+publisher:"Dalhousie University" +contributor:("Yes")

Dalhousie University

1. Velásquez, Marcelo. A Comparative Study of the Environmental Impact of Online and Offline Movie Rental Businesses.

Degree: Master of Electronic Commerce, Faculty of Computer Science, 2010, Dalhousie University

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This thesis contains two papers, recently presented at international conferences and accepted for publication in recognized journals.

The purpose of this thesis is to assess… (more)

Subjects/Keywords: E-Commerce; Carbon Footprinting; Eco-Efficacy; Eco-Efficiency; Energy Consumption; Innovation; Supply Chain Management; and Sustainability

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APA (6^th Edition):

Velásquez, M. (2010). A Comparative Study of the Environmental Impact of Online and Offline Movie Rental Businesses. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12737

Chicago Manual of Style (16^th Edition):

Velásquez, Marcelo. “A Comparative Study of the Environmental Impact of Online and Offline Movie Rental Businesses.” 2010. Masters Thesis, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/12737.

MLA Handbook (7^th Edition):

Velásquez, Marcelo. “A Comparative Study of the Environmental Impact of Online and Offline Movie Rental Businesses.” 2010. Web. 18 Feb 2020.

Vancouver:

Velásquez M. A Comparative Study of the Environmental Impact of Online and Offline Movie Rental Businesses. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/12737.

Council of Science Editors:

Velásquez M. A Comparative Study of the Environmental Impact of Online and Offline Movie Rental Businesses. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12737

Dalhousie University

2. Li, Depeng. GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC NETWORKS.

Degree: PhD, Faculty of Computer Science, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/12766

► In dynamic peer group communications, security has been in high demand by many applications in recent years. One of the more popular mechanisms to satisfy… (more)

▼ In dynamic peer group communications, security has been in high demand by many applications in recent years. One of the more popular mechanisms to satisfy these security requirements is the group key scheme in which the group key is to be shared by each group communication participant. However, how to establish and manage the group key efficiently in order to protect such communications imposes new challenges - especially when such schemes are to be deployed on resource-limited networks such as Mobile Ad hoc Networks (MANETs). The basic needs of such network settings require that the group key schemes must demonstrate not only high performance but also fault-tolerance. Furthermore, to encrypt group communication messages efficiently is essential. Therefore, it is anticipated that the contributions of this thesis will address the development of lightweight and high performance key management protocols for group communications while guaranteeing the same level of security as other approaches. These contributions are listed below: First, two efficient individual rekey schemes, in which most group members process one-way hash functions and other members perform Diffie-Hellman operations, are proposed to obtain performance efficiency. Second, a periodic batch rekey scheme is proposed to handle the out-of-sync problem resulting from individual rekeying schemes in cases where there is a high rate of group member requests for joining/leaving. Third, scalable maximum matching algorithms (M2) are designed to incorporate a tree-based group key generation scheme to forward the partial keys to other group members. Fourth, a hybrid group key management architecture is proposed as well to combine the advantages of centralized and contributory group key schemes. Fifth, a Fast Encryption Algorithm for Multimedia (FEA-M) is enhanced to overcome the vulnerabilities of its original solution and its former improved variant. Performance analyses and experimental results indicate that the proposed approaches reduce computational costs and communication overhead as compared to other popular protocols. Advisors/Committee Members: Dr. Guang Gong (external-examiner), Dr. Vlado Keselj (graduate-coordinator), Dr. Keith Johnson (thesis-reader), Dr. Nur Zincir-Heywood (thesis-reader), Dr. Srinivas Sampalli (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: contributory group communication; group key agreement; applied cryptography; wireless network communication; security technology

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APA (6^th Edition):

Li, D. (2010). GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC NETWORKS. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12766

Chicago Manual of Style (16^th Edition):

Li, Depeng. “GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC NETWORKS.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/12766.

MLA Handbook (7^th Edition):

Li, Depeng. “GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC NETWORKS.” 2010. Web. 18 Feb 2020.

Vancouver:

Li D. GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC NETWORKS. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/12766.

Council of Science Editors:

Li D. GROUP KEY SCHEMES FOR SECURITY IN MOBILE AD HOC NETWORKS. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12766

Dalhousie University

3. Hutchinson, Paula S. Predictors of Better Health Outcomes of Mothers of Children with Autistic Spectrum Disorder.

Degree: PhD, Interdisciplinary PhD Programme, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/12793

► Caring for children with autism place mothers at high risk for poor health outcomes and compromises the health of all family members (e.g., Bristol, 1987;… (more)

▼ Caring for children with autism place mothers at high risk for poor health outcomes and compromises the health of all family members (e.g., Bristol, 1987; Hastings et al., 2005a). Although poor outcomes prevail, some mothers do well despite their caregiving challenges. While ample research exists on mothers’ supports and stress, virtually nothing is known about their strengths. Emerging research suggests that parental self-efficacy and empowerment may contribute to better outcomes in mothers of children with autism. The purpose of the present study was to identify predictors of better outcomes in mothers of children with autism. Relationships among child disruptive behaviour, supports, self-efficacy, empowerment, maternal distress and positive perceptions of parenting were examined using a postal survey design. Mothers (N = 114) of school-age children with autism provided demographic information and completed various scales (i.e., the Developmental Behaviour Checklist, Family Support, Difficult Behaviour Self-Efficacy, Family Empowerment, Hospital Anxiety and Depression, Positive Contribution). Overall, 35% of the variance was explained in maternal distress (i.e., anxiety and depression). After accounting for mothers’ age and child disruptive behaviour, support and empowerment were subsumed by parental self-efficacy in predicting lower levels of maternal distress. Collectively, 17% of the variance was explained in mothers’ positive perceptions of parenting. Self-efficacy partially mediated the moderate effect of disruptive behaviour on mothers’ distress and fully mediated the small effect of disruptive behaviour on mothers’ positive perceptions of parenting. Thus, parental self-efficacy for managing children’s difficult behaviour is very promising for preserving mothers’ health. While discussion focuses on outstanding issues to be addressed, the findings suggest that tailoring formal services to enhance parental efficacy, rather than providing support and consultation services alone, would be more in line with mothers’ needs and possibly improve both children’s and families’ outcomes. Advisors/Committee Members: Dr. Richard Hastings (external-examiner), Dr. Marina Pluzhenskaya (graduate-coordinator), Dr. Penny Corkum, Dr. Isabel Smith, Dr. Jerry Singleton (thesis-reader), Dr. Susan Bryson (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Autism; Mothers; Children; Self-efficacy; Empowerment; Support; Positive Perceptions of Parenting

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APA (6^th Edition):

Hutchinson, P. S. (2010). Predictors of Better Health Outcomes of Mothers of Children with Autistic Spectrum Disorder. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12793

Chicago Manual of Style (16^th Edition):

Hutchinson, Paula S. “Predictors of Better Health Outcomes of Mothers of Children with Autistic Spectrum Disorder.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/12793.

MLA Handbook (7^th Edition):

Hutchinson, Paula S. “Predictors of Better Health Outcomes of Mothers of Children with Autistic Spectrum Disorder.” 2010. Web. 18 Feb 2020.

Vancouver:

Hutchinson PS. Predictors of Better Health Outcomes of Mothers of Children with Autistic Spectrum Disorder. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/12793.

Council of Science Editors:

Hutchinson PS. Predictors of Better Health Outcomes of Mothers of Children with Autistic Spectrum Disorder. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12793

Dalhousie University

4. Xu, Chao Qiang. Localization of Near-Surface Anomalies Using Seismic Rayleigh Waves.

Degree: PhD, Department of Mining & Metallurgical Engineering, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/12812

► The presence of subsurface anomalies, such as cavities, faults, unknown tunnels, etc., either natural or man-made, can cause public safety hazards. The detection of these… (more)

▼ The presence of subsurface anomalies, such as cavities, faults, unknown tunnels, etc., either natural or man-made, can cause public safety hazards. The detection of these features requires the development of new methods. Seismic Rayleigh surface wave imaging is a relatively new non-destructive testing technique (NDT) which generates subsurface images without drilling boreholes into the ground, and in recent years has been widely used for soil characterization in geotechnical investigations. In the last decade, some researchers have applied the technique to near-surface imaging and showed the possibility and potential for engineering applications. This research presents the development of a technique to process seismic Rayleigh waves to detect and image subsurface anomalies. This study conducted investigations of Rayleigh wave behaviors and developed a new strategy for Rayleigh wave isolation from raw field data. The strategy applies wavelet transforms, instead of the conventional spectral analysis of surface waves (SASW) method, or popular multichannel analysis of surface waves (MASW) techniques, to pair-channel analysis of the isolated Rayleigh wave data for dispersion calculation. Finally, a simple steady inversion technique was applied to yield shear velocity as a function of both depth and distance, and shear velocity field images (SVF), for near surface section display. This research consists of development, computer programming, field tests, data processing and interpretation. Three sites in different scenarios were used for seismic investigations: old mining tunnels in medium dipping coal seams in Stellarton coalfield, mining cavities in steeply dipping gold-bearing veins in West Waverley Gold District and an anomaly in nearly horizontal strata in Liverpool. All these sites are in the province of Nova Scotia, Canada. The results from seismic surface wave technique introduced in this research can be evaluated by field observations, documents and borehole logs. The satisfactory interpretations and success of this investigation shows that this technique is suitable for engineering application for subsurface investigations. Advisors/Committee Members: Giovanni Cascante (external-examiner), Margaret Walsh (graduate-coordinator), Craig Lake, Patrick Ryall, Stephen Butt (thesis-reader), Stephen Butt (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Rayleigh wave; cavity; wavelet transform

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APA (6^th Edition):

Xu, C. Q. (2010). Localization of Near-Surface Anomalies Using Seismic Rayleigh Waves. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12812

Chicago Manual of Style (16^th Edition):

Xu, Chao Qiang. “Localization of Near-Surface Anomalies Using Seismic Rayleigh Waves.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/12812.

MLA Handbook (7^th Edition):

Xu, Chao Qiang. “Localization of Near-Surface Anomalies Using Seismic Rayleigh Waves.” 2010. Web. 18 Feb 2020.

