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You searched for +publisher:"Delft University of Technology" +contributor:("Djanashvili, Kristina"). Showing records 1 – 2 of 2 total matches.

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Delft University of Technology

1. Garretsen, Astrid (author). Next-generation neutron capture therapy.

Degree: 2018, Delft University of Technology

Neutron capture therapy (NCT) is a binary form of radiotherapy that utilizes the high cross section of some nonradioactive elements, in particular boron-10 and gadolinium-157, for thermal neutron capture. The energetic charged particles (electrons and alpha particles) released in the capture reaction cause a high localized deposition. For almost a century, NCT has been regarded as the holy grail of targeted radiotherapy, but its superiority over other available treatments has not been demonstrated so far. Limitations included amongst others a poor and non-selective biodistribution of Boron carrier molecules, the limited availability of suitable neutron sources, a lack of tools for patient selection and individualized dosimetry, and a shortage of properly conducted clinical trials. Advisors/Committee Members: Denkova, Antonia (mentor), Vogel, Wouter (mentor), Wolterbeek, Bert (graduation committee), Djanashvili, Kristina (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: Neutron capture therapy; Boron; gadolinium

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Garretsen, A. (. (2018). Next-generation neutron capture therapy. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b

Chicago Manual of Style (16th Edition):

Garretsen, Astrid (author). “Next-generation neutron capture therapy.” 2018. Masters Thesis, Delft University of Technology. Accessed April 11, 2021. http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b.

MLA Handbook (7th Edition):

Garretsen, Astrid (author). “Next-generation neutron capture therapy.” 2018. Web. 11 Apr 2021.

Vancouver:

Garretsen A(. Next-generation neutron capture therapy. [Internet] [Masters thesis]. Delft University of Technology; 2018. [cited 2021 Apr 11]. Available from: http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b.

Council of Science Editors:

Garretsen A(. Next-generation neutron capture therapy. [Masters Thesis]. Delft University of Technology; 2018. Available from: http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b


Delft University of Technology

2. van Aert, Emy (author). Gel dosimetry for a MR-linac: magnetic field and time dependency.

Degree: 2020, Delft University of Technology

The goal of this research was to perform a 3D end-to-end test on a MR-linac to check the whole workflow using a clinical treatment plan. Dosimetric gel was used to obtain 3D spatial information, with the phantom in the same position for irradiation and scanning. In order to achieve this, fundamental elements of gel dosimetry needed to be investigated. In the MR-linac, irradiation is delivered in the presence of a permanent magnetic field. Therefore, the dosimetric response within a 1.5 T magnetic field should be validated. It is also important to investigate the time-dependence of the gel. It is preferable to read-out the gels within approximately one hour, so that the phantom does not have to be moved. Ideally, scanning and irradiation would be done at the same time, to see the dynamical dose delivery. The VIPAR gel was used for this research. The experiments demonstrated that R2 values for doses irradiated with magnetic field were the same as R2 values for the same dose irradiated without magnetic field. R2 values are still proportional to the dose. It was also shown that it is possible to scan the phantom within 20 minutes after irradiation. Sensitivity is at its highest after approximately 8 hours and stays stable afterwards, so scanning after 8 hours will improve the read-out accuracy. It was also possible to make a fit for the R2 versus time plots, which makes it possible to correct for change over time. The fit can be divided in two linear parts if time is plotted on a logarithmic scale, one fit for the time points before 7 hours, one for the time points after 7 hours. The partial doses acquired by the gel during radiation delivery were estimated. The equivalent R2 values then agreed with the extrapolated fit to within 4%. This is a good indication that dynamic gel (4D) dosimetry may be achievable. A protocol for a relative end-to-end test was also developed. From the preliminary results, it appeared that a relative end-to-end test can be performed with the read-out of gel within 1 hour. A new MR sequence needs to be developed. For this end-to-end test, the sequence needs to scan a larger volume with a higher resolution, therefore, the scan time will increase and real-time dosimetry will not be possible. Changing the MR sequence might also change the optimal irradiation-scanning interval and the R2 versus time curve. To perform absolute dosimetry, an extra calibration would be required. Advisors/Committee Members: Denkova, Antonia (mentor), Wolthaus, Jochem (mentor), Woodings, Simon (mentor), Schaart, Dennis (graduation committee), Djanashvili, Kristina (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: gel dosimetry; MR-linac; magnetic field

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

van Aert, E. (. (2020). Gel dosimetry for a MR-linac: magnetic field and time dependency. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:4408f7c6-d16f-4cab-90c0-60dbf03d8a27

Chicago Manual of Style (16th Edition):

van Aert, Emy (author). “Gel dosimetry for a MR-linac: magnetic field and time dependency.” 2020. Masters Thesis, Delft University of Technology. Accessed April 11, 2021. http://resolver.tudelft.nl/uuid:4408f7c6-d16f-4cab-90c0-60dbf03d8a27.

MLA Handbook (7th Edition):

van Aert, Emy (author). “Gel dosimetry for a MR-linac: magnetic field and time dependency.” 2020. Web. 11 Apr 2021.

Vancouver:

van Aert E(. Gel dosimetry for a MR-linac: magnetic field and time dependency. [Internet] [Masters thesis]. Delft University of Technology; 2020. [cited 2021 Apr 11]. Available from: http://resolver.tudelft.nl/uuid:4408f7c6-d16f-4cab-90c0-60dbf03d8a27.

Council of Science Editors:

van Aert E(. Gel dosimetry for a MR-linac: magnetic field and time dependency. [Masters Thesis]. Delft University of Technology; 2020. Available from: http://resolver.tudelft.nl/uuid:4408f7c6-d16f-4cab-90c0-60dbf03d8a27

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