+publisher:"Delft University of Technology" +contributor:("Lathouwers, Danny")

Delft University of Technology

1. van Lobenstein, Nicky (author). Sample-holder design and proof-of-principle experiments with protons: biology versus dosimetry.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:88115311-8f36-459e-b845-55ff94b400a1

► Purpose/Objective: The aim of the thesis project is to design and build a sample-holder that is suited for radiobiological experiments on cell and tissue level… (more)

▼ Purpose/Objective: The aim of the thesis project is to design and build a sample-holder that is suited for radiobiological experiments on cell and tissue level in Holland PTC. In order to create accurate dose plans for radiobiological experiments, dosimetry and range calculations need to be worked out. Finally the sample-holder is used for the first radiobiological experiment at Holland PTC. Materials and Methods: The sample-holder is constructed as a slab phantom that allows secure and easy positioning of a 6-well cultivating plate, fully made out of polystyrene. Water equivalent thickness (WET) measurements are used to calculate the density of the slabs, which can be used for dose calculations in treatment planning and Monte Carlo software. Radiochromic EBT3 film is used to perform dosimetry during experiments, the films are calibrated using an ionization chamber to be able to perform absolute dosimetry. A 70 MeV single pencil beam is delivered to the sample-holder with EBT3 films in between the slabs to compare a reconstructed Bragg peak from the relative doses of the films with dose calculations performed in RayStation and TOPAS MC. Cell survival experiments with U2OS cells are performed by irradiating with X-rays and protons. Circumstances where such that the influence of cells being on room temperature for several hours and cells being without medium inside the wells during irradiation could be studied. With protons, cells were irradiated both in the plateau region and in the Bragg peak. LETd calculations are performed in TOPAS MC in order to study the RBE-LET relation. Results: The slabs of the phantom are uniform and have a density of either 1.04 g/cm3 or 1.06 g/cm3 Using these density values the range of a 70 MeV can be calculated with a 0.5 mm accuracy using TOPAS MC and RayStation. The relative central axis dose profile calculated with TOPAS was accurate within 5% compared to the measured values with EBT3 film. This was 20% for calculations with RayStation. Absolute dose measurements with EBT3 film inside a RW3 phantom agree within 1% with the delivered dose according to the ionization chamber. In the polystyrene sample-holder this difference is 11%. For X-ray irradiation, incubated cells were able to form more colonies after irradiation compared to cells that had been on room temperature for four hours. Cells that were irradiated without medium in the well had a higher surviving fraction than cells that had medium in the well. For proton irradiation the results are limited since all cells that received more than 0.91 Gy had died, but from the available data it can be seen that irradiation in the Bragg peak results in more cell death compared to irradiation in the plateau region. In addition to this, cells that had medium in the wells during irradiation formed less colonies than cells that had no medium in the wells, which is consistent with the results after X-ray irradiation. Dose-averaged LET (LET_d) values are calculated at cell depth for proton irradiation in the plateau region and in the Bragg peak… Advisors/Committee Members: Wolterbeek, Bert (mentor), Lathouwers, Danny (graduation committee), Perko, Zoltan (graduation committee), Delft University of Technology (degree granting institution).

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APA (6^th Edition):

van Lobenstein, N. (. (2019). Sample-holder design and proof-of-principle experiments with protons: biology versus dosimetry. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:88115311-8f36-459e-b845-55ff94b400a1

Chicago Manual of Style (16^th Edition):

van Lobenstein, Nicky (author). “Sample-holder design and proof-of-principle experiments with protons: biology versus dosimetry.” 2019. Masters Thesis, Delft University of Technology. Accessed April 14, 2021. http://resolver.tudelft.nl/uuid:88115311-8f36-459e-b845-55ff94b400a1.

MLA Handbook (7^th Edition):

van Lobenstein, Nicky (author). “Sample-holder design and proof-of-principle experiments with protons: biology versus dosimetry.” 2019. Web. 14 Apr 2021.

Vancouver:

van Lobenstein N(. Sample-holder design and proof-of-principle experiments with protons: biology versus dosimetry. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Apr 14]. Available from: http://resolver.tudelft.nl/uuid:88115311-8f36-459e-b845-55ff94b400a1.

