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You searched for +publisher:"Delft University of Technology" +contributor:("Filatova, Lena"). Showing records 1 – 3 of 3 total matches.

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Delft University of Technology

1. Wu, Yulun (author). Long-term Effect of MPH on White Matter Tracts of Adults with ADHD: An Application of Consistent Model Selection followed by TBSS.

Degree: 2018, Delft University of Technology

We focused on analysis of long-term medication influenced white matter tracts based on diffusion-weighted MRI brain images of patients with ADHD disorder. We applied a framework of consistent model selection with Tract-based spatial statistics (TBSS) to give proper and consistent modelling of fiber-crossing in white matter. An orientation atlas was constructed to give an `orientation prior' during the ball-and-2sticks model estimation. Consistent metrics of fiber properties were obtained for each subject and thus statistical power in crossing-fiber region was improved. Besides, we improved this pipeline by optimising orientation prior and by integrating a high-dimensional image registration.

Applied Physics

Advisors/Committee Members: Vos, Frans (mentor), Filatova, Lena (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: diffusion MRI; DTI; model selection; ADHD disorder; white matter

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wu, Y. (. (2018). Long-term Effect of MPH on White Matter Tracts of Adults with ADHD: An Application of Consistent Model Selection followed by TBSS. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:e06f218d-b22b-410c-8041-3199ff0acdaa

Chicago Manual of Style (16th Edition):

Wu, Yulun (author). “Long-term Effect of MPH on White Matter Tracts of Adults with ADHD: An Application of Consistent Model Selection followed by TBSS.” 2018. Masters Thesis, Delft University of Technology. Accessed March 08, 2021. http://resolver.tudelft.nl/uuid:e06f218d-b22b-410c-8041-3199ff0acdaa.

MLA Handbook (7th Edition):

Wu, Yulun (author). “Long-term Effect of MPH on White Matter Tracts of Adults with ADHD: An Application of Consistent Model Selection followed by TBSS.” 2018. Web. 08 Mar 2021.

Vancouver:

Wu Y(. Long-term Effect of MPH on White Matter Tracts of Adults with ADHD: An Application of Consistent Model Selection followed by TBSS. [Internet] [Masters thesis]. Delft University of Technology; 2018. [cited 2021 Mar 08]. Available from: http://resolver.tudelft.nl/uuid:e06f218d-b22b-410c-8041-3199ff0acdaa.

Council of Science Editors:

Wu Y(. Long-term Effect of MPH on White Matter Tracts of Adults with ADHD: An Application of Consistent Model Selection followed by TBSS. [Masters Thesis]. Delft University of Technology; 2018. Available from: http://resolver.tudelft.nl/uuid:e06f218d-b22b-410c-8041-3199ff0acdaa


Delft University of Technology

2. Versteeg, Edwin (author). Probabilistic tractography for complex fiber orientations with automatic model selection: A tool to study structural connectivity in stroke patients.

Degree: 2017, Delft University of Technology

Stroke is one of the leading causes of both death and disability in the world. Consequently, the processes underlying motor recovery are a hot research topic. Electroencephalography (EEG) and diffusion weighted magnetic resonance imaging (dMRI) are two modalities that can be used to find functional and structural predictors for this motor recovery, respectively. Specifically, EEG measures the sources of activity (dipoles) in the brain while dMRI provides estimates of the properties of white matter (WM) tracts such as the fiber orientation. The estimated fiber orientations can be used to reconstruct WM connections in the brain by performing fiber tractography. In this thesis, we aim to introduce a framework for model selection and probabilistic tractography with parsimonious model selection. Practically, we use a range of multi-tensor models to cope with regions with multiple fiber populations. Furthermore, our probabilistic tractography uses the Cram\'er-Rao lower bound to capture the uncertainty in the fiber orientations. We mitigate the effect of overfitting by using a model selection method that incorporates the ICOMP-TKLD criterion to determine the most appropriate tensor model in each voxel. Ultimately, this framework can be applied to data from stroke patients and combined with functional regions obtained from EEG. We assessed the performance of the model selection method by investigating the influence of b-value and noise on the ability to detect crossing fibers in the fibercup phantom and human data. In the phantom, our model selection reconstructed all the crossings for the b-value combination of 1500 and \SI{2000}{\s\per\mm\squared} and at a signal-to-noise-ratio (SNR) comparable to clinical acquisitions. Moreover, our model selection method was able to identify the crossing of the corpus callosum and corticospinal tract in the human data. A range of step sizes and curvature thresholds was used to investigate the sensitivity of our tractography to its input parameters. In general, a smaller step size and lower curvature thresholds resulted in more deterministic behavior, while a larger step sizes and higher curvature thresholds led to more probabilistic behavior and deeper propagation into the gray matter in human data. We compared the performance of our framework and the open source diffusion MRI toolkit Camino on the fibercup phantom and healthy control data. In this comparison, our framework performed better in curved bundles and reconstructed more lateral projections of the corpus callosum. Lastly, we explored the subdivision of the brain into modules for stroke patients and healthy controls, by combining our framework with sources obtained from EEG. Fewer modules were found in the patient group, which might be attributed to a change in structural connections after stroke. Altogether, we have shown that our framework was able to select the appropriate diffusion models in crossing fiber regions and track across these crossings both in a phantom and… Advisors/Committee Members: Vos, Frans (mentor), Filatova, Lena (mentor), Delft University of Technology (degree granting institution).

