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Dalhousie University

1. Bay, Rachael. Analysis of Functional Constraint and Recombination in Gene Sequences of the Cyanobacteria Prochlorococcus.

Degree: MS, Department of Biology, 2010, Dalhousie University

Lineages of the cyanobacteria Prochlorococcus marinus have diverged into two genetically distinct ‘ecotypes,’ high-light adapted (HL) and low-light adapted (LL), which thrive under different environmental conditions. This type of niche differentiation in prokaryotes is often accompanied by genetic and genomic divergence. Differential selection pressure associated with ecotype divergence can be analyzed using models of codon evolution. However, some characteristics of the Prochlorococcus genome violate underlying assumptions of these models. For example, high levels of recombination between bacterial strains are known to cause false positives for codon models. Therefore, it is important that statistical methods for detecting recombination be reliable. In Chapter 2, I evaluate a set of recombination detection methods under four different scenarios related to functional divergence: 1) varying tree shape, 2) positive selection, 3) non-stationary evolution, and 4) varying levels of recombination and divergence. Advisors/Committee Members: Dr. Jonathan Wright (external-examiner), Dr. Hal Whitehead (graduate-coordinator), Dr. Katherine Dunn (thesis-reader), Dr. Andrew Roger (thesis-reader), Dr. Joseph Bielawski (thesis-supervisor), Not Applicable (ethics-approval), Not Applicable (manuscripts), Not Applicable (copyright-release).

Subjects/Keywords: Cyanobacteria; Recombination; Natural Selection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bay, R. (2010). Analysis of Functional Constraint and Recombination in Gene Sequences of the Cyanobacteria Prochlorococcus. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13021

Chicago Manual of Style (16th Edition):

Bay, Rachael. “Analysis of Functional Constraint and Recombination in Gene Sequences of the Cyanobacteria Prochlorococcus.” 2010. Masters Thesis, Dalhousie University. Accessed May 08, 2021. http://hdl.handle.net/10222/13021.

MLA Handbook (7th Edition):

Bay, Rachael. “Analysis of Functional Constraint and Recombination in Gene Sequences of the Cyanobacteria Prochlorococcus.” 2010. Web. 08 May 2021.

Vancouver:

Bay R. Analysis of Functional Constraint and Recombination in Gene Sequences of the Cyanobacteria Prochlorococcus. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2021 May 08]. Available from: http://hdl.handle.net/10222/13021.

Council of Science Editors:

Bay R. Analysis of Functional Constraint and Recombination in Gene Sequences of the Cyanobacteria Prochlorococcus. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/13021

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