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You searched for +publisher:"Florida Atlantic University" +contributor:("Kang, Yunqing"). Showing records 1 – 3 of 3 total matches.

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Florida Atlantic University

1. Qian, Enze. Development of a Thermosensitive Trimethyl Chitosan Hydrogel for in situ Tissue Engineering.

Degree: MS, 2018, Florida Atlantic University

Chitosan was widely studied for applications in tissue regeneration, because of its biodegradability and biocompatibility. However, its insolubility in a neutral solution and long gelation time limit its wide application in tissue engineering. In this thesis, a new chitosan-based biomaterial was synthesized, and its chemical structure and solubility were characterized. Afterwards, the gelation properties (crosslinker, crosslink time, swelling ratio, drug release and biocompatibility) of TMC material was investigated. Results show that TMC has higher water solubility than chitosan. The TMC liquid solution can transform to a hydrogel quickly at body temperature. The formed hydrogel controlled the release of the model protein. Cytotoxicity result shows the cationic TMC hydrogel brings a toxic effect on stromal cells but it may have the potential to inhibit bacteria or cancer cells, although more studied are required to confirm its potential functions. In summary, this new TMC hydrogel has a promising potential in biomedical fields.

2018

Degree granted: Thesis (M.S.) – Florida Atlantic University, 2018.

Collection: FAU

Advisors/Committee Members: Kang, Yunqing (Thesis advisor), Florida Atlantic University (Degree grantor), College of Engineering and Computer Science, Department of Ocean and Mechanical Engineering.

Subjects/Keywords: Tissue engineering.; Chitosan – Biotechnology.; Hydrogels.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Qian, E. (2018). Development of a Thermosensitive Trimethyl Chitosan Hydrogel for in situ Tissue Engineering. (Masters Thesis). Florida Atlantic University. Retrieved from http://fau.digital.flvc.org/islandora/object/fau:40751

Chicago Manual of Style (16th Edition):

Qian, Enze. “Development of a Thermosensitive Trimethyl Chitosan Hydrogel for in situ Tissue Engineering.” 2018. Masters Thesis, Florida Atlantic University. Accessed October 22, 2019. http://fau.digital.flvc.org/islandora/object/fau:40751.

MLA Handbook (7th Edition):

Qian, Enze. “Development of a Thermosensitive Trimethyl Chitosan Hydrogel for in situ Tissue Engineering.” 2018. Web. 22 Oct 2019.

Vancouver:

Qian E. Development of a Thermosensitive Trimethyl Chitosan Hydrogel for in situ Tissue Engineering. [Internet] [Masters thesis]. Florida Atlantic University; 2018. [cited 2019 Oct 22]. Available from: http://fau.digital.flvc.org/islandora/object/fau:40751.

Council of Science Editors:

Qian E. Development of a Thermosensitive Trimethyl Chitosan Hydrogel for in situ Tissue Engineering. [Masters Thesis]. Florida Atlantic University; 2018. Available from: http://fau.digital.flvc.org/islandora/object/fau:40751


Florida Atlantic University

2. Firoozi, Negar. DEVELOPMENT OF AN ELASTIC POLYMER-BASED DRUG DELIVERY SYSTEM FOR TISSUE REGENERATION.

Degree: 2019, Florida Atlantic University

In spite of the vast research on polymer-based tissue regeneration, extensive studies to develop an elastic and cell-promoting polymer biomaterial are still ongoing. However, using a renewable resource and a simple, environment-friendly synthesis route to synthesize an elastic polymer has not been successfully achieved yet. The objective of this work was to develop an elastic polymer for tissue engineering and drug delivery applications by using non-toxic, inexpensive and renewable monomers. A new nature-derived renewable material, xylitol, was used to synthesize an elastic polymer with the presence of a crosslinking agent, dodecanedioic acid. Here a simple melt condensation polymerization method was used to synthesize the poly(xylitoldodecanedioic acid)(PXDDA). The physicochemical and biological properties of the new PXDDA polymer were characterized. Fourier transform infrared (FTIR) confirmed the formation of ester bonding in the polymer structure, and thermal analysis demonstrated that the polymer was completely amorphous. The polymer shows high elasticity. Increasing the molar ratio of dodecanedioic acid resulted in higher hydrophobicity and lower glass transition temperature. Further, the polymer degradation and in vitro dye release studies revealed that the degradation and dye release from the polymer became slower when the amount of dodecanedioic acid in the composite increased.

2019

Degree granted: Dissertation (Ph.D.) – Florida Atlantic University, 2019.

Collection: FAU

Advisors/Committee Members: Kang, Yunqing (Thesis advisor), Florida Atlantic University (Degree grantor), College of Engineering and Computer Science, Department of Ocean and Mechanical Engineering.

Subjects/Keywords: Drug Delivery Systems; Polymers; Tissue Engineering; Xylitol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Firoozi, N. (2019). DEVELOPMENT OF AN ELASTIC POLYMER-BASED DRUG DELIVERY SYSTEM FOR TISSUE REGENERATION. (Thesis). Florida Atlantic University. Retrieved from http://fau.digital.flvc.org/islandora/object/fau:41926

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Firoozi, Negar. “DEVELOPMENT OF AN ELASTIC POLYMER-BASED DRUG DELIVERY SYSTEM FOR TISSUE REGENERATION.” 2019. Thesis, Florida Atlantic University. Accessed October 22, 2019. http://fau.digital.flvc.org/islandora/object/fau:41926.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Firoozi, Negar. “DEVELOPMENT OF AN ELASTIC POLYMER-BASED DRUG DELIVERY SYSTEM FOR TISSUE REGENERATION.” 2019. Web. 22 Oct 2019.