Subjects/Keywords: Magnetic Resonance Imaging; Diffusion tensor; Tractography

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Versteeg, E. (. (2017). Probabilistic tractography for complex fiber orientations with automatic model selection: A tool to study structural connectivity in stroke patients. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:1d7390d0-005f-4ee1-bb95-cb4c6715d29a

Chicago Manual of Style (16th Edition):

Versteeg, Edwin (author). “Probabilistic tractography for complex fiber orientations with automatic model selection: A tool to study structural connectivity in stroke patients.” 2017. Masters Thesis, Delft University of Technology. Accessed March 08, 2021. http://resolver.tudelft.nl/uuid:1d7390d0-005f-4ee1-bb95-cb4c6715d29a.

MLA Handbook (7th Edition):

Versteeg, Edwin (author). “Probabilistic tractography for complex fiber orientations with automatic model selection: A tool to study structural connectivity in stroke patients.” 2017. Web. 08 Mar 2021.

Vancouver:

Versteeg E(. Probabilistic tractography for complex fiber orientations with automatic model selection: A tool to study structural connectivity in stroke patients. [Internet] [Masters thesis]. Delft University of Technology; 2017. [cited 2021 Mar 08]. Available from: http://resolver.tudelft.nl/uuid:1d7390d0-005f-4ee1-bb95-cb4c6715d29a.

Council of Science Editors:

Versteeg E(. Probabilistic tractography for complex fiber orientations with automatic model selection: A tool to study structural connectivity in stroke patients. [Masters Thesis]. Delft University of Technology; 2017. Available from: http://resolver.tudelft.nl/uuid:1d7390d0-005f-4ee1-bb95-cb4c6715d29a


Delft University of Technology

3. Tian, Runfeng (author). Brain Dynamic Information Flow Estimation Based on EEG and Diffusion MRI: A Proof-of-principle Study and Application in Stroke.

Degree: 2018, Delft University of Technology

In the hemiparetic stroke, functional recovery of paretic limb may occur with the reorganization of neural networks in the brain. Electroencephalography (EEG), with an excellent temporal resolution, can be used to reveal functional changes in the brain following a stroke. This study assessed a novel multimodal brain imaging technique namely Variational Bayesian Multimodal Encephalography (VBMEG), which combines EEG, anatomical MRI and diffusion weighted imaging (DWI), to estimation brain dynamic information flow and its changes following a stroke. EEG data were acquired from individuals suffering from a stroke as well as able-bodied participants while electrical stimuli were delivered sequentially at their index finger in the left and right hand, respectively. The locations of active sources related to this stimulus were precisely identified, resulting in high Variance Accounted For (VAF above 80%). An accurate estimation of dynamic information flow between sources was achieved in this study, showing a high VAF (above 88%) in the cross-validation test. The estimated dynamic information flow was compared between chronic hemiparetic stroke and able-bodied individuals, using matrices lateralization index and activation complexity. The results demonstrate the feasibility of VBMEG method in revealing the changes of information flow in the brain after stroke. This study verified the VBMEG method as an advanced computational approach to track the dynamic information flow in the brain following a stroke. This may lead to the development of a quantitative tool for monitoring functional changes of the cortical neural networks after a unilateral brain injury and therefore facilitate the research into, and the practice of stroke rehabilitation.

Mechanical Engineering

Advisors/Committee Members: van der Helm, Frans (mentor), Yang, Yuan (mentor), Filatova, Lena (mentor), Pool, Daan (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: EEG; diffusion MRI; dynamic information flow; VBMEG

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Tian, R. (. (2018). Brain Dynamic Information Flow Estimation Based on EEG and Diffusion MRI: A Proof-of-principle Study and Application in Stroke. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:1a44d771-6187-4259-9123-de10c5740e52

Chicago Manual of Style (16th Edition):

Tian, Runfeng (author). “Brain Dynamic Information Flow Estimation Based on EEG and Diffusion MRI: A Proof-of-principle Study and Application in Stroke.” 2018. Masters Thesis, Delft University of Technology. Accessed March 08, 2021. http://resolver.tudelft.nl/uuid:1a44d771-6187-4259-9123-de10c5740e52.

MLA Handbook (7th Edition):

Tian, Runfeng (author). “Brain Dynamic Information Flow Estimation Based on EEG and Diffusion MRI: A Proof-of-principle Study and Application in Stroke.” 2018. Web. 08 Mar 2021.

Vancouver:

Tian R(. Brain Dynamic Information Flow Estimation Based on EEG and Diffusion MRI: A Proof-of-principle Study and Application in Stroke. [Internet] [Masters thesis]. Delft University of Technology; 2018. [cited 2021 Mar 08]. Available from: http://resolver.tudelft.nl/uuid:1a44d771-6187-4259-9123-de10c5740e52.

Council of Science Editors:

Tian R(. Brain Dynamic Information Flow Estimation Based on EEG and Diffusion MRI: A Proof-of-principle Study and Application in Stroke. [Masters Thesis]. Delft University of Technology; 2018. Available from: http://resolver.tudelft.nl/uuid:1a44d771-6187-4259-9123-de10c5740e52

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