+publisher:"Freie Universität Berlin" +contributor:("N.N.")

Freie Universität Berlin

1. Sperber, Lena Sophie. Quality control through follow-up examination of discrepant results of a genotyping HPV-Test.

Degree: 2015, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11433

► Background: Carcinoma of the cervix uteri has an incidence of 530,000 per year and is the second most common carcinoma in women worldwide. More than… (more)

▼ Background: Carcinoma of the cervix uteri has an incidence of 530,000 per year and is the second most common carcinoma in women worldwide. More than 270,000 die of it annually. Especially women in countries with no or less developed screening methods are at risk. An undisputable role in developing cervical dysplasia or carcinoma plays infection with the sexually transmitted high- risk(HR)-HPV-types. Therefore, one of the goals of cervical carcinoma prevention is to obviate HPV-infection and cervical dysplasia or respectively detection and treatment at an early stage. This thesis deals with 160 patients tested negative for HPV-infection despite pathologic cytological or histological clinical evidence. By follow-up examinations of discrepant results of a genotyping test for human papillomaviruses discrepancy should be resolved. Methods: Female patients with a Pap-smear of ≥ Pap IIId and/or a CIN in spite of a negative HPV test were included. Out of 1,254 included samples 160 HPV-negative were screened again by the Multiplex HPV Genotyping Kit for Research (Multimetrix) in Epidemiology for a total of 24 HPV-types. 57 samples remained HPV-negative and were therefore sent to laboratories in Jena and Heidelberg. In Heidelberg, the samples were screened by a multiplexed analyzing system for 55 HPV-types and the viral load was estimated. In Jena, the samples were screened for the oncogene E7 for the seven most prevalent HR- HPV-types and also a GP-5+/6+-PCR-EIA was performed. The corresponding cytological/histological samples were subsequently sent to three independent experts for reevaluation of the cytological results. Results: In 102 of 160 HPV-negative samples (63.75 %) Berlin found HPV with the Multimetrix-Kit, which were in conclusion defined as false-negative. One sample was excluded due to lack of material. HPV was found in 13 out of the 57 remaining negative samples in Jena. 44 remained negative. 28 samples were tested HPV-positive in Heidelberg, partly with rare HPV-types not included in the Multimetrix-Kit. 26 remained negative; three were also negative for β-Globin (human DNA) and thus excluded from the screen. All but two Pap-smears were down-graded by at least one expert. Conclusion: In most cases, discrepancy between positive cytology or histology and negative HPV results were resolved. 27 of 160 patients (16.9 %) remained HPV-negative. None of these, whose samples were referred to a cytological reevaluation, had a Pap-smear > Pap IIId. The cytological review as well as the HPV-testing methods showed some differences when comparing the results. Thus, further research is necessary to improve screening examinations for prevention of cervical cancer. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: HPV; Screening; Papillomavirus; CIN; Pap; follow-up; HPV-Test; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sperber, L. S. (2015). Quality control through follow-up examination of discrepant results of a genotyping HPV-Test. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11433

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sperber, Lena Sophie. “Quality control through follow-up examination of discrepant results of a genotyping HPV-Test.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/11433.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sperber, Lena Sophie. “Quality control through follow-up examination of discrepant results of a genotyping HPV-Test.” 2015. Web. 20 Nov 2019.

Vancouver:

Sperber LS. Quality control through follow-up examination of discrepant results of a genotyping HPV-Test. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/11433.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sperber LS. Quality control through follow-up examination of discrepant results of a genotyping HPV-Test. [Thesis]. Freie Universität Berlin; 2015. Available from: https://refubium.fu-berlin.de/handle/fub188/11433

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

2. Lütkepohl, Anna-Caroline. Prevalence and risk factors of ectoparasitic skin diseases and dermatomycoses in a rural community in Amazonia, Brazil.

Degree: 2016, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-13138

► Infectious dermatoses such as ectoparasitoses and dermatomycoses are globally associated with morbidity, loss of income and social exclusion. Their distribution in society is inhomogeneous with… (more)

▼ Infectious dermatoses such as ectoparasitoses and dermatomycoses are globally associated with morbidity, loss of income and social exclusion. Their distribution in society is inhomogeneous with a disproportionately high burden in socioeconomically disadvantaged groups, particularly in countries of the global South. However, little is known about the epidemiological determinants in these populations. This knowledge is essential for effective control measures. In order to generate meaningful data for the Amazon region of Brazil, the inhabitants of Liberdade, a rural district of the small town Coari were systematically examined for the presence of ectoparasites and dermatomycoses. Sociodemographic, economic, environmental and behavioral risk factors were collected using standardized interviews. The diagnoses were made according to established clinical case definitions. At the time of the study Liberdade was inhabited by 1123 individuals. 993 individuals were included in the study (89.8% of the residents of Liberdade); 397 (40%) had at least one type of dermatosis. Pediculosis capitis was the most common dermatosis (20.1%). The second most common dermatosis was foot mycosis (17.1%). Pityriasis versicolor, tinea corporis and tinea capitis had in total a prevalence of 7.8%. The ectoparasitoses cutaneous larva migrans, scabies and tungiasis altogether only had a prevalence of 2.1%. Long hair was the most important independent risk factor for Pediculosis capits (adjusted OR: 5.3 (95% CI: 2.5-11.3)). School age (5-9 years; OR: 9.4 (95% CI: 3.9-22.9)) and female sex (OR: 2.9 (95% CI: 2.1-4.1)) were also important risk factors. The prevalence of foot mycoses increased with increasing age (over 60 years: OR: 60.4 (95% CI: 16.1-227.1)); pityriasis versicolor and tinea corporis were most common among the 15 to 19 years-olds (OR: 3.2 (95% CI: 1.4-7.9)). Sex had no significant influence on the presence of superficial mycoses. Poverty- associated factors, such as sharing clothes and towels, absence of waste collection, unsafe drinking water, crowding, low quality of housing, low household income and food shortages in the past 12 months, showed a significant association with the presence of all infectious dermatoses (with the exception of foot mycoses). It has been shown that infectious dermatoses in rural Amazonia are an important disease group, with an alarmingly high prevalence in the population, and thus represent a public health problem. In addition to age and gender, poverty and poverty-associated characteristics are the main risk factors. The close link between the prevalence of infectious dermatoses and poverty indicates that attempts to eliminate this group of diseases without addressing poverty will not be successful. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: ectoparasitic skin disease; dermatomycosis; epidemiology; risk factors; poverty; rural Amazonia; Brazil; deramatoses; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lütkepohl, A. (2016). Prevalence and risk factors of ectoparasitic skin diseases and dermatomycoses in a rural community in Amazonia, Brazil. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13138

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lütkepohl, Anna-Caroline. “Prevalence and risk factors of ectoparasitic skin diseases and dermatomycoses in a rural community in Amazonia, Brazil.” 2016. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-13138.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lütkepohl, Anna-Caroline. “Prevalence and risk factors of ectoparasitic skin diseases and dermatomycoses in a rural community in Amazonia, Brazil.” 2016. Web. 20 Nov 2019.

Vancouver:

Lütkepohl A. Prevalence and risk factors of ectoparasitic skin diseases and dermatomycoses in a rural community in Amazonia, Brazil. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-13138.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lütkepohl A. Prevalence and risk factors of ectoparasitic skin diseases and dermatomycoses in a rural community in Amazonia, Brazil. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-13138

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

3. Schablowsky, Christoph. Konsequenzen einer zellzyklusunabhängigen viralen Genexpression für den lytischen Infektionszyklus des humanen Zytomegalievirus.

Degree: 2019, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-1767

► Human Cytomegalovirus (HCMV), also known as Human Herpesvirus-5, is a widespread pathogen. In immunocompromised individuals, such as AIDS patients and transplant recipients, as well as… (more)

▼ Human Cytomegalovirus (HCMV), also known as Human Herpesvirus-5, is a widespread pathogen. In immunocompromised individuals, such as AIDS patients and transplant recipients, as well as in neonates, HCMV infection can lead to severe disease and death. It is the most common congenital infection leading to disabilities such as mental retardation and hearing impairment. The available virostatic drugs are characterized by severe side effects and emergence of resistant strains. At the cellular level, HCMV can either remain latent or start its lytic replication cycle. Lytic replication is initiated by the expression of immediate early (IE) genes which trigger a cascade of subsequent gene expression programs, eventually leading to viral DNA replication and the production of new virus progeny. While HCMV is able to enter the cell at any cell cycle stage, IE gene expression can only be initiated in G0/G1 phase cells and is blocked in S/G2 phase cells. This block is mediated by the interaction of cellular cyclin A-dependent kinase and the viral tegument protein pp150. Here, the physiological relevance of cell cycle-dependent IE gene expression for HCMV was addressed by employing a mutant virus lacking the cyclin A-binding motif in the pp150 protein. It was observed that the initiation of IE gene expression in S phase cells results in a stable G2 arrest followed by efficient expression of further viral gene products and viral DNA replication. Only a small subpopulation of cells entered a mitotic arrest and showed no signs of viral DNA replication. The virus-permissive G2-arrest was dependent on pUL21a. This viral protein has recently been shown to destabilize cyclin A, thereby leading to a cell cycle arrest at the transition from G1 to S phase. An HCMV double-point mutant where both pp150 and pUL21a are disabled in cyclin A-binding showed severe negative consequences for virus and host. A majority of infected cells was forced into mitosis accompanied by a sharp decrease of cell viability. Analysis of the production of new virus progeny revealed an approximately 500-fold growth defect. These were not only additive but synergistic effects of pUL21a and pp150 mutations. Taken together, it could be shown that the viral proteins pp150 and pUL21a functionally cooperate to prevent HCMV from entering a non-productive mitotic state of infection. These results may point to a model where cyclin A sensing by pp150 alone is not absolutely required for productive HCMV infection but has been developed to strengthen and support cell cycle synchronization by pUL21a. Advisors/Committee Members: male (gender), N.%2C%20N.N.%22%29&pagesize-30">N.N., N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: HCMV; pp150; cell cycle; pUL21a; cyclin A; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schablowsky, C. (2019). Konsequenzen einer zellzyklusunabhängigen viralen Genexpression für den lytischen Infektionszyklus des humanen Zytomegalievirus. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-1767

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schablowsky, Christoph. “Konsequenzen einer zellzyklusunabhängigen viralen Genexpression für den lytischen Infektionszyklus des humanen Zytomegalievirus.” 2019. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-1767.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schablowsky, Christoph. “Konsequenzen einer zellzyklusunabhängigen viralen Genexpression für den lytischen Infektionszyklus des humanen Zytomegalievirus.” 2019. Web. 20 Nov 2019.

Vancouver:

Schablowsky C. Konsequenzen einer zellzyklusunabhängigen viralen Genexpression für den lytischen Infektionszyklus des humanen Zytomegalievirus. [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-1767.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schablowsky C. Konsequenzen einer zellzyklusunabhängigen viralen Genexpression für den lytischen Infektionszyklus des humanen Zytomegalievirus. [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-1767

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

4. Brandt, Alexander Ulrich. Optical coherence tomography in comparison to magnetic resonance tomography and magnetic resonance spectroscopy as a parameter for neurodegeneration in multiple sclerosis.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10647

► Background: Imaging the eye’s retina with optical coherence tomography (OCT) allows investigating retinal layers. It is now known that the retinal nerve fiber layer (RNFL)… (more)

Subjects/Keywords: multiple sclerosis; OCT; MRI; magnetic resonance spectroscopy; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brandt, A. U. (2014). Optical coherence tomography in comparison to magnetic resonance tomography and magnetic resonance spectroscopy as a parameter for neurodegeneration in multiple sclerosis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10647

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brandt, Alexander Ulrich. “Optical coherence tomography in comparison to magnetic resonance tomography and magnetic resonance spectroscopy as a parameter for neurodegeneration in multiple sclerosis.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-10647.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brandt, Alexander Ulrich. “Optical coherence tomography in comparison to magnetic resonance tomography and magnetic resonance spectroscopy as a parameter for neurodegeneration in multiple sclerosis.” 2014. Web. 20 Nov 2019.

