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You searched for +publisher:"Florida International University" +contributor:("Georg Petroianu"). Showing records 1 – 3 of 3 total matches.

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1. Eckberg, Melanie N. Forensic Toxicological Screening and Confirmation of 800+ Novel Psychoactive Substances by LC-QTOF-MS and 2D-LC Analysis.

Degree: PhD, Chemistry, 2018, Florida International University

Novel psychoactive substances (NPS) represent a great challenge to toxicologists due to the ability of illicit drug manufacturers to alter NPS chemical structures quickly and with ease to circumvent legislation regulating their use. Each time a new structure is introduced, there is a possibility that it has not been previously recorded in law enforcement or scientific databases. Many toxicology laboratories use targeted analytical methods that rely on libraries of known compounds to identify drugs in samples. However, these libraries do not include large numbers of NPS which could result in non-identification or detection. High-resolution mass spectrometry (HRMS) has been suggested as a method for screening a wide variety of analytes due to its higher sensitivity and mass accuracy as compared to some other forms of mass spectrometry. This technique can generate characteristic MS/MS spectral data for use in compound identification. The main goal of this research was to create a high-resolution mass spectrometry (HRMS) library of NPS and metabolites, as well as validate a method for screening and confirmation of these substances. The study consisted of three main tasks which included; the development of a large high-resolution MS/MS spectral library and database, validation of a method for screening and confirmation of over 800 NPS and metabolites, and screening of blind-spiked and authentic urine specimens to determine real-world applicability of the HRMS library and method. During validation, several isomeric and structurally related NPS were observed which could not be adequately separated using traditional LC methods. A fourth task was therefore added to investigate improved separation using two-dimensional liquid chromatography (2D-LC). Increased resolving power is achieved in 2D-LC through the coupling of multiple orthogonal separation systems. Ultimately, an on-line, comprehensive method was developed using orthogonal reversed-phase columns in each dimension (RP x RP) for improved separation of co-eluting and isomeric synthetic cannabinoids. This work can aid laboratories in the identification of NPS through the use of a validated LC-QTOF-MS method for screening and confirmation and HRMS spectral library. In instances where isomeric and structurally related NPS are not sufficiently separated, RP x RP methods can be explored. Advisors/Committee Members: Anthony DeCaprio, Jose Almirall, Yong Cai, Georg Petroianu, Stanislaw Wnuk.

Subjects/Keywords: novel psychoactive substances; forensic toxicology; LC-QTOF-MS; 2D-LC; HRMS; Analytical Chemistry; Other Chemistry

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APA (6th Edition):

Eckberg, M. N. (2018). Forensic Toxicological Screening and Confirmation of 800+ Novel Psychoactive Substances by LC-QTOF-MS and 2D-LC Analysis. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/3923 ; 10.25148/etd.FIDC006984 ; FIDC006984

Chicago Manual of Style (16th Edition):

Eckberg, Melanie N. “Forensic Toxicological Screening and Confirmation of 800+ Novel Psychoactive Substances by LC-QTOF-MS and 2D-LC Analysis.” 2018. Doctoral Dissertation, Florida International University. Accessed August 08, 2020. https://digitalcommons.fiu.edu/etd/3923 ; 10.25148/etd.FIDC006984 ; FIDC006984.

MLA Handbook (7th Edition):

Eckberg, Melanie N. “Forensic Toxicological Screening and Confirmation of 800+ Novel Psychoactive Substances by LC-QTOF-MS and 2D-LC Analysis.” 2018. Web. 08 Aug 2020.

Vancouver:

Eckberg MN. Forensic Toxicological Screening and Confirmation of 800+ Novel Psychoactive Substances by LC-QTOF-MS and 2D-LC Analysis. [Internet] [Doctoral dissertation]. Florida International University; 2018. [cited 2020 Aug 08]. Available from: https://digitalcommons.fiu.edu/etd/3923 ; 10.25148/etd.FIDC006984 ; FIDC006984.

