Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

Sorted by: relevance · author · university · dateNew search

You searched for +publisher:"DIAL (Belgium)" +contributor:("Lanners, Steve"). Showing records 1 – 3 of 3 total matches.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters

1. Martinquet, Samuel. Conception de nanovecteurs à base de matériaux silicatés mésoporeux hautement structurés organomodifiés pour la délivrance contrôlée de molécules médicamenteuses.

Degree: 2009, DIAL (Belgium)

The need for decreasing the side effects related to the employment of such or such drug is further prove. The drug company is always focused on a way to decrease these harmful effects in order to guarantee the wellbeing of the patient but also of being able to benefit from it. The main aim of this thesis is to study the potentiality of mesoporous materials highly structured to fulfill the role of nanovectors for the controlled delivery of medicinal molecules in order to be able to reduce the side effects related to the use of this drug. The first part of this thesis initially approaches the synthesis of various silicate mesoporous CMI-1 matrices having various textural properties in order to study the influence of this parameter on the design of the drug. The design of SBA-15 materials was planned in order to increase the range of textural properties studied. Then, these multiple syntheses allow to optimize the immobilization of the actives molecules within these materials. To finish, the pharmacokinetic profiles, in solutions simulating the mediums gastric and intestinal, of various drugs were compared in order to determine the influence of the textural properties and the potentiality of these matrices to play the part of nanovectors. The second part treats of the functionalization of silicate mesoporous CMI-1 and SBA-15 matrices by an aminopropyl group. This allowed to reinforce the interactions Ibuprofen-matrix. The influence of this function was studied on the immobilization of Ibuprofen and the pharmacokinetic profiles of the designed drugs. The last part of this thesis is devoted to the study of the influence of an ethane function within the silicate network of PMO materials. Just like for the preceding matrices, we studied the influence of these supports on the immobilization of Ibuprofen and the pharmacokinetics profiles.

La nécessité de diminuer les effets secondaires liés à l’emploi de tel ou tel médicament n’est plus à démontrer. L’industrie pharmaceutique est toujours à la recherche de moyens pour diminuer ces effets néfastes afin de garantir le bien-être du patient mais également de pouvoir en tirer profit. L’objectif principal de cette thèse de doctorat est d’étudier la potentialité des matériaux mésoporeux hautement structurés à remplir le rôle de nanovecteur pour la délivrance contrôlée de molécules médicamenteuses afin de pouvoir réduire les effets secondaires liés à l’utilisation de ce médicament. La première partie de cette thèse aborde dans un premier temps la synthèse de différentes matrices mésoporeuses silicatées CMI-1 possédant différentes propriétés texturales afin d’étudier l’influence de ce paramètre sur la conception du médicament. La conception de matériaux SBA-15 a été envisagée afin d’agrandir la gamme de propriétés texturales étudiées. Dans un deuxième temps, ces synthèses multiples ont permis d’optimiser l’immobilisation de l’Ibuprofen au sein de ces matériaux. Enfin, les profils pharmacocinétiques, illustrant le passage dans des solutions simulant les milieux gastrique et…

Advisors/Committee Members: FUNDP - SCHI_GCNM (groupe de chimie des nanomatériaux), FUNDP - -, Su, Bao-Lian, Lanners, Steve, Van Der Voort, Pascal, Leonard, Alexandre, Houssiaux, Laurent.

Subjects/Keywords: nanovecteur drug delivery system mesoporous mésoporeux CMI-1

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Martinquet, S. (2009). Conception de nanovecteurs à base de matériaux silicatés mésoporeux hautement structurés organomodifiés pour la délivrance contrôlée de molécules médicamenteuses. (Thesis). DIAL (Belgium). Retrieved from http://hdl.handle.net/2078.2/24878

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Martinquet, Samuel. “Conception de nanovecteurs à base de matériaux silicatés mésoporeux hautement structurés organomodifiés pour la délivrance contrôlée de molécules médicamenteuses.” 2009. Thesis, DIAL (Belgium). Accessed April 23, 2019. http://hdl.handle.net/2078.2/24878.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Martinquet, Samuel. “Conception de nanovecteurs à base de matériaux silicatés mésoporeux hautement structurés organomodifiés pour la délivrance contrôlée de molécules médicamenteuses.” 2009. Web. 23 Apr 2019.

