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You searched for +publisher:"Florida International University" +contributor:("Stefan Rose"). Showing records 1 – 2 of 2 total matches.

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Florida International University

1. Davis, Philip R.N. The Investigation of Human Scent from Epileptic Patients for the Identification of a Biomarker for Epileptic Seizures.

Degree: PhD, Chemistry, 2017, Florida International University

Studies have shown that some canines have the ability to predict seizures in people with epilepsy, and that canines can be trained to recognize changes in humans before an epileptic seizure and make these predictions. It is not known with any certainty to what the canines are alerting. However, canines’ exceptional sense of smell and their ability to discriminate human scent is well established. Therefore, it is possible that the canines could be responding to an olfactory cue, such as the release of some volatile organic compounds (VOCs) prior to the onset of a seizure. Individuals release a wide array of VOCs, both odorous and non-odorous, from their bodies. The odorous VOCs collectively make up human scent and a number of these VOCs have been identified as biomarkers of different diseases. Evidence suggests that canines can perceive these biomarkers, leading to early detection of underlying physical ailments before individuals are aware of their own symptoms. The main purpose of this study was to use headspace solid phase microextraction (HS-SPME) with gas chromatography-mass spectrometry (GC-MS) to analyze hand odor, saliva and breath samples from epileptic with and without seizure activity to determine if the human scent profiles resulting from a seizure event differs from the scent profiles in the absence of seizure activity. the HS-SPME-GC-MS method was also used to analyze and compare hand odor, saliva and breath samples of healthy individuals and epilepsy patients to determine if the profiles can be differentiated. Comparison of the VOCs in each specimen from healthy individuals and epileptic patients revealed compounds that could be used as potential biomarkers to differentiate between healthy and epileptic individuals. Comparison of the VOCs in each specimen from epileptic patients with and without seizure activity revealed compounds that could be used as potential biomarkers for epileptic seizures. Finally, canine trials were used to verify that these compounds are indeed biomarkers. Advisors/Committee Members: Kenneth Furton, Stefan Rose, Yong Cai, Joong-ho Moon, Nadja Schreiber Compo.

Subjects/Keywords: epilepsy; seizures; volatile organic compounds; Analytical Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Davis, P. R. N. (2017). The Investigation of Human Scent from Epileptic Patients for the Identification of a Biomarker for Epileptic Seizures. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/3520 ; 10.25148/etd.FIDC004043 ; FIDC004043

Chicago Manual of Style (16th Edition):

Davis, Philip R N. “The Investigation of Human Scent from Epileptic Patients for the Identification of a Biomarker for Epileptic Seizures.” 2017. Doctoral Dissertation, Florida International University. Accessed August 15, 2020. https://digitalcommons.fiu.edu/etd/3520 ; 10.25148/etd.FIDC004043 ; FIDC004043.

MLA Handbook (7th Edition):

Davis, Philip R N. “The Investigation of Human Scent from Epileptic Patients for the Identification of a Biomarker for Epileptic Seizures.” 2017. Web. 15 Aug 2020.

Vancouver:

Davis PRN. The Investigation of Human Scent from Epileptic Patients for the Identification of a Biomarker for Epileptic Seizures. [Internet] [Doctoral dissertation]. Florida International University; 2017. [cited 2020 Aug 15]. Available from: https://digitalcommons.fiu.edu/etd/3520 ; 10.25148/etd.FIDC004043 ; FIDC004043.

Council of Science Editors:

Davis PRN. The Investigation of Human Scent from Epileptic Patients for the Identification of a Biomarker for Epileptic Seizures. [Doctoral Dissertation]. Florida International University; 2017. Available from: https://digitalcommons.fiu.edu/etd/3520 ; 10.25148/etd.FIDC004043 ; FIDC004043


Florida International University

2. Kusano, Maiko. Comparison of Medical and Forensic Profiling Potential of Volatile Biomarkers from Different Biological Specimens from Individuals and Across Populations.

Degree: Chemistry, 2010, Florida International University

There is limited scientific knowledge on the composition of human odor from different biological specimens and the effect that physiological and psychological health conditions could have on them. There is currently no direct comparison of the volatile organic compounds (VOCs) emanating from different biological specimens collected from healthy individuals as well as individuals with certain diagnosed medical conditions. Therefore the question of matching VOCs present in human odor across various biological samples and across health statuses remains unanswered. The main purpose of this study was to use analytical instrumental methods to compare the VOCs from different biological specimens from the same individual and to compare the populations evaluated in this project. The goals of this study were to utilize headspace solid-phase microextraction gas chromatography mass spectrometry (HS-SPME-GC/MS) to evaluate its potential for profiling VOCs from specimens collected using standard forensic and medical methods over three different populations: healthy group with no diagnosed medical or psychological condition, one group with diagnosed type 2 diabetes, and one group with diagnosed major depressive disorder. The pre-treatment methods of collection materials developed for the study allowed for the removal of targeted VOCs from the sampling kits prior to sampling, extraction and analysis. Optimized SPME-GC/MS conditions has been demonstrated to be capable of sampling, identifying and differentiating the VOCs present in the five biological specimens collected from different subjects and yielded excellent detection limits for the VOCs from buccal swab, breath, blood, and urine with average limits of detection of 8.3 ng. Visual, Spearman rank correlation, and PCA comparisons of the most abundant and frequent VOCs from each specimen demonstrated that each specimen has characteristic VOCs that allow them to be differentiated for both healthy and diseased individuals. Preliminary comparisons of VOC profiles of healthy individuals, patients with type 2 diabetes, and patients with major depressive disorder revealed compounds that could be used as potential biomarkers to differentiate between healthy and diseased individuals. Finally, a human biological specimen compound database has been created compiling the volatile compounds present in the emanations of human hand odor, oral fluids, breath, blood, and urine. Advisors/Committee Members: Kenneth Furton, John Berry, David Chatfield, Nadja Schreiber Compo, Stefan Rose.

Subjects/Keywords: forensic; human scent; biomarkers; VOC; solid phase microextraction; GC-MS; biological specimens

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kusano, M. (2010). Comparison of Medical and Forensic Profiling Potential of Volatile Biomarkers from Different Biological Specimens from Individuals and Across Populations. (Thesis). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/307 ; 10.25148/etd.FI10120102 ; FI10120102

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Kusano, Maiko. “Comparison of Medical and Forensic Profiling Potential of Volatile Biomarkers from Different Biological Specimens from Individuals and Across Populations.” 2010. Thesis, Florida International University. Accessed August 15, 2020. https://digitalcommons.fiu.edu/etd/307 ; 10.25148/etd.FI10120102 ; FI10120102.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Kusano, Maiko. “Comparison of Medical and Forensic Profiling Potential of Volatile Biomarkers from Different Biological Specimens from Individuals and Across Populations.” 2010. Web. 15 Aug 2020.

Vancouver:

Kusano M. Comparison of Medical and Forensic Profiling Potential of Volatile Biomarkers from Different Biological Specimens from Individuals and Across Populations. [Internet] [Thesis]. Florida International University; 2010. [cited 2020 Aug 15]. Available from: https://digitalcommons.fiu.edu/etd/307 ; 10.25148/etd.FI10120102 ; FI10120102.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kusano M. Comparison of Medical and Forensic Profiling Potential of Volatile Biomarkers from Different Biological Specimens from Individuals and Across Populations. [Thesis]. Florida International University; 2010. Available from: https://digitalcommons.fiu.edu/etd/307 ; 10.25148/etd.FI10120102 ; FI10120102

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.