Council of Science Editors:

van Lobenstein N(. Sample-holder design and proof-of-principle experiments with protons: biology versus dosimetry. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:88115311-8f36-459e-b845-55ff94b400a1

Delft University of Technology

2. Ghesquière-Diérickx, Laura (author). Improvement of tumour heterogeneity quantification in PET images: A study to design and develop a new PET heterogeneous phantom.

Degree: 2017, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:0183c922-76a4-4507-96dd-38362e27da0a

►

In medical images intratumour heterogeneity well translates specific cancer cells properties in a fast and non-invasive way. Medical community and researchers have developed proper tools… (more)

Subjects/Keywords: pet; phantom; heterogeneity; Positron emission tomography

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APA (6^th Edition):

Ghesquière-Diérickx, L. (. (2017). Improvement of tumour heterogeneity quantification in PET images: A study to design and develop a new PET heterogeneous phantom. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:0183c922-76a4-4507-96dd-38362e27da0a

Chicago Manual of Style (16^th Edition):

Ghesquière-Diérickx, Laura (author). “Improvement of tumour heterogeneity quantification in PET images: A study to design and develop a new PET heterogeneous phantom.” 2017. Masters Thesis, Delft University of Technology. Accessed April 14, 2021. http://resolver.tudelft.nl/uuid:0183c922-76a4-4507-96dd-38362e27da0a.

MLA Handbook (7^th Edition):

Ghesquière-Diérickx, Laura (author). “Improvement of tumour heterogeneity quantification in PET images: A study to design and develop a new PET heterogeneous phantom.” 2017. Web. 14 Apr 2021.

Vancouver:

Ghesquière-Diérickx L(. Improvement of tumour heterogeneity quantification in PET images: A study to design and develop a new PET heterogeneous phantom. [Internet] [Masters thesis]. Delft University of Technology; 2017. [cited 2021 Apr 14]. Available from: http://resolver.tudelft.nl/uuid:0183c922-76a4-4507-96dd-38362e27da0a.

Council of Science Editors:

Ghesquière-Diérickx L(. Improvement of tumour heterogeneity quantification in PET images: A study to design and develop a new PET heterogeneous phantom. [Masters Thesis]. Delft University of Technology; 2017. Available from: http://resolver.tudelft.nl/uuid:0183c922-76a4-4507-96dd-38362e27da0a

Delft University of Technology

3. Shafer, Deva (author). Design and Melting Behavior of the MSFR Freeze Plug.

Degree: 2018, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:a2032f51-6948-40f5-ba35-5b40309d1fa2

► The freeze plug is a key safety component of the molten salt fast reactor (MSFR), one of six next-generation nuclear reactor technologies being developed under… (more)

▼ The freeze plug is a key safety component of the molten salt fast reactor (MSFR), one of six next-generation nuclear reactor technologies being developed under the Generation IV International Forum (GIF). It should be designed to melt if an accident occurs, allowing the MSFR to drain before it incurs structural damage. Two freeze plug concepts have been considered in recent years, in which the plug is melted either through the decay heat produced in the core, or through heat generated by special heating rings and stored in steel blocks adjacent to the freeze plug. Variations consisting of both a single freeze plug, and multiple smaller plugs contained in a metal plate, have been proposed. This work seeks to evaluate the feasibility of these designs and study how parameters such as the sub-cooling of the plug affect melting times. Additionally, an alternative, wedge-shaped freeze plug design is proposed for increased reliability. Simulations performed in COMSOL showed that the decay heat plug melts within 600 s only if placed within 0.01 m of the mixed core flow. Because such a placement makes the plug vulnerable to temperature and velocity fluctuations in the core during regular operation of the reactor, this design is considered unfeasible and is not recommended for further study. On the other hand, melting times under 600 s were possible with the heating ring design for a range of sub-cooling amounts and plug configurations, suggesting that this design is promising. A thin frozen layer was shown to form on top of the metal grate in the multi-plug configurations, preventing heat transfer through the top of the plate. Although the melting behavior of this layer warrants further investigation, its insulating effect was found to generally cause the single-plug designs to melt faster than the multi-plug designs. A simplified, isothermal model of the wedge-shaped plug was simulated using the enthalpy-porosity approach to account for convection. To model the sinking of the wedge, an extended Darcy term approach was developed based on an analytical solution which was validated experimentally, with good agreement. This model shows that melting of the wedge is unsteady, and that melting times depend linearly on the wedge angle and sub-cooling. Unfortunately, melting times of the wedge plug could not be estimated with realistic, non-isothermal, time-dependent boundary conditions. For future study, a customizable numerical solver such as OpenFOAM is recommended, which would allow the sinking of the solid phase to be modeled more robustly through an immersed boundary method. Advisors/Committee Members: Delfos, Rene (mentor), Lathouwers, Danny (graduation committee), Breugem, Wim-Paul (graduation committee), Tiberga, Marco (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: phase change materials; COMSOL Multiphysics; numerical methods