Vancouver:

Brandt AU. Optical coherence tomography in comparison to magnetic resonance tomography and magnetic resonance spectroscopy as a parameter for neurodegeneration in multiple sclerosis. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-10647.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brandt AU. Optical coherence tomography in comparison to magnetic resonance tomography and magnetic resonance spectroscopy as a parameter for neurodegeneration in multiple sclerosis. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-10647

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

5. Stecher, Uwe. in-vitro evaluation of 4 chain bridges made by selective laser sintering.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11886

► Over the last decades, technological progress and especially the development of high-performance computer systems have lead to continuous improvements of CAD/CAM systems in general and… (more)

▼ Over the last decades, technological progress and especially the development of high-performance computer systems have lead to continuous improvements of CAD/CAM systems in general and in the manufacturing of dental technical works. Until present, the subtractive milling procedure has become firmly established. Manufacturers advertise selected laser sintering (SLS) as a new manufacturing method, combining efficiency and material-saving CAD/CAM system, designed for production of high quantities of individual prosthetic constructions. This study gives considerations on the qualitative aspects of the SLS-method, also anticipating whether the constructions manufactured are able to meet the requirements of daily dental practice. Subject to in vitro investigations, were four-unit-bridges manufactured using the SLS-technique. This survey rated the quality of the internal structure, the marginal gap and the gap of the cementum geometry, as well as the precision fit resulting from this and the dimension accuracy. Furthermore, analyses were carried out concerning the flexural strength of the bridge frameworks in relation to the cross-sectional geometry. Finally, SLS-bridge frameworks may be certified to render a sufficient structural stability resp. flexural strength. As far as the marginal gaps are concerned, they turned out to be acceptable, even though they show a broad variance scattering of values. The geometry of the cementum gap is hard to predict in SLS-manufacturing. Permanently, there might result cone-shaped structures protruding into the inner part of the crown. They impede the flowing away of viscous cements and thus make it impossible to cement the constructions in the desired final position. The dimension accuracy – especially of the connectors – has not been sufficiently elaborated for dental-technical constructions. The quality of the framework is characterized by various defects in the bulk. Major defects and micro cracks on the surfaces, the appearance of gap corrosion in the inner part/region of the crown with damage of the pulp may be expected. Based on these results, it may be concluded that devices produced using SLS-technique are acceptable in stability and strength, however, not in the prediction of accuracy of the cement gaps. Advisors/Committee Members: m (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: dental bridge; CAD/CAM; SLS; marginal fit; cement gap; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stecher, U. (2014). in-vitro evaluation of 4 chain bridges made by selective laser sintering. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11886

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stecher, Uwe. “in-vitro evaluation of 4 chain bridges made by selective laser sintering.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/11886.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stecher, Uwe. “in-vitro evaluation of 4 chain bridges made by selective laser sintering.” 2014. Web. 20 Nov 2019.

Vancouver:

Stecher U. in-vitro evaluation of 4 chain bridges made by selective laser sintering. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/11886.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stecher U. in-vitro evaluation of 4 chain bridges made by selective laser sintering. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/11886

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

6. Pötzsch, Monique. Histopathological evaluation of cryopreserved arterial allografts.

Degree: 2014, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11845

► Cryopreserved arterial allografts from brain-dead organ donors are used for reconstructive tumor surgery, in the field of infected synthetic grafts, in the management of aneurysm,… (more)

Subjects/Keywords: histopathology; cryopreservation; arterial allografts; atherosclerosis; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pötzsch, M. (2014). Histopathological evaluation of cryopreserved arterial allografts. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11845

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pötzsch, Monique. “Histopathological evaluation of cryopreserved arterial allografts.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/11845.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pötzsch, Monique. “Histopathological evaluation of cryopreserved arterial allografts.” 2014. Web. 20 Nov 2019.

Vancouver:

Pötzsch M. Histopathological evaluation of cryopreserved arterial allografts. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/11845.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pötzsch M. Histopathological evaluation of cryopreserved arterial allografts. [Thesis]. Freie Universität Berlin; 2014. Available from: https://refubium.fu-berlin.de/handle/fub188/11845

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

7. Brendel, Annelie. Legal aspects of diagnostic Lab-on-a-chip-systems in health care.

Degree: 2016, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/10991

► Lab-on-a-chip-systems (LOCs) are in special focus in the field of health- technologies. LOCs are miniaturised, portable analytical systems which offer a wide variety of laboratory… (more)

▼ Lab-on-a-chip-systems (LOCs) are in special focus in the field of health- technologies. LOCs are miniaturised, portable analytical systems which offer a wide variety of laboratory diagnostics and allow for immediate subsequent intervention necessary at the point of care or point of need (POC/PON). This might result in a benefit for a number of medical sectors (e.g. diagnostics of infections and choice of therapy and/or medicinal product, especially in case of life-threatening diseases). Both the dynamic development and the potential of LOCs for the healthcare sector induced this analysis of legal aspects of LOCs and the need for legal amendment in order to provide a successful and thorough integration, especially into the system of the Statutory Health Insurance (SHI), and for the use of „direct-to-consumer“ (DTC) genetic- and HIV- (human immunodeficiency virus) testing. It can be assumed that fully analytical, portable, biomarker- and gene-based LOCs are to be considered a new examination method according to Section 135 of the German Social Code Book V and thus need to be evaluated by the (Federal) Joint Committee (“Gemeinsamer Bundesausschuss”, G-BA) before being incorporated into the Uniform Value Scale (“Einheitlicher Bewertungsmaßstab”, EBM) and become reimbursable. Within the Uniform Value Scale, the Chapters 11 and 32 appear to be suitable for regulations on LOCs. The current lack of reimbursement and the requirement of a preceding evaluation by the G-BA are a particular problem for the use of LOCs as Companion Diagnostics (CDx) in the field of personalised therapy with medicinal products. In order to avoid a de facto exclusion or a delayed use of the concerned medicinal products, it is essential to accelerate the procedure under Section 135 Social Code Book V (e.g. granting the right of application to manufacturers and patient organisations). Besides, a lump sum item should be created within the Uniform Value Scale to enable temporary reimbursement. Self-diagnostics by means of LOCs using DTC gene- and/or HIV-tests is not possible in Germany due to the current legal framework, which also applies for foreign offerers. In this context the Regulation of the European Parliament and of the Council on In Vitro Diagnostic Medical Devices (IVD-VO) provides relevant innovations and an increased standard of quality. However, questions of the distribution of LOCs remain largely unresolved and require detailed regulations with regard to section 6 of the German Gene Diagnostics Act. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: Lab-on-a-chip; LOC; point-of-care; POC; companion diagnostics; legal aspects; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brendel, A. (2016). Legal aspects of diagnostic Lab-on-a-chip-systems in health care. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/10991

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brendel, Annelie. “Legal aspects of diagnostic Lab-on-a-chip-systems in health care.” 2016. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/10991.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brendel, Annelie. “Legal aspects of diagnostic Lab-on-a-chip-systems in health care.” 2016. Web. 20 Nov 2019.

Vancouver:

Brendel A. Legal aspects of diagnostic Lab-on-a-chip-systems in health care. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/10991.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brendel A. Legal aspects of diagnostic Lab-on-a-chip-systems in health care. [Thesis]. Freie Universität Berlin; 2016. Available from: https://refubium.fu-berlin.de/handle/fub188/10991

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

8. Timm, Kristina. Influence of a systemic therapy with alitretinoin (9-cis-retinoic acid) on the skin barrier in patients with chronic hand eczema.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10526

► Chronic hand eczema (CHE) is one of the most common dermatological disorders with a prevalence of approximately 10%. Recent data have shown, that the skin… (more)

▼ Chronic hand eczema (CHE) is one of the most common dermatological disorders with a prevalence of approximately 10%. Recent data have shown, that the skin barrier has a key function in the pathogenesis and therapy of CHE. Both, irritants and allergens are activating keratinocytes and immune cells. This leads to an increased production of inflammatory mediators (e.g. cytokines), which impair the expression of important structural skin barrier proteins (e.g. claudins, filaggrin). Oral alitretinoin (9-cis-retinoic acid), a vitamin A derivate, has been licensed 2008 for the treatment of severe CHE refractory to potent topical corticosteroids. In clinical trials but also in clinical practice alitretinoin has been shown to be an effective and well tolerated systemic therapeutic drug. In this thesis the influence of alitretinoin on the skin barrier in patients with CHE were examined. Therefore the modified manuscore and the transepidermal waterloss (TEWL) were determined and skin biopsies of lesional skin (n=15) were taken before and after therapy with alitretinoin for at least two months. Gene- and protein expression of structural proteins, proliferation- and inflammatory markers of the skin were measured in the biopsies by using PCR and immunohistochemistry. Beside a significant decrease of the modified manuscore (parameter for clinical response) an increased gene- and protein expression of the structural proteins of the skin like tight junction-proteins (claudin1, occludin), intermediate filaments of the cytoskeleton (filaggrin, cytokeratin 10) and proteins of the cornified envelope (loricrin) were detected after treatment with alitretinoin. Furthermore, systemic alitretinoin led to a local decrease of inflammatory cells (CD3+ cells) and of the inflammatory mediator TSLP in the skin. Although dry skin is known as a side effect of retinoids, there was no significant increase of the transepidermal waterloss. The results of this thesis confirm the data of several clinical studies that alitretinoin is a well tolerated and effective systemic therapy for severe CHE. Herein, for the first time it has been shown that alitretinoin improves the epidermal skin barrier by upregulation of structural proteins of the skin and a downregulation of inflammatory markers. How long such a normalization of the skin barrier after therapy with alitretinoin will last and what kind of influence alitretinoin has on the lipid composition of lesional skin, should be investigated in future studies. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: chronic hand eczema; alitretinoin; skin barrier; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Timm, K. (2015). Influence of a systemic therapy with alitretinoin (9-cis-retinoic acid) on the skin barrier in patients with chronic hand eczema. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10526

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Timm, Kristina. “Influence of a systemic therapy with alitretinoin (9-cis-retinoic acid) on the skin barrier in patients with chronic hand eczema.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-10526.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Timm, Kristina. “Influence of a systemic therapy with alitretinoin (9-cis-retinoic acid) on the skin barrier in patients with chronic hand eczema.” 2015. Web. 20 Nov 2019.

Vancouver:

Timm K. Influence of a systemic therapy with alitretinoin (9-cis-retinoic acid) on the skin barrier in patients with chronic hand eczema. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-10526.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Timm K. Influence of a systemic therapy with alitretinoin (9-cis-retinoic acid) on the skin barrier in patients with chronic hand eczema. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-10526

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

9. Paul, Sebastian. Neuropathological examination of tissue samples before and after intraoperative MRI in malignant gliomas.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14296

► Introduction: In this study we investigated whether in neurosurgical interventions histological and immunohistochemical differences between main and resected specimens after an intraoperative MRI guided re-resection… (more)

▼ Introduction: In this study we investigated whether in neurosurgical interventions histological and immunohistochemical differences between main and resected specimens after an intraoperative MRI guided re-resection are detectable. We compared the central tumor with the re-resected tissue. Methods: We searched for relevant cases in the databases of the pathology and the neurosurgery of the Asklepios Klinik Nord. The samples were examined with regard to their behavior at the marker GFAP, MIB-1, IDH-1, and BRAF. Through the demonstration of some cases the clinical sequence are demonstrated. Results: The total cohort consisted of 33 patients. 4 patients were listed twice because of recurrent disease, so a total of 37 cases were processed. The histological examination of the main preparations demonstrated 30 glioblastoma multiforme, 4 anaplastic astrocytomas, 2 anaplastic oligoastrocytomas and one anaplastic oligodendroglioma. Grading of the re-resected specimens was in 15 samples at an identical behavior. In 22 also lower levels were detected. This corresponds to the assumption that a lower Grading is often detected in the suspicious areas noticed by the MRI (tumor margin). In reference to GFAP no new insights have been gained. All specimens were positive for GFAP, with the exception of the oligodendroglioma. Poor information could be gained by the investigation on BRAF. Only one glioblastoma showed a significant positive staining. The comparative study of MIB-1 showed no significant behavior. In a total of 14 samples, a higher index could be detected. In the same number a lower MIB-1 staining is presented. The remaining 9 samples showed no change. The marker IDH-1 was primarily negative in 25 samples and shows difference in the dyeing behavior in the remaining 12 samples. The investigation of the re- resected samples showed no change in 28 of the samples. In 10 tumors a positive staining was observed. Conclusion: Contrary to our expectations in the post-MRI preparations not only low-grade parts of the glioma but also higher grade were present. They did not show themselves fluoroscopically within surgical procedure. Possible reasons for this are discussed. The sample was too small to give valid statistical results. It is to be expected that interesting approaches to the molecular structures will be made. In all samples, taken after the intra-operative MRI, tumor tissue could be detected. We could confirm with our results the current studies regarding intraoperative imaging. Certainly, because of intraoperative MRI the resection rate can be increased and thus gaining better results for our patients. Advisors/Committee Members: m (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: neuropathological examination; intraoperative MRI; IDH1; MIB1; malignant gliomas; glioblastoma multiforme; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Paul, S. (2015). Neuropathological examination of tissue samples before and after intraoperative MRI in malignant gliomas. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Paul, Sebastian. “Neuropathological examination of tissue samples before and after intraoperative MRI in malignant gliomas.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-14296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Paul, Sebastian. “Neuropathological examination of tissue samples before and after intraoperative MRI in malignant gliomas.” 2015. Web. 20 Nov 2019.

