing patients to the high risk of severe perioperative complication. Endobronchial valves have been the preferred approach in the clinical setting among other options of ELVR technique because of its reversibility and better scientific evidence. Studies have shown that patients with complete fissures in the target lobe (CVneg) and heterogeneous lung emphysema respond particularly well from the procedure, although results are highly variable. Therefore, other criteria are needed to predict better treatment response after valve implantation. In addition, a major disadvantage of valve therapy is the high rate of pneumothoraces. It was evaluated whether pneumothorax rate may be reduced with modified post-operative medical management. 406 Chartis measurements were retrospectively analyzed and categorized into four phenotypes using new Chartis criteria. Patients whose target lobe was rated CVneg according to the Chartis criteria demonstrated significant lung volume reduction, improvement in pulmonary function test, quality of life, and exercise capacity after valve implantation. The predictive value for successful treatment could be further improved in another study when the combination of a semiautomated fissure analysis and Chartis assessment was used. Furthermore, correlation analyzes showed that the increase in forced expiratory capacity (FEV1) after valve treatment and the improvement in 6-minute walking test (6MWT) was correlated to perfusion of the ipsilateral adjacent lobe from the target lobe. In a prospective multicenter study, it was also shown that patients with homogeneous lung emphysema demonstrated an improvement in pulmonary function test, exercise capacity and quality of life, that valve therapy should not be withheld from patients with homogeneous lung emphysema. The incidence of pneumothorax was reduced by strict bed-rest after valve implantation and cough suppression if needed without affecting clinical outcome. In summary, this work shows that patients with severe COPD benefit from ELVR by optimizing selection criteria and reducing complications. Some studies have yet to be proven in prospective studies. Advisors/Committee Members: [email protected] (contact), m (gender), Prof. Dr. C. Vogelmeier (firstReferee), Prof. Dr. K. F. Rabe (furtherReferee).

Subjects/Keywords: COPD; endoscopic lung volume reduction; endobronchiale valve; collateral ventilation; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hübner, R. (2018). Endobronchial valve treatment in patients with severe lung emphysema. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7663

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Hübner, Ralf-Harto. “Endobronchial valve treatment in patients with severe lung emphysema.” 2018. Thesis, Freie Universität Berlin. Accessed December 08, 2019. http://dx.doi.org/10.17169/refubium-7663.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Hübner, Ralf-Harto. “Endobronchial valve treatment in patients with severe lung emphysema.” 2018. Web. 08 Dec 2019.

Vancouver:

Hübner R. Endobronchial valve treatment in patients with severe lung emphysema. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2019 Dec 08]. Available from: http://dx.doi.org/10.17169/refubium-7663.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hübner R. Endobronchial valve treatment in patients with severe lung emphysema. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-7663

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.