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APA (6^th Edition):

Shafer, D. (. (2018). Design and Melting Behavior of the MSFR Freeze Plug. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:a2032f51-6948-40f5-ba35-5b40309d1fa2

Chicago Manual of Style (16^th Edition):

Shafer, Deva (author). “Design and Melting Behavior of the MSFR Freeze Plug.” 2018. Masters Thesis, Delft University of Technology. Accessed April 14, 2021. http://resolver.tudelft.nl/uuid:a2032f51-6948-40f5-ba35-5b40309d1fa2.

MLA Handbook (7^th Edition):

Shafer, Deva (author). “Design and Melting Behavior of the MSFR Freeze Plug.” 2018. Web. 14 Apr 2021.

Vancouver:

Shafer D(. Design and Melting Behavior of the MSFR Freeze Plug. [Internet] [Masters thesis]. Delft University of Technology; 2018. [cited 2021 Apr 14]. Available from: http://resolver.tudelft.nl/uuid:a2032f51-6948-40f5-ba35-5b40309d1fa2.

Council of Science Editors:

Shafer D(. Design and Melting Behavior of the MSFR Freeze Plug. [Masters Thesis]. Delft University of Technology; 2018. Available from: http://resolver.tudelft.nl/uuid:a2032f51-6948-40f5-ba35-5b40309d1fa2

Delft University of Technology

4. Briggeman, Ilja (author). Novel automated treatment planning approaches to deal with microscopic disease in radiotherapy.

Degree: 2020, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:140e8df1-2ec0-474b-b1e6-8b817e05e4f6

► The scope of a radiotherapy treatment is to induce damage to tumor cells by irradiating them with ionizing radiation. The radiation should target the tumor… (more)

▼ The scope of a radiotherapy treatment is to induce damage to tumor cells by irradiating them with ionizing radiation. The radiation should target the tumor as visible in images, also called the macroscopic disease. There is, however, a risk of small, invisible groups of cancer cells in the area surrounding the macroscopic tumor, the microscopic disease. For an optimal clinical outcome of radiotherapy, the microscopic disease needs to be irradiated as well. In current treatment planning, the macroscopic tumor is extended with a margin to better ensure full disease coverage. Because there is uncertainty in the extent of the microscopic disease, also the margin definition is uncertain. Moreover, in current planning, the same margin is used for all patients, and there is no patient-specific exploration of the trade-offs between dose extensions to cover potentially present microscopic disease vs radiation-induced toxicity because of enhanced dose in organs at risk (OARs) surrounding the tumor. This study aimed to explore whether the margin concept could be replaced by more advanced, individualized approaches for irradiation of volumes just outside the macroscopic tumor. All plans were generated automatically to avoid bias by human planners and to reduce workload. Two novel treatment planning approaches were investigated. The first focused on increasing dose coverage of the microscopic disease while at the same time controlling the resulting increased dose to the healthy tissues surrounding the macroscopic tumor, including OARs. Several treatment plans were generated to explore a range of trade-offs between dose in microscopic disease and dose in OARs. The results showed that for optimal microscopic disease irradiation, both low and high OAR doses needed to worsen. However, the most significant increase in microscopic disease coverage could be obtained when accepting higher OAR low doses, that is generally less important for induction of negative side-effects. In the second approach, an expected Tumor Control Probability (expected TCP) cost function was used to control dose delivery in areas close to the macroscopic tumor. Basis of the expected TCP model was a function describing the probability of finding microscopic disease at a specific distance from the macroscopic tumor. The results again demonstrated opportunities to increase dose to areas close to the tumor, at the cost of enhanced doses in OARs. In conclusion, both approaches had a positive impact on microscopic disease dose coverage. However, improved irradiation of the microscopic disease was always at a price of enhanced dose in OARs. Complementary studies, involving clinicians, need to be carried out to investigate if and how the approaches could be used to replace the current planning with fixed margins. Advisors/Committee Members: Lathouwers, Danny (mentor), Denkova, Antonia (graduation committee), Perko, Zoltan (graduation committee), Heijmen, Ben (graduation committee), Rossi, Linda (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: radiotherapy; CTV margin; microscopic disease; tumor