Vancouver:

Paul S. Neuropathological examination of tissue samples before and after intraoperative MRI in malignant gliomas. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-14296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Paul S. Neuropathological examination of tissue samples before and after intraoperative MRI in malignant gliomas. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-14296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

10. Richter, Florian. a retrospective cohort-study.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10038

► Introduction: Patients at paediatric intensive care units (PICUs) are at risk for harmful medication errors. Most errors occur at the stage of prescription and result… (more)

▼ Introduction: Patients at paediatric intensive care units (PICUs) are at risk for harmful medication errors. Most errors occur at the stage of prescription and result frequently in dosage-errors. A class of medication associated most frequently are antibiotics. Potential consequences include organ toxicity and ineffective therapy. This is known from international publications, studies on German PICUs are missing. Methods: Investigating the antibiotic therapy on a PICU during the year 2010, the adherence to standard-dosage-protocols (SDP) was evaluated in a retrospective cohort-study. Two primary, combined outcome measures – Organ Dysfunction (OD) and Severe Events (SE) – were correlated with adherence to SDP. OD was defined as liver cell damage or renal impairment. SE was defined as duration of length of stay over median, duration of ventilation over median or fatal outcome. Results: 305 patients were included into the study. They received 4021 dosages of antibiotics, of which 59,9 % were correctly dosed, 36,1 % were underdosed and 4,0 % were overdosed. A huge variability in the number of dosage errors concerning a single patient was seen: 57 % of the patients only received dosages in accordance to the SDP, those patients were summarized in the high adherence group (HAG). In contrast 43 % of the patients received at least one dosage differing from the SPD, those patients were summarized as the low adherence group (LAG). Patients in the LAG suffered statistically significantly more often from OD (11,5 % versus 1,7 %; OR 6,8; 95-%-CI: 1,9 - 24,5; p = 0,003) and from SE (64,4 % versus 31,4 %; OR 3,7; 95-%-CI: 2,1 - 6,7; p < 0,001). Multiple regression analysis also including the confounders: age, weight, sex, ventilation and mode of admission, confirmed the significance. Analysis of secondary outcome measures associated being in the LAG with significantly higher occurrence of prolonged ventilation, prolonged length of stay, liver cell damage and renal impairment. Conclusion: Overall, there is potential to optimize antibiotic-dosing in the setting of the PICU. As retrospective studies do not allow causal determination, the results may be interpreted as signals for higher occurrence of complicated patient course and organ damage in the presence of dosage- errors. Existing literature describes positive effects on error-rate and outcome measures by implementing formal physician training, chart-review by clinical pharmacologists or computerized prescription-support systems. Advisors/Committee Members: berlin%40googlemail.com%22%29&pagesize-30">richterf.berlin@googlemail.com (contact), m (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: medicine; pediatrics; pediatric intensive care untit; antibiotic therapy; medical error; medication error; dosage error; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Richter, F. (2018). a retrospective cohort-study. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Richter, Florian. “a retrospective cohort-study.” 2018. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-10038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Richter, Florian. “a retrospective cohort-study.” 2018. Web. 20 Nov 2019.

Vancouver:

Richter F. a retrospective cohort-study. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-10038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Richter F. a retrospective cohort-study. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-10038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

11. Dinter, Juliane. Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10264

► G-protein coupled receptors (GPCRs) are involved in the control of all basic cellular and physiological functions such as metabolism, cell differentiation and growth. The characteristics… (more)

▼ G-protein coupled receptors (GPCRs) are involved in the control of all basic cellular and physiological functions such as metabolism, cell differentiation and growth. The characteristics and mechanisms of GPCRs are complex, while each individual receptor needs to be investigated individually and considered in context to each other. Within this paper receptors were ascertained which are particularly involved in the energy homeostasis but which still hold gaps in understanding their functionality. The focus was placed on five selected GPCRs, the G-protein coupled receptor 83 (GPR 83), the melanocortin-4 receptor (MC4R), the beta-adrenergic receptors 1 and 2 (ADRB1 and ADRB2), and the trace amine-associated receptor 1 (TAAR1). The aim was to unravel signaling pathways of the orphan (ligand unknown) GPR83, regulatory interaction mechanisms of the most important GPCR in appetite regulation of the MC4R, and differential signaling modulations of ADRB1 and ADRB2. In the scope of these projects and the resulting publications listed here the most important signaling pathways were functionally characterized using cell-based stimulation assays. On the other hand GPCR-GPCR interactions were investigated using a sandwich-ELISA approach. The investigations showed that the GPR83 is activated in combination with zinc (II) in the Gq/11-signaling pathway, is basally active (ligand independent), can be activated constitutively for Gq/11 by a certain mutation, and moreover is present as homodimer. Through the MC4R studies it was shown that the intracellular loop 2 and parts of the conjoined transmembrane helices 3 and 4 are essential for MC4R homodimer formation. Modifications of these components led to a selective separation of the homodimers and increased the ligand independent basal activity suggesting an inhibitory influence by the dimerization. The trace amines tyramine, beta-phenylethylamine and octopamine are not only agonists at TAAR1, but also act as partial antagonists or agonists at ADRB1 and ADRB2. The differential modulation was exhibited in either a blockade or an activation of the Gs-signaling pathway. Consideration of structure models in combination with the obtained functional data led to the conclusion that the shared ligands of TAAR1, ADRB1 and ADRB2 are localized in a specific ligand binding region due to their high amino acid similarity, thus acting ortho- or allosterically. In summary, all three main projects led to new insights providing information and knowledge for further studies. New details unraveling the functional selectivity of GPCRs in the complex regulation are shown which may help to reduce the increasing obesity as problem of the world population by intervening with selective pharmaceuticals. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: GPCR; functional selectivity; energy homeostasis; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dinter, J. (2015). Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10264

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dinter, Juliane. “Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-10264.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dinter, Juliane. “Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis.” 2015. Web. 20 Nov 2019.

Vancouver:

Dinter J. Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-10264.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dinter J. Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-10264

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

12. Walter, Dietmar. Consecutive cross-sectional surveys during the immunization campaign against pandemic influenza in season 2009/10.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10382

► After the first emergence of the pandemic influenza virus in spring 2009 the German immunization campaign against pandemic influenza started in autumn 2009. At initiative… (more)

▼ After the first emergence of the pandemic influenza virus in spring 2009 the German immunization campaign against pandemic influenza started in autumn 2009. At initiative of the Robert Koch Institute thirteen consecutive cross- sectional telephone-surveys accompanying the vaccination campaign were performed between November 2009 and April 2010. Primary objectives were to determine immunization rates against pandemic and seasonal influenza in the total population and in target groups as well as to assess factors influencing the campaign. The sample size of each survey was approximately 1,000 interviewees. Computer assisted Telephone Interviews (CATI) were conducted using structured questionnaires. The study population consisted of German speaking individuals of ≥14 years of age living in private households. Our results show that during the pandemic 2009/10 vaccination coverage against pandemic influenza was not only low in the general population but also in risk groups. The immunization campaign hereby often reached persons who received a vaccination against seasonal influenza. The in-depth analysis on knowledge, attitude and behavior showed that main reasons for low acceptance of the vaccine were feared risks of the vaccine related adverse events and a low risk perception for pandemic influenza. The low risk perception for the disease observed shortly after the start of the immunization campaign decreased even further at the turn of the year 2009/10. Our surveys in addition showed that despite a good level of information immunization rates remained low. High media coverage of the pandemic 2009/10 was reflected by a high proportion of surveyed naming mass media as their main source of information. Moreover, the results of the conducted surveys stress the importance of informational behavior, e.g. having been informed by a medical expert was associated with a positive risk-benefit judgment in the immunization decision process. Using consecutive surveys allowed for a real-time assessment of knowledge, attitude and behavior as well as to monitor the dynamics in the course of the immunization campaign against pandemic influenza in season 2009/10. The here established method of consecutive cross-sectional telephone-surveys is an important tool to evaluate the success of preventive measures in a pandemic. Advisors/Committee Members: m (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: vaccination; survey; influenza; pandemic; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Walter, D. (2013). Consecutive cross-sectional surveys during the immunization campaign against pandemic influenza in season 2009/10. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10382

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Walter, Dietmar. “Consecutive cross-sectional surveys during the immunization campaign against pandemic influenza in season 2009/10.” 2013. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-10382.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Walter, Dietmar. “Consecutive cross-sectional surveys during the immunization campaign against pandemic influenza in season 2009/10.” 2013. Web. 20 Nov 2019.

Vancouver:

Walter D. Consecutive cross-sectional surveys during the immunization campaign against pandemic influenza in season 2009/10. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-10382.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Walter D. Consecutive cross-sectional surveys during the immunization campaign against pandemic influenza in season 2009/10. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-10382

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

13. Kern, Sina. Analyse des Behandlungserlöses minimalinvasiver Eingriffe bei Patientinnen mit Uterus myomatosus.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-683

► Objective: Uterine fibroids are the most common benign tumors in women of reproductive age. They grow hormon-dependently. Patients present with various clinical symptoms. Gold standard… (more)

▼ Objective: Uterine fibroids are the most common benign tumors in women of reproductive age. They grow hormon-dependently. Patients present with various clinical symptoms. Gold standard therapy is surgery preferably by minimally invasive techniques with or without organ preservation. These operations are conducted in specialised centres with focus on quality protection and optimization plus enhanced quality regarding processes, results and certification. Reimbursement in case rates by the German DRG- System poses problems of funding, affecting the subject of benign operative gynaecology by inadequate case-representation and underfunded extreme cases. Surgical techniques are not factored, despite varied material- and personnel costs. In case of remuneration for hysterectomy and enucleation, the organ preserving method is not favoured over resection despite a high impact on the patient. Aim of this study was the economical analysis of minimally invasive surgeries in patients with uterine fibroids and identification of cost-creating factors among treatment data. Patients and Methods: Data of 236 patients who underwent minimally invasive surgery at the Minimally Invasive Center ZMIT by Charité University hospital in 2012 to 2014 was analysed. Selection criteria were the principal diagnoses and conducted surgery technique. 73 patients (30,9%) were treated by assisted laparoscopic vaginal hysterectomy and 163 patient (69,1%) by laparoscopic myomectomy. 221 specimen weights (93,6%) were documented. Results: Cases were underfunded by median -228€ (IQR -1031,25 – 463,75€) with 2-3 days earlier discharge than mean hospitalization period and intensive postoperative care- dependency. Mean proceeds of hysterectomy were -533,56€ ±1318,36€ (Min.-7567€, Max.1410€) and of fibroid enucleation -229€ (IQR -973 – 454€, Min.-7659€, Max.1704€). Patient clinical complexity level was 0 in >78% of the collective. No single factor was shown responsible for financial undercoverage of the cases but a statistically significant correlation of case-proceeds with specimen weights and operation time was found. Cut- offs were found at 290g specimen weight and 120 minutes operation time. 8,1% of specimen weighed ≥501g; amongst hysterectomies 18,1%. Specimen weight correlates significantly with operation time, Body-Mass-Index, age, hospitalization period and postoperative care-dependency. Operation time also increased significantly with specimen weights of 290g and more. Mild correlation was shown with intraoperative blood loss. Proceeds correlate significantly with intraoperative blood loss, hospitalization period and postoperative care-dependency. Blood loss was 80ml median in the whole collective, thus meagre. Age and Body-Mass-Index showed mild or no correlation. Conclusion: An underfunding of minimally invasive surgeries of uterine fibroids was shown for which an adjustment of German DRGs is needed. We propose a distinction by use of resources for better representation of severity, especially expense of surgery. A combination of specimen weight… Advisors/Committee Members: female (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: Uterus myomatosus; G-DRG; laparoscopy; economical analysis; minimally invasive surgery; fibroid; hysterectomy; enucleation; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kern, S. (2018). Analyse des Behandlungserlöses minimalinvasiver Eingriffe bei Patientinnen mit Uterus myomatosus. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-683

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kern, Sina. “Analyse des Behandlungserlöses minimalinvasiver Eingriffe bei Patientinnen mit Uterus myomatosus.” 2018. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-683.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kern, Sina. “Analyse des Behandlungserlöses minimalinvasiver Eingriffe bei Patientinnen mit Uterus myomatosus.” 2018. Web. 20 Nov 2019.