Vancouver:

Firoozi N. DEVELOPMENT OF AN ELASTIC POLYMER-BASED DRUG DELIVERY SYSTEM FOR TISSUE REGENERATION. [Internet] [Thesis]. Florida Atlantic University; 2019. [cited 2019 Oct 22]. Available from: http://fau.digital.flvc.org/islandora/object/fau:41926.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Firoozi N. DEVELOPMENT OF AN ELASTIC POLYMER-BASED DRUG DELIVERY SYSTEM FOR TISSUE REGENERATION. [Thesis]. Florida Atlantic University; 2019. Available from: http://fau.digital.flvc.org/islandora/object/fau:41926

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Florida Atlantic University

3. Lin, Maohua. 3D-Printed Flexible Polylactic Acid/ Thermoplatic Polyurethane (PLA/TPU) Stents for Esophageal Malignancies.

Degree: 2019, Florida Atlantic University

Palliation therapy for dysphagia using esophageal stents is the current treatment of choice for those patients with inoperable esophageal malignancies. However, the stents currently used in the clinical setting, regardless of the type of metal mesh or plastic mesh stents (covered/uncovered), may cause complications, such as tumor ingrowth and stent migration into the stomach. Furthermore, metal mesh stents have limited capacities for loading anti-cancer drugs. To effectively reduce/overcome those complications and enhance the efficacy of drug release, we designed and 3D-printed a tubular, flexible polymer stent with spirals, and then load anti-cancer drug, paclitaxel, on the stent for drug release. Non- spiral 3D-printed tubular and mesh polymer stents served as controls. The self-expansion and anti migration properties, cytotoxicity, drug release profile, and cancer cell inhibition of the 3D-printed stent were fully characterized. Results showed the self-expansion force of the 3D-printed polymer stent with spirals was slightly higher than the stent without spirals. The anti-migration force of the 3D-printed stent with spirals was significantly higher than the anti-migration force of a non-spiral stent. Furthermore, the stent with spirals significantly decreased the migration distance compared to the migration distance of the non-spiral 3D-printed polymer stent. The in vitro cytotoxicity of the new stent was examined through the viability test of human esophagus epithelial cells, and results indicated that the polymer stent does not have any cytotoxicity. The results of in vitro cell viability of esophageal cancer cells further indicated that the paclitaxel in the spiral stent treated esophageal cancer cells much more efficiently than that in the mesh stent. Furthermore, the results of the in vitro drug release profile and drug permeation showed that the dense tubular drug-loaded stent could efficiently be delivered more paclitaxel through the esophageal mucosa/submucosa layers in a unidirectional way than mesh stent that delivered less paclitaxel to the esophageal mucosa/submucosa but more to the lumen. In summary, these results showed that the 3D-printed dense polymer stent with spirals has promising potential to treat esophageal malignancies.

2019

Degree granted: Dissertation (Ph.D.) – Florida Atlantic University, 2019.

Collection: FAU

Advisors/Committee Members: Kang, Yunqing (Thesis advisor), Tsai, Chi-Tay (Thesis advisor), Florida Atlantic University (Degree grantor), College of Engineering and Computer Science, Department of Ocean and Mechanical Engineering.

Subjects/Keywords: Paclitaxel; Stents; Esophageal Neoplasms; 3-D printing; Polymers in medicine

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lin, M. (2019). 3D-Printed Flexible Polylactic Acid/ Thermoplatic Polyurethane (PLA/TPU) Stents for Esophageal Malignancies. (Thesis). Florida Atlantic University. Retrieved from http://fau.digital.flvc.org/islandora/object/fau:41370

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lin, Maohua. “3D-Printed Flexible Polylactic Acid/ Thermoplatic Polyurethane (PLA/TPU) Stents for Esophageal Malignancies.” 2019. Thesis, Florida Atlantic University. Accessed October 22, 2019. http://fau.digital.flvc.org/islandora/object/fau:41370.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lin, Maohua. “3D-Printed Flexible Polylactic Acid/ Thermoplatic Polyurethane (PLA/TPU) Stents for Esophageal Malignancies.” 2019. Web. 22 Oct 2019.

Vancouver:

Lin M. 3D-Printed Flexible Polylactic Acid/ Thermoplatic Polyurethane (PLA/TPU) Stents for Esophageal Malignancies. [Internet] [Thesis]. Florida Atlantic University; 2019. [cited 2019 Oct 22]. Available from: http://fau.digital.flvc.org/islandora/object/fau:41370.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin M. 3D-Printed Flexible Polylactic Acid/ Thermoplatic Polyurethane (PLA/TPU) Stents for Esophageal Malignancies. [Thesis]. Florida Atlantic University; 2019. Available from: http://fau.digital.flvc.org/islandora/object/fau:41370

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.