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APA (6^th Edition):

Briggeman, I. (. (2020). Novel automated treatment planning approaches to deal with microscopic disease in radiotherapy. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:140e8df1-2ec0-474b-b1e6-8b817e05e4f6

Chicago Manual of Style (16^th Edition):

Briggeman, Ilja (author). “Novel automated treatment planning approaches to deal with microscopic disease in radiotherapy.” 2020. Masters Thesis, Delft University of Technology. Accessed April 14, 2021. http://resolver.tudelft.nl/uuid:140e8df1-2ec0-474b-b1e6-8b817e05e4f6.

MLA Handbook (7^th Edition):

Briggeman, Ilja (author). “Novel automated treatment planning approaches to deal with microscopic disease in radiotherapy.” 2020. Web. 14 Apr 2021.

Vancouver:

Briggeman I(. Novel automated treatment planning approaches to deal with microscopic disease in radiotherapy. [Internet] [Masters thesis]. Delft University of Technology; 2020. [cited 2021 Apr 14]. Available from: http://resolver.tudelft.nl/uuid:140e8df1-2ec0-474b-b1e6-8b817e05e4f6.

Council of Science Editors:

Briggeman I(. Novel automated treatment planning approaches to deal with microscopic disease in radiotherapy. [Masters Thesis]. Delft University of Technology; 2020. Available from: http://resolver.tudelft.nl/uuid:140e8df1-2ec0-474b-b1e6-8b817e05e4f6

Delft University of Technology

5. WU, Ivan (author). Evaluation of transport properties of radionuclides in clay materials.

Degree: 2017, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:c81e8b08-b764-40e7-8bd1-6ea97791f19a

► Feasibility study of Dutch concept of deep geological repository for radioactive waste is at present widely conducted in the Netherlands. In this project, transport properties… (more)

Subjects/Keywords: radionuclide; transport; electromigration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

WU, I. (. (2017). Evaluation of transport properties of radionuclides in clay materials. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:c81e8b08-b764-40e7-8bd1-6ea97791f19a

Chicago Manual of Style (16^th Edition):

WU, Ivan (author). “Evaluation of transport properties of radionuclides in clay materials.” 2017. Masters Thesis, Delft University of Technology. Accessed April 14, 2021. http://resolver.tudelft.nl/uuid:c81e8b08-b764-40e7-8bd1-6ea97791f19a.

MLA Handbook (7^th Edition):

WU, Ivan (author). “Evaluation of transport properties of radionuclides in clay materials.” 2017. Web. 14 Apr 2021.

Vancouver:

WU I(. Evaluation of transport properties of radionuclides in clay materials. [Internet] [Masters thesis]. Delft University of Technology; 2017. [cited 2021 Apr 14]. Available from: http://resolver.tudelft.nl/uuid:c81e8b08-b764-40e7-8bd1-6ea97791f19a.

Council of Science Editors:

WU I(. Evaluation of transport properties of radionuclides in clay materials. [Masters Thesis]. Delft University of Technology; 2017. Available from: http://resolver.tudelft.nl/uuid:c81e8b08-b764-40e7-8bd1-6ea97791f19a

Delft University of Technology

6. Garcia Santos, Alba (author). Optimization of the Track Reconstruction Algorithm in a Pixel Based Range Telescope for Proton Computed Tomography.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:e8d3f687-43ff-4d5f-a594-2e7d805f146b

►

The use of protons to treat cancer has expanded rapidly in the past two decades. For safe and effective proton therapy, the proton range in… (more)

