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You searched for +publisher:"Delft University of Technology" +contributor:("Fratila-Apachitei, L."). Showing records 1 – 3 of 3 total matches.

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Delft University of Technology

1. Fernando, J.D.L. (author). Surface-cell interactions: Can PEO topography outsmart surface calcium?.

Degree: 2014, Delft University of Technology

Titanium surfaces modified by plasma electrolytic oxidation (PEO) have attractive physico-chemical characteristics that may favor osseointegration of bone implants. This study aimed at delineating the effects of PEO topography and surface calcium on the in vitro pre-osteoblasts response. Two different surfaces were generated by varying the oxidation time of Ti6Al7Nb alloy from 1 minute (PEO-3Ca) to 5 minutes (PEO-9Ca) in a calcium phosphate based electrolyte. These surfaces were compared to another surface without calcium (PEO-0Ca) yet with controlled topography produced by oxidation of Ti6Al7Nb alloy in a phosphorous based electrolyte. The in vitro response of pre-osteoblasts (SV-HFO) on these surfaces clearly indicated that surface calcium is not the main player in influencing cells behaviour as the growth, differentiation and mineralization of pre-osteoblasts were not affected on surface without calcium (PEO-0Ca). Furthermore, at initial stages the pre-osteoblasts response to surface without calcium was even enhanced than on the surface that had high calcium (PEO-9Ca). These findings show that surface calcium is not the key factor in promoting cells response and suggests that PEO topography can be a strong surface cue for modulating cells response.

BME

BioMechanical Engineering

Mechanical, Maritime and Materials Engineering

Advisors/Committee Members: Dankelman, J. (mentor), Fratila-Apachitei, L. (mentor).

Subjects/Keywords: Ti6Al7Nb; SV-HFO; growth; differentiation; mineralization

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APA (6th Edition):

Fernando, J. D. L. (. (2014). Surface-cell interactions: Can PEO topography outsmart surface calcium?. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:5cf09033-4da3-420b-8ae3-ac3f3a02cd84

Chicago Manual of Style (16th Edition):

Fernando, J D L (author). “Surface-cell interactions: Can PEO topography outsmart surface calcium?.” 2014. Masters Thesis, Delft University of Technology. Accessed October 30, 2020. http://resolver.tudelft.nl/uuid:5cf09033-4da3-420b-8ae3-ac3f3a02cd84.

MLA Handbook (7th Edition):

Fernando, J D L (author). “Surface-cell interactions: Can PEO topography outsmart surface calcium?.” 2014. Web. 30 Oct 2020.

Vancouver:

Fernando JDL(. Surface-cell interactions: Can PEO topography outsmart surface calcium?. [Internet] [Masters thesis]. Delft University of Technology; 2014. [cited 2020 Oct 30]. Available from: http://resolver.tudelft.nl/uuid:5cf09033-4da3-420b-8ae3-ac3f3a02cd84.

Council of Science Editors:

Fernando JDL(. Surface-cell interactions: Can PEO topography outsmart surface calcium?. [Masters Thesis]. Delft University of Technology; 2014. Available from: http://resolver.tudelft.nl/uuid:5cf09033-4da3-420b-8ae3-ac3f3a02cd84


Delft University of Technology

2. De Groot, N. (author). The response of SV-HFO cells to Ti6Al7Nb surfaces modified by Plasma Electrolytic Oxidation.

Degree: 2012, Delft University of Technology

The aim of this study was to assess the response of preosteoblasts (SV-HFO), from adhesion to matrix mineralization, on Ti6Al7Nb surfaces modified by plasma electrolytic oxidation (PEO). Two different surfaces have been generated by changing the oxidation duration from 1 to 5 minutes. The resultant (PEO1 and PEO5) surfaces showed uniform porous topographies with pores mostly in the submicron range and a mixture of anatase and rutile TiO2 phases. However, the average surface roughness, maximum peak-to-valley height, pore size and Ca/P ratio increased with oxidation time whereas pore density and surface porosity decreased. On the PEO1 surface SV-HFO cells attached and spread easily using the pores as anchoring sites for their extensions and showing cell-cell contact after 48 hours. The larger pores protruding from the PEO5 surface suppressed cell adhesion. Deposition of extracellular matrix started earlier on the PEO1 surface and after 21 incubation days a net-like structure well integrated with the porous surface was visible. Matrix mineralization was evidenced on both surfaces after 21 days. However, more uniform mineralized areas were observed on the PEO1 surface whereas an accelerated mineralization was noticed after 14 days on the PEO5 surface. In conclusion, by varying only one PEO process condition, significant changes occurred on the surface of Ti6Al7Nb alloy, which influenced both the early and late response of SV-HFO cells. The observed surface-induced effects indicated that surfaces produced at shorter oxidation time may be more beneficial for early osteogenesis.

BME

BioMechanical Engineering

Mechanical, Maritime and Materials Engineering

Advisors/Committee Members: Fratila-Apachitei, L. (mentor), Duszczyk, J. (mentor), Van Leeuwen, J.P.T.M. (mentor).