Vancouver:

Xu CQ. Localization of Near-Surface Anomalies Using Seismic Rayleigh Waves. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/12812.

Council of Science Editors:

Xu CQ. Localization of Near-Surface Anomalies Using Seismic Rayleigh Waves. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12812

Dalhousie University

5. Beaton, Stephen A. Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases.

Degree: MS, Department of Chemistry, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/12815

► The study of many of glycosyltransferases is limited due to an inadequate access to sugar nucleotides. Preparation of sugar nucleotides through the use of nucleotidylyltransferases… (more)

Subjects/Keywords: Nucleotidylyltransferases; organic synthesis; enzymes; sugar nucleotides

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APA (6^th Edition):

Beaton, S. A. (2010). Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12815

Chicago Manual of Style (16^th Edition):

Beaton, Stephen A. “Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases.” 2010. Masters Thesis, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/12815.

MLA Handbook (7^th Edition):

Beaton, Stephen A. “Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases.” 2010. Web. 18 Feb 2020.

Vancouver:

Beaton SA. Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/12815.

Council of Science Editors:

Beaton SA. Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12815

Dalhousie University

6. Pelletier, Nathaniel L. WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL LIVESTOCK PRODUCTION.

Degree: PhD, Interdisciplinary PhD Programme, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/12821

► Achieving environmental s¬ustainability in human organization is the defining challenge of the modern era. In light of the inability of the existing economic paradigm to… (more)

▼ Achieving environmental s¬ustainability in human organization is the defining challenge of the modern era. In light of the inability of the existing economic paradigm to provide for sustainability objectives, novel approaches to understanding and managing economic activities are required. Towards this end, the emergent field of ecological economics provides an alternative paradigm that expressly prioritizes the development of the theory and tools necessary to operationalize environmental sustainability in economic activity, which is viewed as prerequisite to sustainability in any other sphere. Here, I advance an internally consistent framework for understanding and implementing the core ecological economic sustainability criteria: appropriate scale relative to biocapacity; distributive justice; and efficient allocation. This framework includes: (1) an ecological communitarian conception of distributive justice which recognizes environmental sustainability as the first principle of distributive justice; (2) the rationale for biophysically-consistent ecological economic modeling of human activities as a basis for environmentally-enlightened policy and management; and (3) an appeal for scale-oriented environmental governance as could potentially be operationalized by a strong, centralized World Environment Organization. I further apply this framework to evaluating the current and future status of livestock production systems at regional and global scales with respect to efficiency considerations as well as their relationships to sustainability boundary conditions for human activities as a whole. It is suggested that the current and projected scale of the livestock sector is fundamentally unsustainable, and that all leverage points must be exploited to rein in this sector in the interest of preventing irreversible ecological change. This must include, but cannot be limited to, strong eco-efficiency measures and changes in production technologies, species substitutions, and consumption patterns and volumes. Outcomes are interpreted in terms of their implications for environmental policy and governance oriented towards the sustainability objective. Advisors/Committee Members: Dr. Steven Young (external-examiner), Dr. Marina Pluzhenskaya (graduate-coordinator), Dr. Richard Apostle (thesis-reader), Dr. David VanderZwaag (thesis-reader), Dr. Peter Tyedmers (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: ecological economics; sustainability; environmental governance; environmental ethics; life cycle assessment; livestock

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APA (6^th Edition):

Pelletier, N. L. (2010). WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL LIVESTOCK PRODUCTION. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12821

Chicago Manual of Style (16^th Edition):

Pelletier, Nathaniel L. “WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL LIVESTOCK PRODUCTION.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/12821.

MLA Handbook (7^th Edition):

Pelletier, Nathaniel L. “WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL LIVESTOCK PRODUCTION.” 2010. Web. 18 Feb 2020.

Vancouver:

Pelletier NL. WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL LIVESTOCK PRODUCTION. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/12821.

Council of Science Editors:

Pelletier NL. WHAT’S AT STEAK? ECOLOGICAL ECONOMIC SUSTAINABILITY AND THE ETHICAL, ENVIRONMENTAL, AND POLICY IMPLICATIONS FOR GLOBAL LIVESTOCK PRODUCTION. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12821

Dalhousie University

7. Grover, Vaneeta Kaur. An Examination of Hardy-Weinberg Disequilibrium and Statistical Testing in Genetic Association Studies.

Degree: PhD, Department of Mathematics & Statistics - Statistics Division, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/12845

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Departure from HWE (HWD) in a sample may indicate genotyping error, population stratification, selection bias, or some combination thereof. Therefore, loci exhibiting HWD are often… (more)

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Departure from HWE (HWD) in a sample may indicate genotyping error, population stratification, selection bias, or some combination thereof. Therefore, loci exhibiting HWD are often excluded from association studies. However, it has been shown that in case-control studies HWD can result from a genetic effect at the locus, and HWD at a marker locus can be interpreted as evidence for association with a disease. In an unpublished study in Toronto it was observed that cases were in Hardy- Weinberg equilibrium at a locus whereas their family members were in HWD. It has been shown that the HWD coefficient for a multiplicative genetic model is zero. This led to an investigation of relatives of affected individuals to see whether the multiplicative model could be revealed by a nonzero HWD coefficient in relatives. Genotypic frequencies and HWD coefficients were derived for affected individuals and their affected and unaffected relatives. A substantial HWD was found in both individuals in dominant and recessive genetic models but HWD is only slightly nonzero for additive and multiplicative models. Methods were also developed to test for association using data from affected individuals and their relatives. Parameter estimates for these models can be obtained using maximum likelihood methods, and estimates provide valuable information regarding the mode of inheritance of the disease. The methods were applied to 112 discordant sib pairs with Alzheimer’s disease typed for the ApoE polymorphism and a significant association was observed between the "4 ApoE allele and Alzheimer’s disease. Case-control studies may indicate spurious association with a marker locus in a stratified population. Methods were developed to determine if the HWD observed in a data set from a stratified population can be explained by both genetic association and stratification. Parameter estimates for these models can be obtained using maximum likelihood methods, and used to deduce the mode of inheritance of the disease. Applying the model to the R990G SNP of the CASR gene, it was found that the HWD was adequately explained by a recessive genetic association and a stratification proportion of 10%, consistent with the population of Toronto.

In an unpublished study in Toronto it was observed that cases were in Hardy-Weinberg Equilibrium at a locus whereas their family members were in Hardy-Weinberg Disequilibrium (HWD). This led to an investigation of relatives of affected individuals to see whether the multiplicative model could be revealed by a nonzero HWD coefficient in relatives. Genotypic frequencies and HWD coefficients were derived for affected individuals and their affected and unaffected relatives. Methods were also developed to test for association using data from affected individuals and their relatives. In addition, a model was developed to assess whether the HWD observed in a data set from a stratified population can be explained by both genetic association and stratification. Parameter estimates for these models can be obtained using maximum…

Advisors/Committee Members: Dr. J Concepcin Loredo-Osti (external-examiner), Dr. Ed Susko (graduate-coordinator), Dr. Chris Field (thesis-reader), Dr. Bruce Smith (thesis-reader), Dr. David Hamilton (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Hardy-Weinberg equilibrium; Stratification; Relative pairs; discordant pairs; association studies; likelihood

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APA (6^th Edition):

Grover, V. K. (2010). An Examination of Hardy-Weinberg Disequilibrium and Statistical Testing in Genetic Association Studies. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12845

Chicago Manual of Style (16^th Edition):

Grover, Vaneeta Kaur. “An Examination of Hardy-Weinberg Disequilibrium and Statistical Testing in Genetic Association Studies.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/12845.

MLA Handbook (7^th Edition):

Grover, Vaneeta Kaur. “An Examination of Hardy-Weinberg Disequilibrium and Statistical Testing in Genetic Association Studies.” 2010. Web. 18 Feb 2020.

Vancouver:

Grover VK. An Examination of Hardy-Weinberg Disequilibrium and Statistical Testing in Genetic Association Studies. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/12845.

Council of Science Editors:

Grover VK. An Examination of Hardy-Weinberg Disequilibrium and Statistical Testing in Genetic Association Studies. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12845

Dalhousie University

8. Landry, Karen. An Analysis of Time-Loss Duration Following Work-Related Traumatic Injuries to the Hand and Wrist.

Degree: MS, School of Physiotherapy, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/12877

► Objective: The purposes of this thesis included: i) To explore the annual incidence and time-loss duration of traumatic, work-related injuries of four nature-of-injury (fractures, nerve… (more)

▼ Objective: The purposes of this thesis included: i) To explore the annual incidence and time-loss duration of traumatic, work-related injuries of four nature-of-injury (fractures, nerve lacerations, tendon lacerations/disruptions and amputations) and two part-of-body categories (hand and wrist); and ii) To identify the incidence and time-loss duration, and examine explanatory variables that were associated with time-loss duration for subjects with hand fractures. Methodology: Data on incidence, time-loss duration and explanatory variables were reviewed on claims accepted between January – December 2006 at WorkSafe-New Brunswick. Descriptive statistics and non-parametric tests were used to explore incidence and time-loss duration. Using a biopsychosocial framework, explanatory variables associated with time-loss duration were analyzed using Cox Proportional Hazards regression. Results: The incidence for hand and wrist trauma involving fractures, tendon lacerations/disruptions and amputations was low (3%). Incidence was significantly higher for fractures and for injuries to the hand, while time-loss duration was significantly higher for the wrist (p< .05). The incidence rate of hand fractures was low (1.5%) and average time-loss duration was high (92 days). Increased time-loss duration was associated with greater medical aid costs (used as a proxy for injury severity) older age and increased receipt of therapy (Physiotherapy/Occupational Therapy). Conclusions: The annual incidence of specific injuries involving the hand and wrist is challenging to compare to the literature since incidence is presented in many ways. Time-loss duration following hand and wrist injuries is highly variable. Time-loss duration for hand fractures exceeded reports in the literature and predicted values reported in disability duration guidelines. Consideration of the impairment, personal and environmental factors is warranted to provide a framework to the return-to-work process for all stakeholders involved in the care of the hand- and wrist-injured worker. Advisors/Committee Members: - (external-examiner), Dr. Marie Earl (graduate-coordinator), Dr. Cheryl Hubley-Kozey, Dr. Brenda Merritt (thesis-reader), Dr. Anne Fenety (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Hand injuries; wrist injuries; disability duration; return-to-work; workplace trauma

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APA (6^th Edition):

Landry, K. (2010). An Analysis of Time-Loss Duration Following Work-Related Traumatic Injuries to the Hand and Wrist. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12877

Chicago Manual of Style (16^th Edition):

Landry, Karen. “An Analysis of Time-Loss Duration Following Work-Related Traumatic Injuries to the Hand and Wrist.” 2010. Masters Thesis, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/12877.