▼

The use of protons to treat cancer has expanded rapidly in the past two decades. For safe and effective proton therapy, the proton range in a patient’s body must be accurately determined. Current treatment planning is based on X-ray computed tomography images, which might cause uncertainty because of the different behaviour between protons and X-rays. As an alternative, proton Computed Tomography (pCT) has been proposed to directly measure the Relative Stopping Power (RSP) map in the patient and reduce this uncertainty. During a proton CT scan, a high-energy proton beam is directed at the patient. Then, the proton’s residual energy and position are measured with a detector placed behind the patient. This information is used to calculate the volumetric RSP. In the case of using a pixel based detector, a tracking algorithm is required in order to increase the proton intensity capacity of the detector. A proton track reconstruction system has been already developed by Pettersen [1], however, it has some limitations on the track density that can be reconstructed correctly. The algorithm is based on the track-following scheme, in which a growing track searches for deeper- laying activated pixels. This thesis introduces proton therapy and the advantages of pCT and proton radiography for treatment planning. Then, the main track reconstruction techniques found in the literature are reviewed. Improvements in the reconstruction process are proposed and their efficiencies are discussed. While current algorithm begins from the layer closest to the patient, in the present study a new reconstruction algorithm is developed. It differs by starting the reconstruction process from the distal end of the detector. Based on this new algorithm, studies related to its optimization are conducted. Lastly, an algorithm based on the identification of the most probable scenario is developed. The potential algorithms are evaluated on data simulated with GATE (based on Monte Carlo interactions) and PROCASIM (design to simplify the physical interactions between protons and the detector). The fraction of correctly reconstructed tracks and the computational eciency of the algorithms are analyzed to determine the most viable one. [1] H. E. S. Pettersen. A Digital Tracking Calorimeter for Proton Computed Tomography. PhD thesis, University of Bergen, Norway, February 2018.

Biomedical Engineering

Advisors/Committee Members: Lathouwers, Danny (mentor), Peitzmann, Thomas (mentor), Pettersen, Helge Egil Seime (mentor), Perko, Zoltan (graduation committee), van der Kolk, Erik (graduation committee), Delft University of Technology (degree granting institution), Utrecht University (degree granting institution).

Subjects/Keywords: proton Computed Tomography; tracking algorithm; Digital Tracking Calorimeter

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garcia Santos, A. (. (2019). Optimization of the Track Reconstruction Algorithm in a Pixel Based Range Telescope for Proton Computed Tomography. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:e8d3f687-43ff-4d5f-a594-2e7d805f146b

Chicago Manual of Style (16^th Edition):

Garcia Santos, Alba (author). “Optimization of the Track Reconstruction Algorithm in a Pixel Based Range Telescope for Proton Computed Tomography.” 2019. Masters Thesis, Delft University of Technology. Accessed April 14, 2021. http://resolver.tudelft.nl/uuid:e8d3f687-43ff-4d5f-a594-2e7d805f146b.

MLA Handbook (7^th Edition):

Garcia Santos, Alba (author). “Optimization of the Track Reconstruction Algorithm in a Pixel Based Range Telescope for Proton Computed Tomography.” 2019. Web. 14 Apr 2021.

Vancouver:

Garcia Santos A(. Optimization of the Track Reconstruction Algorithm in a Pixel Based Range Telescope for Proton Computed Tomography. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Apr 14]. Available from: http://resolver.tudelft.nl/uuid:e8d3f687-43ff-4d5f-a594-2e7d805f146b.

Council of Science Editors:

Garcia Santos A(. Optimization of the Track Reconstruction Algorithm in a Pixel Based Range Telescope for Proton Computed Tomography. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:e8d3f687-43ff-4d5f-a594-2e7d805f146b

Delft University of Technology

7. Oud, Michelle (author). Automated multi-criterial treatment planning for adaptive high-dose-rate brachytherapy for locally advanced cervical cancer.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:13b2d5c9-f99d-4f2f-8f9f-079fe0c2b091

► Purpose - To develop and evaluate a fast and automated multi-criterial treatment planning strategy for High-Dose-Rate (HDR) brachytherapy (BT) for patients with locally advanced cervical… (more)

