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Dalhousie University
1.
Velásquez, Marcelo.
A Comparative Study of the Environmental Impact of Online
and Offline Movie Rental Businesses.
Degree: Master of Electronic Commerce, Faculty of Computer Science, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/12737
► This thesis contains two papers, recently presented at international conferences and accepted for publication in recognized journals.
The purpose of this thesis is to assess…
(more)
▼ This thesis contains two papers, recently presented at
international conferences and accepted for publication in
recognized journals.
The purpose of this thesis is to assess and compare
the energy consumption and carbon footprints of two, online and
offline, major movie rental services in Canada. The thesis is
divided into two parts that represent two papers that are being
published. The comprehensive literature survey provides the
state-of-the-art in E-Commerce carbon footprinting with a new
categorization framework. The model development and application
compares the energy consumption and carbon footprints of the two
business models via a systems approach and the Economic Input
Output Life Cycle Assessment (EIO-LCA) model and evaluates
environmental performances. The portions of the logistics chains
that were different in the two business models were analyzed and
processes that were common were excluded. Regarding findings, the
analyses conclude that the online movie rental service has lower
carbon footprint than the offline one. We suggest practical
implications for policy makers, government, businesses, and
customers in movie rental industry.
Advisors/Committee Members: Not Applicable (external-examiner), Not Applicable (graduate-coordinator), Dr. Robert Blunden, Dr. Michael Bliemel (thesis-reader), Dr. Abdul-Rahim Ahmad (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: E-Commerce; Carbon Footprinting; Eco-Efficacy;
Eco-Efficiency; Energy Consumption; Innovation; Supply Chain
Management; and Sustainability
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Velásquez, M. (2010). A Comparative Study of the Environmental Impact of Online
and Offline Movie Rental Businesses. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12737
Chicago Manual of Style (16th Edition):
Velásquez, Marcelo. “A Comparative Study of the Environmental Impact of Online
and Offline Movie Rental Businesses.” 2010. Masters Thesis, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/12737.
MLA Handbook (7th Edition):
Velásquez, Marcelo. “A Comparative Study of the Environmental Impact of Online
and Offline Movie Rental Businesses.” 2010. Web. 04 Mar 2021.
Vancouver:
Velásquez M. A Comparative Study of the Environmental Impact of Online
and Offline Movie Rental Businesses. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/12737.
Council of Science Editors:
Velásquez M. A Comparative Study of the Environmental Impact of Online
and Offline Movie Rental Businesses. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12737

Dalhousie University
2.
Li, Depeng.
GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC
NETWORKS.
Degree: PhD, Faculty of Computer Science, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/12766
► In dynamic peer group communications, security has been in high demand by many applications in recent years. One of the more popular mechanisms to satisfy…
(more)
▼ In dynamic peer group communications, security has
been in high demand by many applications in recent years. One of
the more popular mechanisms to satisfy these security requirements
is the group key scheme in which the group key is to be shared by
each group communication participant. However, how to establish and
manage the group key efficiently in order to protect such
communications imposes new challenges - especially when such
schemes are to be deployed on resource-limited networks such as
Mobile Ad hoc Networks (MANETs). The basic needs of such network
settings require that the group key schemes must demonstrate not
only high performance but also fault-tolerance. Furthermore, to
encrypt group communication messages efficiently is essential.
Therefore, it is anticipated that the contributions of this thesis
will address the development of lightweight and high performance
key management protocols for group communications while
guaranteeing the same level of security as other approaches. These
contributions are listed below: First, two efficient individual
rekey schemes, in which most group members process one-way hash
functions and other members perform Diffie-Hellman operations, are
proposed to obtain performance efficiency. Second, a periodic batch
rekey scheme is proposed to handle the out-of-sync problem
resulting from individual rekeying schemes in cases where there is
a high rate of group member requests for joining/leaving. Third,
scalable maximum matching algorithms (M2) are designed to
incorporate a tree-based group key generation scheme to forward the
partial keys to other group members. Fourth, a hybrid group key
management architecture is proposed as well to combine the
advantages of centralized and contributory group key schemes.
Fifth, a Fast Encryption Algorithm for Multimedia (FEA-M) is
enhanced to overcome the vulnerabilities of its original solution
and its former improved variant. Performance analyses and
experimental results indicate that the proposed approaches reduce
computational costs and communication overhead as compared to other
popular protocols.
Advisors/Committee Members: Dr. Guang Gong (external-examiner), Dr. Vlado Keselj (graduate-coordinator), Dr. Keith Johnson (thesis-reader), Dr. Nur Zincir-Heywood (thesis-reader), Dr. Srinivas Sampalli (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: contributory group communication; group key agreement; applied cryptography; wireless network communication; security technology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Li, D. (2010). GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC
NETWORKS. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12766
Chicago Manual of Style (16th Edition):
Li, Depeng. “GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC
NETWORKS.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/12766.
MLA Handbook (7th Edition):
Li, Depeng. “GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC
NETWORKS.” 2010. Web. 04 Mar 2021.
Vancouver:
Li D. GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC
NETWORKS. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/12766.
Council of Science Editors:
Li D. GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC
NETWORKS. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12766

Dalhousie University
3.
Hutchinson, Paula S.
Predictors of Better Health Outcomes of Mothers of Children
with Autistic Spectrum Disorder.
Degree: PhD, Interdisciplinary PhD Programme, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/12793
► Caring for children with autism place mothers at high risk for poor health outcomes and compromises the health of all family members (e.g., Bristol, 1987;…
(more)
▼ Caring for children with autism place mothers at high
risk for poor health outcomes and compromises the health of all
family members (e.g., Bristol, 1987; Hastings et al., 2005a).
Although poor outcomes prevail, some mothers do well despite their
caregiving challenges. While ample research exists on mothers’
supports and stress, virtually nothing is known about their
strengths. Emerging research suggests that parental self-efficacy
and empowerment may contribute to better outcomes in mothers of
children with autism. The purpose of the present study was to
identify predictors of better outcomes in mothers of children with
autism. Relationships among child disruptive behaviour, supports,
self-efficacy, empowerment, maternal distress and positive
perceptions of parenting were examined using a postal survey
design. Mothers (N = 114) of school-age children with autism
provided demographic information and completed various scales
(i.e., the Developmental Behaviour Checklist, Family Support,
Difficult Behaviour Self-Efficacy, Family Empowerment, Hospital
Anxiety and Depression, Positive Contribution). Overall, 35% of the
variance was explained in maternal distress (i.e., anxiety and
depression). After accounting for mothers’ age and child disruptive
behaviour, support and empowerment were subsumed by parental
self-efficacy in predicting lower levels of maternal distress.
Collectively, 17% of the variance was explained in mothers’
positive perceptions of parenting. Self-efficacy partially mediated
the moderate effect of disruptive behaviour on mothers’ distress
and fully mediated the small effect of disruptive behaviour on
mothers’ positive perceptions of parenting. Thus, parental
self-efficacy for managing children’s difficult behaviour is very
promising for preserving mothers’ health. While discussion focuses
on outstanding issues to be addressed, the findings suggest that
tailoring formal services to enhance parental efficacy, rather than
providing support and consultation services alone, would be more in
line with mothers’ needs and possibly improve both children’s and
families’ outcomes.
Advisors/Committee Members: Dr. Richard Hastings (external-examiner), Dr. Marina Pluzhenskaya (graduate-coordinator), Dr. Penny Corkum, Dr. Isabel Smith, Dr. Jerry Singleton (thesis-reader), Dr. Susan Bryson (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Autism; Mothers; Children; Self-efficacy; Empowerment;
Support; Positive Perceptions of Parenting
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hutchinson, P. S. (2010). Predictors of Better Health Outcomes of Mothers of Children
with Autistic Spectrum Disorder. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12793
Chicago Manual of Style (16th Edition):
Hutchinson, Paula S. “Predictors of Better Health Outcomes of Mothers of Children
with Autistic Spectrum Disorder.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/12793.
MLA Handbook (7th Edition):
Hutchinson, Paula S. “Predictors of Better Health Outcomes of Mothers of Children
with Autistic Spectrum Disorder.” 2010. Web. 04 Mar 2021.
Vancouver:
Hutchinson PS. Predictors of Better Health Outcomes of Mothers of Children
with Autistic Spectrum Disorder. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/12793.
Council of Science Editors:
Hutchinson PS. Predictors of Better Health Outcomes of Mothers of Children
with Autistic Spectrum Disorder. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12793

Dalhousie University
4.
Xu, Chao Qiang.
Localization of Near-Surface Anomalies Using Seismic
Rayleigh Waves.
Degree: PhD, Department of Mining & Metallurgical
Engineering, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/12812
► The presence of subsurface anomalies, such as cavities, faults, unknown tunnels, etc., either natural or man-made, can cause public safety hazards. The detection of these…
(more)
▼ The presence of subsurface anomalies, such as
cavities, faults, unknown tunnels, etc., either natural or
man-made, can cause public safety hazards. The detection of these
features requires the development of new methods. Seismic Rayleigh
surface wave imaging is a relatively new non-destructive testing
technique (NDT) which generates subsurface images without drilling
boreholes into the ground, and in recent years has been widely used
for soil characterization in geotechnical investigations. In the
last decade, some researchers have applied the technique to
near-surface imaging and showed the possibility and potential for
engineering applications. This research presents the development of
a technique to process seismic Rayleigh waves to detect and image
subsurface anomalies. This study conducted investigations of
Rayleigh wave behaviors and developed a new strategy for Rayleigh
wave isolation from raw field data. The strategy applies wavelet
transforms, instead of the conventional spectral analysis of
surface waves (SASW) method, or popular multichannel analysis of
surface waves (MASW) techniques, to pair-channel analysis of the
isolated Rayleigh wave data for dispersion calculation. Finally, a
simple steady inversion technique was applied to yield shear
velocity as a function of both depth and distance, and shear
velocity field images (SVF), for near surface section display. This
research consists of development, computer programming, field
tests, data processing and interpretation. Three sites in different
scenarios were used for seismic investigations: old mining tunnels
in medium dipping coal seams in Stellarton coalfield, mining
cavities in steeply dipping gold-bearing veins in West Waverley
Gold District and an anomaly in nearly horizontal strata in
Liverpool. All these sites are in the province of Nova Scotia,
Canada. The results from seismic surface wave technique introduced
in this research can be evaluated by field observations, documents
and borehole logs. The satisfactory interpretations and success of
this investigation shows that this technique is suitable for
engineering application for subsurface
investigations.
Advisors/Committee Members: Giovanni Cascante (external-examiner), Margaret Walsh (graduate-coordinator), Craig Lake, Patrick Ryall, Stephen Butt (thesis-reader), Stephen Butt (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Rayleigh wave; cavity; wavelet transform
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Xu, C. Q. (2010). Localization of Near-Surface Anomalies Using Seismic
Rayleigh Waves. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12812
Chicago Manual of Style (16th Edition):
Xu, Chao Qiang. “Localization of Near-Surface Anomalies Using Seismic
Rayleigh Waves.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/12812.
MLA Handbook (7th Edition):
Xu, Chao Qiang. “Localization of Near-Surface Anomalies Using Seismic
Rayleigh Waves.” 2010. Web. 04 Mar 2021.
Vancouver:
Xu CQ. Localization of Near-Surface Anomalies Using Seismic
Rayleigh Waves. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/12812.
Council of Science Editors:
Xu CQ. Localization of Near-Surface Anomalies Using Seismic
Rayleigh Waves. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12812