MLA Handbook (7^th Edition):

Landry, Karen. “An Analysis of Time-Loss Duration Following Work-Related Traumatic Injuries to the Hand and Wrist.” 2010. Web. 18 Feb 2020.

Vancouver:

Landry K. An Analysis of Time-Loss Duration Following Work-Related Traumatic Injuries to the Hand and Wrist. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/12877.

Council of Science Editors:

Landry K. An Analysis of Time-Loss Duration Following Work-Related Traumatic Injuries to the Hand and Wrist. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12877

Dalhousie University

9. Lin, Yuehua. Circulation and Associated Variability in the Intra-Americas Sea: the Role of Loop Current Intrusion and Caribbean Eddies.

Degree: PhD, Department of Oceanography, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/12996

► Circulation and associated variability in the Intra-Americas Sea (IAS) are examined using observations and numerical models. Vertically integrated transport variations through the Yucatan Channel in… (more)

▼ Circulation and associated variability in the Intra-Americas Sea (IAS) are examined using observations and numerical models. Vertically integrated transport variations through the Yucatan Channel in the model are found to be related to the intrusion of the Loop Current into the Gulf of Mexico. We argue that the transport variations are part of a “compensation effect” by which transport variations through the Yucatan Channel are at least partly compensated by flow around Cuba. Numerical experiments show that the transport variations result from the interaction between the density anomalies associated with the Loop Current intrusion and the variable bottom topography. The compensation effect is found to be associated with baroclinic (2-layer) flow through the Yucatan Channel at timescales longer than a month, while at shorter timescales (less than a month) the vertical structure of the flow is barotropic. An index, that can be computed from satellite data, is proposed for measuring the impact of the Loop Current intrusion on the transport variability through the Yucatan Channel. This index is shown to be significantly correlated at low frequencies (cutoff 120 days) with the cable estimates of transport between Florida and the Bahamas. We argue that it is the geometric connectivity between the Yucatan Channel and the Straits of Florida between Florida and the Bahamas that accounts for the relationship. A three-dimensional, data-assimilative, ocean circulation model is developed in order to simulate circulation, hydrography and associated variability in the IAS from 1999 to 2002. The model performance is assessed by comparing model results with various observations made in the IAS during this period. Model results are used to study the role played by Caribbean eddies in the dynamics of monthly to seasonal (with timescales of 30-120 days) circulation variability in the IAS. It is shown that the variations in vertically integrated transport between Nicaragua and Jamaica are linked to the interaction of Caribbean eddies with the Nicaraguan Rise. The mechanism can be explained in terms of the form drag effect acting across the Nicaraguan Rise. Advisors/Committee Members: Lars Petter Røed (external-examiner), Dan Kelly (graduate-coordinator), Youyu Lu, Kumiko Azetsu-Scott (thesis-reader), Jinyu Sheng, Richard Greatbatch (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Intra-Americas Sea; Loop Current Intrusion; Caribbean Eddy; Circulation Variability

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APA (6^th Edition):

Lin, Y. (2010). Circulation and Associated Variability in the Intra-Americas Sea: the Role of Loop Current Intrusion and Caribbean Eddies. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12996

Chicago Manual of Style (16^th Edition):

Lin, Yuehua. “Circulation and Associated Variability in the Intra-Americas Sea: the Role of Loop Current Intrusion and Caribbean Eddies.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/12996.

MLA Handbook (7^th Edition):

Lin, Yuehua. “Circulation and Associated Variability in the Intra-Americas Sea: the Role of Loop Current Intrusion and Caribbean Eddies.” 2010. Web. 18 Feb 2020.

Vancouver:

Lin Y. Circulation and Associated Variability in the Intra-Americas Sea: the Role of Loop Current Intrusion and Caribbean Eddies. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/12996.

Council of Science Editors:

Lin Y. Circulation and Associated Variability in the Intra-Americas Sea: the Role of Loop Current Intrusion and Caribbean Eddies. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12996

Dalhousie University

10. MacDonald, William. GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN.

Degree: PhD, Department of Biology, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/13023

► Genomic imprinting is an epigenetic phenomenon whereby the expression of a gene, chromosomal region, or entire chromosome, depends on the sex of the transmitting parent.… (more)

Subjects/Keywords: Drosophila; Imprinting; Epigenetics

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APA (6^th Edition):

MacDonald, W. (2010). GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13023

Chicago Manual of Style (16^th Edition):

MacDonald, William. “GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13023.

MLA Handbook (7^th Edition):

MacDonald, William. “GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN.” 2010. Web. 18 Feb 2020.

Vancouver:

MacDonald W. GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13023.

Council of Science Editors:

MacDonald W. GENOMIC IMPRINTING IN Drosophila melanogaster: EPIGENETIC REGULATION OF THE Dp(1;f)LJ9 IMPRINTED DOMAIN. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13023

Dalhousie University

11. Briand, Julie. EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS.

Degree: Master of Applied Science, Department of Civil Engineering, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/13037

► The early detection of damage of in-service structural or mechanical systems is of vital importance. With early detection, the damage may be repaired before the… (more)

Subjects/Keywords: Vibration-based damage detection; structural health monitoring; piezoceramic sensors; bolted pipeline joint; empirical mode decomposition

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APA (6^th Edition):

Briand, J. (2010). EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13037

Chicago Manual of Style (16^th Edition):

Briand, Julie. “EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS.” 2010. Masters Thesis, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13037.

MLA Handbook (7^th Edition):

Briand, Julie. “EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS.” 2010. Web. 18 Feb 2020.

Vancouver:

Briand J. EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13037.

Council of Science Editors:

Briand J. EXPERIMENTAL VALIDATION OF A NOVEL STRUCTURAL HEALTH MONITORING STRATEGY FOR BOLTED PIPELINE JOINTS. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13037

Dalhousie University

12. McEachern, Lori A. INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1 TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER.

Degree: PhD, Department of Biology, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/13036

► Transgenic organisms are a valuable tool for studying epigenetics, as they provide significant insight into the evolutionary conservation of epigenetic control sequences, the interacting proteins,… (more)

▼ Transgenic organisms are a valuable tool for studying epigenetics, as they provide significant insight into the evolutionary conservation of epigenetic control sequences, the interacting proteins, and the underlying molecular mechanisms. Paramutation is an epigenetic phenomenon in which the epigenetic status and expression level of one allele is heritably altered after pairing with another. At the b1 locus in maize, a control region consisting of seven 853 bp tandem repeats is required for paramutation. To study the conservation of the epigenetic mechanisms underlying maize b1 paramutation, I created transgenic Drosophila carrying the maize b1 control region flanked by FRT sites and adjacent to the Drosophila white reporter gene. The maize b1 tandem repeats caused epigenetic silencing in Drosophila, as white expression consistently increased following repeat removal. A single copy of the tandem repeat sequence was sufficient to cause silencing, and silencing strength increased as the number of repeats increased. Trans interactions, such as pairing-sensitive silencing, were also observed and appear to require a threshold number of b1 tandem repeats, similar to paramutation in maize. Analysis of transcription from the repeats showed that the b1 tandem repeats are transcribed from both strands in Drosophila, as they are in maize. Bidirectional transcription was found to extend to the regions flanking the repeats, and persisted in “repeats-out” transgenes following repeat removal. However, aberrant transcription was lost when a zero-repeat transgene was moved to a new genomic position, suggesting that it may be due to an epigenetic mark that is retained from the previous silenced state. A search for modifiers of b1 repeat-mediated silencing demonstrated that Polycomb group proteins are involved. Together, these results indicate considerable conservation of an epigenetic silencing process between the plant and animal kingdoms. Genomic imprinting is a related epigenetic process in which parent-specific epigenetic states are inherited and maintained in progeny. The conservation of epigenetic mechanisms was further explored via an in-depth review of the molecular mechanisms underlying genomic imprinting in plants, mammals and insects, and identification of potentially imprinted genes in Drosophila by microarray analysis. Advisors/Committee Members: Dr. Lori Wallrath (external-examiner), Dr. Hal Whitehead (graduate-coordinator), Dr. Bill Pohajdak (thesis-reader), Dr. Ian Meinertzhagen (thesis-reader), Dr. Vett Lloyd (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Epigenetics; Drosophila melanogaster; Paramutation; Tandem repeats; Transcription; Silencing; Genomic imprinting

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APA (6^th Edition):

McEachern, L. A. (2010). INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1 TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13036

Chicago Manual of Style (16^th Edition):

McEachern, Lori A. “INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1 TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13036.

MLA Handbook (7^th Edition):

McEachern, Lori A. “INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1 TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER.” 2010. Web. 18 Feb 2020.

Vancouver:

McEachern LA. INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1 TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13036.