Vancouver:

Martinquet S. Conception de nanovecteurs à base de matériaux silicatés mésoporeux hautement structurés organomodifiés pour la délivrance contrôlée de molécules médicamenteuses. [Internet] [Thesis]. DIAL (Belgium); 2009. [cited 2019 Apr 23]. Available from: http://hdl.handle.net/2078.2/24878.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martinquet S. Conception de nanovecteurs à base de matériaux silicatés mésoporeux hautement structurés organomodifiés pour la délivrance contrôlée de molécules médicamenteuses. [Thesis]. DIAL (Belgium); 2009. Available from: http://hdl.handle.net/2078.2/24878

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Moineaux, Laurence. Conception, synthèse et étude d’inhibiteurs de latryptophane 2,3-dioxygénase (TDO), une cibleprometteuse pour le traitement du cancer.

Degree: 2013, DIAL (Belgium)

An immune system, enhanced by the immunotherapy, is able to recognize and destroy tumor cells. In vivo, cancer cells are able to develop mechanisms for tumors to resist and escape the immune system. Among these, two enzymes are the key players: indoleamine 2,3- dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO). These enzymes catalyze the breakdown of an essential amino acid, L-tryptophan (L-trp) in kynurenine, to form different physiologically active molecules. This results in a local decrease in L-trp, which is significantly affecting the proliferation of T lymphocytes. The activity of IDO and TDO is particularly immunosuppressive, justifying this choice of therapeutic targets for cancer therapy. In this work, we will focus on TDO, to date, the unique reference inhibitor, the fluoroindole 680C91. Nevertheless, in vivo, it has a poor oral bioavailability. Therefore, the aim of this thesis is to design new specific inhibitors of TDO and characterize their interactions with the enzyme using theoretical and experimental approaches. Once the compounds synthesized, a global cellular assay has identified promising inhibitors. The first series has, throughout a fundamental study, led to the characterization of three chloride isomers namely: 5, 6, 7-chloro-3-(2-pyridin-3-ylvinyle)-1H-indole, resulting into a better understanding of the influence of the position of a halogen on the structural and physico-chemical properties. This study highlights the crystalline packing and intermolecular interactions between different molecules of the lattice. Moreover, a study of electronic properties exhibited the dipole moment and the electrostatic potential. Finally, the model study of inhibition was correlated with the biological results, the IC50 on hTDO. The second set of molecules has two acid derivatives of the vinyl-1H-indoles series. The characterization, in vitro, of these molecules has shown that they are not substrates of hTDO. It also permits to determine their Ki. Additionally, the IC50 of these molecules on cells was evaluated. Then, structural and physico-chemical characterization provided different properties, ie, pKa, solubility, selectivity and stability. Finally, crystallographic assays were conducted in the presence of active and purified enzyme (rmTDO), alone or in complex with the inhibitor, in order to better understand the interactions within the active site. All these studies have highlighted the most promising molecules in terms of inhibition but also pharmaceutically. The latter has been studied in vivo with mices and shows promise.

L’immunothérapie est une stratégie qui vise à stimuler le système immunitaire afin qu’il reconnaisse et détruise les cellules tumorales. Pourtant, in vivo, les cellules cancéreuses sont capables de développer des mécanismes permettant aux tumeurs de résister et d’échapper au système immunitaire. Parmi ceux-ci, deux enzymes représentent les acteurs essentiels : l’indoleamine 2,3-dioxygénase (IDO) et la tryptophane 2,3-dioxygenase (TDO). Ces enzymes catalysent la dégradation…

Advisors/Committee Members: FUNDP - SCHI_GCPTS (groupe de chimie physique, théorique et structurale), FUNDP - -, wouters, johan, Lanners, steve, masereel, Bernard, Frédérick, Raphaël, Galleni, Moreno.

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Moineaux, L. (2013). Conception, synthèse et étude d’inhibiteurs de latryptophane 2,3-dioxygénase (TDO), une cibleprometteuse pour le traitement du cancer. (Thesis). DIAL (Belgium). Retrieved from http://hdl.handle.net/2078.2/124354

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Moineaux, Laurence. “Conception, synthèse et étude d’inhibiteurs de latryptophane 2,3-dioxygénase (TDO), une cibleprometteuse pour le traitement du cancer.” 2013. Thesis, DIAL (Belgium). Accessed April 23, 2019. http://hdl.handle.net/2078.2/124354.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Moineaux, Laurence. “Conception, synthèse et étude d’inhibiteurs de latryptophane 2,3-dioxygénase (TDO), une cibleprometteuse pour le traitement du cancer.” 2013. Web. 23 Apr 2019.