▼ Purpose - To develop and evaluate a fast and automated multi-criterial treatment planning strategy for High-Dose-Rate (HDR) brachytherapy (BT) for patients with locally advanced cervical cancer. This automated strategy avoids suboptimal and slow manual treatment planning and results in reproducible and conformal treatment plans with a clinically favorable trade-off between multiple treatment objectives. Methods and Materials - An automated treatment planning approach was developed using the Erasmus- iCycle framework. A wish-list containing hard constraints and prioritized objectives is required as input was configured according to the clinical protocol using 22 single-fraction training plans. Special at- tention was paid to establishing the clinically desired ‘pear-shaped’ dose distribution. To evaluate the dwell time optimization approach, 66 automatically generated single-fraction plans (PLANauto) were compared against the clinically delivered plans (PLANref ), both by blind-pairwise comparison carried out by an expert clinician and by the analysis of dosimetric plan parameters. Subsequently, for 17 complete fractioned BT treatments each consisting of 3 single-fraction BT plans, automatically generated plans (TREATMENTauto) were compared against the clinically delivered plans (TREATMENTref) to evaluate dosimetric plan parameters according to the clinical protocol. The possibility of extending the algorithm with a needle selection objective was also explored on 13 test cases and its performance was evaluated by studying the number of needles selected in the optimized plans and its effect on the remaining treatment objectives.Results - All PLANauto were considered clinically acceptable by the clinician. The clinician’s plan comparison pointed strongly at an overall preference for the automated plans: in 62/66 cases the clincian preferred PLANauto over PLANref , in three cases the overall quality was considered equal and for one case the clinical plan was preferred. For PLANauto, the mean HR-CTV D90% improved while also the rectum was spared compared to PLANref . The average optimization time was 19.5 seconds (range [4.4 – 106.4] s). The mean D90% for TREATMENTauto improved by + 3.0 Gy (in EQD2) (p<0.005) over the whole radiotherapy treatment with differences ranging from -4.3 to +6.0 Gy, while the bladder and rectum were spared similarly (p=0.01, p=0.02 respectively). In 6/13 of the plans, the number of needles that were implanted could be reduced while still establishing sufficient plan quality. Conclusions - Fast automated multi-criterial treatment planning for locally advanced cervical cancer HDR-BT is feasible. High-quality treatment plans are automatically generated within a clinically acceptable time frame and treatment plans have a clinically preferable trade-off between all treat- ment objectives. The observed improvement in dosimetric parameters, mainly the improvement of the dose to the HR-CTV, is clinically relevant. The algorithm can be extended with an approach for the optimization of the implant… Advisors/Committee Members: Breedveld, Sebastiaan (mentor), Lathouwers, Danny (graduation committee), Perko, Zoltan (graduation committee), Kolkman-Deurloo, Inger-Karine (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: brachytherapy; Automated treatment planning; optimization; HDR; Treatment Planning; radiotherapy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oud, M. (. (2019). Automated multi-criterial treatment planning for adaptive high-dose-rate brachytherapy for locally advanced cervical cancer. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:13b2d5c9-f99d-4f2f-8f9f-079fe0c2b091

Chicago Manual of Style (16^th Edition):

Oud, Michelle (author). “Automated multi-criterial treatment planning for adaptive high-dose-rate brachytherapy for locally advanced cervical cancer.” 2019. Masters Thesis, Delft University of Technology. Accessed April 14, 2021. http://resolver.tudelft.nl/uuid:13b2d5c9-f99d-4f2f-8f9f-079fe0c2b091.

MLA Handbook (7^th Edition):

Oud, Michelle (author). “Automated multi-criterial treatment planning for adaptive high-dose-rate brachytherapy for locally advanced cervical cancer.” 2019. Web. 14 Apr 2021.

Vancouver:

Oud M(. Automated multi-criterial treatment planning for adaptive high-dose-rate brachytherapy for locally advanced cervical cancer. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Apr 14]. Available from: http://resolver.tudelft.nl/uuid:13b2d5c9-f99d-4f2f-8f9f-079fe0c2b091.

Council of Science Editors:

Oud M(. Automated multi-criterial treatment planning for adaptive high-dose-rate brachytherapy for locally advanced cervical cancer. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:13b2d5c9-f99d-4f2f-8f9f-079fe0c2b091

Delft University of Technology

8. Bennan, Amit (author). Automated Treatment Planning in HDR Brachytherapy for Prostate Cancer.

Degree: 2017, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:2c0ade14-fc3a-413d-bebc-a6f9ff71fb25

► Introduction: High Dose Rate (HDR) Brachytherapy is a radiotherapy modality that involves temporarily introducing a highly radioactive source into the target volume with the use… (more)