Council of Science Editors:

McEachern LA. INTER-KINGDOM EPIGENETICS: CHARACTERIZATION OF MAIZE B1 TANDEM REPEAT-MEDIATED SILENCING IN DROSOPHILA MELANOGASTER. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13036

Dalhousie University

13. Andrew, Melissa Kathryn. Social Vulnerability and Health in Older Adults.

Degree: PhD, Interdisciplinary PhD Programme, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/13102

► Vulnerability to adverse health outcomes can be intrinsic (e.g. illnesses, disability, frailty, genetics) or extrinsic (e.g. physical and social environments). The contribution of social factors… (more)

▼ Vulnerability to adverse health outcomes can be intrinsic (e.g. illnesses, disability, frailty, genetics) or extrinsic (e.g. physical and social environments). The contribution of social factors to extrinsic vulnerability in older adults is the subject of this thesis. Social vulnerability is the degree to which a person’s overall social situation leaves them susceptible to further insults, either health-related or social. This thesis begins with an exploration of how various social factors are associated with health and can be considered to contribute to a holistic concept of social vulnerability. Using a social ecology perspective, seven domains of social vulnerability (engagement, contextual socio-economic status, social support, living situation, self-esteem, mastery, and relations with others) are defined. A social vulnerability index is then developed, in which social factors from all of these domains are combined into a single index, allowing the complexity of social circumstances experienced by older people to be embraced. Social vulnerability, defined using this index, is then studied in relation to health, and is found to be associated with frailty, mortality and cognitive decline. The important impact of social vulnerability on the survival of the fittest older adults (those who are not at all frail) is studied as a special case. How social vulnerability changes over time is then examined using a transitions model based on a parametric Markov chain, with the finding that older people tend to accumulate social deficits over time, but that, importantly, this relentless accumulation of social problems is not a universal experience. The thesis then turns to consideration of frontal lobe cognitive function as a possible mechanism for the association between social vulnerability and health, given the importance of the frontal lobes to social interaction in humans. It finds that the most socially vulnerable people have impaired performance on tests of frontal lobe cognition, but that performance on non-frontal tasks is not similarly associated. The findings presented in this thesis support the importance of social factors for health of older people, and suggest that the social vulnerability index shows potential as a measure which embraces the complexity of older adults’ social circumstances while reducing dimensionality. Advisors/Committee Members: Jean Woo (external-examiner), Marina Pluzhenskaya (graduate-coordinator), Susan Kirkland, Arnold Mitnitski, Janice Keefe (thesis-reader), Kenneth Rockwood (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Heath; older adults; social; frailty; mortality

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APA (6^th Edition):

Andrew, M. K. (2010). Social Vulnerability and Health in Older Adults. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13102

Chicago Manual of Style (16^th Edition):

Andrew, Melissa Kathryn. “Social Vulnerability and Health in Older Adults.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13102.

MLA Handbook (7^th Edition):

Andrew, Melissa Kathryn. “Social Vulnerability and Health in Older Adults.” 2010. Web. 18 Feb 2020.

Vancouver:

Andrew MK. Social Vulnerability and Health in Older Adults. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13102.

Council of Science Editors:

Andrew MK. Social Vulnerability and Health in Older Adults. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13102

Dalhousie University

14. van Hengstum, Peter. Quaternary Sea-Level and Climate Signatures in Phreatic Coastal Caves.

Degree: PhD, Department of Earth Sciences, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/13123

► Underwater (phreatic) caves are a ubiquitous landform on coastal karst terrain, but the marine geological processes operating in these systems are largely unknown. This dissertation… (more)

▼ Underwater (phreatic) caves are a ubiquitous landform on coastal karst terrain, but the marine geological processes operating in these systems are largely unknown. This dissertation redresses the problem by asking if Bermudian phreatic cave sediments archive sea-level and climate information? An important premise is that coastal cave environments are not identical. They can be categorized based on whether they are terrestrially-influenced (anchialine), completely flooded by saline groundwater (submarine), positioned at sea level (littoral) or in the vadose zone (vadose). For the first time the boundary between modern anchialine and submarine cave environments has been distinguished in Green Bay Cave using a multi-proxy approach (benthic foraminifera, sedimentary organic matter content and carbon isotopic composition - ?13Corg, and grain-size analysis). Twelve push cores were extracted from Green Bay Cave and dated with twenty 14C dates, recovering the first underwater cave succession spanning the Holocene (13 ka to present). Green Bay Cave transitioned through all major cave environments during Holocene sea-level rise (vadose, littoral, anchialine, and submarine), providing a sedimentary model for global cave successions. These relationships provide a novel means to solve Quaternary sea-level and climate problems. For sea level, two examples indicate that the littoral cave can be used as a sea-level indicator, distinguished stratigraphically by microfossil or sedimentary proxies. First, the elevation and timing of when Green Bay Cave was a littoral environment indicates Bermuda experienced an abrupt ~6.4 m sea-level rise at 7.7 ka, coinciding with final collapse of the Labrador sector of the Laurentide Ice Sheet. Second, microfossils preserved in elevated caves at +21 m above modern sea level and dated to marine isotope stage 11 (U-series, amino acid racemization) are consistent with modern Bermudian caves and co-stratigraphic sea level. For climate problems, annual temperature monitoring in Walsingham Cave indicates that cave water is thermally comparable to regional oceanographic conditions in the Sargasso Sea. Three sediment cores dated with sixteen radiocarbon dates indicate that Bermuda’s coldest and stormiest conditions of the last 3.2 ka occurred during the Little Ice Age (proxies: ?18Oc, grain size, bulk organic matter). Advisors/Committee Members: Dr. Martin Buzas (external-examiner), Dr. Nicholas Culshaw (graduate-coordinator), Dr. John Gosse, Dr. Martin Gibling, Dr. Grant Wach (thesis-reader), Dr. David B. Scott (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Caves; sea level; foraminifera; anchialine; submarine; North Atlantic Oscillation; Quaternary

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APA (6^th Edition):

van Hengstum, P. (2010). Quaternary Sea-Level and Climate Signatures in Phreatic Coastal Caves. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13123

Chicago Manual of Style (16^th Edition):

van Hengstum, Peter. “Quaternary Sea-Level and Climate Signatures in Phreatic Coastal Caves.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13123.

MLA Handbook (7^th Edition):

van Hengstum, Peter. “Quaternary Sea-Level and Climate Signatures in Phreatic Coastal Caves.” 2010. Web. 18 Feb 2020.

Vancouver:

van Hengstum P. Quaternary Sea-Level and Climate Signatures in Phreatic Coastal Caves. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13123.

Council of Science Editors:

van Hengstum P. Quaternary Sea-Level and Climate Signatures in Phreatic Coastal Caves. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13123

Dalhousie University

15. Kellett, Dawn. Tectonic Evolution of the South Tibetan Detachment System, Bhutan Himalaya.

Degree: PhD, Department of Earth Sciences, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/13153

► Syn-convergent low-angle normal-sense detachments (LANDs) are found in many orogens around the world. However, those tectonic processes which result in their formation are little known.… (more)

▼ Syn-convergent low-angle normal-sense detachments (LANDs) are found in many orogens around the world. However, those tectonic processes which result in their formation are little known. The South Tibetan detachment system (STDS) is the best-studied example worldwide of a syn-convergent LAND, and formed in the Miocene due to the continental collision of India and Asia. In Bhutan, eastern Himalaya, the STDS is duplicated. Here I investigate the tectonic history of the inner STDS and particularly the outer STDS in Bhutan, to determine whether the duplicated STDS can be explained by or used to constrain models of Himalayan orogenesis. A range of geochronometric, thermochronologic, petrologic, structural, thermobarometric, thermometric, and isotopic tools are used to constrain: the onset and cessation of motion on the outer STDS; the cessation of motion on the inner STDS; the peak metamorphic conditions in the hanging wall and footwall of the outer STDS; the pressure-temperature-time paths of tectonites in the hanging wall and footwall of the outer STDS; the structural history of the hanging wall rocks of the outer STDS, and; the paleogeographic affinity of the hanging wall rocks of the outer STDS. The results of these studies are compared to thermo-mechanical models of Himalayan- type continental collision. Similarities in model predictions of the type and timing of structures, peak metamorphic conditions of hanging wall and footwall tectonites, pressure-temperature-time paths, and other regional tectonic observations lead to two main conclusions. 1. The STDS is a system of three main types of LANDs: those that formed during channel flow of low-viscosity mid-crustal rocks, those that formed by extrusion of cooled channel rocks to the surface, and those that formed by destabilization of the upper crust above a dome of mid-crustal channel rocks. 2. The STDS was duplicated by underthrusting of a crustal ramp into the Himalayan orogen since early Miocene. The underthrusting led to extrusion of a dome of weak mid-crustal above a previously-extruded channel. The crustal ramp may be local to the eastern Himalaya due to higher convergence and/or erosion rates, or due to local underthrusting of relatively strong crust behind weaker crust. Advisors/Committee Members: Clark Burchfiel (external-examiner), Nick Culshaw (graduate-coordinator), Rebecca Jamieson (thesis-reader), Isabelle Coutand (thesis-reader), John Gosse (thesis-reader), Djordje Grujic (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Himalaya; Bhutan; geochronology; tectonics; structural geology

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APA (6^th Edition):

Kellett, D. (2010). Tectonic Evolution of the South Tibetan Detachment System, Bhutan Himalaya. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13153

Chicago Manual of Style (16^th Edition):

Kellett, Dawn. “Tectonic Evolution of the South Tibetan Detachment System, Bhutan Himalaya.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13153.

MLA Handbook (7^th Edition):

Kellett, Dawn. “Tectonic Evolution of the South Tibetan Detachment System, Bhutan Himalaya.” 2010. Web. 18 Feb 2020.

Vancouver:

Kellett D. Tectonic Evolution of the South Tibetan Detachment System, Bhutan Himalaya. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13153.