Vancouver:

Moineaux L. Conception, synthèse et étude d’inhibiteurs de latryptophane 2,3-dioxygénase (TDO), une cibleprometteuse pour le traitement du cancer. [Internet] [Thesis]. DIAL (Belgium); 2013. [cited 2019 Apr 23]. Available from: http://hdl.handle.net/2078.2/124354.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moineaux L. Conception, synthèse et étude d’inhibiteurs de latryptophane 2,3-dioxygénase (TDO), une cibleprometteuse pour le traitement du cancer. [Thesis]. DIAL (Belgium); 2013. Available from: http://hdl.handle.net/2078.2/124354

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Meunier, Christophe. Conception de Matériaux bio-hybrides photosynthétiques par immobilisation de biosystèmes végétaux au sein de matrices silicées.

Degree: 2010, DIAL (Belgium)

Evolution pressure typically forces natural systems to become highly optimized, sophisticated and efficient. Specifically, the living systems are able to perform a series of complex and attractive catalytic reactions. Consequently, their integration into new devices has the potential to produce breakthroughs in both fundamental science and possibly leads to new technologies in diverse fields (environment, energy, health). However, cells, isolated from their native environment, are generally fragile or unsuitable in the development of technologies. In the past few years, abundant researches have proved that encapsulation of biomolecules, enzymes and microorganisms into various artificial matrices can be very attractive to create new functional bio-composites. This ever-growing field of research is very promising in the development of new eco-friendly technologies such as whole cell sensors, depolluting devices, stable bioreactors and artificial organs. The aim of this thesis consists of a fundamental study on the elaboration of functional and stable bio-hybrid materials via the immobilisation of organelles or photosynthetic plant cells within various silica matrices in order to design a photo-bioreactor. The first part of this work was devoted to the development of immobilisation methods adapted for the in situ incorporation of fragile biological species (thylakoids, chloroplasts, cells) within porous silica scaffold. Several inorganic precursors and synthesis parameters were studied in order to determine their effects on the morphological, textural and rheological properties of the silica matrices. Particularly, the bioactivity of entrapped thylakoids was investigated and correlated with the properties of the support. Since these photosynthetic structures are very sensitive, a biocompatible synthesis pathway has been designed to allow the formation of stable hybrid materials. In these conditions, the photochemical activity of thylakoids can be preserved for more than 40 days whereas no enzymatic activity can be detected after 3 days in a free suspension of thylakoids. The second part was focused on the realisation of a solid photobioreactor via the in situ or post-synthesis immobilisation of plant cells (Arabidopsis thaliana). With this in mind, the biological activity and the cell-matrix interactions were investigated by using several techniques. A control of the chemical surface properties of silica has shown to be crucial in order to avoid the mineralization of cell walls and prolong the cellular viability of plant cells. Additionally, the porosity of the matrix was also studied. This parameter is able to control the growth and the confinement of cells within the material. Encapsulated within an organo-modified silica matrix, the photoautotrophic plant cells are able to convert water into O2 and produce valuable compounds from CO2 under light irradiation. In the future, such bio-hybrid gels could play a key role in the development of new sustainable technologies.

Après plusieurs milliards d’années d’évolution,…

Advisors/Committee Members: FUNDP - SCHI_GCNM (groupe de chimie des nanomatériaux), FUNDP - Ecole doctorale en sciences, Su, Bao-Lian, Van Cutsem, Pierre, Lanners, Steve, Livage, Jacques, Vincent, Stéphane, Krief, Alain, Léonard, Alexandre.

Subjects/Keywords: Encapsulation; Silice; Cellule; Bioréacteur; Biominéralisation; interface cellulaire; Matériaux hybrides

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Meunier, C. (2010). Conception de Matériaux bio-hybrides photosynthétiques par immobilisation de biosystèmes végétaux au sein de matrices silicées. (Thesis). DIAL (Belgium). Retrieved from http://hdl.handle.net/2078.2/32295

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Meunier, Christophe. “Conception de Matériaux bio-hybrides photosynthétiques par immobilisation de biosystèmes végétaux au sein de matrices silicées.” 2010. Thesis, DIAL (Belgium). Accessed April 23, 2019. http://hdl.handle.net/2078.2/32295.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Meunier, Christophe. “Conception de Matériaux bio-hybrides photosynthétiques par immobilisation de biosystèmes végétaux au sein de matrices silicées.” 2010. Web. 23 Apr 2019.

Vancouver:

Meunier C. Conception de Matériaux bio-hybrides photosynthétiques par immobilisation de biosystèmes végétaux au sein de matrices silicées. [Internet] [Thesis]. DIAL (Belgium); 2010. [cited 2019 Apr 23]. Available from: http://hdl.handle.net/2078.2/32295.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Meunier C. Conception de Matériaux bio-hybrides photosynthétiques par immobilisation de biosystèmes végétaux au sein de matrices silicées. [Thesis]. DIAL (Belgium); 2010. Available from: http://hdl.handle.net/2078.2/32295

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.