▼ Introduction: High Dose Rate (HDR) Brachytherapy is a radiotherapy modality that involves temporarily introducing a highly radioactive source into the target volume with the use of an applicator. With respect to HDR brachytherapy for prostate cancer, an 192Iridium source is driven into the target volume through catheters implanted into the prostate. The dose delivered to a point in the prostate depends on the time the source dwells at a given position. Treatment planning for brachytherapy involve the optimization of dwell times and dwell positions. The aim of the treatment plan is to deliver the prescribed dose to the target volume, the prostate, while minimizing the dose to the organs at risk (OAR), namely the urethra, bladder and rectum. In current clinical practice, the process of treatment planning involves the manual manipulation of the parameters of an optimizer until the desired dose distribution is achieved. This implies that the plan quality depends on the experience of the planner, and there is variation in plan quality between planners. The aim of this project was to develop an automated treatment planning system that would able to generate clinically acceptable plans with minimal human intervention. The brachytherapy treatment planning module is named B-iCycle and may be integrated in the future with the treatment planning software suite, called Erasmus-iCycle, developed at the Erasmus MC. Materials and methods: At the core of the treatment planning system (TPS) is a precise and fast dose engine that is able to simulate the dose to be delivered. In this project, we employ the TG-43 dose calculation formalism as it is the most widely implemented method in dose engines for brachytherapy treatment planning systems. The dose engine is then verified against the dose engine of the clinical treatment planning system. B-iCycle uses the 2-phase ϵ-constraint (2pϵc) algorithm to optimize the dwell times and positions. The 2pϵc algorithm requires a ‘wish-list’, which encapsulates the treatment protocol as goals and constraints for each critical structure. For this project three treatment protocols were chosen, four fractions of 9.5 Gy, single fraction of 19 Gy and single fraction of 20 Gy, and wish-lists were generated for each protocol. Three patient groups with different catheter geometries were selected. Treatment plans were generated for each patient and compared against the plans that were generated, for the same patients, in the clinic. The treatment plans that were generated in B-iCycle were then exported to the clinical treatment planning system (Oncentra from Elekta) to obtain the dose characteristics. The plans were compared based on the dose characteristics and the Conformity Index (COIN). The plans were also verified by a radiation oncologist. Results: The TG-43 dose engine was successfully verified against the clinical dose engine. The Gamma analysis showed that only 0.68% of the voxels failed the gamma analysis and these voxels were located within the catheters therefore they can be ignored as… Advisors/Committee Members: Schaart, Dennis (mentor), Breedveld, S. (mentor), Kolkman-Deurloo, I.K.K. (mentor), Heijman, B.J.M. (mentor), Lathouwers, Danny (mentor), Goorden, Marlies (mentor), Delft University of Technology (degree granting institution).

Subjects/Keywords: brachytherapy; Treatment Planning; prostate cancer; HDR

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APA (6^th Edition):

Bennan, A. (. (2017). Automated Treatment Planning in HDR Brachytherapy for Prostate Cancer. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:2c0ade14-fc3a-413d-bebc-a6f9ff71fb25

Chicago Manual of Style (16^th Edition):

Bennan, Amit (author). “Automated Treatment Planning in HDR Brachytherapy for Prostate Cancer.” 2017. Masters Thesis, Delft University of Technology. Accessed April 14, 2021. http://resolver.tudelft.nl/uuid:2c0ade14-fc3a-413d-bebc-a6f9ff71fb25.

MLA Handbook (7^th Edition):

Bennan, Amit (author). “Automated Treatment Planning in HDR Brachytherapy for Prostate Cancer.” 2017. Web. 14 Apr 2021.

Vancouver:

Bennan A(. Automated Treatment Planning in HDR Brachytherapy for Prostate Cancer. [Internet] [Masters thesis]. Delft University of Technology; 2017. [cited 2021 Apr 14]. Available from: http://resolver.tudelft.nl/uuid:2c0ade14-fc3a-413d-bebc-a6f9ff71fb25.

Council of Science Editors:

Bennan A(. Automated Treatment Planning in HDR Brachytherapy for Prostate Cancer. [Masters Thesis]. Delft University of Technology; 2017. Available from: http://resolver.tudelft.nl/uuid:2c0ade14-fc3a-413d-bebc-a6f9ff71fb25

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