Council of Science Editors:

Kellett D. Tectonic Evolution of the South Tibetan Detachment System, Bhutan Himalaya. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13153

Dalhousie University

16. Edwards, Tara N. GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA MELANOGASTER.

Degree: PhD, Department of Biology, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/13142

► The visual system of the fruit fly is ideal for studying the association between neurons and glia. These interact during the morphogenesis of brain neuropiles… (more)

▼ The visual system of the fruit fly is ideal for studying the association between neurons and glia. These interact during the morphogenesis of brain neuropiles and, in the adult, work together to maintain an ideal environment for neuronal function. In this thesis I characterise the pupal metamorphosis and adult structure of glia in the optic lobe’s lamina and medulla neuropiles. Photoreceptor axons from the fly’s compound eyes terminate at locations within these neuropiles that allow them intimate contact with glia. Some neuropile glia take up and inactivate the neurotransmitter histamine after its release at photoreceptor synapses. A shuttle pathway between the glia and photoreceptors then transports inactivated histamine back to photoreceptors for reuse. The gene CG12120 encodes the protein Tan, which liberates recycled histamine within the photoreceptor cytoplasm, it is then pumped into vesicles for re-release. Histamine, however, is not exclusive to the visual system. A system of glial barriers in the lamina, and around the brain, controls the movement of histamine between neuropiles as well as between the body and the brain. How histamine is reciprocally transported between photoreceptors and glia remains unknown despite attempts to uncover candidate transporters. Photoreceptor-specific capitate projections form as invaginations from neuropile glia into photoreceptor terminals. The transmitter needs of the photoreceptor appear to dictate the dynamic structure of capitate projections, which change in shape and number after perturbations that affect terminal location, synapse number or histamine release at the photoreceptor. This dynamism suggests that capitate projections play an important role, not only in recycling synaptic vesicles, but also in recycling histamine. Advisors/Committee Members: D. Krantz (external-examiner), C. Neville (graduate-coordinator), S.R. Shaw, V.K. Lloyd (thesis-reader), I.A. Meinertzhagen (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Drosophila; glia; vision; histamine; Tan

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APA (6^th Edition):

Edwards, T. N. (2010). GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA MELANOGASTER. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13142

Chicago Manual of Style (16^th Edition):

Edwards, Tara N. “GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA MELANOGASTER.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13142.

MLA Handbook (7^th Edition):

Edwards, Tara N. “GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA MELANOGASTER.” 2010. Web. 18 Feb 2020.

Vancouver:

Edwards TN. GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA MELANOGASTER. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13142.

Council of Science Editors:

Edwards TN. GLIAL DEVELOPMENT, SYNAPTIC PLASTICITY AND NEUROTRANSMITTER RECYCLING IN THE VISUAL SYSTEM OF THE FRUIT FLY DROSOPHILA MELANOGASTER. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13142

Dalhousie University

17. Ferretti, Francesco. THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS OF PREDATOR REMOVAL.

Degree: PhD, Department of Biology, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/13171

► Elasmobranchs are among the oldest and most successful predators in the ocean, yet one of the most vulnerable to the direct and indirect effects of… (more)

▼ Elasmobranchs are among the oldest and most successful predators in the ocean, yet one of the most vulnerable to the direct and indirect effects of fishing. Many populations are rapidly declining around the world, and an increasing number is listed as threatened or endangered. The broader ecosystem consequences of these declines, and whether other marine predators can replace sharks, are open questions. In this thesis, I used a diverse set of data and modeling techniques to analyze long-term changes in elasmobranch populations in the Mediterranean Sea, and the consequences of shark declines on marine ecosystems. Because of its long history of fishing, the Mediterranean offers a unique perspective on the response of marine communities to exploitation over long time scales. Here, I reconstructed the history of elasmobranch exploitation over the past 200 years in pelagic, coastal and demersal communities. Results were combined meta-analytically to derive a general pattern of change for the entire region. Overall, I detected multiple cases of regional species extirpations, a strong correlation between historical intensity of exploitation and the stage of community degradation, and some cases of compensatory species increases. My results suggest that compared to other marine ecosystems worldwide, the Mediterranean Sea might be in an advanced stage of overexploitation. To gain more general conclusions about the patterns and consequences of shark declines in the ocean, I reviewed and reanalyzed documented changes in exploited elasmobranch communities around the world, and synthesized the effects of sharks on their prey and wider communities. This work revealed that sharks are abundant and diverse in little exploited or unexploited marine ecosystems but vulnerable to even light levels of fishing. The decline in large sharks has reduced natural mortality in a range of their prey, contributing to changes in abundance, distribution, and behaviour of marine megafauna that have few other predators. In some cases, this has resulted in cascading changes in prey populations and food-web structure. Overall, my thesis greatly enhanced our knowledge about the critical state of elasmobranchs in the Mediterranean Sea and the consequences of the declines of these important marine predators on marine ecosystems. Advisors/Committee Members: Jeremy Collie (external-examiner), Hal Whitehead (graduate-coordinator), Boris Worm (thesis-reader), Edward Susko (thesis-reader), Heike K. Lotze and Andrew A. Rosenberg (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Elasmobranchs; extinction risk; generalized linear models; historical population trends; meta-analysis; overfishing; predators; top-down control; ecological role; ecosystem; fishing; mesopredator release; predation; risk effects; trophic cascades; sharks; trawl surveys

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APA (6^th Edition):

Ferretti, F. (2010). THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS OF PREDATOR REMOVAL. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13171

Chicago Manual of Style (16^th Edition):

Ferretti, Francesco. “THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS OF PREDATOR REMOVAL.” 2010. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13171.

MLA Handbook (7^th Edition):

Ferretti, Francesco. “THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS OF PREDATOR REMOVAL.” 2010. Web. 18 Feb 2020.

Vancouver:

Ferretti F. THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS OF PREDATOR REMOVAL. [Internet] [Doctoral dissertation]. Dalhousie University; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13171.

Council of Science Editors:

Ferretti F. THE ROLE OF SHARKS IN MARINE ECOSYSTEMS: EVALUATING OVEREXPLOITED MARINE FISH COMMUNITIES TO DETECT LONG-TERM EFFECTS OF PREDATOR REMOVAL. [Doctoral Dissertation]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13171

Dalhousie University

18. Nourpanah, Nikzad. Integrity and Fracture Response of Offshore Pipelines Subject to Large Plastic Strains.

Degree: PhD, Department of Civil Engineering, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/13299

► Steel pipelines are widely used in offshore oil/gas facilities. To achieve economically feasible designs, regulatory codes permit utilization of the pipelines well past their elastic… (more)

▼ Steel pipelines are widely used in offshore oil/gas facilities. To achieve economically feasible designs, regulatory codes permit utilization of the pipelines well past their elastic response limit. This requires thorough integrity check of the pipeline subject to large scale yielding (LSY). Engineering criticality assessments (ECA) are used to justify the integrity of a cracked pipeline against fracture failure. The currently used ECA crack driving force equation was developed for load-controlled components subject to very limited crack-tip plasticity. Moreover, fracture toughness data are extracted from deeply-cracked laboratory specimens that produce the lowest margin of toughness values. Therefore, the current framework can be overly conservative (or include non-uniform inaccuracies) for ECA of modern pipelines that undergo LSY and ductile crack growth prior to failure. The two main goals of this thesis are: (i) Development of an alternative crack driving force estimation scheme, (ii) Justification of the use of use of shallow-cracked single edge notch tensile (SENT) specimens for the ECA. Strain concentration in concrete coated pipelines, and effect of Lüders plateau on the fracture response are also investigated. A new reference strain J-estimation scheme is proposed and calibrated to 300 nonlinear parametric FE models, which takes advantage of the linear evolution of the J with LSY bending strains. The scheme is hence strain-based and needless of limit load solutions, providing additional accuracy and robustness. The near-tip stress and strain fields of cracked pipelines were also investigated and compared to those obtained from a K-T type formulation. It is shown that the J-Q constraint theory can satisfactorily characterize these fields up to extreme plastic bending levels. Similar J-Q trajectories were also observed in the SENT and pipeline models. Subsequently, FE models utilizing a voided plasticity material were used to parametrically investigate ductile crack growth and subsequent failure of pipelines subject to a biaxial stress state. Plastic strain and stress triaxiality fields ahead of the propagating crack, along with R-curves, were compared among SENT and pipeline models. It is concluded that the SENT specimen could be a viable option for ECA of such pipes based on the observed crack tip constraint similarity. Advisors/Committee Members: Dr. Kamran Nikbin (external-examiner), Dr. Margaret Walsh (graduate-coordinator), Dr. Tamunoiyala Koko (thesis-reader), Dr. Jiunn-Ming Chuang (thesis-reader), Dr. Farid Taheri (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Pipelines; Fracture Mechanics; Crack Tip Constraint; Large Scale Yielding; Strain Concentration; Lüders Plateau

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APA (6^th Edition):

Nourpanah, N. (2011). Integrity and Fracture Response of Offshore Pipelines Subject to Large Plastic Strains. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13299

Chicago Manual of Style (16^th Edition):

Nourpanah, Nikzad. “Integrity and Fracture Response of Offshore Pipelines Subject to Large Plastic Strains.” 2011. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13299.

MLA Handbook (7^th Edition):

Nourpanah, Nikzad. “Integrity and Fracture Response of Offshore Pipelines Subject to Large Plastic Strains.” 2011. Web. 18 Feb 2020.

Vancouver:

Nourpanah N. Integrity and Fracture Response of Offshore Pipelines Subject to Large Plastic Strains. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13299.