Vancouver:

Kern S. Analyse des Behandlungserlöses minimalinvasiver Eingriffe bei Patientinnen mit Uterus myomatosus. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-683.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kern S. Analyse des Behandlungserlöses minimalinvasiver Eingriffe bei Patientinnen mit Uterus myomatosus. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-683

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

14. Alutis, Marie Elisabeth. Molecular mechanisms of campylobacter jejuni induced intestinal and extra- intestinal immunopathologies in a gnotobiotic IL-10-deficient mouse model.

Degree: 2016, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9680

► Campylobacter (C.) jejuni infections exhibit a high prevalence worldwide, but the underlying immunopathological mechanisms are not entirely understood. Until now in vivo models mimicking human… (more)

▼ Campylobacter (C.) jejuni infections exhibit a high prevalence worldwide, but the underlying immunopathological mechanisms are not entirely understood. Until now in vivo models mimicking human C. jejuni infections and hence allowing for detailed analyses of pathogenic-host interactions are scarce. Previously, we have generated the gnotobiotic (secondary abiotic) IL-10-deficient (IL-10-/-) mouse model for investigating C. jejuni infection in vivo. Upon peroral infection, the intestinal tract of gnotobiotic IL-10-/- mice could be stably colonized by the pathogen in high loads irrespective of the applied strain. Subsequently, mice developed non-selflimiting ulcerative enterocolitis within one week postinfection. In the present work, in vivo studies of three distinct groups of proteins or protein classes that are primarily attributed to the C. jejuni pathogenicity have been summarized. Namely, we analysed the role of the serineprotease htrA (high temperature requirement A), which plays an important role in the cellular invasion and transmigration of C. jejuni in vitro and could demonstrate that following infection with a C. jejuni strain lacking the htrA gene, mice displayed less pronounced intestinal immunopathological sequelae as compared to parental (wildtype) strain infection. Similar results (i.e. less immunopathology) could be obtained upon infection with a C. jejuni strain lacking cj0268c, a gene encoding a protein playing a significant role in pathogenic invasion in vitro. Furthermore, we focussed on the role of the matrix metalloproteinases (MMPs) -2 and -9 (also referred to gelatinases A and B, respectively) during C. jejuni infection, given that MMP-2 and -9 are highly expressed in inflamed intestinal tissues of mice and men and selective gelatinase inhibition by the synthetic component RO28-2653 resulted in less distinct acute small and large intestinal inflammation of mice. Following gelatinase blockage, pro- inflammatory immune responses in colons of C. jejuni infected gnotobiotic IL-10-/- mice were less pronounced as compared to placebo controls. Taken together, the three distinct proteins or protein classes under investigation (namely HtrA, Cj0268c and MMP-2- and -9) are involved in C. jejuni induced immunopathology in vivo. Advisors/Committee Members: [email protected] (contact), w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: Campylobacter jejuni; IL-10-Knockout; intestinal; extra-intestinal; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alutis, M. E. (2016). Molecular mechanisms of campylobacter jejuni induced intestinal and extra- intestinal immunopathologies in a gnotobiotic IL-10-deficient mouse model. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alutis, Marie Elisabeth. “Molecular mechanisms of campylobacter jejuni induced intestinal and extra- intestinal immunopathologies in a gnotobiotic IL-10-deficient mouse model.” 2016. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-9680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alutis, Marie Elisabeth. “Molecular mechanisms of campylobacter jejuni induced intestinal and extra- intestinal immunopathologies in a gnotobiotic IL-10-deficient mouse model.” 2016. Web. 20 Nov 2019.

Vancouver:

Alutis ME. Molecular mechanisms of campylobacter jejuni induced intestinal and extra- intestinal immunopathologies in a gnotobiotic IL-10-deficient mouse model. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-9680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alutis ME. Molecular mechanisms of campylobacter jejuni induced intestinal and extra- intestinal immunopathologies in a gnotobiotic IL-10-deficient mouse model. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-9680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

15. Behrendt, Kai Alexander. Value of the MRI in the preoperative diagnosis in adenomyosis uteri and deep infiltrating endometriosis.

Degree: 2017, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-7002

► Objectives: Endometriosis is a benign chronic disease caused by the presence of ectopic endometrial glands outside the uterus. It is present in 10 -15% of… (more)

Subjects/Keywords: endometriosis; adenomyosis; MRI diagnostics; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Behrendt, K. A. (2017). Value of the MRI in the preoperative diagnosis in adenomyosis uteri and deep infiltrating endometriosis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7002

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Behrendt, Kai Alexander. “Value of the MRI in the preoperative diagnosis in adenomyosis uteri and deep infiltrating endometriosis.” 2017. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-7002.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Behrendt, Kai Alexander. “Value of the MRI in the preoperative diagnosis in adenomyosis uteri and deep infiltrating endometriosis.” 2017. Web. 20 Nov 2019.

Vancouver:

Behrendt KA. Value of the MRI in the preoperative diagnosis in adenomyosis uteri and deep infiltrating endometriosis. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-7002.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Behrendt KA. Value of the MRI in the preoperative diagnosis in adenomyosis uteri and deep infiltrating endometriosis. [Thesis]. Freie Universität Berlin; 2017. Available from: http://dx.doi.org/10.17169/refubium-7002

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

16. Klippenstein, Viktoria. Photoinaktivierung von Glutamatrezeptoren durch genetisch-kodierte unnatürliche Aminosäuren.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11290

► Ionotrope Glutamatrezeptoren (iGluRs) gehören zu einer der häufigsten Rezeptorfamilien in unserem Gehirn, wobei der AMPA-Subtyp mit seiner Erzeugung von glutamat-aktivierten elektrischen Strömen in der Postsynapse… (more)

▼ Ionotrope Glutamatrezeptoren (iGluRs) gehören zu einer der häufigsten Rezeptorfamilien in unserem Gehirn, wobei der AMPA-Subtyp mit seiner Erzeugung von glutamat-aktivierten elektrischen Strömen in der Postsynapse eine zentrale Rolle bei der Signalübertragung zwischen Nervenzellen spielt. Im Rahmen dieser Arbeit wurden photoaktive unnatürliche Aminosäuren wie p-Benzoyl-L-phenylalanin (BzF, auch bekannt als Bpa) oder p-Azido-L-phenylalanin (AzF) positions-spezifisch innerhalb von AMPA- Rezeptoren eingebaut, die in Säugetierzellen (HEK-293) exprimiert wurden. Der Einbau erfolgte über die so genannte genetisch-kodierte unnatürliche Aminosäure-Mutagenese, die auf die Verwendung spezifischer orthogonaler tRNA / tRNA-Synthetase-Paare beruht. Die Nutzung unnatürlicher Aminosäuren hat sich in früheren Studien als eine leistungsstarke Erweiterung der herkömmlichen positions-spezifischen Mutagenese bewiesen und erlaubte systematische Struktur-Funktions-Studien an einer Reihe von Ionenkanälen. Ihre Anwendung auf Liganden-gesteuerte Ionenkanäle, wie etwa der Glutamatrezeptoren, war jedoch bislang spärlich. Das Ziel dieser Studie bestand darin, die Nutzung von unnatürlichen Aminosäuren auf AMPA-Rezeptoren zu übertragen und dadurch ihre Photoinaktivierung auszulösen. Die Etablierung sowie gründliche Charakterisierung der Photoinaktivierung von AMPA-Rezeptoren mittels unnatürlicher Aminosäuren war ein grundlegender Bestandteil der Studie. Die Rezeptorphotoinaktivierung wurde methodisch mittels elektrischer Stromableitungen aus “outside-out patches” nach rascher Glutamatperfusion untersucht und die Ergebnisse wurden durch biochemische Experimente bestätigt. Die elektrophysiologischen Messungen haben ergeben, dass die unnatürlichen Aminosäuren AzF und BzF erfolgreich in die untere Ligandenbindedomäne (LBD) des Rezeptors eingebaut wurden, wobei die mutierten AMPA-Rezeptoren ähnliche kinetische Eigenschaften wie die Wildtyp (WT)-Ionenkanäle zeigten. Der orts- spezifische Einbau von BzF in die LBD erlaubte eine Vernetzung von Rezeptoruntereinheiten, welche durch eine UV-Bestrahlung bei 365 nm aus einer Quecksilberlampe induziert wurde. Die Photoinaktivierung zeichnete sich durch eine 90%ige Reduzierung der Amplitude des abgeleiteten Stromes innerhalb von ~10 Sekunden kumulativer UV-Belichtung aus. Der Einbau von BzF führte zu einer selektiven UV-ausgelösten Photoinaktivierung sowohl in homomeren (GluA2) als auch in heteromeren (GluA2:GluA1) AMPA-Rezeptoren. Dadurch konnten verschiedene funktionale Zustände des Rezeptors eingefangen werden, die der vorausgesagten Verformung der LBDen, sowie der strukturellen Umlagerungen während der AMPA-Rezeptor-Desensibilisierung, entsprachen. Die präsentierten Ergebnisse zeigen, dass unnatürliche Aminosäuren hervorragend dazu geeignet sind, strukturelle Änderungen von AMPA-Rezeptoren zu untersuchen und dementsprechend die Anwendung der Photoinaktivierung auf native Systeme übertragen werden könnte. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: Light-sensitive glutamate receptor; unnatural amino acids; optogenetics; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Klippenstein, V. (2015). Photoinaktivierung von Glutamatrezeptoren durch genetisch-kodierte unnatürliche Aminosäuren. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11290

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Klippenstein, Viktoria. “Photoinaktivierung von Glutamatrezeptoren durch genetisch-kodierte unnatürliche Aminosäuren.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-11290.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Klippenstein, Viktoria. “Photoinaktivierung von Glutamatrezeptoren durch genetisch-kodierte unnatürliche Aminosäuren.” 2015. Web. 20 Nov 2019.