Council of Science Editors:

Eckberg MN. Forensic Toxicological Screening and Confirmation of 800+ Novel Psychoactive Substances by LC-QTOF-MS and 2D-LC Analysis. [Doctoral Dissertation]. Florida International University; 2018. Available from: https://digitalcommons.fiu.edu/etd/3923 ; 10.25148/etd.FIDC006984 ; FIDC006984


Florida International University

2. Rodzinski, Alexandra. Targeted and Controlled Anticancer Drug Delivery and Release with Magnetoelectric Nanoparticles.

Degree: PhD, Medicine, 2016, Florida International University

A major challenge of cancer treatment is successful discrimination of cancer cells from healthy cells. Nanotechnology offers multiple venues for efficient cancer targeting. Magnetoelectric nanoparticles (MENs) are a novel, multifaceted, physics-based cancer treatment platform that enables high specificity cancer targeting and externally controlled loaded drug release. The unique magnetoelectric coupling of MENs allows them to convert externally applied magnetic fields into intrinsic electric signals, which allows MENs to both be drawn magnetically towards the cancer site and to electrically interface with cancer cells. Once internalized, the MEN payload release can be externally triggered with a magnetic field. MENs uniquely allow for discrete manipulation of the drug delivery and drug release mechanisms to allow an unprecedented level of control in cancer targeting. In this study, we demonstrate the physics behind the MEN drug delivery platform, test the MEN drug delivery platform for the first time in a humanized mouse model of cancer, and characterize the biodistribution and clearance of MENs. We found that MENs were able to fully cure the model cancer, which in this case was human ovarian carcinoma treated with paclitaxel. When compared to conventional magnetic nanoparticles and FDA approved organic PLGA nanoparticles, MENs are the highest performing treatment, even in the absence of peripheral active targeting molecules. We also mapped the movement through peripheral organs and established clearance trends of the MENs. The MENs cancer treatment platform has immense potential for future medicine, as it is generalizable, personalizable, and readily traceable in the context of treating essentially any type of cancer. Advisors/Committee Members: Sakhrat Khizroev, Georg Petroianu, Stavros V. Georgakopoulos, Osama A. Mohammed, Carolyn D. Runowicz.

Subjects/Keywords: magnetoelectric nanoparticles; magnetic nanoparticles; personalized medicine; cancer; nanomedicine; nanotechnology; drug delivery; nanoparticle biodistribution; Cancer Biology; Medical Biophysics; Medical Biotechnology; Nanomedicine; Nanotechnology; Oncology

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APA (6th Edition):

Rodzinski, A. (2016). Targeted and Controlled Anticancer Drug Delivery and Release with Magnetoelectric Nanoparticles. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/2976 ; 10.25148/etd.FIDC001249 ; FIDC001249

Chicago Manual of Style (16th Edition):

Rodzinski, Alexandra. “Targeted and Controlled Anticancer Drug Delivery and Release with Magnetoelectric Nanoparticles.” 2016. Doctoral Dissertation, Florida International University. Accessed August 08, 2020. https://digitalcommons.fiu.edu/etd/2976 ; 10.25148/etd.FIDC001249 ; FIDC001249.

MLA Handbook (7th Edition):

Rodzinski, Alexandra. “Targeted and Controlled Anticancer Drug Delivery and Release with Magnetoelectric Nanoparticles.” 2016. Web. 08 Aug 2020.

Vancouver:

Rodzinski A. Targeted and Controlled Anticancer Drug Delivery and Release with Magnetoelectric Nanoparticles. [Internet] [Doctoral dissertation]. Florida International University; 2016. [cited 2020 Aug 08]. Available from: https://digitalcommons.fiu.edu/etd/2976 ; 10.25148/etd.FIDC001249 ; FIDC001249.