Council of Science Editors:

Nourpanah N. Integrity and Fracture Response of Offshore Pipelines Subject to Large Plastic Strains. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13299

Dalhousie University

19. Braubach, Oliver Robert. Development, Organization and Plasticity of the Zebrafish Olfactory System.

Degree: PhD, Department of Physiology & Biophysics with Neuroscience, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/13342

► Olfaction is vitally important to animals in all environments and is used to identify food, habitat, conspecifics and predators. Some odors, like pheromones or the… (more)

▼ Olfaction is vitally important to animals in all environments and is used to identify food, habitat, conspecifics and predators. Some odors, like pheromones or the pungent smell of spoiled foods, can trigger pre-existing behavioral responses that appear to require no learning. Most odors, however, are only attended to as a result of prior experience. It is believed that different types of odors are processed in different olfactory pathways in the forebrain. This thesis examines the relationship between innate and learned olfactory behaviors and the anatomy of the neural pathways that underlie them, using the zebrafish olfactory system as a model. I first characterized an appetitive olfactory behavior, which is displayed promptly by zebrafish when they encounter amino acid odors. A similar appetitive behavior can also be learned by the fish for another, initially neutral odorant, if it is repeatedly paired with food rewards. Zebrafish can therefore respond to, and learn to respond to certain odors. I then conducted an in-depth anatomical analysis of the structure and distribution of glomeruli in the zebrafish olfactory system. Glomeruli are spheroidal synaptic aggregates that organize and shape olfactory information that arrives in the brain. Throughout the development of zebrafish, I identified two distinct populations of glomeruli. One population consisted of 25 individually identifiable, anatomically stereotypic glomeruli that closely resembled specialized glomeruli in mammals and insects. These glomeruli were already formed during embryonic development and persisted in remarkably stable configurations throughout later developmental stages. I hypothesize that the 25 individually identifiable glomeruli constitute stable olfactory pathways (i.e., for innate olfactory behaviors). Most glomeruli, however, were anatomically variable and displayed different distributions within coarsely circumscribed regions in the zebrafish olfactory bulbs. The development of these glomeruli could be modified by sensory experience, suggesting that they may comprise plastic olfactory pathways that subserve the establishment of learned olfactory behaviors. Collectively my results show that innate and learned olfactory behaviors may indeed be represented in different olfactory pathways, and that these types of pathways may be located in both main and accessory olfactory systems. Advisors/Committee Members: Dr. Thomas Finger (external-examiner), Dr. Elizabeth Cowley (graduate-coordinator), Dr. Frank Smith (thesis-reader), Dr. Richard Brown (thesis-reader), Dr. Roger Croll, Dr. Alan Fine (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: In vivo; neuroscience; sensory system; zebrafish; anatomy; transgenic; plasticity; development; olfaction

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APA (6^th Edition):

Braubach, O. R. (2011). Development, Organization and Plasticity of the Zebrafish Olfactory System. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13342

Chicago Manual of Style (16^th Edition):

Braubach, Oliver Robert. “Development, Organization and Plasticity of the Zebrafish Olfactory System.” 2011. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13342.

MLA Handbook (7^th Edition):

Braubach, Oliver Robert. “Development, Organization and Plasticity of the Zebrafish Olfactory System.” 2011. Web. 18 Feb 2020.

Vancouver:

Braubach OR. Development, Organization and Plasticity of the Zebrafish Olfactory System. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13342.

Council of Science Editors:

Braubach OR. Development, Organization and Plasticity of the Zebrafish Olfactory System. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13342

Dalhousie University

20. Gilbert, Chad S. The Biological and Demographic Factors Determining Popultion Connectivity in Sea Scallops (Placopecten magellanicus) on Georges Bank.

Degree: MS, Department of Engineering Mathematics, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/13426

► The Georges Bank (GB) scallop (Placopecten magellanicus) population is an economically valuable fishery in Canada and the US. The roles of biological factors such as… (more)

Subjects/Keywords: Subject Not Available

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APA (6^th Edition):

Gilbert, C. S. (2011). The Biological and Demographic Factors Determining Popultion Connectivity in Sea Scallops (Placopecten magellanicus) on Georges Bank. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13426

Chicago Manual of Style (16^th Edition):

Gilbert, Chad S. “The Biological and Demographic Factors Determining Popultion Connectivity in Sea Scallops (Placopecten magellanicus) on Georges Bank.” 2011. Masters Thesis, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13426.

MLA Handbook (7^th Edition):

Gilbert, Chad S. “The Biological and Demographic Factors Determining Popultion Connectivity in Sea Scallops (Placopecten magellanicus) on Georges Bank.” 2011. Web. 18 Feb 2020.

Vancouver:

Gilbert CS. The Biological and Demographic Factors Determining Popultion Connectivity in Sea Scallops (Placopecten magellanicus) on Georges Bank. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13426.

Council of Science Editors:

Gilbert CS. The Biological and Demographic Factors Determining Popultion Connectivity in Sea Scallops (Placopecten magellanicus) on Georges Bank. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13426

Dalhousie University

21. Zemlak, Tyler Stephen. THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID FISHES.

Degree: PhD, Department of Biology, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/13790

► Using GIS-based tools and a review of the relevant geological and climatic literature, I attempt to identify the key implications of Quaternary glacial cycles for… (more)

▼ Using GIS-based tools and a review of the relevant geological and climatic literature, I attempt to identify the key implications of Quaternary glacial cycles for drainage evolution in eastern Patagonia. In doing so, the stage is set for the proper integration of existing biogeographic and phylogeographic ideas to develop a suite of inferences aimed at elucidating how these processes influenced aquatic biodiversity of Patagonian Argentina. A primary finding of this research is that the southern mainland and/or Tierra del Fuego served as an important cryptic refuge for cold-adapted species, including aquatic taxa. At least one additional aquatic refuge is likely to have existed in either central or northern Patagonia. The low position of the Atlantic shoreline during glacial periods also revealed a much larger and inter-connected drainage network in southern Patagonia. During sea-levels stands below 100m, two new drainage coalescence points on the exposed continental shelf can be recognized among the Chico/Santa Cruz, Coyle and Gallegos river basins and between the Grande and Fuego rivers. Enhanced hydrological discharge during the deglaciation period of Late-Quaternary cycles is expected to have facilitated extensive inter-drainage connections within each of the northern and southern regions of eastern Patagonia via proglacial lake and/or stream coalescence. A large proglacial lake in the Nahuel Huapi Lake region is also recognized as the most likely temporary gateway for aquatic organisms to disperse between the Neuquen and Northern Patagonian Tablelands. I also recognize climate-induced drainage reversals as a bidirectional mechanism of trans-Andean dispersal and an important factor in determining the biogeography of widespread aquatic organisms in Patagonia. Advisors/Committee Members: Steven Lougheed (external-examiner), Patricia Lane (graduate-coordinator), Paul Bentzen (thesis-reader), Daniel Ruzzante & Sandra Walde (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Phylogeography; Patagonia; Freshwater; Fishes; Quaternary; Pleistocene Glaciation; Andes; Galaxias

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APA (6^th Edition):

Zemlak, T. S. (2011). THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID FISHES. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13790

Chicago Manual of Style (16^th Edition):

Zemlak, Tyler Stephen. “THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID FISHES.” 2011. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13790.

MLA Handbook (7^th Edition):

Zemlak, Tyler Stephen. “THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID FISHES.” 2011. Web. 18 Feb 2020.

Vancouver:

Zemlak TS. THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID FISHES. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13790.

Council of Science Editors:

Zemlak TS. THE INFLUENCES OF QUATERNARY PROCESSES ON NATIVE FRESHWATER DIVERSITY IN PATAGONIA: MOLECULAR INSIGHTS FROM THE GALAXIID FISHES. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13790

Dalhousie University

22. Gawryluk, Ryan. Comparative Proteomics: Studies on the Composition and Evolution of the Mitochondrial Proteome in Eukaryotic Microbes (Protists).

Degree: PhD, Department of Biochemistry & Molecular Biology, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/14078

► Mitochondria are eukaryotic organelles derived in evolution from within the ? subdivision of Proteobacteria. Although mitochondria are structurally and metabolically complex, modern-day mitochondrial genomes (mtDNA)… (more)

▼ Mitochondria are eukaryotic organelles derived in evolution from within the ? subdivision of Proteobacteria. Although mitochondria are structurally and metabolically complex, modern-day mitochondrial genomes (mtDNA) encode only a small number of RNAs and proteins predominantly involved in adenosine triphosphate (ATP) formation through electron transport coupled to oxidative phosphorylation, as well as translation of mtDNA-encoded proteins. In humans, only 13 of the >1000 polypeptides that constitute the complete mitochondrial protein complement (proteome) are encoded in mtDNA; the remainder is encoded by nuclear DNA (nuDNA). It is therefore imperative to comprehensively catalog nuDNA-encoded mitochondrial proteins in order to understand holistically the evolution of mitochondria. Mitochondrial proteome investigations of animals, fungi and land plants have dramatically altered our conception of mitochondrial evolution: in contrast to mtDNA-encoded proteins, few nuDNA-encoded mitochondrial proteins are demonstrably derived from the eubacterial progenitor of mitochondria, and many are found only in eukaryotes. Notably, however, little is known about the mitochondria of eukaryotic microbes (protists), which constitute the bulk of biochemical and genetic diversity within the domain Eucarya. The proteomic characterization of protist mitochondria is therefore crucial to fully elucidating mitochondrial function and evolution. Employing tandem mass spectrometry (MS/MS), I have analyzed highly purified mitochondria from Acanthamoeba castellanii (Amoebozoa). In combination, nearly 750 nuDNA- and mtDNA-encoded proteins were identified. These data were used to catalog metabolic pathways and protein complexes, and to infer functional and evolutionary profiles of A. castellanii mitochondria. My analyses suggest that while A. castellanii mitochondria have many features in common with other eukaryotes, they possess several novel attributes and pronounced metabolic versatility. An analysis of the A. castellanii electron transport chain (ETC) was also performed, utilizing a combination of blue native polyacrylamide gel electrophoresis (BN-PAGE), MS/MS and bioinformatic queries. A significant proportion of A. castellanii ETC proteins was identified, yielding several insights into ETC evolution in eukaryotes. Lastly, I present two unusual cases of ‘split’ mitochondrial proteins: the iron-sulfur subunit SdhB of succinate:ubiquinone oxidoreductase (Complex II), in the phylum Euglenozoa and Cox1 of cytochrome c:O2 oxidoreductase (Complex IV) in various eukaryotes, including A. castellanii. Functional and evolutionary implications of these findings are discussed. Advisors/Committee Members: Bernard Lemire (external-examiner), Richard Singer (graduate-coordinator), John Archibald (thesis-reader), Jan Rainey (thesis-reader), Andrew Roger (thesis-reader), Michael W. Gray (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: mitochondria; evolution; proteomics; electron transport chain; protist

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APA (6^th Edition):

Gawryluk, R. (2011). Comparative Proteomics: Studies on the Composition and Evolution of the Mitochondrial Proteome in Eukaryotic Microbes (Protists). (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14078

Chicago Manual of Style (16^th Edition):

Gawryluk, Ryan. “Comparative Proteomics: Studies on the Composition and Evolution of the Mitochondrial Proteome in Eukaryotic Microbes (Protists).” 2011. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/14078.

MLA Handbook (7^th Edition):

Gawryluk, Ryan. “Comparative Proteomics: Studies on the Composition and Evolution of the Mitochondrial Proteome in Eukaryotic Microbes (Protists).” 2011. Web. 18 Feb 2020.