Vancouver:

Klippenstein V. Photoinaktivierung von Glutamatrezeptoren durch genetisch-kodierte unnatürliche Aminosäuren. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-11290.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Klippenstein V. Photoinaktivierung von Glutamatrezeptoren durch genetisch-kodierte unnatürliche Aminosäuren. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-11290

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

17. Wagner, Philine. Ets-1 induced Tissue Factor promotor activation by autoantibodies in systemic sclerosis.

Degree: 2016, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12994

► Systemic sclerosis (SSc) is a multisystem autoimmune disease, which is characterized by skin fibrosis and fibrosis of internal organs, vascular damage and autoimmunity. Functional autoantibodies… (more)

▼ Systemic sclerosis (SSc) is a multisystem autoimmune disease, which is characterized by skin fibrosis and fibrosis of internal organs, vascular damage and autoimmunity. Functional autoantibodies (AT1R/ETAR-IgG) against angiotensin II type 1 receptor and endothelin-1 type A receptor play a central role in the pathogenesis of this disease and are associated with a higher risk of mortality. Endothelial dysfunction triggers not only endothelial proliferation and fibrosis but also in situ thrombosis, resulting in obliterative vasculopathy, especially of the microvascular system. Tissue Factor (TF), which initiates the blood coagulation cascade in vivo, plays a key role in creating in situ thrombosis. As an underlying hypothesis, a transcriptional regulation of the TF promoter by AT1R/ETAR-IgG is assumed for the purpose of this research. Methods The experiments were performed with two different cell lines: Human embryonic kidney cells (HEK-293) as well as human microvascular endothelial cells (HMEC-1). To illustrate the transcriptional regulation of the TF, different sizes of TF promotor fragments were cloned in a pGL4.10 [luc] vector with a Firefly Luciferase-Gen and lead to the production of recombinant plasmids. The TF promotor activation was measured by a Dual- Luciferase Reporter Assay, which was proportional to the light emission by Firefly Luciferase. Cells were stimulated with AT1R/ETAR-IgG and natural ligands Angiotensin-II (Ang II) and Endothelin-1 (ET-1) and blocked with specific AT1 and ETA receptor blockers. Results It could be shown that AT1R/ETAR-IgG, isolated from patients with SSc, as well as the natural ligands Ang II and ET-1 lead to an activation of the TF promoter in HMEC-1. This activation could be abolished with specific AT1 and ETA receptor blockers. Furthermore, it could be proven that the TF promotor includes a highly specific binding site for the transcription factor Ets-1 (- 448 to -441 bp) which was induced by AT1R/ETAR-IgG and natural ligands. Conclusion In interaction with AT1R/ETAR-IgG, TF and Ets-1 are involved in the pathogenesis of obliterative vasculopathy by SSc via activation of AT1R and ETAR. This finding has potential to lead towards new therapy method Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: Ets-1; Tissue Factor; systemic sclerosis; autoantibodies; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wagner, P. (2016). Ets-1 induced Tissue Factor promotor activation by autoantibodies in systemic sclerosis. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12994

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wagner, Philine. “Ets-1 induced Tissue Factor promotor activation by autoantibodies in systemic sclerosis.” 2016. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/12994.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wagner, Philine. “Ets-1 induced Tissue Factor promotor activation by autoantibodies in systemic sclerosis.” 2016. Web. 20 Nov 2019.

Vancouver:

Wagner P. Ets-1 induced Tissue Factor promotor activation by autoantibodies in systemic sclerosis. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/12994.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wagner P. Ets-1 induced Tissue Factor promotor activation by autoantibodies in systemic sclerosis. [Thesis]. Freie Universität Berlin; 2016. Available from: https://refubium.fu-berlin.de/handle/fub188/12994

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

18. Pfitzer, Constanze Elisabeth. longitudinal study.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4351

► Background: Fertility impairment and recovery after chemo and radiotherapy have been reported in male and female childhood cancer survivors, but little is known about the… (more)

▼ Background: Fertility impairment and recovery after chemo and radiotherapy have been reported in male and female childhood cancer survivors, but little is known about the dynamics. This study aimed to describe the development of fertility impairment and possible recovery in childhood brain tumour and allogeneic haematopoietic stem cell transplantation (HSCT) survivors. Methods: The pilot longitudinal study included 144 brain tumour survivors, who were treated in two German paediatric oncology centres between 2000 and 2005. A further European multicentre longitudinal study was conducted with 361 HSCT survivors. Both studies used fertility and treatment data, retrieved from medical records up to 12 years after diagnosis/HSCT. Results: In the pilot study, participants aged ≥13 at the time of hormone analysis, who had received cranial irradiation ≥30 Gray (n=23), including 83% (n=19) with craniospinal irradiation, had higher median FSH concentrations, compared to 29 patients without chemo and radiotherapy: 8.3 IU/l (IQR 6.5-11.2) vs. 4.1 IU/l (IQR 3.2-5.1) 2 years after initial treatment; 8.9 IU/l (IQR 8.5-10.8) vs. 4.2 IU/l (IQR 2.4-6.7) after 8 years and 7.1 IU/l (IQR 6.7-7.7) vs. 3.5 IU/l (IQR 2.8-4.2) after 10 years. Altogether, 11/65 women reported the onset of amenorrhea after a median time of 6.0 years (range 1-10) after diagnosis. Five of these women later developed a regular menstrual cycle without hormone replacement therapy. Patients’ chance of recovering fertility increased with time after diagnosis (p=0.074). In the multicentre study, the development of fertility impairment was observed in males (123/217, 56%) after a median time of 2.6 years (range 0.1-11.4) and in females (82/144, 57%) after 2.3 years (range 0.1-12.0) after HSCT. Recovery of fertility was observed in 17 participants after a median time of 4.1 years (range 1-10.6) in females (10/144, 7%) and 2.0 years (range 1-6.3) in males (7/217, 3%) after first signs of fertility impairment. Conclusion: In brain tumour survivors, signs of fertility impairment such as amenorrhea and elevated FSH levels were observed at variable time points between one and twelve years after chemo and radiotherapy. Decreasing FSH levels were observed one to seven years after elevation, and were interpreted either as an atrophy of the pituitary gland or as recovery from fertility impairment. HSCT survivors developed infertility shortly after treatment with a small potential to recover fertility. In light of the dynamics of fertility impairment and recovery, HSCT and brain tumour survivors should be counselled comprehensively regarding fertility conservation procedures. Advisors/Committee Members: [email protected] (contact), w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: fertility; gonadotoxic therapy; allogeneic haematopoietic stem cell transplantation; radiotherapy; childhood; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pfitzer, C. E. (2014). longitudinal study. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pfitzer, Constanze Elisabeth. “longitudinal study.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-4351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pfitzer, Constanze Elisabeth. “longitudinal study.” 2014. Web. 20 Nov 2019.

Vancouver:

Pfitzer CE. longitudinal study. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-4351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pfitzer CE. longitudinal study. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-4351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

19. Schneider, Tanja. Flow cytometry-based maturity score as a novel prognostic parameter in AML.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11197

► Background: In Acute Myeloid Leukemia (AML), molecular genetic and cytogenetic changes in leukemic blasts are the strongest AML-related prognostic factors and the basis for the… (more)

▼ Background: In Acute Myeloid Leukemia (AML), molecular genetic and cytogenetic changes in leukemic blasts are the strongest AML-related prognostic factors and the basis for the European LeukemiaNet (ELN) risk classification. Additionally, it has been suggested that individual surface antigen patterns, which reflect maturity or immaturity may also have prognostic relevance. However, there are no prior studies analyzing the impact of blast maturity within the different ELN risk groups. Objective: The aim of this study was to clarify whether AML blast maturity as measured by flow cytometry only reflects specific cytogenetic or molecular phenotypes or whether it also has a prognostic value within the different ELN risk groups. Materials and Methods: 300 patients newly diagnosed with AML from 01/2003 through 04/2012 at Charité – University Medical Center Berlin, Campus Virchow Klinikum, were analyzed with regard to their flow cytometric cell maturity and their ELN risk group. For this purpose, a quantitative flow cytometric score based on CD34, CD117 and TdT antigen expression has been developed and patients were classified as “mature” (AML-R) or “immature” (AML-U). The influence of this maturity score on clinical parameters such as remission rate (CR / CRi rate), relapse-free survival (RFS), and overall survival (OS) was evaluated for both the total cohort and the different ELN risk groups. Results: AML-R showed a significantly longer RFS and OS than AML-U (p < 0,001). Significant accumulation of good-risk mutations (NPM1, PML-RARA) was observed in patients with AML-R; high-risk phenotypes (monosomal and complex aberrant karyotype, -5, (del)5q, -7) were frequently seen in AML-U. However, the differences in RFS and OS in favor of AML-R were also confirmed within the different ELN risk groups, particularly within the group “intermediate risk”, in which this difference was statistically significant (RFS: 7.0 vs. 3.3 years; p = 0,002; OS: 5.1 vs. 3.0 years; p = 0,022). In contrast, no correlation was observed between CR / CRi rate and blast maturity (p > 0,050). Conclusion: The present data show that our flow cytometric score might allow further prognostic stratification within the different ELN risk groups. Our results should be confirmed in a prospective trial in a larger cohort of AML patients. In the future, the flow cytometric score might become an additional criterion for the choice of the most appropriate post remission therapy in AML, particularly within the intermediate risk group according to ELN. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: AML; maturity score; flow cytometry; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schneider, T. (2015). Flow cytometry-based maturity score as a novel prognostic parameter in AML. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11197

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schneider, Tanja. “Flow cytometry-based maturity score as a novel prognostic parameter in AML.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-11197.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schneider, Tanja. “Flow cytometry-based maturity score as a novel prognostic parameter in AML.” 2015. Web. 20 Nov 2019.

Vancouver:

Schneider T. Flow cytometry-based maturity score as a novel prognostic parameter in AML. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-11197.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schneider T. Flow cytometry-based maturity score as a novel prognostic parameter in AML. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-11197

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

20. Sokolowski, Felix. Extracardiac findings at cardiac MR Imaging: a single-center retrospective study over 14 years.

Degree: 2019, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-2612

► Introduction: Cardiovascular disease represent the most common cause of death in industrial nations. Therefore, they are of great socioeconomic interest. There are various different modalities… (more)

▼ Introduction: Cardiovascular disease represent the most common cause of death in industrial nations. Therefore, they are of great socioeconomic interest. There are various different modalities to detect cardiovascular disease and their complications, reaching from the evaluation of peripheral vascular system via doppler sonography to invasive (coronary-)angiography to cardiac imaging via magnetic resonance (MR) imaging and computed tomography (CT). Especially CT and MR examinations represent a challenge because of the possibility to detect extra-cardiac findings (ECF). In this paper we want to identify the prevalence and significance of extra-cardiac findings in cardiac MR imaging. Methods: We extracted all cardiac MR reports from our RIS/PACS database for the years 2000 – 2014 (5170 reports). From all reports we worked out the extra-cardiac findings as well as the indication leading to the cardiac MR. When the radiologist recommended further evaluation of an ECF, it was considered as “major” finding. For these cases we explored our database for additional information. If the ECF was leading to a significant change in patients’ therapy, it indicated a “relevant” ECF. To analyse the association of indication, age and gender with extra-cardiac findings, Poisson regression and computed incidence rate ratios (IRR) were evaluated. Results: Overall, we found 1670 extra-cardiac findings in 1209 patients. 789 of those were of vascular and 881 of non-vascular origin in 594 and 706 patients, respectively. Major ECF were found in 122 patients with a total of 126 findings. 33 of these findings were classified as relevant ECF. The prevalence for any, major and relevant ECF was 34 % (95 % confidence interval (CI) 32.5-35.6 %), 3.4 % (95 % CI 2.9-4.1 %) and 0.9 % (95% CI 0.7-1.3 %). Different indications had different probabilities for the occurrents of ECF, e.g. patients with congenital heart disease were significantly more likely to have ECF compared to patients with myocarditis (IRR 6 (CI 5.2-7.2), p<0.001). Older patients were significantly more likely to have non-vascular findings. Gender had no significant influence on ECF prevalence. Discussion: To our knowledge this is the largest cohort concerning the issue of extra-cardiac findings in cardiac MR imaging. We were able to show that ECF are common in cardiac MR (34%) and that one out of 100 findings changes patients’ management significantly. Our data suggest that the indication is associated with ECF prevalence. This could be one of the reasons for the wide heterogeneity in prior studies with EKB prevalence ranging from 5.3 to 81 %. Advisors/Committee Members: male (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: Magnetic resonance imaging; Cardiac imaging technique; Chest; Extracardiac abnormalities; Incidental findings; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA (6^th Edition):

Sokolowski, F. (2019). Extracardiac findings at cardiac MR Imaging: a single-center retrospective study over 14 years. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-2612

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sokolowski, Felix. “Extracardiac findings at cardiac MR Imaging: a single-center retrospective study over 14 years.” 2019. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-2612.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sokolowski, Felix. “Extracardiac findings at cardiac MR Imaging: a single-center retrospective study over 14 years.” 2019. Web. 20 Nov 2019.