Council of Science Editors:

Rodzinski A. Targeted and Controlled Anticancer Drug Delivery and Release with Magnetoelectric Nanoparticles. [Doctoral Dissertation]. Florida International University; 2016. Available from: https://digitalcommons.fiu.edu/etd/2976 ; 10.25148/etd.FIDC001249 ; FIDC001249

3. Swortwood, Madeleine Jean. Comprehensive Forensic Toxicological Analysis of Designer Drugs.

Degree: PhD, Chemistry, 2013, Florida International University

New designer drugs are constantly emerging onto the illicit drug market and it is often difficult to validate and maintain comprehensive analytical methods for accurate detection of these compounds. Generally, toxicology laboratories utilize a screening method, such as immunoassay, for the presumptive identification of drugs of abuse. When a positive result occurs, confirmatory methods, such as gas chromatography (GC) or liquid chromatography (LC) coupled with mass spectrometry (MS), are required for more sensitive and specific analyses. In recent years, the need to study the activities of these compounds in screening assays as well as to develop confirmatory techniques to detect them in biological specimens has been recognized. Severe intoxications and fatalities have been encountered with emerging designer drugs, presenting analytical challenges for detection and identification of such novel compounds. The first major task of this research was to evaluate the performance of commercially available immunoassays to determine if designer drugs were cross-reactive. The second major task was to develop and validate a confirmatory method, using LC-MS, to identify and quantify these designer drugs in biological specimens. Cross-reactivity towards the cathinone derivatives was found to be minimal. Several other phenethylamines demonstrated cross-reactivity at low concentrations, but results were consistent with those published by the assay manufacturer or as reported in the literature. Current immunoassay-based screening methods may not be ideal for presumptively identifying most designer drugs, including the “bath salts.” For this reason, an LC-MS based confirmatory method was developed for 32 compounds, including eight cathinone derivatives, with limits of quantification in the range of 1-10 ng/mL. The method was fully validated for selectivity, matrix effects, stability, recovery, precision, and accuracy. In order to compare the screening and confirmatory techniques, several human specimens were analyzed to demonstrate the importance of using a specific analytical method, such as LC-MS, to detect designer drugs in serum as immunoassays lack cross-reactivity with the novel compounds. Overall, minimal cross-reactivity was observed, highlighting the conclusion that these presumptive screens cannot detect many of the designer drugs and that a confirmatory technique, such as the LC-MS, is required for the comprehensive forensic toxicological analysis of designer drugs. Advisors/Committee Members: Anthony DeCaprio, Piero Gardinali, W. Lee Hearn, Jaroslava Mikšovská, Georg Petroianu.

Subjects/Keywords: designer drugs; toxicology; LC-MS; ELISA; EMIT; cross-reactivity; cathinone derivatives; forensic toxicology; bath salts; Analytical Chemistry; Toxicology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Swortwood, M. J. (2013). Comprehensive Forensic Toxicological Analysis of Designer Drugs. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/997 ; 10.25148/etd.FI13120611 ; FI13120611

Chicago Manual of Style (16th Edition):

Swortwood, Madeleine Jean. “Comprehensive Forensic Toxicological Analysis of Designer Drugs.” 2013. Doctoral Dissertation, Florida International University. Accessed August 08, 2020. https://digitalcommons.fiu.edu/etd/997 ; 10.25148/etd.FI13120611 ; FI13120611.

MLA Handbook (7th Edition):

Swortwood, Madeleine Jean. “Comprehensive Forensic Toxicological Analysis of Designer Drugs.” 2013. Web. 08 Aug 2020.

Vancouver:

Swortwood MJ. Comprehensive Forensic Toxicological Analysis of Designer Drugs. [Internet] [Doctoral dissertation]. Florida International University; 2013. [cited 2020 Aug 08]. Available from: https://digitalcommons.fiu.edu/etd/997 ; 10.25148/etd.FI13120611 ; FI13120611.

Council of Science Editors:

Swortwood MJ. Comprehensive Forensic Toxicological Analysis of Designer Drugs. [Doctoral Dissertation]. Florida International University; 2013. Available from: https://digitalcommons.fiu.edu/etd/997 ; 10.25148/etd.FI13120611 ; FI13120611

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