Dalhousie University
5.
Beaton, Stephen A.
Evaluation and Synthesis of Sugar 1-Phosphate Substrates for
Nucleotidylyltransferases.
Degree: MS, Department of Chemistry, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/12815
► The study of many of glycosyltransferases is limited due to an inadequate access to sugar nucleotides. Preparation of sugar nucleotides through the use of nucleotidylyltransferases…
(more)
▼ The study of many of glycosyltransferases is limited
due to an inadequate access to sugar nucleotides. Preparation of
sugar nucleotides through the use of nucleotidylyltransferases with
broad substrate specificities is gaining significant interest and
offers high yields and stereospecificity. Physiologically, the
glucose 1-phosphate thymidylyltransferase catalyzes the
condensation of ?-D-glucose 1-phosphate and deoxythymidine
triphosphate to yield deoxythymidine diphospho glucose. Exploiting
and targeting these enzymes also has the potential of yielding new
therapeutics. Cps2L is a thymidylyltransferase isolated from
Streptococcus pneumoniae, with broad substrate flexibility. The
substrate specificity of Cps2L was evaluated with new sugar
1-phosphate analogues to gain further insight into substrate and
inhibitor requirements. Several sugar 1-phosphate analogues
including sugar 1C-phosphonates (and analogues thereof),
2-deoxy-2-fluorosugar 1-phosphates, and glucopyranose 1-
boranophosphates have been used to probe the sugar 1-phosphate
modification tolerance of Cps2L. In addition, NMR spectroscopy was
used to determine the anomeric stereochemistry of
2-deoxy-2-fluorosugars nucleotide products. For those substrates
that were accepted by Cps2L, steady-state kinetic parameters were
determined. The enzyme is able to almost equally form Michaelis
complexes with different sugar substrates, whereas the turnover
values for obtaining the corresponding sugar nucleotide were
different. The evaluation of the substrate tolerance of Cps2L, as
well as the synthesis of ?-D-glucose-1C-thiophosphonate, a difluoro
and a bisphosphono analogue of ?-D-glucose 1C-phosphonate will be
described.
Advisors/Committee Members: N/A (external-examiner), Dr. R.L. White (graduate-coordinator), Dr. S.L. Bearne, Dr. N.D. Schepp, Dr. T.B. Grindley (thesis-reader), Dr David L. Jakeman (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Nucleotidylyltransferases; organic synthesis; enzymes;
sugar nucleotides
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Beaton, S. A. (2010). Evaluation and Synthesis of Sugar 1-Phosphate Substrates for
Nucleotidylyltransferases. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12815
Chicago Manual of Style (16th Edition):
Beaton, Stephen A. “Evaluation and Synthesis of Sugar 1-Phosphate Substrates for
Nucleotidylyltransferases.” 2010. Masters Thesis, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/12815.
MLA Handbook (7th Edition):
Beaton, Stephen A. “Evaluation and Synthesis of Sugar 1-Phosphate Substrates for
Nucleotidylyltransferases.” 2010. Web. 04 Mar 2021.
Vancouver:
Beaton SA. Evaluation and Synthesis of Sugar 1-Phosphate Substrates for
Nucleotidylyltransferases. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/12815.
Council of Science Editors:
Beaton SA. Evaluation and Synthesis of Sugar 1-Phosphate Substrates for
Nucleotidylyltransferases. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12815

Dalhousie University
6.
Pelletier, Nathaniel L.
WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE
ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL
LIVESTOCK PRODUCTION.
Degree: PhD, Interdisciplinary PhD Programme, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/12821
► Achieving environmental s¬ustainability in human organization is the defining challenge of the modern era. In light of the inability of the existing economic paradigm to…
(more)
▼ Achieving environmental s¬ustainability in human
organization is the defining challenge of the modern era. In light
of the inability of the existing economic paradigm to provide for
sustainability objectives, novel approaches to understanding and
managing economic activities are required. Towards this end, the
emergent field of ecological economics provides an alternative
paradigm that expressly prioritizes the development of the theory
and tools necessary to operationalize environmental sustainability
in economic activity, which is viewed as prerequisite to
sustainability in any other sphere. Here, I advance an internally
consistent framework for understanding and implementing the core
ecological economic sustainability criteria: appropriate scale
relative to biocapacity; distributive justice; and efficient
allocation. This framework includes: (1) an ecological
communitarian conception of distributive justice which recognizes
environmental sustainability as the first principle of distributive
justice; (2) the rationale for biophysically-consistent ecological
economic modeling of human activities as a basis for
environmentally-enlightened policy and management; and (3) an
appeal for scale-oriented environmental governance as could
potentially be operationalized by a strong, centralized World
Environment Organization. I further apply this framework to
evaluating the current and future status of livestock production
systems at regional and global scales with respect to efficiency
considerations as well as their relationships to sustainability
boundary conditions for human activities as a whole. It is
suggested that the current and projected scale of the livestock
sector is fundamentally unsustainable, and that all leverage points
must be exploited to rein in this sector in the interest of
preventing irreversible ecological change. This must include, but
cannot be limited to, strong eco-efficiency measures and changes in
production technologies, species substitutions, and consumption
patterns and volumes. Outcomes are interpreted in terms of their
implications for environmental policy and governance oriented
towards the sustainability objective.
Advisors/Committee Members: Dr. Steven Young (external-examiner), Dr. Marina Pluzhenskaya (graduate-coordinator), Dr. Richard Apostle (thesis-reader), Dr. David VanderZwaag (thesis-reader), Dr. Peter Tyedmers (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: ecological economics; sustainability; environmental governance; environmental ethics; life cycle assessment; livestock
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pelletier, N. L. (2010). WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE
ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL
LIVESTOCK PRODUCTION. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12821
Chicago Manual of Style (16th Edition):
Pelletier, Nathaniel L. “WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE
ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL
LIVESTOCK PRODUCTION.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/12821.
MLA Handbook (7th Edition):
Pelletier, Nathaniel L. “WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE
ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL
LIVESTOCK PRODUCTION.” 2010. Web. 04 Mar 2021.
Vancouver:
Pelletier NL. WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE
ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL
LIVESTOCK PRODUCTION. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/12821.
Council of Science Editors:
Pelletier NL. WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE
ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL
LIVESTOCK PRODUCTION. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12821

Dalhousie University
7.
Grover, Vaneeta Kaur.
An Examination of Hardy-Weinberg Disequilibrium and
Statistical Testing in Genetic Association Studies.
Degree: PhD, Department of Mathematics & Statistics - Statistics
Division, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/12845
► Departure from HWE (HWD) in a sample may indicate genotyping error, population stratification, selection bias, or some combination thereof. Therefore, loci exhibiting HWD are often…
(more)
▼ Departure from HWE (HWD) in a sample may indicate
genotyping error, population stratification, selection bias, or
some combination thereof. Therefore, loci exhibiting HWD are often
excluded from association studies. However, it has been shown that
in case-control studies HWD can result from a genetic effect at the
locus, and HWD at a marker locus can be interpreted as evidence for
association with a disease. In an unpublished study in Toronto it
was observed that cases were in Hardy- Weinberg equilibrium at a
locus whereas their family members were in HWD. It has been shown
that the HWD coefficient for a multiplicative genetic model is
zero. This led to an investigation of relatives of affected
individuals to see whether the multiplicative model could be
revealed by a nonzero HWD coefficient in relatives. Genotypic
frequencies and HWD coefficients were derived for affected
individuals and their affected and unaffected relatives. A
substantial HWD was found in both individuals in dominant and
recessive genetic models but HWD is only slightly nonzero for
additive and multiplicative models. Methods were also developed to
test for association using data from affected individuals and their
relatives. Parameter estimates for these models can be obtained
using maximum likelihood methods, and estimates provide valuable
information regarding the mode of inheritance of the disease. The
methods were applied to 112 discordant sib pairs with Alzheimer’s
disease typed for the ApoE polymorphism and a significant
association was observed between the "4 ApoE allele and Alzheimer’s
disease. Case-control studies may indicate spurious association
with a marker locus in a stratified population. Methods were
developed to determine if the HWD observed in a data set from a
stratified population can be explained by both genetic association
and stratification. Parameter estimates for these models can be
obtained using maximum likelihood methods, and used to deduce the
mode of inheritance of the disease. Applying the model to the R990G
SNP of the CASR gene, it was found that the HWD was adequately
explained by a recessive genetic association and a stratification
proportion of 10%, consistent with the population of
Toronto.
In an unpublished study in Toronto it was observed
that cases were in Hardy-Weinberg Equilibrium at a locus whereas
their family members were in Hardy-Weinberg Disequilibrium (HWD).
This led to an investigation of relatives of affected individuals
to see whether the multiplicative model could be revealed by a
nonzero HWD coefficient in relatives. Genotypic frequencies and HWD
coefficients were derived for affected individuals and their
affected and unaffected relatives. Methods were also developed to
test for association using data from affected individuals and their
relatives. In addition, a model was developed to assess whether the
HWD observed in a data set from a stratified population can be
explained by both genetic association and stratification. Parameter
estimates for these models can be obtained using maximum…
Advisors/Committee Members: Dr. J Concepcin Loredo-Osti (external-examiner), Dr. Ed Susko (graduate-coordinator), Dr. Chris Field (thesis-reader), Dr. Bruce Smith (thesis-reader), Dr. David Hamilton (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Hardy-Weinberg equilibrium; Stratification; Relative
pairs; discordant pairs; association studies; likelihood
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Grover, V. K. (2010). An Examination of Hardy-Weinberg Disequilibrium and
Statistical Testing in Genetic Association Studies. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12845
Chicago Manual of Style (16th Edition):
Grover, Vaneeta Kaur. “An Examination of Hardy-Weinberg Disequilibrium and
Statistical Testing in Genetic Association Studies.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/12845.
MLA Handbook (7th Edition):
Grover, Vaneeta Kaur. “An Examination of Hardy-Weinberg Disequilibrium and
Statistical Testing in Genetic Association Studies.” 2010. Web. 04 Mar 2021.
Vancouver:
Grover VK. An Examination of Hardy-Weinberg Disequilibrium and
Statistical Testing in Genetic Association Studies. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/12845.
Council of Science Editors:
Grover VK. An Examination of Hardy-Weinberg Disequilibrium and
Statistical Testing in Genetic Association Studies. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12845

Dalhousie University
8.
Landry, Karen.
An Analysis of Time-Loss Duration Following Work-Related
Traumatic Injuries to the Hand and Wrist.
Degree: MS, School of Physiotherapy, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/12877
► Objective: The purposes of this thesis included: i) To explore the annual incidence and time-loss duration of traumatic, work-related injuries of four nature-of-injury (fractures, nerve…
(more)
▼ Objective: The purposes of this thesis included: i) To
explore the annual incidence and time-loss duration of traumatic,
work-related injuries of four nature-of-injury (fractures, nerve
lacerations, tendon lacerations/disruptions and amputations) and
two part-of-body categories (hand and wrist); and ii) To identify
the incidence and time-loss duration, and examine explanatory
variables that were associated with time-loss duration for subjects
with hand fractures. Methodology: Data on incidence, time-loss
duration and explanatory variables were reviewed on claims accepted
between January – December 2006 at WorkSafe-New Brunswick.
Descriptive statistics and non-parametric tests were used to
explore incidence and time-loss duration. Using a biopsychosocial
framework, explanatory variables associated with time-loss duration
were analyzed using Cox Proportional Hazards regression. Results:
The incidence for hand and wrist trauma involving fractures, tendon
lacerations/disruptions and amputations was low (3%). Incidence was
significantly higher for fractures and for injuries to the hand,
while time-loss duration was significantly higher for the wrist
(p< .05). The incidence rate of hand fractures was low (1.5%)
and average time-loss duration was high (92 days). Increased
time-loss duration was associated with greater medical aid costs
(used as a proxy for injury severity) older age and increased
receipt of therapy (Physiotherapy/Occupational Therapy).
Conclusions: The annual incidence of specific injuries involving
the hand and wrist is challenging to compare to the literature
since incidence is presented in many ways. Time-loss duration
following hand and wrist injuries is highly variable. Time-loss
duration for hand fractures exceeded reports in the literature and
predicted values reported in disability duration guidelines.
Consideration of the impairment, personal and environmental factors
is warranted to provide a framework to the return-to-work process
for all stakeholders involved in the care of the hand- and
wrist-injured worker.
Advisors/Committee Members: - (external-examiner), Dr. Marie Earl (graduate-coordinator), Dr. Cheryl Hubley-Kozey, Dr. Brenda Merritt (thesis-reader), Dr. Anne Fenety (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Hand injuries; wrist injuries; disability duration;
return-to-work; workplace trauma
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Landry, K. (2010). An Analysis of Time-Loss Duration Following Work-Related
Traumatic Injuries to the Hand and Wrist. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12877
Chicago Manual of Style (16th Edition):
Landry, Karen. “An Analysis of Time-Loss Duration Following Work-Related
Traumatic Injuries to the Hand and Wrist.” 2010. Masters Thesis, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/12877.
MLA Handbook (7th Edition):
Landry, Karen. “An Analysis of Time-Loss Duration Following Work-Related
Traumatic Injuries to the Hand and Wrist.” 2010. Web. 04 Mar 2021.
Vancouver:
Landry K. An Analysis of Time-Loss Duration Following Work-Related
Traumatic Injuries to the Hand and Wrist. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/12877.
Council of Science Editors:
Landry K. An Analysis of Time-Loss Duration Following Work-Related
Traumatic Injuries to the Hand and Wrist. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12877

Dalhousie University
9.
Lin, Yuehua.
Circulation and Associated Variability in the Intra-Americas
Sea: the Role of Loop Current Intrusion and Caribbean
Eddies.
Degree: PhD, Department of Oceanography, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/12996
► Circulation and associated variability in the Intra-Americas Sea (IAS) are examined using observations and numerical models. Vertically integrated transport variations through the Yucatan Channel in…
(more)
▼ Circulation and associated variability in the
Intra-Americas Sea (IAS) are examined using observations and
numerical models. Vertically integrated transport variations
through the Yucatan Channel in the model are found to be related to
the intrusion of the Loop Current into the Gulf of Mexico. We argue
that the transport variations are part of a “compensation effect”
by which transport variations through the Yucatan Channel are at
least partly compensated by flow around Cuba. Numerical experiments
show that the transport variations result from the interaction
between the density anomalies associated with the Loop Current
intrusion and the variable bottom topography. The compensation
effect is found to be associated with baroclinic (2-layer) flow
through the Yucatan Channel at timescales longer than a month,
while at shorter timescales (less than a month) the vertical
structure of the flow is barotropic. An index, that can be computed
from satellite data, is proposed for measuring the impact of the
Loop Current intrusion on the transport variability through the
Yucatan Channel. This index is shown to be significantly correlated
at low frequencies (cutoff 120 days) with the cable estimates of
transport between Florida and the Bahamas. We argue that it is the
geometric connectivity between the Yucatan Channel and the Straits
of Florida between Florida and the Bahamas that accounts for the
relationship. A three-dimensional, data-assimilative, ocean
circulation model is developed in order to simulate circulation,
hydrography and associated variability in the IAS from 1999 to
2002. The model performance is assessed by comparing model results
with various observations made in the IAS during this period. Model
results are used to study the role played by Caribbean eddies in
the dynamics of monthly to seasonal (with timescales of 30-120
days) circulation variability in the IAS. It is shown that the
variations in vertically integrated transport between Nicaragua and
Jamaica are linked to the interaction of Caribbean eddies with the
Nicaraguan Rise. The mechanism can be explained in terms of the
form drag effect acting across the Nicaraguan Rise.
Advisors/Committee Members: Lars Petter Røed (external-examiner), Dan Kelly (graduate-coordinator), Youyu Lu, Kumiko Azetsu-Scott (thesis-reader), Jinyu Sheng, Richard Greatbatch (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Intra-Americas Sea; Loop Current Intrusion; Caribbean
Eddy; Circulation Variability
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lin, Y. (2010). Circulation and Associated Variability in the Intra-Americas
Sea: the Role of Loop Current Intrusion and Caribbean
Eddies. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12996
Chicago Manual of Style (16th Edition):
Lin, Yuehua. “Circulation and Associated Variability in the Intra-Americas
Sea: the Role of Loop Current Intrusion and Caribbean
Eddies.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/12996.
MLA Handbook (7th Edition):
Lin, Yuehua. “Circulation and Associated Variability in the Intra-Americas
Sea: the Role of Loop Current Intrusion and Caribbean
Eddies.” 2010. Web. 04 Mar 2021.
Vancouver:
Lin Y. Circulation and Associated Variability in the Intra-Americas
Sea: the Role of Loop Current Intrusion and Caribbean
Eddies. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/12996.
Council of Science Editors:
Lin Y. Circulation and Associated Variability in the Intra-Americas
Sea: the Role of Loop Current Intrusion and Caribbean
Eddies. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12996

Dalhousie University
10.
MacDonald, William.
GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC
REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN.
Degree: PhD, Department of Biology, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/13023
► Genomic imprinting is an epigenetic phenomenon whereby the expression of a gene, chromosomal region, or entire chromosome, depends on the sex of the transmitting parent.…
(more)
▼ Genomic imprinting is an epigenetic phenomenon whereby
the expression of a gene, chromosomal region, or entire chromosome,
depends on the sex of the transmitting parent. Imprinting results
in an otherwise fully functional gene being transcriptionally
silenced when transmitted by one parent, yet the same gene, with
identical DNA sequence, is active when transmitted by the other.
Thus, the gene retains an imprint or “memory” of its genetic
history, which is reversible and reset each successive generation
by passage through the germline. Within this thesis, I present my
findings that show genomic imprinting in Drosophila is regulated by
distinct epigenetic mechanisms at different stages of
embryogenesis, suggesting the requirement of a transitional stage
to stabilize the imprint between establishment in the germline and
maintenance in the soma. I futher show that Drosophila utilize
epigenetic mechanisms that are involved in regulating genomic
imprinting in mammals and plants, such as DNA methylation, histone
modification, antisense RNA, and chromatin insulators. These
findings demonstrate convergence of the epigenetic mechanisms that
regulate genomic imprinting in diverse organisms.
Advisors/Committee Members: Dr. Denise Clark (external-examiner), Dr. Hal Whitehead (graduate-coordinator), Dr. Mark Johnston (thesis-reader), Dr. Bill Pohajdak (thesis-reader), Dr. Vett Lloyd (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Drosophila; Imprinting; Epigenetics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
MacDonald, W. (2010). GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC
REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13023
Chicago Manual of Style (16th Edition):
MacDonald, William. “GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC
REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13023.
MLA Handbook (7th Edition):
MacDonald, William. “GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC
REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN.” 2010. Web. 04 Mar 2021.
Vancouver:
MacDonald W. GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC
REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13023.
Council of Science Editors:
MacDonald W. GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC
REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13023

Dalhousie University
11.
Briand, Julie.
EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH
MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS.
Degree: Master of Applied Science, Department of Civil Engineering, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/13037
► The early detection of damage of in-service structural or mechanical systems is of vital importance. With early detection, the damage may be repaired before the…
(more)
▼ The early detection of damage of in-service structural
or mechanical systems is of vital importance. With early detection,
the damage may be repaired before the integrity of the system is
jeopardized, avoiding possible monetary losses, environmental
impacts, injury and death. With this goal in mind, many structural
health monitoring techniques have been developed which use a
combination of sensors and algorithms to collect, process and
interpret data to detect damage in a structure. This thesis
presents work completed in support of the experimental validation
of a novel structural health monitoring technique developed with
the aim of providing improved qualitative results compared to those
methods currently available.
Advisors/Committee Members: Dr. Serguei Iakovlev (external-examiner), Dr. Margaret Walsh (graduate-coordinator), Dr. T.S. Koko (thesis-reader), Dr. Farid Taheri (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Vibration-based damage detection; structural health
monitoring; piezoceramic sensors; bolted pipeline joint; empirical
mode decomposition
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Briand, J. (2010). EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH
MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13037
Chicago Manual of Style (16th Edition):
Briand, Julie. “EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH
MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS.” 2010. Masters Thesis, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13037.
MLA Handbook (7th Edition):
Briand, Julie. “EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH
MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS.” 2010. Web. 04 Mar 2021.
Vancouver:
Briand J. EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH
MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13037.
Council of Science Editors:
Briand J. EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH
MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13037

Dalhousie University
12.
McEachern, Lori A.
INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1
TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER.
Degree: PhD, Department of Biology, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/13036
► Transgenic organisms are a valuable tool for studying epigenetics, as they provide significant insight into the evolutionary conservation of epigenetic control sequences, the interacting proteins,…
(more)
▼ Transgenic organisms are a valuable tool for studying
epigenetics, as they provide significant insight into the
evolutionary conservation of epigenetic control sequences, the
interacting proteins, and the underlying molecular mechanisms.
Paramutation is an epigenetic phenomenon in which the epigenetic
status and expression level of one allele is heritably altered
after pairing with another. At the b1 locus in maize, a control
region consisting of seven 853 bp tandem repeats is required for
paramutation. To study the conservation of the epigenetic
mechanisms underlying maize b1 paramutation, I created transgenic
Drosophila carrying the maize b1 control region flanked by FRT
sites and adjacent to the Drosophila white reporter gene. The maize
b1 tandem repeats caused epigenetic silencing in Drosophila, as
white expression consistently increased following repeat removal. A
single copy of the tandem repeat sequence was sufficient to cause
silencing, and silencing strength increased as the number of
repeats increased. Trans interactions, such as pairing-sensitive
silencing, were also observed and appear to require a threshold
number of b1 tandem repeats, similar to paramutation in maize.
Analysis of transcription from the repeats showed that the b1
tandem repeats are transcribed from both strands in Drosophila, as
they are in maize. Bidirectional transcription was found to extend
to the regions flanking the repeats, and persisted in “repeats-out”
transgenes following repeat removal. However, aberrant
transcription was lost when a zero-repeat transgene was moved to a
new genomic position, suggesting that it may be due to an
epigenetic mark that is retained from the previous silenced state.
A search for modifiers of b1 repeat-mediated silencing demonstrated
that Polycomb group proteins are involved. Together, these results
indicate considerable conservation of an epigenetic silencing
process between the plant and animal kingdoms. Genomic imprinting
is a related epigenetic process in which parent-specific epigenetic
states are inherited and maintained in progeny. The conservation of
epigenetic mechanisms was further explored via an in-depth review
of the molecular mechanisms underlying genomic imprinting in
plants, mammals and insects, and identification of potentially
imprinted genes in Drosophila by microarray analysis.
Advisors/Committee Members: Dr. Lori Wallrath (external-examiner), Dr. Hal Whitehead (graduate-coordinator), Dr. Bill Pohajdak (thesis-reader), Dr. Ian Meinertzhagen (thesis-reader), Dr. Vett Lloyd (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Epigenetics; Drosophila melanogaster; Paramutation; Tandem repeats; Transcription; Silencing; Genomic imprinting
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McEachern, L. A. (2010). INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1
TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13036
Chicago Manual of Style (16th Edition):
McEachern, Lori A. “INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1
TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13036.
MLA Handbook (7th Edition):
McEachern, Lori A. “INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1
TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER.” 2010. Web. 04 Mar 2021.
Vancouver:
McEachern LA. INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1
TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13036.
Council of Science Editors:
McEachern LA. INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1
TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13036