Vancouver:

Sokolowski F. Extracardiac findings at cardiac MR Imaging: a single-center retrospective study over 14 years. [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-2612.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sokolowski F. Extracardiac findings at cardiac MR Imaging: a single-center retrospective study over 14 years. [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-2612

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

21. Böhmer, Merle Margarete. Vaccination coverage, behaviour and acceptance among adults in Germany.

Degree: 2013, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11020

► Detailed and up-to-date information on vaccination coverage is essential to monitor the degree of realization of a vaccination recommendation or the success of immunization programmes… (more)

▼ Detailed and up-to-date information on vaccination coverage is essential to monitor the degree of realization of a vaccination recommendation or the success of immunization programmes and – if necessary – to enhance communication activities. Since data on vaccination coverage is systematically collected only at school entry in Germany, respective data for the adult population was lacking so far. The main objectives of this dissertation were i) to assess coverage for standard vaccinations for adults (seasonal influenza, tetanus, pertussis) and for the vaccination against pandemic influenza (season 2009/10) and ii) to identify factors associated with low vaccination coverage. For this purpose we used data from the ‘German Health Update’ Survey (GEDA). GEDA is a large (~22,000 participants), computer assisted telephone interviewing (CATI) survey on health-relevant topics. The study population of GEDA is representative for the German-speaking adult population in Germany. GEDA was implemented in 2009 and is conducted annually by the Robert Koch Institute as part of Germany’s national health monitoring. For this dissertation data from GEDA09, GEDA10 and a follow-up interviewing of ~2,500 GEDA10 participants were analysed. In a comparison of the three main target groups for seasonal influenza vaccination, health care workers (HCW) had a significantly lower vaccination coverage (seasons 2007/08-2010/11: average coverage 26%) than persons ≥60 years (52%) and persons with underlying chronic diseases (42%). The EU-goal of reaching coverage of ≥75% in elderly and chronically ill persons has not been achieved in Germany yet. Acceptance of pandemic influenza vaccination in season 2009/10 was very low in the German adult population (coverage: 9%). In total, 73% of adults had an adequate tetanus vaccination status (vaccination in the past ten years). Only 11% of persons belonging to a risk group for pertussis (e.g. HCW, persons with close contact to infants) had an adequate pertussis vaccination status. Among other things living in the Eastern federal states and being of younger age were independently associated with both higher tetanus and pertussis vaccination coverage. This dissertation contributed to closing the data gap regarding vaccination coverage of adults living in Germany. Moreover, population subgroups with particular low coverage were identified (e.g. HCW for seasonal influenza vaccination, elderly persons for tetanus vaccination). Our results can be used to develop tailored strategies to close vaccination gaps among adults in Germany. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: vaccination coverage; adults; influenza; tetanus; pertussis; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Böhmer, M. M. (2013). Vaccination coverage, behaviour and acceptance among adults in Germany. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Böhmer, Merle Margarete. “Vaccination coverage, behaviour and acceptance among adults in Germany.” 2013. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/11020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Böhmer, Merle Margarete. “Vaccination coverage, behaviour and acceptance among adults in Germany.” 2013. Web. 20 Nov 2019.

Vancouver:

Böhmer MM. Vaccination coverage, behaviour and acceptance among adults in Germany. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/11020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Böhmer MM. Vaccination coverage, behaviour and acceptance among adults in Germany. [Thesis]. Freie Universität Berlin; 2013. Available from: https://refubium.fu-berlin.de/handle/fub188/11020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

22. Stärk, Markus. evaluation of 35.391 cases from the prenatal medical view.

Degree: 2017, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10243

► Approximately 10.4% of the current world population is consanguineous. Due to the process of globalization an increasing number of people from regions where consanguineous marriage… (more)

▼ Approximately 10.4% of the current world population is consanguineous. Due to the process of globalization an increasing number of people from regions where consanguineous marriage is widespread are now living in Europe. So far the connection of consanguineous marriage and an elevated risk for major anomalies - defined as malformations that lead to death or severe handicap without therapy - has been described by multiple studies either casuistic or focusing on the postnatal situation. But several of the anomalies related to consanguinity lead to intrauterine or early neonatal death and are not recorded in such studies. Therefore the aim of the study at hand is to assess the risk for major anomalies of the offspring from consanguineous parents including the data of the prenatal, perinatal and direct postnatal situation. During a time interval of 20 years (1993-2012) a total of 35.391 fetuses were examined by a single physician using prenatal sonography. In 675 cases of these examinations (1.9%) the parents were consanguineous, in 307 of these cases (45.5%) the couples were related by means of first cousins (F=0.0625), in 368 cases (55.5%) the couples were related beyond the degree of first cousin (F<0.0625). Information on the course of pregnancy was obtained in 31.709 of all 35.391 cases (89.6%), 31.141/34.716 (89.7%) from non- consanguineous couples and 568/675 (84.1%) from consanguineous couples (first cousin 275/307; beyond first cousin 293/368). The overall prevalence of major anomalies among fetuses with non-consanguineous parents was 2.9% (893/31.141), the overall prevalence among fetuses with consanguineous parents was 10.9% (62/568; first cousin 13.8% (38/275); beyond first cousin 8.2% (24/293)). Excluding fetuses with a major anomaly because of an index case in a mothers’ earlier pregnancy and extracting other cases probably influencing the statistics (e.g. age-dependent trisomies) the prevalence of major anomalies for non-consanguineous is 2.0% (621/30.869) and for consanguineous 5.9% (32/538; first cousin 8.1% (21/258); beyond first cousin 3.9% (11/280)). This results in a consanguinity-associated excess of at least 3.9% in comparison to a non-consanguineous population (first cousin 6.1%; beyond first cousin 1.9%). Our data shows that the frequency of fetal major anomalies in the offspring of consanguineous couples is higher than suggested by studies that are solely based on postnatal data. For a better genetic counseling it is essential to share this information with all pregnancies related medical institutions especially in regions with multi-ethnic population or with a high frequency of consanguinity. Advisors/Committee Members: m (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: consanguinity; prenatal ultrasound; genetics; major anomaly; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stärk, M. (2017). evaluation of 35.391 cases from the prenatal medical view. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stärk, Markus. “evaluation of 35.391 cases from the prenatal medical view.” 2017. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-10243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stärk, Markus. “evaluation of 35.391 cases from the prenatal medical view.” 2017. Web. 20 Nov 2019.

Vancouver:

Stärk M. evaluation of 35.391 cases from the prenatal medical view. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-10243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stärk M. evaluation of 35.391 cases from the prenatal medical view. [Thesis]. Freie Universität Berlin; 2017. Available from: http://dx.doi.org/10.17169/refubium-10243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

23. Korsing, Sören. Experimentelle Studie zur Wirksamkeit der niedermolekularen Tyrosinkinase-Inhibitoren BMS-777607, LDC-41267 und MPCD-84111 in Modellen des Glioblastoms.

Degree: 2019, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-2587

► Zielsetzung: Die Rezeptortyrosinkinase Axl stellt einen bedeutenden Vermittler der Proliferation, Migration und Invasion der Gliomzellen dar. In der Mehrzahl der humanen Glioblastome findet sich eine… (more)

▼ Zielsetzung: Die Rezeptortyrosinkinase Axl stellt einen bedeutenden Vermittler der Proliferation, Migration und Invasion der Gliomzellen dar. In der Mehrzahl der humanen Glioblastome findet sich eine Überexpression von Axl. Daher gilt Axl als potenzielles Angriffsziel in der Behandlung des Glioblastoms. In dieser Studie wurden die Effekte einer zielgerichteten Inhibierung von Axl durch die selektiven, niedermolekularen Tyrosinkinase-Inhibitoren BMS-777607, LDC-41267 und MPCD-84111 in Modellen des Glioblastoms in vitro, ex vivo und in vivo evaluiert. Methodik: Die Axl-Inhibitoren wurden an den Gliom-Zelllinien SF126 und U118MG getestet. Die Effekte auf die Zellviabilität, Apoptose, Zellmigration und Invasion wurden mittels funktioneller Assays (MTT-Assay, CPP32-Assay, Boyden-Kammer-Assay, Sphäroid-Invasions- Assay) analysiert. Zur Testung der Axl-Inhibitoren unter in vivo-Bedingungen erfolgte die stereotaktische, intrazerebrale Implantation der Gliomzellen in CD1 Nu/Nu-Mäusen. Das intrakranielle Tumorwachstum wurde mittels MRT-Kontrollen beurteilt. Das Tumorgewebe wurde hinsichtlich der intratumoralen Proliferation, Apoptose und Vaskularisation durch Immunfluoreszenzfärbungen (Ki-67, ApopTag®, CD31) untersucht. Ergebnisse: Die Behandlung mit BMS-777607, LDC-41267 und MPCD-84111 resultierte in einer signifikanten Reduktion der Zellviabilität, der Zellmigration sowie der Invasion der Gliomzellen in vitro und ex vivo. BMS-777607 induzierte eine Reduktion des intrakraniellen Tumorwachstums von 56 % im Tumormodell SF126 sowie von über 90 % im Tumormodell U118MG in vivo. Weiterhin erzielte BMS-777607 eine Reduktion Ki-67-positiver Gliomzellen sowie einen signifikanten Anstieg ApopTag®-positiver Gliomzellen im Tumorgewebe. Unter LDC-41267 zeigte sich kein Effekt auf das Tumorwachstum in vivo. Tierversuche mit MPCD-84111 wurden aufgrund toxischer Effekte abgebrochen. Fazit: BMS-777607, LDC-41267 und MPCD-84111 erzielten multiple Anti-Tumor-Effekte in Modellen des Glioblastoms. Unsere Studie zeigt, dass die zielgerichtete Inhibierung von Axl durch selektive, niedermolekulare Tyrosinkinase-Inhibitoren einen vielversprechenden Therapieansatz für Patienten mit Glioblastom darstellen könnte. Advisors/Committee Members: male (gender), N.%22%29&pagesize-30">N.N. (inspector), N.%22%29&pagesize-30">N.N. (firstReferee).

Subjects/Keywords: glioblastoma multiforme (GBM); invasion; receptor tyrosine kinase AXL; xenograft model; LDC-41267; MPCD-84111; BMS-777607; small molecule inhibitor; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Korsing, S. (2019). Experimentelle Studie zur Wirksamkeit der niedermolekularen Tyrosinkinase-Inhibitoren BMS-777607, LDC-41267 und MPCD-84111 in Modellen des Glioblastoms. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-2587

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Korsing, Sören. “Experimentelle Studie zur Wirksamkeit der niedermolekularen Tyrosinkinase-Inhibitoren BMS-777607, LDC-41267 und MPCD-84111 in Modellen des Glioblastoms.” 2019. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-2587.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Korsing, Sören. “Experimentelle Studie zur Wirksamkeit der niedermolekularen Tyrosinkinase-Inhibitoren BMS-777607, LDC-41267 und MPCD-84111 in Modellen des Glioblastoms.” 2019. Web. 20 Nov 2019.

Vancouver:

Korsing S. Experimentelle Studie zur Wirksamkeit der niedermolekularen Tyrosinkinase-Inhibitoren BMS-777607, LDC-41267 und MPCD-84111 in Modellen des Glioblastoms. [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-2587.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Korsing S. Experimentelle Studie zur Wirksamkeit der niedermolekularen Tyrosinkinase-Inhibitoren BMS-777607, LDC-41267 und MPCD-84111 in Modellen des Glioblastoms. [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-2587

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

24. Brantner, Benedikt. Risk factors for postoperative pain in need for intervention after general anaesthesia.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5657

► To identify patients at high risk for postoperative pain allows timely initiation of therapy and a more adequate treatment planning as well as the prophylactic… (more)

Subjects/Keywords: pain; risk factor; postoperative pain; general anaesthesia; age; gender; BMI; nitrous oxide; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brantner, B. (2015). Risk factors for postoperative pain in need for intervention after general anaesthesia. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5657

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brantner, Benedikt. “Risk factors for postoperative pain in need for intervention after general anaesthesia.” 2015. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-5657.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brantner, Benedikt. “Risk factors for postoperative pain in need for intervention after general anaesthesia.” 2015. Web. 20 Nov 2019.