Subjects/Keywords: SV-HFO; Ti6Al7NB; PEO

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

De Groot, N. (. (2012). The response of SV-HFO cells to Ti6Al7Nb surfaces modified by Plasma Electrolytic Oxidation. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:ae0196e2-971a-4536-a5cc-b3e7061e65a8

Chicago Manual of Style (16th Edition):

De Groot, N (author). “The response of SV-HFO cells to Ti6Al7Nb surfaces modified by Plasma Electrolytic Oxidation.” 2012. Masters Thesis, Delft University of Technology. Accessed October 30, 2020. http://resolver.tudelft.nl/uuid:ae0196e2-971a-4536-a5cc-b3e7061e65a8.

MLA Handbook (7th Edition):

De Groot, N (author). “The response of SV-HFO cells to Ti6Al7Nb surfaces modified by Plasma Electrolytic Oxidation.” 2012. Web. 30 Oct 2020.

Vancouver:

De Groot N(. The response of SV-HFO cells to Ti6Al7Nb surfaces modified by Plasma Electrolytic Oxidation. [Internet] [Masters thesis]. Delft University of Technology; 2012. [cited 2020 Oct 30]. Available from: http://resolver.tudelft.nl/uuid:ae0196e2-971a-4536-a5cc-b3e7061e65a8.

Council of Science Editors:

De Groot N(. The response of SV-HFO cells to Ti6Al7Nb surfaces modified by Plasma Electrolytic Oxidation. [Masters Thesis]. Delft University of Technology; 2012. Available from: http://resolver.tudelft.nl/uuid:ae0196e2-971a-4536-a5cc-b3e7061e65a8


Delft University of Technology

3. Cuschieri, M. (author). Nitinol Drug Eluting Surfaces for Coronary Stents.

Degree: 2012, Delft University of Technology

Nowadays, drug eluting stents (DES) are the treatment of choice for de novo atherosclerotic lesions. Novel DES are shifting to polymer-free (PF) drug delivery in order to avoid the problem of late stent thrombosis associated with long term polymer presence in the vessel lumen. The scope of this study was to assess the potential of a microporous layer of TiO2 produced on Nitinol by means of electropolishing followed by plasma electrolytic oxidation (EP+PEO) to act as a PF carrier for 6-mercaptopurine, which is a novel anti-restenotic drug. The surface porosity obtained was characterised and the roughness and hydrophilicy of the samples were measured. The drug has been loaded by spray coating and its release in acidified Phosphate Buffered Saline over a period of 5 days was analysed by high performance liquid chromatography. The results obtained were compared to those obtained from electropolished samples loaded under similar conditions.The findings revealed that EP samples had a drug loading efficiency of 26.8%, a drug reservoir capacity of 18.2?g/cm2 and released 95% of the loaded drug within 10 minutes of immersion. On the other hand, EP+PEO samples, with a surface porosity of about 10%, showed a drug loading efficiency of 41.9%, a drug reservoir capacity of 30.6 ?g/cm2 and released 42% of the drug within 10 minutes and a total of 52% within the 5 day immersion period studied. PEO treated surfaces showed two-phase release kinetics where a short fast release phase was followed by a long-term slow release phase and was therefore modelled by means of a two-phase Fickian diffusion model (r = 0.99866). The preliminary findings of this study indicate that PEO-treated NiTi surfaces have potential as PF drug carrier for DES.

BME

BioMechanical Engineering

Mechanical, Maritime and Materials Engineering

Advisors/Committee Members: Dankelman, J. (mentor), Duszczyk, J. (mentor), Fratila-Apachitei, L. (mentor).

Subjects/Keywords: Nitinol; Drug Elution; PEO

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Cuschieri, M. (. (2012). Nitinol Drug Eluting Surfaces for Coronary Stents. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:c2980ed5-fcfb-4c25-813f-99308e66b773

Chicago Manual of Style (16th Edition):

Cuschieri, M (author). “Nitinol Drug Eluting Surfaces for Coronary Stents.” 2012. Masters Thesis, Delft University of Technology. Accessed October 30, 2020. http://resolver.tudelft.nl/uuid:c2980ed5-fcfb-4c25-813f-99308e66b773.

MLA Handbook (7th Edition):

Cuschieri, M (author). “Nitinol Drug Eluting Surfaces for Coronary Stents.” 2012. Web. 30 Oct 2020.

Vancouver:

Cuschieri M(. Nitinol Drug Eluting Surfaces for Coronary Stents. [Internet] [Masters thesis]. Delft University of Technology; 2012. [cited 2020 Oct 30]. Available from: http://resolver.tudelft.nl/uuid:c2980ed5-fcfb-4c25-813f-99308e66b773.

Council of Science Editors:

Cuschieri M(. Nitinol Drug Eluting Surfaces for Coronary Stents. [Masters Thesis]. Delft University of Technology; 2012. Available from: http://resolver.tudelft.nl/uuid:c2980ed5-fcfb-4c25-813f-99308e66b773

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