Dalhousie University
13.
Andrew, Melissa Kathryn.
Social Vulnerability and Health in Older Adults.
Degree: PhD, Interdisciplinary PhD Programme, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/13102
► Vulnerability to adverse health outcomes can be intrinsic (e.g. illnesses, disability, frailty, genetics) or extrinsic (e.g. physical and social environments). The contribution of social factors…
(more)
▼ Vulnerability to adverse health outcomes can be
intrinsic (e.g. illnesses, disability, frailty, genetics) or
extrinsic (e.g. physical and social environments). The contribution
of social factors to extrinsic vulnerability in older adults is the
subject of this thesis. Social vulnerability is the degree to which
a person’s overall social situation leaves them susceptible to
further insults, either health-related or social. This thesis
begins with an exploration of how various social factors are
associated with health and can be considered to contribute to a
holistic concept of social vulnerability. Using a social ecology
perspective, seven domains of social vulnerability (engagement,
contextual socio-economic status, social support, living situation,
self-esteem, mastery, and relations with others) are defined. A
social vulnerability index is then developed, in which social
factors from all of these domains are combined into a single index,
allowing the complexity of social circumstances experienced by
older people to be embraced. Social vulnerability, defined using
this index, is then studied in relation to health, and is found to
be associated with frailty, mortality and cognitive decline. The
important impact of social vulnerability on the survival of the
fittest older adults (those who are not at all frail) is studied as
a special case. How social vulnerability changes over time is then
examined using a transitions model based on a parametric Markov
chain, with the finding that older people tend to accumulate social
deficits over time, but that, importantly, this relentless
accumulation of social problems is not a universal experience. The
thesis then turns to consideration of frontal lobe cognitive
function as a possible mechanism for the association between social
vulnerability and health, given the importance of the frontal lobes
to social interaction in humans. It finds that the most socially
vulnerable people have impaired performance on tests of frontal
lobe cognition, but that performance on non-frontal tasks is not
similarly associated. The findings presented in this thesis support
the importance of social factors for health of older people, and
suggest that the social vulnerability index shows potential as a
measure which embraces the complexity of older adults’ social
circumstances while reducing dimensionality.
Advisors/Committee Members: Jean Woo (external-examiner), Marina Pluzhenskaya (graduate-coordinator), Susan Kirkland, Arnold Mitnitski, Janice Keefe (thesis-reader), Kenneth Rockwood (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Heath; older adults; social; frailty; mortality
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Andrew, M. K. (2010). Social Vulnerability and Health in Older Adults. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13102
Chicago Manual of Style (16th Edition):
Andrew, Melissa Kathryn. “Social Vulnerability and Health in Older Adults.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13102.
MLA Handbook (7th Edition):
Andrew, Melissa Kathryn. “Social Vulnerability and Health in Older Adults.” 2010. Web. 04 Mar 2021.
Vancouver:
Andrew MK. Social Vulnerability and Health in Older Adults. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13102.
Council of Science Editors:
Andrew MK. Social Vulnerability and Health in Older Adults. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13102

Dalhousie University
14.
van Hengstum, Peter.
Quaternary Sea-Level and Climate Signatures in Phreatic
Coastal Caves.
Degree: PhD, Department of Earth Sciences, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/13123
► Underwater (phreatic) caves are a ubiquitous landform on coastal karst terrain, but the marine geological processes operating in these systems are largely unknown. This dissertation…
(more)
▼ Underwater (phreatic) caves are a ubiquitous landform
on coastal karst terrain, but the marine geological processes
operating in these systems are largely unknown. This dissertation
redresses the problem by asking if Bermudian phreatic cave
sediments archive sea-level and climate information? An important
premise is that coastal cave environments are not identical. They
can be categorized based on whether they are
terrestrially-influenced (anchialine), completely flooded by saline
groundwater (submarine), positioned at sea level (littoral) or in
the vadose zone (vadose). For the first time the boundary between
modern anchialine and submarine cave environments has been
distinguished in Green Bay Cave using a multi-proxy approach
(benthic foraminifera, sedimentary organic matter content and
carbon isotopic composition - ?13Corg, and grain-size analysis).
Twelve push cores were extracted from Green Bay Cave and dated with
twenty 14C dates, recovering the first underwater cave succession
spanning the Holocene (13 ka to present). Green Bay Cave
transitioned through all major cave environments during Holocene
sea-level rise (vadose, littoral, anchialine, and submarine),
providing a sedimentary model for global cave successions. These
relationships provide a novel means to solve Quaternary sea-level
and climate problems. For sea level, two examples indicate that the
littoral cave can be used as a sea-level indicator, distinguished
stratigraphically by microfossil or sedimentary proxies. First, the
elevation and timing of when Green Bay Cave was a littoral
environment indicates Bermuda experienced an abrupt ~6.4 m
sea-level rise at 7.7 ka, coinciding with final collapse of the
Labrador sector of the Laurentide Ice Sheet. Second, microfossils
preserved in elevated caves at +21 m above modern sea level and
dated to marine isotope stage 11 (U-series, amino acid
racemization) are consistent with modern Bermudian caves and
co-stratigraphic sea level. For climate problems, annual
temperature monitoring in Walsingham Cave indicates that cave water
is thermally comparable to regional oceanographic conditions in the
Sargasso Sea. Three sediment cores dated with sixteen radiocarbon
dates indicate that Bermuda’s coldest and stormiest conditions of
the last 3.2 ka occurred during the Little Ice Age (proxies: ?18Oc,
grain size, bulk organic matter).
Advisors/Committee Members: Dr. Martin Buzas (external-examiner), Dr. Nicholas Culshaw (graduate-coordinator), Dr. John Gosse, Dr. Martin Gibling, Dr. Grant Wach (thesis-reader), Dr. David B. Scott (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Caves; sea level; foraminifera; anchialine; submarine;
North Atlantic Oscillation; Quaternary
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
van Hengstum, P. (2010). Quaternary Sea-Level and Climate Signatures in Phreatic
Coastal Caves. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13123
Chicago Manual of Style (16th Edition):
van Hengstum, Peter. “Quaternary Sea-Level and Climate Signatures in Phreatic
Coastal Caves.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13123.
MLA Handbook (7th Edition):
van Hengstum, Peter. “Quaternary Sea-Level and Climate Signatures in Phreatic
Coastal Caves.” 2010. Web. 04 Mar 2021.
Vancouver:
van Hengstum P. Quaternary Sea-Level and Climate Signatures in Phreatic
Coastal Caves. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13123.
Council of Science Editors:
van Hengstum P. Quaternary Sea-Level and Climate Signatures in Phreatic
Coastal Caves. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13123

Dalhousie University
15.
Kellett, Dawn.
Tectonic Evolution of the South Tibetan Detachment System,
Bhutan Himalaya.
Degree: PhD, Department of Earth Sciences, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/13153
► Syn-convergent low-angle normal-sense detachments (LANDs) are found in many orogens around the world. However, those tectonic processes which result in their formation are little known.…
(more)
▼ Syn-convergent low-angle normal-sense detachments
(LANDs) are found in many orogens around the world. However, those
tectonic processes which result in their formation are little
known. The South Tibetan detachment system (STDS) is the
best-studied example worldwide of a syn-convergent LAND, and formed
in the Miocene due to the continental collision of India and Asia.
In Bhutan, eastern Himalaya, the STDS is duplicated. Here I
investigate the tectonic history of the inner STDS and particularly
the outer STDS in Bhutan, to determine whether the duplicated STDS
can be explained by or used to constrain models of Himalayan
orogenesis. A range of geochronometric, thermochronologic,
petrologic, structural, thermobarometric, thermometric, and
isotopic tools are used to constrain: the onset and cessation of
motion on the outer STDS; the cessation of motion on the inner
STDS; the peak metamorphic conditions in the hanging wall and
footwall of the outer STDS; the pressure-temperature-time paths of
tectonites in the hanging wall and footwall of the outer STDS; the
structural history of the hanging wall rocks of the outer STDS,
and; the paleogeographic affinity of the hanging wall rocks of the
outer STDS. The results of these studies are compared to
thermo-mechanical models of Himalayan- type continental collision.
Similarities in model predictions of the type and timing of
structures, peak metamorphic conditions of hanging wall and
footwall tectonites, pressure-temperature-time paths, and other
regional tectonic observations lead to two main conclusions. 1. The
STDS is a system of three main types of LANDs: those that formed
during channel flow of low-viscosity mid-crustal rocks, those that
formed by extrusion of cooled channel rocks to the surface, and
those that formed by destabilization of the upper crust above a
dome of mid-crustal channel rocks. 2. The STDS was duplicated by
underthrusting of a crustal ramp into the Himalayan orogen since
early Miocene. The underthrusting led to extrusion of a dome of
weak mid-crustal above a previously-extruded channel. The crustal
ramp may be local to the eastern Himalaya due to higher convergence
and/or erosion rates, or due to local underthrusting of relatively
strong crust behind weaker crust.
Advisors/Committee Members: Clark Burchfiel (external-examiner), Nick Culshaw (graduate-coordinator), Rebecca Jamieson (thesis-reader), Isabelle Coutand (thesis-reader), John Gosse (thesis-reader), Djordje Grujic (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Himalaya; Bhutan; geochronology; tectonics; structural
geology
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Kellett, D. (2010). Tectonic Evolution of the South Tibetan Detachment System,
Bhutan Himalaya. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13153
Chicago Manual of Style (16th Edition):
Kellett, Dawn. “Tectonic Evolution of the South Tibetan Detachment System,
Bhutan Himalaya.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13153.
MLA Handbook (7th Edition):
Kellett, Dawn. “Tectonic Evolution of the South Tibetan Detachment System,
Bhutan Himalaya.” 2010. Web. 04 Mar 2021.
Vancouver:
Kellett D. Tectonic Evolution of the South Tibetan Detachment System,
Bhutan Himalaya. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13153.
Council of Science Editors:
Kellett D. Tectonic Evolution of the South Tibetan Detachment System,
Bhutan Himalaya. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13153

Dalhousie University
16.
Edwards, Tara N.
GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER
RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA
MELANOGASTER.
Degree: PhD, Department of Biology, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/13142
► The visual system of the fruit fly is ideal for studying the association between neurons and glia. These interact during the morphogenesis of brain neuropiles…
(more)
▼ The visual system of the fruit fly is ideal for
studying the association between neurons and glia. These interact
during the morphogenesis of brain neuropiles and, in the adult,
work together to maintain an ideal environment for neuronal
function. In this thesis I characterise the pupal metamorphosis and
adult structure of glia in the optic lobe’s lamina and medulla
neuropiles. Photoreceptor axons from the fly’s compound eyes
terminate at locations within these neuropiles that allow them
intimate contact with glia. Some neuropile glia take up and
inactivate the neurotransmitter histamine after its release at
photoreceptor synapses. A shuttle pathway between the glia and
photoreceptors then transports inactivated histamine back to
photoreceptors for reuse. The gene CG12120 encodes the protein Tan,
which liberates recycled histamine within the photoreceptor
cytoplasm, it is then pumped into vesicles for re-release.
Histamine, however, is not exclusive to the visual system. A system
of glial barriers in the lamina, and around the brain, controls the
movement of histamine between neuropiles as well as between the
body and the brain. How histamine is reciprocally transported
between photoreceptors and glia remains unknown despite attempts to
uncover candidate transporters. Photoreceptor-specific capitate
projections form as invaginations from neuropile glia into
photoreceptor terminals. The transmitter needs of the photoreceptor
appear to dictate the dynamic structure of capitate projections,
which change in shape and number after perturbations that affect
terminal location, synapse number or histamine release at the
photoreceptor. This dynamism suggests that capitate projections
play an important role, not only in recycling synaptic vesicles,
but also in recycling histamine.
Advisors/Committee Members: D. Krantz (external-examiner), C. Neville (graduate-coordinator), S.R. Shaw, V.K. Lloyd (thesis-reader), I.A. Meinertzhagen (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Drosophila; glia; vision; histamine; Tan
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Edwards, T. N. (2010). GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER
RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA
MELANOGASTER. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13142
Chicago Manual of Style (16th Edition):
Edwards, Tara N. “GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER
RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA
MELANOGASTER.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13142.
MLA Handbook (7th Edition):
Edwards, Tara N. “GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER
RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA
MELANOGASTER.” 2010. Web. 04 Mar 2021.
Vancouver:
Edwards TN. GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER
RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA
MELANOGASTER. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13142.
Council of Science Editors:
Edwards TN. GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER
RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA
MELANOGASTER. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13142

Dalhousie University
17.
Ferretti, Francesco.
THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING
OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS
OF PREDATOR REMOVAL.
Degree: PhD, Department of Biology, 2010, Dalhousie University
URL: http://hdl.handle.net/10222/13171
► Elasmobranchs are among the oldest and most successful predators in the ocean, yet one of the most vulnerable to the direct and indirect effects of…
(more)
▼ Elasmobranchs are among the oldest and most successful
predators in the ocean, yet one of the most vulnerable to the
direct and indirect effects of fishing. Many populations are
rapidly declining around the world, and an increasing number is
listed as threatened or endangered. The broader ecosystem
consequences of these declines, and whether other marine predators
can replace sharks, are open questions. In this thesis, I used a
diverse set of data and modeling techniques to analyze long-term
changes in elasmobranch populations in the Mediterranean Sea, and
the consequences of shark declines on marine ecosystems. Because of
its long history of fishing, the Mediterranean offers a unique
perspective on the response of marine communities to exploitation
over long time scales. Here, I reconstructed the history of
elasmobranch exploitation over the past 200 years in pelagic,
coastal and demersal communities. Results were combined
meta-analytically to derive a general pattern of change for the
entire region. Overall, I detected multiple cases of regional
species extirpations, a strong correlation between historical
intensity of exploitation and the stage of community degradation,
and some cases of compensatory species increases. My results
suggest that compared to other marine ecosystems worldwide, the
Mediterranean Sea might be in an advanced stage of
overexploitation. To gain more general conclusions about the
patterns and consequences of shark declines in the ocean, I
reviewed and reanalyzed documented changes in exploited
elasmobranch communities around the world, and synthesized the
effects of sharks on their prey and wider communities. This work
revealed that sharks are abundant and diverse in little exploited
or unexploited marine ecosystems but vulnerable to even light
levels of fishing. The decline in large sharks has reduced natural
mortality in a range of their prey, contributing to changes in
abundance, distribution, and behaviour of marine megafauna that
have few other predators. In some cases, this has resulted in
cascading changes in prey populations and food-web structure.
Overall, my thesis greatly enhanced our knowledge about the
critical state of elasmobranchs in the Mediterranean Sea and the
consequences of the declines of these important marine predators on
marine ecosystems.
Advisors/Committee Members: Jeremy Collie (external-examiner), Hal Whitehead (graduate-coordinator), Boris Worm (thesis-reader), Edward Susko (thesis-reader), Heike K. Lotze and Andrew A. Rosenberg (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Elasmobranchs; extinction risk; generalized linear models;
historical population trends; meta-analysis; overfishing;
predators; top-down control; ecological role; ecosystem; fishing;
mesopredator release; predation; risk effects; trophic cascades;
sharks; trawl surveys
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ferretti, F. (2010). THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING
OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS
OF PREDATOR REMOVAL. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13171
Chicago Manual of Style (16th Edition):
Ferretti, Francesco. “THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING
OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS
OF PREDATOR REMOVAL.” 2010. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13171.
MLA Handbook (7th Edition):
Ferretti, Francesco. “THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING
OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS
OF PREDATOR REMOVAL.” 2010. Web. 04 Mar 2021.
Vancouver:
Ferretti F. THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING
OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS
OF PREDATOR REMOVAL. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13171.
Council of Science Editors:
Ferretti F. THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING
OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS
OF PREDATOR REMOVAL. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13171

Dalhousie University
18.
Nourpanah, Nikzad.
Integrity and Fracture Response of Offshore Pipelines
Subject to Large Plastic Strains.
Degree: PhD, Department of Civil Engineering, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/13299
► Steel pipelines are widely used in offshore oil/gas facilities. To achieve economically feasible designs, regulatory codes permit utilization of the pipelines well past their elastic…
(more)
▼ Steel pipelines are widely used in offshore oil/gas
facilities. To achieve economically feasible designs, regulatory
codes permit utilization of the pipelines well past their elastic
response limit. This requires thorough integrity check of the
pipeline subject to large scale yielding (LSY). Engineering
criticality assessments (ECA) are used to justify the integrity of
a cracked pipeline against fracture failure. The currently used ECA
crack driving force equation was developed for load-controlled
components subject to very limited crack-tip plasticity. Moreover,
fracture toughness data are extracted from deeply-cracked
laboratory specimens that produce the lowest margin of toughness
values. Therefore, the current framework can be overly conservative
(or include non-uniform inaccuracies) for ECA of modern pipelines
that undergo LSY and ductile crack growth prior to failure. The two
main goals of this thesis are: (i) Development of an alternative
crack driving force estimation scheme, (ii) Justification of the
use of use of shallow-cracked single edge notch tensile (SENT)
specimens for the ECA. Strain concentration in concrete coated
pipelines, and effect of Lüders plateau on the fracture response
are also investigated. A new reference strain J-estimation scheme
is proposed and calibrated to 300 nonlinear parametric FE models,
which takes advantage of the linear evolution of the J with LSY
bending strains. The scheme is hence strain-based and needless of
limit load solutions, providing additional accuracy and robustness.
The near-tip stress and strain fields of cracked pipelines were
also investigated and compared to those obtained from a K-T type
formulation. It is shown that the J-Q constraint theory can
satisfactorily characterize these fields up to extreme plastic
bending levels. Similar J-Q trajectories were also observed in the
SENT and pipeline models. Subsequently, FE models utilizing a
voided plasticity material were used to parametrically investigate
ductile crack growth and subsequent failure of pipelines subject to
a biaxial stress state. Plastic strain and stress triaxiality
fields ahead of the propagating crack, along with R-curves, were
compared among SENT and pipeline models. It is concluded that the
SENT specimen could be a viable option for ECA of such pipes based
on the observed crack tip constraint similarity.
Advisors/Committee Members: Dr. Kamran Nikbin (external-examiner), Dr. Margaret Walsh (graduate-coordinator), Dr. Tamunoiyala Koko (thesis-reader), Dr. Jiunn-Ming Chuang (thesis-reader), Dr. Farid Taheri (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Pipelines; Fracture Mechanics; Crack Tip Constraint; Large Scale Yielding; Strain Concentration; Lüders Plateau
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nourpanah, N. (2011). Integrity and Fracture Response of Offshore Pipelines
Subject to Large Plastic Strains. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13299
Chicago Manual of Style (16th Edition):
Nourpanah, Nikzad. “Integrity and Fracture Response of Offshore Pipelines
Subject to Large Plastic Strains.” 2011. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13299.
MLA Handbook (7th Edition):
Nourpanah, Nikzad. “Integrity and Fracture Response of Offshore Pipelines
Subject to Large Plastic Strains.” 2011. Web. 04 Mar 2021.
Vancouver:
Nourpanah N. Integrity and Fracture Response of Offshore Pipelines
Subject to Large Plastic Strains. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13299.
Council of Science Editors:
Nourpanah N. Integrity and Fracture Response of Offshore Pipelines
Subject to Large Plastic Strains. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13299

Dalhousie University
19.
Braubach, Oliver Robert.
Development, Organization and Plasticity of the Zebrafish
Olfactory System.
Degree: PhD, Department of Physiology & Biophysics with
Neuroscience, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/13342
► Olfaction is vitally important to animals in all environments and is used to identify food, habitat, conspecifics and predators. Some odors, like pheromones or the…
(more)
▼ Olfaction is vitally important to animals in all
environments and is used to identify food, habitat, conspecifics
and predators. Some odors, like pheromones or the pungent smell of
spoiled foods, can trigger pre-existing behavioral responses that
appear to require no learning. Most odors, however, are only
attended to as a result of prior experience. It is believed that
different types of odors are processed in different olfactory
pathways in the forebrain. This thesis examines the relationship
between innate and learned olfactory behaviors and the anatomy of
the neural pathways that underlie them, using the zebrafish
olfactory system as a model. I first characterized an appetitive
olfactory behavior, which is displayed promptly by zebrafish when
they encounter amino acid odors. A similar appetitive behavior can
also be learned by the fish for another, initially neutral odorant,
if it is repeatedly paired with food rewards. Zebrafish can
therefore respond to, and learn to respond to certain odors. I then
conducted an in-depth anatomical analysis of the structure and
distribution of glomeruli in the zebrafish olfactory system.
Glomeruli are spheroidal synaptic aggregates that organize and
shape olfactory information that arrives in the brain. Throughout
the development of zebrafish, I identified two distinct populations
of glomeruli. One population consisted of 25 individually
identifiable, anatomically stereotypic glomeruli that closely
resembled specialized glomeruli in mammals and insects. These
glomeruli were already formed during embryonic development and
persisted in remarkably stable configurations throughout later
developmental stages. I hypothesize that the 25 individually
identifiable glomeruli constitute stable olfactory pathways (i.e.,
for innate olfactory behaviors). Most glomeruli, however, were
anatomically variable and displayed different distributions within
coarsely circumscribed regions in the zebrafish olfactory bulbs.
The development of these glomeruli could be modified by sensory
experience, suggesting that they may comprise plastic olfactory
pathways that subserve the establishment of learned olfactory
behaviors. Collectively my results show that innate and learned
olfactory behaviors may indeed be represented in different
olfactory pathways, and that these types of pathways may be located
in both main and accessory olfactory systems.
Advisors/Committee Members: Dr. Thomas Finger (external-examiner), Dr. Elizabeth Cowley (graduate-coordinator), Dr. Frank Smith (thesis-reader), Dr. Richard Brown (thesis-reader), Dr. Roger Croll, Dr. Alan Fine (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: In vivo; neuroscience; sensory system; zebrafish; anatomy;
transgenic; plasticity; development; olfaction
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Braubach, O. R. (2011). Development, Organization and Plasticity of the Zebrafish
Olfactory System. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13342
Chicago Manual of Style (16th Edition):
Braubach, Oliver Robert. “Development, Organization and Plasticity of the Zebrafish
Olfactory System.” 2011. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13342.
MLA Handbook (7th Edition):
Braubach, Oliver Robert. “Development, Organization and Plasticity of the Zebrafish
Olfactory System.” 2011. Web. 04 Mar 2021.
Vancouver:
Braubach OR. Development, Organization and Plasticity of the Zebrafish
Olfactory System. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13342.
Council of Science Editors:
Braubach OR. Development, Organization and Plasticity of the Zebrafish
Olfactory System. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13342

Dalhousie University
20.
Gilbert, Chad S.
The Biological and Demographic Factors Determining Popultion
Connectivity in Sea Scallops (Placopecten magellanicus) on Georges
Bank.
Degree: MS, Department of Engineering Mathematics, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/13426
► The Georges Bank (GB) scallop (Placopecten magellanicus) population is an economically valuable fishery in Canada and the US. The roles of biological factors such as…
(more)
▼ The Georges Bank (GB) scallop (Placopecten
magellanicus) population is an economically valuable fishery in
Canada and the US. The roles of biological factors such as larval
swimming behaviour, development rates and spawning season and of
demographic factors such as adult distribution and larval mortality
in determining population connectivity in scallops on GB are
currently unknown. In this thesis, a new particle-tracking model is
developed and used to simulate larval dispersal in realistic 3D
currents. It highlights the influences of biological and
demographic factors, and quantifies their effects on larval
dispersal and population connectivity. Larval depth-distribution
and adult distribution are found to have significant impacts, and
further, it is suggested that the previously overlooked spring
spawning event may contribute significantly to population
connectivity. These results are used to help prioritize future
field, lab and modelling work that is requisite to understanding
the connectivity in this metapopulation.
Advisors/Committee Members: Claudio DiBacco (external-examiner), Guy Kember (graduate-coordinator), Wendy C Gentleman (thesis-reader), Gordon A Fenton (thesis-reader), Wendy Gentleman (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Subject Not Available
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gilbert, C. S. (2011). The Biological and Demographic Factors Determining Popultion
Connectivity in Sea Scallops (Placopecten magellanicus) on Georges
Bank. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13426
Chicago Manual of Style (16th Edition):
Gilbert, Chad S. “The Biological and Demographic Factors Determining Popultion
Connectivity in Sea Scallops (Placopecten magellanicus) on Georges
Bank.” 2011. Masters Thesis, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13426.
MLA Handbook (7th Edition):
Gilbert, Chad S. “The Biological and Demographic Factors Determining Popultion
Connectivity in Sea Scallops (Placopecten magellanicus) on Georges
Bank.” 2011. Web. 04 Mar 2021.
Vancouver:
Gilbert CS. The Biological and Demographic Factors Determining Popultion
Connectivity in Sea Scallops (Placopecten magellanicus) on Georges
Bank. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13426.
Council of Science Editors:
Gilbert CS. The Biological and Demographic Factors Determining Popultion
Connectivity in Sea Scallops (Placopecten magellanicus) on Georges
Bank. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13426

Dalhousie University
21.
Zemlak, Tyler Stephen.
THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER
DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID
FISHES.
Degree: PhD, Department of Biology, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/13790
► Using GIS-based tools and a review of the relevant geological and climatic literature, I attempt to identify the key implications of Quaternary glacial cycles for…
(more)
▼ Using GIS-based tools and a review of the relevant
geological and climatic literature, I attempt to identify the key
implications of Quaternary glacial cycles for drainage evolution in
eastern Patagonia. In doing so, the stage is set for the proper
integration of existing biogeographic and phylogeographic ideas to
develop a suite of inferences aimed at elucidating how these
processes influenced aquatic biodiversity of Patagonian Argentina.
A primary finding of this research is that the southern mainland
and/or Tierra del Fuego served as an important cryptic refuge for
cold-adapted species, including aquatic taxa. At least one
additional aquatic refuge is likely to have existed in either
central or northern Patagonia. The low position of the Atlantic
shoreline during glacial periods also revealed a much larger and
inter-connected drainage network in southern Patagonia. During
sea-levels stands below 100m, two new drainage coalescence points
on the exposed continental shelf can be recognized among the
Chico/Santa Cruz, Coyle and Gallegos river basins and between the
Grande and Fuego rivers. Enhanced hydrological discharge during the
deglaciation period of Late-Quaternary cycles is expected to have
facilitated extensive inter-drainage connections within each of the
northern and southern regions of eastern Patagonia via proglacial
lake and/or stream coalescence. A large proglacial lake in the
Nahuel Huapi Lake region is also recognized as the most likely
temporary gateway for aquatic organisms to disperse between the
Neuquen and Northern Patagonian Tablelands. I also recognize
climate-induced drainage reversals as a bidirectional mechanism of
trans-Andean dispersal and an important factor in determining the
biogeography of widespread aquatic organisms in
Patagonia.
Advisors/Committee Members: Steven Lougheed (external-examiner), Patricia Lane (graduate-coordinator), Paul Bentzen (thesis-reader), Daniel Ruzzante & Sandra Walde (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Phylogeography; Patagonia; Freshwater; Fishes; Quaternary; Pleistocene Glaciation; Andes; Galaxias
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zemlak, T. S. (2011). THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER
DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID
FISHES. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13790
Chicago Manual of Style (16th Edition):
Zemlak, Tyler Stephen. “THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER
DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID
FISHES.” 2011. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13790.
MLA Handbook (7th Edition):
Zemlak, Tyler Stephen. “THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER
DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID
FISHES.” 2011. Web. 04 Mar 2021.
Vancouver:
Zemlak TS. THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER
DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID
FISHES. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13790.
Council of Science Editors:
Zemlak TS. THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER
DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID
FISHES. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13790

Dalhousie University
22.
Gawryluk, Ryan.
Comparative Proteomics: Studies on the Composition and
Evolution of the Mitochondrial Proteome in Eukaryotic Microbes
(Protists).
Degree: PhD, Department of Biochemistry & Molecular
Biology, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/14078
► Mitochondria are eukaryotic organelles derived in evolution from within the ? subdivision of Proteobacteria. Although mitochondria are structurally and metabolically complex, modern-day mitochondrial genomes (mtDNA)…
(more)
▼ Mitochondria are eukaryotic organelles derived in
evolution from within the ? subdivision of Proteobacteria. Although
mitochondria are structurally and metabolically complex, modern-day
mitochondrial genomes (mtDNA) encode only a small number of RNAs
and proteins predominantly involved in adenosine triphosphate (ATP)
formation through electron transport coupled to oxidative
phosphorylation, as well as translation of mtDNA-encoded proteins.
In humans, only 13 of the >1000 polypeptides that constitute the
complete mitochondrial protein complement (proteome) are encoded in
mtDNA; the remainder is encoded by nuclear DNA (nuDNA). It is
therefore imperative to comprehensively catalog nuDNA-encoded
mitochondrial proteins in order to understand holistically the
evolution of mitochondria. Mitochondrial proteome investigations of
animals, fungi and land plants have dramatically altered our
conception of mitochondrial evolution: in contrast to mtDNA-encoded
proteins, few nuDNA-encoded mitochondrial proteins are demonstrably
derived from the eubacterial progenitor of mitochondria, and many
are found only in eukaryotes. Notably, however, little is known
about the mitochondria of eukaryotic microbes (protists), which
constitute the bulk of biochemical and genetic diversity within the
domain Eucarya. The proteomic characterization of protist
mitochondria is therefore crucial to fully elucidating
mitochondrial function and evolution. Employing tandem mass
spectrometry (MS/MS), I have analyzed highly purified mitochondria
from Acanthamoeba castellanii (Amoebozoa). In combination, nearly
750 nuDNA- and mtDNA-encoded proteins were identified. These data
were used to catalog metabolic pathways and protein complexes, and
to infer functional and evolutionary profiles of A. castellanii
mitochondria. My analyses suggest that while A. castellanii
mitochondria have many features in common with other eukaryotes,
they possess several novel attributes and pronounced metabolic
versatility. An analysis of the A. castellanii electron transport
chain (ETC) was also performed, utilizing a combination of blue
native polyacrylamide gel electrophoresis (BN-PAGE), MS/MS and
bioinformatic queries. A significant proportion of A. castellanii
ETC proteins was identified, yielding several insights into ETC
evolution in eukaryotes. Lastly, I present two unusual cases of
‘split’ mitochondrial proteins: the iron-sulfur subunit SdhB of
succinate:ubiquinone oxidoreductase (Complex II), in the phylum
Euglenozoa and Cox1 of cytochrome c:O2 oxidoreductase (Complex IV)
in various eukaryotes, including A. castellanii. Functional and
evolutionary implications of these findings are
discussed.
Advisors/Committee Members: Bernard Lemire (external-examiner), Richard Singer (graduate-coordinator), John Archibald (thesis-reader), Jan Rainey (thesis-reader), Andrew Roger (thesis-reader), Michael W. Gray (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: mitochondria; evolution; proteomics; electron transport chain; protist
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gawryluk, R. (2011). Comparative Proteomics: Studies on the Composition and
Evolution of the Mitochondrial Proteome in Eukaryotic Microbes
(Protists). (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14078
Chicago Manual of Style (16th Edition):
Gawryluk, Ryan. “Comparative Proteomics: Studies on the Composition and
Evolution of the Mitochondrial Proteome in Eukaryotic Microbes
(Protists).” 2011. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/14078.
MLA Handbook (7th Edition):
Gawryluk, Ryan. “Comparative Proteomics: Studies on the Composition and
Evolution of the Mitochondrial Proteome in Eukaryotic Microbes
(Protists).” 2011. Web. 04 Mar 2021.
Vancouver:
Gawryluk R. Comparative Proteomics: Studies on the Composition and
Evolution of the Mitochondrial Proteome in Eukaryotic Microbes
(Protists). [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/14078.
Council of Science Editors:
Gawryluk R. Comparative Proteomics: Studies on the Composition and
Evolution of the Mitochondrial Proteome in Eukaryotic Microbes
(Protists). [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14078

Dalhousie University
23.
MacDonald, Mark.
X-ray Spectroscopic Studies of Gold-thiolate
Nanoclusters.
Degree: MS, Department of Chemistry, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/13980
► Structural characterization of nanomaterials represents one of the largest challenges in modern nanoscience. Recent advances in the synthesis and crystallography of gold-thiolate nanoclusters have led…
(more)
▼ Structural characterization of nanomaterials
represents one of the largest challenges in modern nanoscience.
Recent advances in the synthesis and crystallography of
gold-thiolate nanoclusters have led to enormous progress in
understanding the properties of these materials, however, many
questions still exist about how the structure and bonding of these
nanoclusters vary with cluster size, composition and material
phase. The precisely defined size and composition of gold-thiolate
nanoclusters offers a great opportunity to systematically
illustrate the structure and bonding of these materials from an
atomic-site-specific perspective. Towards this end, X-ray
absorption and photoemission spectroscopies were employed in the
study of compositionally precise gold-thiolate nanoclusters. First,
a high-precision, site-specific illustration of the bonding in a
144 Au atom nanocluster is presented. Following this, a comparison
of the structure of a 38 Au atom nanocluster in the solid state and
solution-phase is presented and discussed in terms of local
structural and electronic effects. Finally, the structural changes
experienced by a 25 Au atom nanocluster in response to temperature
and solvation are observed from a site-specific perspective. In
addition, size-specific bonding trends for these clusters are
presented from both the sulfur and gold perspectives. This work
represents the first X-ray absorption spectroscopy study of
compositionally precise gold-thiolate nanomaterials. These studies
help to develop a thorough picture of the bonding properties of
gold thiolate nanoclusters, and have potential implications for the
development and application of gold-thiolate
nanomaterials.
Advisors/Committee Members: Dr. Josef Zwanziger (external-examiner), Dr. Jean Burnell (graduate-coordinator), Dr. Mary Anne White (thesis-reader), Dr. Norm Schepp (thesis-reader), Dr. Peng Zhang (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Subject Not Available
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
MacDonald, M. (2011). X-ray Spectroscopic Studies of Gold-thiolate
Nanoclusters. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13980
Chicago Manual of Style (16th Edition):
MacDonald, Mark. “X-ray Spectroscopic Studies of Gold-thiolate
Nanoclusters.” 2011. Masters Thesis, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13980.
MLA Handbook (7th Edition):
MacDonald, Mark. “X-ray Spectroscopic Studies of Gold-thiolate
Nanoclusters.” 2011. Web. 04 Mar 2021.
Vancouver:
MacDonald M. X-ray Spectroscopic Studies of Gold-thiolate
Nanoclusters. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13980.
Council of Science Editors:
MacDonald M. X-ray Spectroscopic Studies of Gold-thiolate
Nanoclusters. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13980

Dalhousie University
24.
van Donkelaar, Aaron.
AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE
ANALYZED WITH A GLOBAL MODEL.
Degree: PhD, Department of Physics & Atmospheric
Science, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/13990
► We interpret satellite, aircraft, and ground-based measurements using the GEOS-Chem Chemical Transport Model (CTM) to better understand the global transport and distribution of fine aerosol…
(more)
▼ We interpret satellite, aircraft, and ground-based
measurements using the GEOS-Chem Chemical Transport Model (CTM) to
better understand the global transport and distribution of fine
aerosol (PM2.5). Using satellite retrievals of Aerosol Optical
Depth (AOD) from the Moderate Resolution Imaging Spectroradiometer
(MODIS) and the Multiangle Imaging Spectroradiometer (MISR), we
estimate an annual growth in Chinese sulfur emissions of 6.2-9.6%
between 2000-2006, in agreement with bottom-up inventories. Using
aircraft measurements from the Intercontinental Chemical Transport
Experiment (INTEX-B) with a CTM, we calculate that 56% of measured
sulfate between 500-900 hPa over British Columbia is due to East
Asian sources. We find evidence of a 72-85% increase in the
relative contribution of East Asian sulfate to the total burden in
spring off the northwest coast of the United States since 1985. We
interpret retrievals AOD from MODIS and MISR using GEOS-Chem to
estimate global long-term (2001-2006) mean PM2.5 concentrations at
a resolution of 0.1° x 0.1°. Evaluation of the satellite-derived
estimate with ground-based in-situ measurements indicates
significant spatial agreement with North American measurements (r =
0.77, slope = 1.07, n = 1057) and with non-coincident measurements
elsewhere (r = 0.83, slope = 0.86, n = 244). The one standard
deviation uncertainty in the satellite-derived PM2.5 is 25%,
inferred from the AOD retrieval and aerosol vertical profiles
errors and sampling. The global population-weighted mean
uncertainty is 6.7 µg/m3. We find a global population-weighted
geometric mean PM2.5 concentration of 20 ?g/m3. The World Health
Organization Air Quality PM2.5 Interim Target-1 (35 µg/m3 annual
average) is exceeded over central and eastern Asia for 38% and 50%
of the population, respectively. Annual mean PM2.5 concentrations
exceed 80 µg/m3 over Eastern China. We test the capability of
remotely-sensed PM2.5 to capture extreme short-term events by
examining the major biomass burning event around Moscow in summer
2010. We find good agreement (r2=0.85, slope=1.06) between daily
estimates of PM2.5 from in-situ and satellite-derived sources in
the Moscow region during the fires. Both satellite-derived and
in-situ values have peak daily mean concentrations of approximately
600 ?g/m3 on August 7, 2010 in the Moscow region.
Advisors/Committee Members: Sundar Christopher (external-examiner), Randall Martin (graduate-coordinator), Jeff Pierce (thesis-reader), Glen Lesins (thesis-reader), Randall Martin (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Aerosol; PM2.5; MODIS; Remote Sensing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
van Donkelaar, A. (2011). AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE
ANALYZED WITH A GLOBAL MODEL. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13990
Chicago Manual of Style (16th Edition):
van Donkelaar, Aaron. “AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE
ANALYZED WITH A GLOBAL MODEL.” 2011. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/13990.
MLA Handbook (7th Edition):
van Donkelaar, Aaron. “AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE
ANALYZED WITH A GLOBAL MODEL.” 2011. Web. 04 Mar 2021.
Vancouver:
van Donkelaar A. AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE
ANALYZED WITH A GLOBAL MODEL. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/13990.
Council of Science Editors:
van Donkelaar A. AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE
ANALYZED WITH A GLOBAL MODEL. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13990

Dalhousie University
25.
Dawson, Paul WH.
Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy.
Degree: MS, Department of Microbiology &
Immunology, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/14156
► Hepatitis B virus (HBV) is a significant global threat to human health due to its ability to cause chronic infections that can lead to hepatocellular…
(more)
▼ Hepatitis B virus (HBV) is a significant global threat
to human health due to its ability to cause chronic infections that
can lead to hepatocellular carcinoma (HCC). While the process by
which HBV increases the risk of HCC is unclear, evidence suggests
that the hepatitis B X protein (HBx) may be a contributing factor.
Cellular senescence is an important barrier to tumorigenesis,
blocking the proliferation of cells that harbor excessive DNA
damage or contain activated oncogenes. Autophagy is a
non-proteasomal degradative pathway used by cells to recycle
cytoplasmic contents under periods of nutrient starvation. This
pathway is induced in response to a wide range of cellular stress
factors, and has also been characterized as an effector mechanism
for the establishment of cellular senescence. In this study,
retroviral transduction of HepG2 cells with HBx resulted in the
induction of cellular senescence and autophagy. The mechanism by
which HBx can induce senescence is unclear. However, an increase in
the accumulation of DNA damage was observed. HBx did not modulate
the levels of the anti-apoptotic proteins Bcl-2, Bcl-xL, or Mcl-1,
which can inhibit autophagy through interactions with the autophagy
regulator Beclin 1. As well, the activity and phosphorylation
status of JNK/SAPK, an inducer of autophagy via Bcl-2
phosphorylation, was unchanged. These results suggest that
senescence may act as a barrier to HBx-induced oncogenesis, and may
offer some explanation as to why HBx does not function as a more
potent oncogene. Also, we propose that HBx modulates autophagy
through a mechanism other than Bcl-2 phosphorylation or expression
over the time course of this study.
Advisors/Committee Members: John Rohde (external-examiner), Rafael Garduno (graduate-coordinator), Craig McCormick (thesis-reader), Roy Duncan (thesis-reader), Chris Richardson (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Hepatitis B; Autophagy; Cellular Senescence; HBx
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dawson, P. W. (2011). Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14156
Chicago Manual of Style (16th Edition):
Dawson, Paul WH. “Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy.” 2011. Masters Thesis, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/14156.
MLA Handbook (7th Edition):
Dawson, Paul WH. “Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy.” 2011. Web. 04 Mar 2021.
Vancouver:
Dawson PW. Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/14156.
Council of Science Editors:
Dawson PW. Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14156

Dalhousie University
26.
Pellerin, Brian.
Modelling Biennial Bearing in Apple Trees.
Degree: MS, Nova Scotia Agricultural College, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/14275
► Many commercially grown apple cultivars have a biennial cropping habit, producing many small fruit in one year and few or none in the following year.…
(more)
▼ Many commercially grown apple cultivars have a
biennial cropping habit, producing many small fruit in one year and
few or none in the following year. The production of fruits is
known to inhibit flower initiation for the following year. This
undesirable trait is frequently managed by removing (thinning) some
flowers or young fruit in years of heavy flowering which improves
the size of remaining fruits, but does not reliably improve
flowering in the following year. The effect of thinning on flower
initiation is not well understood. Two mathematical models are
developed describing the relationship between flowering in one year
and the next. The first models the effects of thinning on return
bloom and attempts to define maximum repeatable flower number. The
second models how proximity of growing points may impact biennial
bearing and maximum annual flower number. This second model may be
useful to advance research into biennial bearing in
apple.
Advisors/Committee Members: Dr. Gaetan Bourgeois (external-examiner), Dr. Dian Patterson (graduate-coordinator), Dr. Deborah Buszard, Dr. Charlie Embree (thesis-reader), Drs. Deborah Buszard, Kris Pruski (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Mathematical modelling; optimization; maximum annual
flower bud number
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pellerin, B. (2011). Modelling Biennial Bearing in Apple Trees. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14275
Chicago Manual of Style (16th Edition):
Pellerin, Brian. “Modelling Biennial Bearing in Apple Trees.” 2011. Masters Thesis, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/14275.
MLA Handbook (7th Edition):
Pellerin, Brian. “Modelling Biennial Bearing in Apple Trees.” 2011. Web. 04 Mar 2021.
Vancouver:
Pellerin B. Modelling Biennial Bearing in Apple Trees. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/14275.
Council of Science Editors:
Pellerin B. Modelling Biennial Bearing in Apple Trees. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14275

Dalhousie University
27.
Gillis, Joseph Daniel.
Monitoring Organic Contaminant Concentrations and Carbon
Mineralization in Field Soils Receiving Alkaline-Stabilized
Biosolids.
Degree: MS, Nova Scotia Agricultural College, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/14188
► The application of municipal sewage biosolids to agricultural land is a common practice worldwide. Increasing attention is being directed at the presence of organic contaminants…
(more)
▼ The application of municipal sewage biosolids to
agricultural land is a common practice worldwide. Increasing
attention is being directed at the presence of organic contaminants
bound to the organic phase during wastewater treatment, which end
up in the biosolids. The goal of this study was to investigate the
decomposition of an alkaline-stabilized biosolid being used as an
agricultural soil amendment containing unknown organic
contaminants. A two year field trial and a 120 day laboratory soil
incubation using increasing rates (0, 7, 14, 28, and 42 Mg ha-1) of
an alkaline-stabilized biosolid (ASB) were set up to monitor
biosolid decomposition and concentrations of selected contaminants
over time. The seven contaminants selected for monitoring
(p-cresol, indole, 4-t-octylphenol, phenanthrene, triclosan,
carbamazepine, and benzo[a]pyrene) represent a wide range of
physico-chemical properties and fall under several different
chemical classes. The decomposition of ASB in soil was examined in
the incubation study. Almost half of the CO2-C evolved from ASB
amended soils occurred within the first 6 days, indicating that a
relatively labile pool of carbon remains in ASB following the
sewage treatment process. By day 121, between 71 to 78% of the
total carbon added to soil had been evolved as CO2-C. A new model
developed during this study to describe carbon mineralization, a
first order plus logistic function (FLOG), performed better than
other commonly used models. The method chosen to analyze organic
contaminants in soil was only able to determine four out of seven
compounds reliably, with recoveries greater than 50% for
4-t-octylphenol, phenanthrene, triclosan, and benzo[a]pyrene. In
treated soils, only triclosan was able to be detected and
quantified. Average triclosan concentration in the incubation study
ranged from a high of 143 ng g-1 on day 3 to a low of 26 ng g-1 by
day 121, representing an 81% decrease over a roughly 4 month period
under idealized conditions. In the field, triclosan concentrations
following a Fall biosolids application in Oct. 2008 increased to
detectable levels (29 to 47 ng g-1) in all three plots measured in
Nov. 2008, which remained elevated (29 to 66 ng g-1) over the
winter period in two out of three plots when sampled in May 2009.
Following the Spring application in June 2009, measured triclosan
concentrations in July 2009 samples from these same two plots were
lower than predicted (33 to 48 ng g-1) and eventually decreased to
levels below the detection limit by the Oct. 2009
sampling.
Advisors/Committee Members: Shiv O. Prasher (external-examiner), Heather Hughes (graduate-coordinator), Glenn W. Stratton (thesis-reader), Gordon W. Price, David L. Burton (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: biosolid; sewage sludge; carbon mineralization; modelling; triclosan
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gillis, J. D. (2011). Monitoring Organic Contaminant Concentrations and Carbon
Mineralization in Field Soils Receiving Alkaline-Stabilized
Biosolids. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14188
Chicago Manual of Style (16th Edition):
Gillis, Joseph Daniel. “Monitoring Organic Contaminant Concentrations and Carbon
Mineralization in Field Soils Receiving Alkaline-Stabilized
Biosolids.” 2011. Masters Thesis, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/14188.
MLA Handbook (7th Edition):
Gillis, Joseph Daniel. “Monitoring Organic Contaminant Concentrations and Carbon
Mineralization in Field Soils Receiving Alkaline-Stabilized
Biosolids.” 2011. Web. 04 Mar 2021.
Vancouver:
Gillis JD. Monitoring Organic Contaminant Concentrations and Carbon
Mineralization in Field Soils Receiving Alkaline-Stabilized
Biosolids. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/14188.
Council of Science Editors:
Gillis JD. Monitoring Organic Contaminant Concentrations and Carbon
Mineralization in Field Soils Receiving Alkaline-Stabilized
Biosolids. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14188