Vancouver:

Brantner B. Risk factors for postoperative pain in need for intervention after general anaesthesia. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-5657.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brantner B. Risk factors for postoperative pain in need for intervention after general anaesthesia. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-5657

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

25. de Punder, Karin. Characterization in humans of in vitro leukocyte maximal telomerase activity capacity (mTAC) and association with stress.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-721

► Hintergrund: Telomerase, ein zelluläres Transkriptionsenzym, das der Telomerverkürzung entgegenwirkt und wichtig ist für gesunde Zellfunktion, ist ein vielversprechender Biomarker hinsichtlich pathologischer Folgen von Stress auf… (more)

▼ Hintergrund: Telomerase, ein zelluläres Transkriptionsenzym, das der Telomerverkürzung entgegenwirkt und wichtig ist für gesunde Zellfunktion, ist ein vielversprechender Biomarker hinsichtlich pathologischer Folgen von Stress auf zelluläre Alterungsprozesse. Bisherige Studien zur Messung von Telomeraseaktivität oder -expression haben dies meistens unter basalen Bedingungen durchgeführt. Basale Telomerase-Werte sind jedoch aufgrund der niedrigen Expressionsrate und der dynamischen Regulation der Telomerase in Leukozyten sehr schwierig zu messen und zu interpretieren. Im Gegensatz zur basalen Expressionsrate kann Telomerase-Aktivität im Rahmen eines ökologisch-validen Challenge Tests wie der in vitro Mitogen-Stimulation quantifiziert werden. Ein potentieller Vorteil dieses Verfahrens ist, dass dadurch die o.a. Einschränkungen der Interpretierbarkeit der basalen Telomerase-Aktivität umgangen werden können, und man somit die Möglichkeit hat, individuelle Unterschiede zu erfassen in der Kapazität des Telomersystems auf einem immunologischen Stimulus zu reagieren. Ziel: Das Ziel der Studie bestand in der Entwicklung und Validierung eines Maßes der maximalen Telomerase-Aktivitätskapazität (mTAC) zur Nutzung in Humanstudien im Bereich der Telomer-Biologie. Außerdem wurde der Zusammenhang dieses Maßes mit Stress bzw. Stressreaktivität untersucht. Methoden: Zuerst wurde der optimale post-stimulative Zeitverlauf zur mTAC-Charakterisierung mit einem in vitro Mitogen-Challenge-Protokoll (PHA ergänzt durch Interleukin(IL)-2) bestimmt. Danach wurden sowohl mTAC in Leukozyten und Cortisolkonzentrationen im Speichel von 28 jungen gesunden Proband/innen zu verschiedenen Messzeitpunkten im Verlauf des Tages und im Rahmen eines standardisierten Paradigmas zur Induktion psychosozialen Stresses im Labor gemessen. Darüber hinaus wurde in einem Teil der Stichprobe Durchflusszytometrie verwendet, um die Immunzell-Verteilung vor Stimulation zu bestimmen. Die wahrgenommene (chronische) Stressbelastung wurde durch die Perceived Stress Scale erfasst. Resultate: Der optimale Zeitpunkt zur Quantifizierung von mTAC in humanen Leukozyten liegt bei 72 Stunden nach Mitogen-Stimulation. mTAC weist eine erhebliche Stabilität innerhalb von Personen auf und wird nicht durch situationsbedingte Faktoren wie Tageszeit, Cortisol, akute Stressexposition und Immunzell-Verteilung beeinflusst. Ein signifikanter Anteil der Varianz zwischen Personen in mTAC wird durch chronische Stressbelastung und biologische Stressreaktivität erklärt. Insbesondere waren mTAC-Werte bei Personen mit hoher wahrgenommener Stressbelastung um 25% niedriger im Vergleich zu Probanden mit mittlerem oder niedriger wahrgenommener Stressbelastung. Außerdem erklärten individuelle Unterschiede in der Cortisolreaktion auf Laborstressexposition 32% der Varianz von mTAC. Fazit: Basierend auf diesen Ergebnissen kann man schlussfolgern, dass mTAC einen nützlichen individuellen Marker für stressbezogene Humanstudien im Bereich der Telomerbiologie darstellt. Advisors/Committee Members: female (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: Telomerase activity; Leukocytes; Stress; Phytohaemagglutinin (PHA); 600 Technology, Medicine, Applied sciences::610 Medical sciences; Medicine::610 Medical sciences; Medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

de Punder, K. (2018). Characterization in humans of in vitro leukocyte maximal telomerase activity capacity (mTAC) and association with stress. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-721

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

de Punder, Karin. “Characterization in humans of in vitro leukocyte maximal telomerase activity capacity (mTAC) and association with stress.” 2018. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-721.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

de Punder, Karin. “Characterization in humans of in vitro leukocyte maximal telomerase activity capacity (mTAC) and association with stress.” 2018. Web. 20 Nov 2019.

Vancouver:

de Punder K. Characterization in humans of in vitro leukocyte maximal telomerase activity capacity (mTAC) and association with stress. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-721.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

de Punder K. Characterization in humans of in vitro leukocyte maximal telomerase activity capacity (mTAC) and association with stress. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-721

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

26. Schädel, Jana. Effects of an antimicrobial stewardship program in febrile patients with neutropenia.

Degree: 2016, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4591

► Background: The misuse of antibiotics has contributed to the growing problem of antibiotic resistance The goal of antimicrobial stewardship programs (ASPs) is to improve the… (more)

▼ Background: The misuse of antibiotics has contributed to the growing problem of antibiotic resistance The goal of antimicrobial stewardship programs (ASPs) is to improve the quality of antibiotic therapy by optimizing clinical outcomes while minimizing toxicity and emergence of resistance. Febrile neutropenia (FN) is a common medical condition, requiring immediate antimicrobial therapy. However, data on the effectiveness of ASP in patients with FN are scarce. Methods: A before-and-after-study with inpatients with FN was initiated to assess the quality of clinical management. The efficacy of the ASP was evaluated by use of evidence based measures for structure, process and outcome quality. Inclusion criteria were hematooncological diseases, fever (≥38.3°C and ≥38.0°C for at least 1 hour or twice in 12 hours) and neutropenia (ANC/absolute neutrophil count <0.5/nL). ASP interventions were implementation of a local guideline and standardised documentation tools, staff member trainings and twice weekly ID specialists audits. Results: Overall, 58 patients with 82 febrile episodes and 64 patients with 83 febrile episodes were recorded during a retrospective and prospective 6-month period, respectively. Documentation of physical findings were completed in 40% (33/82) and 59% (49/83) of febrile episodes during the retrospective and prospective period, respectively (p=0.02). The rate of double set blood cultures increased from 23% (19/82) to 66% (55/83) (p<0.0001). The rate of patients with fever of unknown origin decreased from 59% (48/82) to 39% (32/83) (p=0.013), whereas the rate of microbiologically defined infections increased from 18% (15/82) to 33% (27/83) (p=0.049). Unjustified continuation of antibacterial therapy beyond guideline termination recommendations in cases with fever of unknown origin (FUO) were found in similar frequencies (42% (20/48) vs. 38% (12/32) p=0.82). However its median duration decreased from 6 to 2.5 days (p=0.014) during the ASP period indicating a calculated reduction of unjustified antibiotic consumption of 140 defined daily doses. There was no significant difference in the 30-day mortality rates of the control and ASP cohort (9%, 5/58 vs 13%, 8/64, p=0.566). Conclusions: The use of evidence-based quality measures is well suited to assess the efficacy of ASP programs. Various process and outcome measures improved during the ASP intervention. In particular, the ASP increased the proportion of infectiological diagnoses and led to a substantial reduction of unjustified antibiotic usage. Longer lasting studies with more patients are needed to demonstrate an influence on mortality. The implementation of multimodale ASPs in Patients with febrile neutropenia seems safe and effective. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: antimicrobial; antibiotic; stewardship; neutropenia; neutropenic; fever; ASP; hematology; cancer; immunocompromised; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schädel, J. (2016). Effects of an antimicrobial stewardship program in febrile patients with neutropenia. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4591

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schädel, Jana. “Effects of an antimicrobial stewardship program in febrile patients with neutropenia.” 2016. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-4591.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schädel, Jana. “Effects of an antimicrobial stewardship program in febrile patients with neutropenia.” 2016. Web. 20 Nov 2019.

Vancouver:

Schädel J. Effects of an antimicrobial stewardship program in febrile patients with neutropenia. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-4591.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schädel J. Effects of an antimicrobial stewardship program in febrile patients with neutropenia. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-4591

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

27. Lau, Inga. challenges in the implementation of a complex antiretroviral prophylaxis regimen.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9282

► Approximately 370,000 children are infected every year with the human immunodeficiency virus (HIV). Most of them are living in sub-Saharan Africa, where they are usually… (more)

▼ Approximately 370,000 children are infected every year with the human immunodeficiency virus (HIV). Most of them are living in sub-Saharan Africa, where they are usually infected by their mothers during pregnancy, delivery or breastfeeding. In June 2008, Tanzania changed its guide-lines for the prevention of mother-to-child-transmission (PMTCT) of HIV to a combination medication regimen, in an effort to lower transmission rates and to curb the development of drug-resistance against the formerly recommended nevirapine single-dose. However, the feasi-bility of this new regimen in areas of limited resources is questionable due to concerns regarding adherence, the subsequent complex drug-resistance, and toxic side effects. This thesis aims to evaluate the implementation of the combination prophylaxis regimen under real-life conditions in rural Tanzania. In the Kyela District Hospital, 184 HIV-positive pregnant women were enrolled in this observa-tional study, which was further divided into several substudies. Substudy 1 analyzed adherence to the combination prophylaxis using standardized questionnaires. Ultimately, only one mother-child-pair could maintain at least 95% adherence throughout the prophylactic intervention. An early gestational stage at the first prenatal care visit was identified as a risk-factor for not starting pre-delivery prophylaxis, while HIV-status disclosure to a person of trust was related to higher adherence rates during the gestational period. The emergence of resistance against antiretroviral drugs was quantified in Substudy 2. Allele- specific polymerase chain reactions were used to de-tect resistant viral strains in 40% of the women. The prenatal intake of zidovudine (AZT) mono- prophylaxis for more than ten weeks was associated with increased emergence of AZT-resistance at the time of delivery. Substudy 3 monitored blood counts, showing mostly mild and transient changes for the mothers, while few children presented cases of severe haematological toxicity. Overall, the implementation of the combination prophylaxis regimen in rural Tanzania has shown to be a major challenge for the affected mothers, as well as for healthcare workers. Ad-herence rates could be drastically improved by enhancing the provision of social support to the affected women, as well as scaling up PMTCT training for staff. In an effort to minimize cases of rejection of prophylaxis, Tanzania has introduced an early prophylaxis start during pregnancy. Unfortunately, a prolonged AZT-intake during pregnancy increases the risk of AZT-resistance, so that the use of a drug combination early in the regimen would be advisable. At the same time, monitoring blood counts should be implemented as a constituent part of any PMTCT services using AZT-containing regimen in order not to oversee cases of severe haematological toxicity. Advisors/Committee Members: [email protected] (contact), w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: PMTCT; HIV; vertical transmission; resource limited setting; combination prophylaxis; compliance; adherence; Tanzania; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lau, I. (2013). challenges in the implementation of a complex antiretroviral prophylaxis regimen. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9282

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lau, Inga. “challenges in the implementation of a complex antiretroviral prophylaxis regimen.” 2013. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-9282.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lau, Inga. “challenges in the implementation of a complex antiretroviral prophylaxis regimen.” 2013. Web. 20 Nov 2019.