Vancouver:

Gawryluk R. Comparative Proteomics: Studies on the Composition and Evolution of the Mitochondrial Proteome in Eukaryotic Microbes (Protists). [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/14078.

Council of Science Editors:

Gawryluk R. Comparative Proteomics: Studies on the Composition and Evolution of the Mitochondrial Proteome in Eukaryotic Microbes (Protists). [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14078

Dalhousie University

23. MacDonald, Mark. X-ray Spectroscopic Studies of Gold-thiolate Nanoclusters.

Degree: MS, Department of Chemistry, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/13980

► Structural characterization of nanomaterials represents one of the largest challenges in modern nanoscience. Recent advances in the synthesis and crystallography of gold-thiolate nanoclusters have led… (more)

Subjects/Keywords: Subject Not Available

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APA (6^th Edition):

MacDonald, M. (2011). X-ray Spectroscopic Studies of Gold-thiolate Nanoclusters. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13980

Chicago Manual of Style (16^th Edition):

MacDonald, Mark. “X-ray Spectroscopic Studies of Gold-thiolate Nanoclusters.” 2011. Masters Thesis, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13980.

MLA Handbook (7^th Edition):

MacDonald, Mark. “X-ray Spectroscopic Studies of Gold-thiolate Nanoclusters.” 2011. Web. 18 Feb 2020.

Vancouver:

MacDonald M. X-ray Spectroscopic Studies of Gold-thiolate Nanoclusters. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13980.

Council of Science Editors:

MacDonald M. X-ray Spectroscopic Studies of Gold-thiolate Nanoclusters. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13980

Dalhousie University

24. van Donkelaar, Aaron. AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE ANALYZED WITH A GLOBAL MODEL.

Degree: PhD, Department of Physics & Atmospheric Science, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/13990

► We interpret satellite, aircraft, and ground-based measurements using the GEOS-Chem Chemical Transport Model (CTM) to better understand the global transport and distribution of fine aerosol… (more)

▼ We interpret satellite, aircraft, and ground-based measurements using the GEOS-Chem Chemical Transport Model (CTM) to better understand the global transport and distribution of fine aerosol (PM2.5). Using satellite retrievals of Aerosol Optical Depth (AOD) from the Moderate Resolution Imaging Spectroradiometer (MODIS) and the Multiangle Imaging Spectroradiometer (MISR), we estimate an annual growth in Chinese sulfur emissions of 6.2-9.6% between 2000-2006, in agreement with bottom-up inventories. Using aircraft measurements from the Intercontinental Chemical Transport Experiment (INTEX-B) with a CTM, we calculate that 56% of measured sulfate between 500-900 hPa over British Columbia is due to East Asian sources. We find evidence of a 72-85% increase in the relative contribution of East Asian sulfate to the total burden in spring off the northwest coast of the United States since 1985. We interpret retrievals AOD from MODIS and MISR using GEOS-Chem to estimate global long-term (2001-2006) mean PM2.5 concentrations at a resolution of 0.1° x 0.1°. Evaluation of the satellite-derived estimate with ground-based in-situ measurements indicates significant spatial agreement with North American measurements (r = 0.77, slope = 1.07, n = 1057) and with non-coincident measurements elsewhere (r = 0.83, slope = 0.86, n = 244). The one standard deviation uncertainty in the satellite-derived PM2.5 is 25%, inferred from the AOD retrieval and aerosol vertical profiles errors and sampling. The global population-weighted mean uncertainty is 6.7 µg/m3. We find a global population-weighted geometric mean PM2.5 concentration of 20 ?g/m3. The World Health Organization Air Quality PM2.5 Interim Target-1 (35 µg/m3 annual average) is exceeded over central and eastern Asia for 38% and 50% of the population, respectively. Annual mean PM2.5 concentrations exceed 80 µg/m3 over Eastern China. We test the capability of remotely-sensed PM2.5 to capture extreme short-term events by examining the major biomass burning event around Moscow in summer 2010. We find good agreement (r2=0.85, slope=1.06) between daily estimates of PM2.5 from in-situ and satellite-derived sources in the Moscow region during the fires. Both satellite-derived and in-situ values have peak daily mean concentrations of approximately 600 ?g/m3 on August 7, 2010 in the Moscow region. Advisors/Committee Members: Sundar Christopher (external-examiner), Randall Martin (graduate-coordinator), Jeff Pierce (thesis-reader), Glen Lesins (thesis-reader), Randall Martin (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Aerosol; PM2.5; MODIS; Remote Sensing

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APA (6^th Edition):

van Donkelaar, A. (2011). AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE ANALYZED WITH A GLOBAL MODEL. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13990

Chicago Manual of Style (16^th Edition):

van Donkelaar, Aaron. “AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE ANALYZED WITH A GLOBAL MODEL.” 2011. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/13990.

MLA Handbook (7^th Edition):

van Donkelaar, Aaron. “AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE ANALYZED WITH A GLOBAL MODEL.” 2011. Web. 18 Feb 2020.

Vancouver:

van Donkelaar A. AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE ANALYZED WITH A GLOBAL MODEL. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/13990.

Council of Science Editors:

van Donkelaar A. AEROSOL OBSERVATIONS FROM SPACE, AIRCRAFT AND SURFACE ANALYZED WITH A GLOBAL MODEL. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13990

Dalhousie University

25. Dawson, Paul WH. Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy.

Degree: MS, Department of Microbiology & Immunology, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/14156

► Hepatitis B virus (HBV) is a significant global threat to human health due to its ability to cause chronic infections that can lead to hepatocellular… (more)

Subjects/Keywords: Hepatitis B; Autophagy; Cellular Senescence; HBx

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APA (6^th Edition):

Dawson, P. W. (2011). Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14156

Chicago Manual of Style (16^th Edition):

Dawson, Paul WH. “Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy.” 2011. Masters Thesis, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/14156.

MLA Handbook (7^th Edition):

Dawson, Paul WH. “Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy.” 2011. Web. 18 Feb 2020.

Vancouver:

Dawson PW. Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/14156.

Council of Science Editors:

Dawson PW. Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14156

Dalhousie University

26. Pellerin, Brian. Modelling Biennial Bearing in Apple Trees.

Degree: MS, Nova Scotia Agricultural College, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/14275

► Many commercially grown apple cultivars have a biennial cropping habit, producing many small fruit in one year and few or none in the following year.… (more)

Subjects/Keywords: Mathematical modelling; optimization; maximum annual flower bud number

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APA (6^th Edition):

Pellerin, B. (2011). Modelling Biennial Bearing in Apple Trees. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14275

Chicago Manual of Style (16^th Edition):

Pellerin, Brian. “Modelling Biennial Bearing in Apple Trees.” 2011. Masters Thesis, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/14275.

MLA Handbook (7^th Edition):

Pellerin, Brian. “Modelling Biennial Bearing in Apple Trees.” 2011. Web. 18 Feb 2020.

Vancouver:

Pellerin B. Modelling Biennial Bearing in Apple Trees. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/14275.

Council of Science Editors:

Pellerin B. Modelling Biennial Bearing in Apple Trees. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14275

Dalhousie University

27. Gillis, Joseph Daniel. Monitoring Organic Contaminant Concentrations and Carbon Mineralization in Field Soils Receiving Alkaline-Stabilized Biosolids.

Degree: MS, Nova Scotia Agricultural College, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/14188

► The application of municipal sewage biosolids to agricultural land is a common practice worldwide. Increasing attention is being directed at the presence of organic contaminants… (more)

▼ The application of municipal sewage biosolids to agricultural land is a common practice worldwide. Increasing attention is being directed at the presence of organic contaminants bound to the organic phase during wastewater treatment, which end up in the biosolids. The goal of this study was to investigate the decomposition of an alkaline-stabilized biosolid being used as an agricultural soil amendment containing unknown organic contaminants. A two year field trial and a 120 day laboratory soil incubation using increasing rates (0, 7, 14, 28, and 42 Mg ha-1) of an alkaline-stabilized biosolid (ASB) were set up to monitor biosolid decomposition and concentrations of selected contaminants over time. The seven contaminants selected for monitoring (p-cresol, indole, 4-t-octylphenol, phenanthrene, triclosan, carbamazepine, and benzo[a]pyrene) represent a wide range of physico-chemical properties and fall under several different chemical classes. The decomposition of ASB in soil was examined in the incubation study. Almost half of the CO2-C evolved from ASB amended soils occurred within the first 6 days, indicating that a relatively labile pool of carbon remains in ASB following the sewage treatment process. By day 121, between 71 to 78% of the total carbon added to soil had been evolved as CO2-C. A new model developed during this study to describe carbon mineralization, a first order plus logistic function (FLOG), performed better than other commonly used models. The method chosen to analyze organic contaminants in soil was only able to determine four out of seven compounds reliably, with recoveries greater than 50% for 4-t-octylphenol, phenanthrene, triclosan, and benzo[a]pyrene. In treated soils, only triclosan was able to be detected and quantified. Average triclosan concentration in the incubation study ranged from a high of 143 ng g-1 on day 3 to a low of 26 ng g-1 by day 121, representing an 81% decrease over a roughly 4 month period under idealized conditions. In the field, triclosan concentrations following a Fall biosolids application in Oct. 2008 increased to detectable levels (29 to 47 ng g-1) in all three plots measured in Nov. 2008, which remained elevated (29 to 66 ng g-1) over the winter period in two out of three plots when sampled in May 2009. Following the Spring application in June 2009, measured triclosan concentrations in July 2009 samples from these same two plots were lower than predicted (33 to 48 ng g-1) and eventually decreased to levels below the detection limit by the Oct. 2009 sampling. Advisors/Committee Members: Shiv O. Prasher (external-examiner), Heather Hughes (graduate-coordinator), Glenn W. Stratton (thesis-reader), Gordon W. Price, David L. Burton (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: biosolid; sewage sludge; carbon mineralization; modelling; triclosan

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APA (6^th Edition):

Gillis, J. D. (2011). Monitoring Organic Contaminant Concentrations and Carbon Mineralization in Field Soils Receiving Alkaline-Stabilized Biosolids. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14188

Chicago Manual of Style (16^th Edition):

Gillis, Joseph Daniel. “Monitoring Organic Contaminant Concentrations and Carbon Mineralization in Field Soils Receiving Alkaline-Stabilized Biosolids.” 2011. Masters Thesis, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/14188.

MLA Handbook (7^th Edition):

Gillis, Joseph Daniel. “Monitoring Organic Contaminant Concentrations and Carbon Mineralization in Field Soils Receiving Alkaline-Stabilized Biosolids.” 2011. Web. 18 Feb 2020.

Vancouver:

Gillis JD. Monitoring Organic Contaminant Concentrations and Carbon Mineralization in Field Soils Receiving Alkaline-Stabilized Biosolids. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/14188.

Council of Science Editors:

Gillis JD. Monitoring Organic Contaminant Concentrations and Carbon Mineralization in Field Soils Receiving Alkaline-Stabilized Biosolids. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14188

Dalhousie University

28. Wright, Lisa Dawn. Stress responding in periadolescent rats exposed to cat odour and long-term outcomes for stress-related aspects of the adult phenotype.

Degree: PhD, Department of Psychology with Neuroscience, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/14190

► Prior work has shown important effects of the early life environment on development of adult stress response systems in both rats and humans. The present… (more)

▼ Prior work has shown important effects of the early life environment on development of adult stress response systems in both rats and humans. The present thesis is based on experiments that attempt to explore: 1) adolescent stress responding at hormonal and behavioural levels, and 2) the effects of repeated adolescent stressor exposure on adult stress responding (hormonal and behavioural) and levels of dopamine receptors expressed in prefrontal cortex, using both male and female rats. Defensive behaviours exhibited during stressor exposure and post-stress levels of circulating corticosterone were quantified as behavioural and hormonal measures of stress responding, respectively. In the first study, responses were compared among groups of adolescent rats exposed repeatedly to one of two different types of cat odour stressor stimuli (J-cloth coated in hair/dander or cat collar previously worn by a cat) or control stimuli, and long-term outcomes were examined in adulthood. Adolescent rats showed behavioural responses to both stressor stimuli, but behavioural inhibition was more consistent using repeated cat collar exposure, and this treatment resulted in long-term increases in anxiety-like behaviour in adulthood, whereas a stress-induced adolescent corticosterone elevation was observed only in the group that received exposure to the J-cloth stimuli. In the second study, adolescent and adult rats were compared directly using repeated exposure to the cat collar stressor or control stimuli. Adolescents were found to be more sensitive to the effects of the stressor stimuli, relative to adults. Finally, in the third study, repeated exposure to the J-cloth stressor or control stimuli was used, and stressor-exposed females showed elevated baseline corticosterone levels prior to the final exposure. Furthermore, stressor-exposed males and females showed lower levels of the D2 dopamine receptor in infralimbic and dorsopeduncular cortices of the prefrontal cortex in adulthood. In addition, these studies together provide evidence that sex differences in corticosterone levels emerge during the adolescent period. It may be concluded that adolescence should be considered a sensitive developmental timeframe for stress response programming. Advisors/Committee Members: Dr. Cheryl McCormick (external-examiner), Dr. Tracy Taylor-Helmick (graduate-coordinator), Dr. Richard Brown (thesis-reader), Dr. Younes Anini (thesis-reader), Dr. Tara Perrot (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: rat; adolescence; stress responding; defensive behaviour; corticosterone; dopamine receptors; prefrontal cortex

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wright, L. D. (2011). Stress responding in periadolescent rats exposed to cat odour and long-term outcomes for stress-related aspects of the adult phenotype. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14190

Chicago Manual of Style (16^th Edition):

Wright, Lisa Dawn. “Stress responding in periadolescent rats exposed to cat odour and long-term outcomes for stress-related aspects of the adult phenotype.” 2011. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/14190.

MLA Handbook (7^th Edition):

Wright, Lisa Dawn. “Stress responding in periadolescent rats exposed to cat odour and long-term outcomes for stress-related aspects of the adult phenotype.” 2011. Web. 18 Feb 2020.

Vancouver:

Wright LD. Stress responding in periadolescent rats exposed to cat odour and long-term outcomes for stress-related aspects of the adult phenotype. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/14190.

Council of Science Editors:

Wright LD. Stress responding in periadolescent rats exposed to cat odour and long-term outcomes for stress-related aspects of the adult phenotype. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14190

Dalhousie University

29. Ernst, Matthew. CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS.

Degree: PhD, Department of Pharmacology, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/14305

► Obesity, characterized by an excess of adipose tissue, is an established risk factor for cardiovascular disease and type II diabetes. Different mechanisms linking obesity with… (more)

▼ Obesity, characterized by an excess of adipose tissue, is an established risk factor for cardiovascular disease and type II diabetes. Different mechanisms linking obesity with these comorbidities have been postulated but remain poorly understood. Adipose tissue secretes bioactive signaling molecules, termed adipokines, which regulate various biological functions including appetite, energy balance, glucose homeostasis, and inflammation. Chemerin is a novel adipokine that regulates adipocyte differentiation and metabolism by binding to and activating the G protein-coupled receptor chemokine like receptor-1 (CMKLR1). Herein, we have shown that serum levels of the novel adipokine chemerin are significantly elevated in mouse models of obesity/diabetes. Administration of exogenous chemerin exacerbates glucose intolerance, lowers serum insulin levels, and decreases tissue glucose uptake in obese/diabetic but not normoglycemic mice. In CMKLR1-deficient mice food consumption, total body mass, and percent body fat are lower compared to wildtype controls, regardless of diet (low or high fat). CMKLR1-/- mice also exhibited decreased hepatic and white adipose tissue TNF? and IL-6 mRNA levels coincident with decreased hepatic dendritic cell infiltration, decreased adipose CD3+ T cells and increased adipose natural killer cells. CMKLR1-/- mice were also glucose intolerant compared to wildtype mice, and this was associated with decreased glucose stimulated insulin secretion as well as decreased skeletal muscle and white adipose tissue glucose uptake. Collectively, these data provide compelling evidence that chemerin/CMKLR1 signaling influences adipose tissue development, inflammation, and glucose homeostasis and may contribute to the metabolic derangements characteristic of obesity and obesity-related diseases. Advisors/Committee Members: Dr. David Dyck (external-examiner), Dr. Jana Sawynok (graduate-coordinator), Dr. Eileen Denova-Wright (thesis-reader), Dr. Tom Ransom (thesis-reader), Dr. Christopher Sinal (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: Chemerin; Adipokine; Obesity; Diabetes; Glucose tolerance; insulin resistance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ernst, M. (2011). CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14305

Chicago Manual of Style (16^th Edition):

Ernst, Matthew. “CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS.” 2011. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/14305.

MLA Handbook (7^th Edition):

Ernst, Matthew. “CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS.” 2011. Web. 18 Feb 2020.

Vancouver:

Ernst M. CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS. [Internet] [Doctoral dissertation]. Dalhousie University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/14305.

Council of Science Editors:

Ernst M. CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS. [Doctoral Dissertation]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14305

Dalhousie University

30. Meisner, Jason George. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.

Degree: PhD, Department of Anatomy & Neurobiolgy with Neuroscience, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/14411

► Neuropathic pain is a significant and frequent outcome of spinal cord injury (SCI), and is often refractory to treatment. A better understanding of the pathological… (more)

▼ Neuropathic pain is a significant and frequent outcome of spinal cord injury (SCI), and is often refractory to treatment. A better understanding of the pathological processes following injury that contribute to the development of neuropathic pain will aid the search for novel therapeutics. In the second chapter of this thesis a murine model of post-SCI below-lesion neuropathic pain was utilized to investigate changes in GABAergic tone. The gad1:GFP transgenic mouse line allowed the study of a subpopulation of GFPlabeled GABAergic neurons under control of the GABA synthesizing glutamate decarboxylase enzyme. SCI was observed to result in a loss of GABAergic neurons, and secondary markers of GABAergic tone supported this observation. This finding suggests that GABAergic interneuron cell death accounts for the decreased GABAergic tone previously reported post-SCI. In the third chapter of this thesis it was attempted to prevent the death of GABAergic neurons post-SCI using a transgenic mouse line expressing increased levels of the X-linked inhibitor of apoptosis (XIAP) under the ubiquitin C promoter. No differences were observed between ubXIAP and wildtype mice, indicating that increased expression of XIAP is not sufficient to prevent the development of neuropathic pain post- SCI. The fourth chapter of this thesis attempted to prevent the development of neuropathic pain through a novel treatment schedule of the drug pregabalin. Pregabalin administered shortly after SCI prevented the development of neuropathic pain. Pregabalin initiated 1 week post-SCI had no effect. Early pregabalin treatment did not appear to dramatically alter glial activation, or expression of the pregabalin receptor, but we observed changes in markers associated with synaptic plasticity. My findings build upon our knowledge of the mechanisms underlying post-SCI below-lesion neuropathic pain, and suggest new avenues of research, such as the uses of preemptive treatment with pregabalin, that offer promise for translation to clinical use. Advisors/Committee Members: Claire Hulsebosch (external-examiner), Kazue Semba (graduate-coordinator), William Baldridge (thesis-reader), Ronald Leslie (thesis-reader), Stefan Kruger (thesis-reader), Daniel Marsh (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: SPINAL CORD INJURY; PAIN; GABA; PREGABALIN

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Meisner, J. G. (2012). POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14411

Chicago Manual of Style (16^th Edition):

Meisner, Jason George. “POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.” 2012. Doctoral Dissertation, Dalhousie University. Accessed February 18, 2020. http://hdl.handle.net/10222/14411.

MLA Handbook (7^th Edition):

Meisner, Jason George. “POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.” 2012. Web. 18 Feb 2020.

Vancouver:

Meisner JG. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. [Internet] [Doctoral dissertation]. Dalhousie University; 2012. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10222/14411.

Council of Science Editors:

Meisner JG. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. [Doctoral Dissertation]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/14411

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Open Access Theses and Dissertations