Dalhousie University
28.
Wright, Lisa Dawn.
Stress responding in periadolescent rats exposed to cat
odour and long-term outcomes for stress-related aspects of the
adult phenotype.
Degree: PhD, Department of Psychology with Neuroscience, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/14190
► Prior work has shown important effects of the early life environment on development of adult stress response systems in both rats and humans. The present…
(more)
▼ Prior work has shown important effects of the early
life environment on development of adult stress response systems in
both rats and humans. The present thesis is based on experiments
that attempt to explore: 1) adolescent stress responding at
hormonal and behavioural levels, and 2) the effects of repeated
adolescent stressor exposure on adult stress responding (hormonal
and behavioural) and levels of dopamine receptors expressed in
prefrontal cortex, using both male and female rats. Defensive
behaviours exhibited during stressor exposure and post-stress
levels of circulating corticosterone were quantified as behavioural
and hormonal measures of stress responding, respectively. In the
first study, responses were compared among groups of adolescent
rats exposed repeatedly to one of two different types of cat odour
stressor stimuli (J-cloth coated in hair/dander or cat collar
previously worn by a cat) or control stimuli, and long-term
outcomes were examined in adulthood. Adolescent rats showed
behavioural responses to both stressor stimuli, but behavioural
inhibition was more consistent using repeated cat collar exposure,
and this treatment resulted in long-term increases in anxiety-like
behaviour in adulthood, whereas a stress-induced adolescent
corticosterone elevation was observed only in the group that
received exposure to the J-cloth stimuli. In the second study,
adolescent and adult rats were compared directly using repeated
exposure to the cat collar stressor or control stimuli. Adolescents
were found to be more sensitive to the effects of the stressor
stimuli, relative to adults. Finally, in the third study, repeated
exposure to the J-cloth stressor or control stimuli was used, and
stressor-exposed females showed elevated baseline corticosterone
levels prior to the final exposure. Furthermore, stressor-exposed
males and females showed lower levels of the D2 dopamine receptor
in infralimbic and dorsopeduncular cortices of the prefrontal
cortex in adulthood. In addition, these studies together provide
evidence that sex differences in corticosterone levels emerge
during the adolescent period. It may be concluded that adolescence
should be considered a sensitive developmental timeframe for stress
response programming.
Advisors/Committee Members: Dr. Cheryl McCormick (external-examiner), Dr. Tracy Taylor-Helmick (graduate-coordinator), Dr. Richard Brown (thesis-reader), Dr. Younes Anini (thesis-reader), Dr. Tara Perrot (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: rat; adolescence; stress responding; defensive behaviour; corticosterone; dopamine receptors; prefrontal cortex
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❌
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Chicago ·
MLA ·
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APA (6th Edition):
Wright, L. D. (2011). Stress responding in periadolescent rats exposed to cat
odour and long-term outcomes for stress-related aspects of the
adult phenotype. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14190
Chicago Manual of Style (16th Edition):
Wright, Lisa Dawn. “Stress responding in periadolescent rats exposed to cat
odour and long-term outcomes for stress-related aspects of the
adult phenotype.” 2011. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/14190.
MLA Handbook (7th Edition):
Wright, Lisa Dawn. “Stress responding in periadolescent rats exposed to cat
odour and long-term outcomes for stress-related aspects of the
adult phenotype.” 2011. Web. 04 Mar 2021.
Vancouver:
Wright LD. Stress responding in periadolescent rats exposed to cat
odour and long-term outcomes for stress-related aspects of the
adult phenotype. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/14190.
Council of Science Editors:
Wright LD. Stress responding in periadolescent rats exposed to cat
odour and long-term outcomes for stress-related aspects of the
adult phenotype. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14190

Dalhousie University
29.
Ernst, Matthew.
CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS.
Degree: PhD, Department of Pharmacology, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/14305
► Obesity, characterized by an excess of adipose tissue, is an established risk factor for cardiovascular disease and type II diabetes. Different mechanisms linking obesity with…
(more)
▼ Obesity, characterized by an excess of adipose tissue,
is an established risk factor for cardiovascular disease and type
II diabetes. Different mechanisms linking obesity with these
comorbidities have been postulated but remain poorly understood.
Adipose tissue secretes bioactive signaling molecules, termed
adipokines, which regulate various biological functions including
appetite, energy balance, glucose homeostasis, and inflammation.
Chemerin is a novel adipokine that regulates adipocyte
differentiation and metabolism by binding to and activating the G
protein-coupled receptor chemokine like receptor-1 (CMKLR1).
Herein, we have shown that serum levels of the novel adipokine
chemerin are significantly elevated in mouse models of
obesity/diabetes. Administration of exogenous chemerin exacerbates
glucose intolerance, lowers serum insulin levels, and decreases
tissue glucose uptake in obese/diabetic but not normoglycemic mice.
In CMKLR1-deficient mice food consumption, total body mass, and
percent body fat are lower compared to wildtype controls,
regardless of diet (low or high fat). CMKLR1-/- mice also exhibited
decreased hepatic and white adipose tissue TNF? and IL-6 mRNA
levels coincident with decreased hepatic dendritic cell
infiltration, decreased adipose CD3+ T cells and increased adipose
natural killer cells. CMKLR1-/- mice were also glucose intolerant
compared to wildtype mice, and this was associated with decreased
glucose stimulated insulin secretion as well as decreased skeletal
muscle and white adipose tissue glucose uptake. Collectively, these
data provide compelling evidence that chemerin/CMKLR1 signaling
influences adipose tissue development, inflammation, and glucose
homeostasis and may contribute to the metabolic derangements
characteristic of obesity and obesity-related
diseases.
Advisors/Committee Members: Dr. David Dyck (external-examiner), Dr. Jana Sawynok (graduate-coordinator), Dr. Eileen Denova-Wright (thesis-reader), Dr. Tom Ransom (thesis-reader), Dr. Christopher Sinal (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Chemerin; Adipokine; Obesity; Diabetes; Glucose tolerance; insulin resistance
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ernst, M. (2011). CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14305
Chicago Manual of Style (16th Edition):
Ernst, Matthew. “CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS.” 2011. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/14305.
MLA Handbook (7th Edition):
Ernst, Matthew. “CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS.” 2011. Web. 04 Mar 2021.
Vancouver:
Ernst M. CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/14305.
Council of Science Editors:
Ernst M. CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14305

Dalhousie University
30.
Meisner, Jason George.
POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN:
MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.
Degree: PhD, Department of Anatomy & Neurobiolgy with
Neuroscience, 2012, Dalhousie University
URL: http://hdl.handle.net/10222/14411
► Neuropathic pain is a significant and frequent outcome of spinal cord injury (SCI), and is often refractory to treatment. A better understanding of the pathological…
(more)
▼ Neuropathic pain is a significant and frequent outcome
of spinal cord injury (SCI), and is often refractory to treatment.
A better understanding of the pathological processes following
injury that contribute to the development of neuropathic pain will
aid the search for novel therapeutics. In the second chapter of
this thesis a murine model of post-SCI below-lesion neuropathic
pain was utilized to investigate changes in GABAergic tone. The
gad1:GFP transgenic mouse line allowed the study of a subpopulation
of GFPlabeled GABAergic neurons under control of the GABA
synthesizing glutamate decarboxylase enzyme. SCI was observed to
result in a loss of GABAergic neurons, and secondary markers of
GABAergic tone supported this observation. This finding suggests
that GABAergic interneuron cell death accounts for the decreased
GABAergic tone previously reported post-SCI. In the third chapter
of this thesis it was attempted to prevent the death of GABAergic
neurons post-SCI using a transgenic mouse line expressing increased
levels of the X-linked inhibitor of apoptosis (XIAP) under the
ubiquitin C promoter. No differences were observed between ubXIAP
and wildtype mice, indicating that increased expression of XIAP is
not sufficient to prevent the development of neuropathic pain post-
SCI. The fourth chapter of this thesis attempted to prevent the
development of neuropathic pain through a novel treatment schedule
of the drug pregabalin. Pregabalin administered shortly after SCI
prevented the development of neuropathic pain. Pregabalin initiated
1 week post-SCI had no effect. Early pregabalin treatment did not
appear to dramatically alter glial activation, or expression of the
pregabalin receptor, but we observed changes in markers associated
with synaptic plasticity. My findings build upon our knowledge of
the mechanisms underlying post-SCI below-lesion neuropathic pain,
and suggest new avenues of research, such as the uses of preemptive
treatment with pregabalin, that offer promise for translation to
clinical use.
Advisors/Committee Members: Claire Hulsebosch (external-examiner), Kazue Semba (graduate-coordinator), William Baldridge (thesis-reader), Ronald Leslie (thesis-reader), Stefan Kruger (thesis-reader), Daniel Marsh (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: SPINAL CORD INJURY; PAIN; GABA; PREGABALIN
Record Details
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Share »
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Meisner, J. G. (2012). POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN:
MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14411
Chicago Manual of Style (16th Edition):
Meisner, Jason George. “POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN:
MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.” 2012. Doctoral Dissertation, Dalhousie University. Accessed March 04, 2021.
http://hdl.handle.net/10222/14411.
MLA Handbook (7th Edition):
Meisner, Jason George. “POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN:
MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.” 2012. Web. 04 Mar 2021.
Vancouver:
Meisner JG. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN:
MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. [Internet] [Doctoral dissertation]. Dalhousie University; 2012. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10222/14411.
Council of Science Editors:
Meisner JG. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN:
MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. [Doctoral Dissertation]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/14411
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