Vancouver:

Lau I. challenges in the implementation of a complex antiretroviral prophylaxis regimen. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-9282.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lau I. challenges in the implementation of a complex antiretroviral prophylaxis regimen. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-9282

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

28. Hüttel, Eleanor. Pregnancy outcome of first trimester exposure to the vitamin K antagonist phenprocoumon depends on duration of treatment.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11757

► Introduction Coumarin derivatives carry a teratogenic risk and are fetotoxic when used beyond the first trimester. Experience in pregnancy is mainly based on warfarin. Phenprocoumon… (more)

▼ Introduction Coumarin derivatives carry a teratogenic risk and are fetotoxic when used beyond the first trimester. Experience in pregnancy is mainly based on warfarin. Phenprocoumon is the preferred coumarin derivative in Germany. It is used for treatment and prophylaxis of arterial and venous thrombosis and embolism. Its half-live of 6.5 days is much longer than that of warfarin (40 hours). This study evaluates the outcome of phenprocoumon exposed pregnancies ascertained by the German Embryotox institute. Study goal is to enhance the safety of anticoagulative treatment in pregnancy. Methods The design of this study is a prospective cohort study. The exposed group consists of women with at least one exposure to phenprocoumon anytime during 5 weeks before the first day of the last menstrual period and gestational week (GW) 12 + 6. The comparison cohort consists of pregnancies neither exposed to coumarin derivatives nor to other known teratogens or fetotoxicants. Exposed and comparison pregnancies were identified through the institute’s risk consultation activities between 1988 and 2014. The main focus of this study was to assess the risks of birth defects and spontaneous abortion (SAB) after maternal exposure to phenprocoumon during the first trimester. Results 408 pregnancies exposed to phenprocoumon during the 1st trimester were compared to 1.642 non exposed pregnancies. There was no typical warfarin embryopathy in our exposed cohort. The overall rate of major birth defects was significantly increased (7.4% vs. 2.3%; adjusted odds ratio [ORadj] 2.14; 95% confidence interval [CI] 1.4 – 3.4). When treatment was stopped until 5 completed GW the rate of major malformations was comparable with the non-exposed cohort (2.4% vs 2.3%; ORadj 1.07; 95% CI 0.2 – 3.6). With increasing duration of exposure longer than GW 7 the rate of major birth defects increased up to fivefold (10.8% vs 2.3%; ORadj 5.18; 95% CI 2.0 – 11.6). The overall risk of SAB was 38.0% vs. 17.5% (adjusted hazard ratio (HRadj) 2.9; 95% CI 2.2 – 3.9). The time of discontinuation had significant influence on the SAB risk (Hazard ratio [HR] 1.12; 95% CI 1.01 – 1.25 per each additional week). Conclusion Phenprocoumon increases the risk for birth defects and spontaneous abortion. Both risks appear to be time-dependent and significantly increase with prolonged exposure beyond GW 5. Women of childbearing age should be informed about these risks and advised to carefully observe their menstrual cycle in order to ensure treatment switch (e.g. to heparins) latest during early pregnancy if maternal disease permits. Advisors/Committee Members: [email protected] (contact), w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: phenprocoumon; pregnancy; thrombosis prophylaxis; spontaneous abortion; congenital malformation; vitamin k antagonist; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hüttel, E. (2017). Pregnancy outcome of first trimester exposure to the vitamin K antagonist phenprocoumon depends on duration of treatment. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11757

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hüttel, Eleanor. “Pregnancy outcome of first trimester exposure to the vitamin K antagonist phenprocoumon depends on duration of treatment.” 2017. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/11757.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hüttel, Eleanor. “Pregnancy outcome of first trimester exposure to the vitamin K antagonist phenprocoumon depends on duration of treatment.” 2017. Web. 20 Nov 2019.

Vancouver:

Hüttel E. Pregnancy outcome of first trimester exposure to the vitamin K antagonist phenprocoumon depends on duration of treatment. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/11757.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hüttel E. Pregnancy outcome of first trimester exposure to the vitamin K antagonist phenprocoumon depends on duration of treatment. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/11757

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

29. Ohde, Julia. Knee joint stability, kinematic and kinetic after successful reconstruction of the posterior cruciate ligament - a clinical follow-up.

Degree: 2016, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12409

► Introduction: Injuries of the posterior cruciate ligament (PCL) and other ligaments of the knee are serious and severe which often occur in high-energy mechanisms. Former… (more)

▼ Introduction: Injuries of the posterior cruciate ligament (PCL) and other ligaments of the knee are serious and severe which often occur in high-energy mechanisms. Former studies pointed out that there are differences between subjective and objective examinations which could be an indicator, that knee function is not fully restored. The purpose of this study was to perform clinical follow-up and gait analysis on patients with PCL and multiple ligament reconstruction. The focus of the study is on the joint stability, kinematics and kinetics. Methodology: Thirty-four patients who underwent a PCL reconstruction five to fifteen years ago participate in this study. We performed clinical examination, radiological exam including PCL stress radiographs (Telos), three-dimensional gait analysis (Vicon Nexus) and a clinical score evaluation (IKDC, Lysholm, KOOS). To detect the motions of the patients while acitivities of daily life (walk, stairs up and down) and calculate kinematics we used ten infrared cameras (120 Hz) to perform gait analysis. To evaluate the collected data of the operated knee they were compared to the data of the contalateral and healthy group. Results: ROM extension/ flexion 10/0/120-145, mid-thigh-circumference 1,1 mm less on reconstructed knees, mean posterior translation 9mm, SSD 5 mm, 33-50% reduction; Median IKDC Score was 73, Lysholm Score 75, KOOS Score 81%; Significantly reduced knee flexion moment in the reconstructed knee compared to contralateral knee. Significantly different Knee flexion angles, moments and external rotation angles and moments compared tot he healthy controls. Significantly lower PFA in the contralateral knee of the thirty year old patients compared to the twenty to twenty-nine ones while ascending and descending a step. Conclusion: The results of this study indicate that persons who underwent reconstruction of the PCL and other ligaments are able to return to normal daily activities and sports five to fifteen years after the operation. The clinical follow-up revealed good results. Posterior drawer could be reduced and subjective scores demonstrate that the patients are satisfied with the postoperative results. Gait analysis shows that patients are able to return to normal gait patterns but with different biomechanical forces and functional deficits. Advisors/Committee Members: w (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: pcl injury; knee joint instability; pcl deficiency; gait analysis; kinematics; multiple knee ligament injury; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ohde, J. (2016). Knee joint stability, kinematic and kinetic after successful reconstruction of the posterior cruciate ligament - a clinical follow-up. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12409

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ohde, Julia. “Knee joint stability, kinematic and kinetic after successful reconstruction of the posterior cruciate ligament - a clinical follow-up.” 2016. Thesis, Freie Universität Berlin. Accessed November 20, 2019. https://refubium.fu-berlin.de/handle/fub188/12409.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ohde, Julia. “Knee joint stability, kinematic and kinetic after successful reconstruction of the posterior cruciate ligament - a clinical follow-up.” 2016. Web. 20 Nov 2019.

Vancouver:

Ohde J. Knee joint stability, kinematic and kinetic after successful reconstruction of the posterior cruciate ligament - a clinical follow-up. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2019 Nov 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/12409.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ohde J. Knee joint stability, kinematic and kinetic after successful reconstruction of the posterior cruciate ligament - a clinical follow-up. [Thesis]. Freie Universität Berlin; 2016. Available from: https://refubium.fu-berlin.de/handle/fub188/12409

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

30. Arafat, Ayman M. Die Insulin-unabhängige, Glucagon-induzierte Suppression von Ghrelin und das Sättigungsgefühl bei Adipositas und Typ-1-Diabetes mellitus.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9573

► Einleitung Die zugrunde liegenden Mechanismen des Glukagon-induzierten Einflusses auf das Sättigungsgefühl sind unklar. Wir haben bereits gezeigt, dass Glukagon die Ausschüttung des 28-Aminosäuren-langen orexigenen Peptids… (more)

▼ Einleitung Die zugrunde liegenden Mechanismen des Glukagon-induzierten Einflusses auf das Sättigungsgefühl sind unklar. Wir haben bereits gezeigt, dass Glukagon die Ausschüttung des 28-Aminosäuren-langen orexigenen Peptids "Ghrelin" hemmt, welches die Nahrungsaufnahme reguliert und somit eine Rolle bei der Entstehung von Adipositas spielen könnte. Wir haben ebenfalls zeigen können, dass Glukagon diese Effekte auf hypothalamisch-hypophysärer Ebene induziert. Gegenstand unserer aktuellen Arbeit ist, die Glucagon-induzierte Hemmung des zirkulierenden "Gesamt-Ghrelins" und dessen aktivierten Form "Acyl-Ghrelin" bei Adipositas und Typ-1 Diabetes mellitus (T1DM), sowie die Zusammenhänge mit Appetit-Regulation, zu untersuchen. Außerdem sollte untersucht werden, ob die Glukagon-induzierten Veränderungen durch den Einfluss auf das körpereigene Insulin vermittelt werden. Methodik In unserer prospektiven, doppelblinden , Placebo-kontrollierten Studie untersuchten wir die endokrinen und metabolischen Einflüsse des intramuskulär-applizierten Glukagons bei 13 Patienten mit Typ-1 Diabetes mellitus (T1DM : 6 Männer/ 7 Frauen; BMI 24,8 ± 0,95 kg/m2), bei 11 adipösen Teilnehmern (OP : 5/ 6; 34,4 ± 1,7 kg/m2) und bei 13 normalgewichtigen sonst gesunden Probanden (LP : 6/ 7; 21,7 ± 0,6 kg/m2) . Ergebnisse Der Glucagon-Spiegel zeigte nach i.m. Gabe einen ~ 8-9 fachen Anstieg in allen Studiengruppen mit einem Rückgang auf das Ausgangsniveau nach 240 min. Hingegen zeigte der Insulin-Spiegel einen maximalen Anstieg nach 30 min, gefolgt von einem Rückgang auf das Basisniveau nach 120 min in OP und LP (p <0,01), aber nicht bei Patienten mit T1DM. Im Vergleich zu Placebo induzierte Glukagon einen signifikanten Anstieg im Sättigungsindex ( SI) bei T1DM und in LP (p <0,001). Allerdings zeigte Glukagon bei adipösen Teilnehmern keinen Einfluss auf das Hungergefühl (p = 0,152). Das Glucagon-induzierte Sättigungsgefühl war bei LP und T1DM sogar nach 24h nachweisbar (p <0,01). Glukagon induzierte eine signifikante Hemmung des Gesamt-Ghrelin-Spiegels bei allen Studienteilnehmern (p <0,01). Acyl- Ghrelin zeigte ebenfalls einen signifikanten Abfall bei LP ( p < 0,01). Allerdings zeigte der Acyl-Ghrelin-Spiegel keine Veränderung bei OP (p = 0,248) und sogar einen signifikanten Anstieg bei T1DM (p <0,01). Die Veränderungen in der Acyl-Ghrelin-Konzentrationen korrelierten positiv mit den Veränderungen in den NEFA-Konzentrationen in allen Gruppen (r = 0,31 bis 0,43 , p < 0,01). Schlussfolgerung Die Glukagon-induzierte Hemmung des Gesamt- Ghrelin-Spiegels blieb erhalten, sowohl bei normalgewichtigen Teilnehmern als auch bei adipösen und bei Patienten mit T1DM, was auf einen von dem endogenen Insulinspiegel unabhängigen Mechanismus hinweist. Unsere neu gewonnenen Erkenntnisse zeigten auch, dass das Glucagon-induzierte Sättigungsgefühl bei T1DM erhalten geblieben ist, aber nicht bei adipösen Teilnehmern trotz intakter hypothalamisch-hypophysären Achsen. Der Insulin-unabhängige Glukagon- induzierte Einfluss auf die Sättigung ist jedoch nicht durch Veränderungen… Advisors/Committee Members: m (gender), N.%22%29&pagesize-30">N.N. (firstReferee), N.%22%29&pagesize-30">N.N. (furtherReferee).

Subjects/Keywords: glucagon; ghrelin; obesity; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arafat, A. M. (2014). Die Insulin-unabhängige, Glucagon-induzierte Suppression von Ghrelin und das Sättigungsgefühl bei Adipositas und Typ-1-Diabetes mellitus. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arafat, Ayman M. “Die Insulin-unabhängige, Glucagon-induzierte Suppression von Ghrelin und das Sättigungsgefühl bei Adipositas und Typ-1-Diabetes mellitus.” 2014. Thesis, Freie Universität Berlin. Accessed November 20, 2019. http://dx.doi.org/10.17169/refubium-9573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arafat, Ayman M. “Die Insulin-unabhängige, Glucagon-induzierte Suppression von Ghrelin und das Sättigungsgefühl bei Adipositas und Typ-1-Diabetes mellitus.” 2014. Web. 20 Nov 2019.

Vancouver:

Arafat AM. Die Insulin-unabhängige, Glucagon-induzierte Suppression von Ghrelin und das Sättigungsgefühl bei Adipositas und Typ-1-Diabetes mellitus. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2019 Nov 20]. Available from: http://dx.doi.org/10.17169/refubium-9573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arafat AM. Die Insulin-unabhängige, Glucagon-induzierte Suppression von Ghrelin und das Sättigungsgefühl bei Adipositas und Typ-1-Diabetes mellitus. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-9573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations