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You searched for +publisher:"DIAL (Belgium)" +contributor:("Aprile, Carmela"). Showing records 1 – 3 of 3 total matches.

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1. Dandoy, Philippe. Encapsulation de cellules animales au sein de billes inorganiques poreuses minéralisées : vers la création d'organes artificiels.

Degree: 2011, DIAL (Belgium)

The desire to find new treatments against non-infectious diseases like diabetes leads modern medicine to look towards emerging technologies. Current solutions to treat diabetes, such as organ graft and insulin therapy, present major drawbacks, thus when considering the limited supply of live organs for transplantation, the development of artificial organs to replace deficient ones becomes a principle goal for clinicians. Cell transplants are an adequate solution and have already proved to be successful. However, this method only offers short time relief. This drives the need to develop a method where cells are protected against rejection without the continual use of immunosuppressive drugs. Considering the progress in biological entities immobilisation from bacteria, yeasts and plant cells, animal cell immobilisation shows great potential in the treatment of pathological disorders. For example a type 1 diabetic patient could be offered an implant comprised of live beta-cells immobilised within a porous, biocompatible and robust material, which could improve their day-to-day life. The aim of this project was to create a hybrid material which could act as a surrogate organ in place of the deficient one, offering new hope in the domain of cell therapy. In this thesis, research on the design of an artificial organ and the materials developed are described. With the aid of a suite of techniques, these matrices have been characterised to outline their properties and highlight their affinity with animal cells. Results show that cells were alive several weeks post-immobilisation. In vivo experiments using the most promising matrix were performed to study the integration of hybrid beads within a whole body, highlighting that very low to no inflammatory response in laboratory animals was caused by the subcutaneous implant. Final results suggest that an appropriate material, which was both robust and biocompatible, was successfully synthesised with a porous diameter fulfilling the requirements for cell immuno-isolation. Moreover, it did not provoke inflammation in the connective tissues surrounding the implant during the one-month in vivo study.

Le désir d’élaborer de nouveaux traitements face aux maladies non-infectieuses comme le diabète pousse la médecine moderne à se tourner vers les nouvelles technologies. La greffe d’organe étant aussi contraignante que l’insulinothérapie, la création d’organes artificiels pour suppléer un jour les organes déficients fait partie des rêves les plus convoités berçant l’imagination du praticien. Si la transplantation de cellules est une solution envisageable et déjà couronnée d’un certain succès, ce traitement n’a malheureusement que peu d’efficacité à long terme et impose de développer une méthode qui permettrait de protéger les nouvelles cellules du rejet sans recourir à la prise de médicaments immunosuppressifs. Devant les progrès obtenus pour l’immobilisation d’entités biologiques comme les bactéries, les levures ou les cellules végétales, celle de cellules animales est une nouvelle…

Advisors/Committee Members: FUNDP - SCHI_GCNM (groupe de chimie des nanomatériaux), FUNDP - -, Su, Bao-Lian, Michiels, Carine, Aprile, Carmela, Krief, Alain, Léonard, Alexandre, Meunier, Christophe, Wouters, Johan.

Subjects/Keywords: Cellules animales; Billes minéralisées; Biocompatibilité; Silice; Alginate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Dandoy, P. (2011). Encapsulation de cellules animales au sein de billes inorganiques poreuses minéralisées : vers la création d'organes artificiels. (Thesis). DIAL (Belgium). Retrieved from http://hdl.handle.net/2078.2/76437

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Dandoy, Philippe. “Encapsulation de cellules animales au sein de billes inorganiques poreuses minéralisées : vers la création d'organes artificiels.” 2011. Thesis, DIAL (Belgium). Accessed July 16, 2019. http://hdl.handle.net/2078.2/76437.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Dandoy, Philippe. “Encapsulation de cellules animales au sein de billes inorganiques poreuses minéralisées : vers la création d'organes artificiels.” 2011. Web. 16 Jul 2019.

Vancouver:

Dandoy P. Encapsulation de cellules animales au sein de billes inorganiques poreuses minéralisées : vers la création d'organes artificiels. [Internet] [Thesis]. DIAL (Belgium); 2011. [cited 2019 Jul 16]. Available from: http://hdl.handle.net/2078.2/76437.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dandoy P. Encapsulation de cellules animales au sein de billes inorganiques poreuses minéralisées : vers la création d'organes artificiels. [Thesis]. DIAL (Belgium); 2011. Available from: http://hdl.handle.net/2078.2/76437

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Mohnani, Gul Stefan. Synthetic Approaches Towards Modified Peptide Nucleic Acids (PNAs) for Biomimetical Nanostructured Surfaces.

Degree: 2011, DIAL (Belgium)

“There is plenty of room at the bottom”. These were the famous words of Richard P. Feynman in 1959 that led to the birth of nanotechnology and nanoscience. Electronic devices based on inorganic semiconductors have been part of our daily lives for the last 60 years. Their miniaturisation has occurred gradually over the years, however, according to Moore’s law the contemporary microelectronic industry’s “top-down” manufacturing technique will soon reach its limits. Therefore, the recent development and increased knowledge of organic semiconductors has led to a tendency to explore alternative avenues with a focus on the creation of electronic devices based on organic molecules. The invention of techniques such STM (1981) and AFM (1986) have facilitated this research, allowing the imaging and manipulation of surfaces and molecules at the nanometre scale (0.1-100 nm). The next step is therefore the development of methods for the controlled fabrication of molecular assemblies and their integration into usable macroscopic systems. In this respect, the “bottom-up” approach offers considerable advantages over any other methodology (i.e. “top-down”) for the construction of nanoscale functional materials and devices. This approach generally exploits the hierarchical self-assembly of functional molecules through multiple non-covalent interactions to prepare long range ordered and defect-free assemblies barely accessible through conventional covalent synthesis. However, an intrinsic drawback of investigating such systems in solution or in a crystal is that molecular components cannot be directly addressed on a nanometric scale. As a consequence, the best engineering methodology involves modifying the surfaces of bulk materials such as metals or semiconductors by deposition of functional organic materials. The modified surfaces are then characterised using scanning probe microscopies (e.g. STM, AFM). To this end, surface-confined, supramolecularly constructed, bi-dimensional (2D) networks, featuring regular porous domains (controllable both in shape and size) are of particular significance in this research domain because their cavities can be used as receptors for the confinement of other remotely controlled functional molecules (e.g. molecular switches, luminescent chromophores). Since these complex nanostructures could ultimately find applications as optoelectronic devices, research efforts in this domain have been gathering momentum in recent years. In Chapter 1, the reader is introduced to the methods employed to construct porous networks on surfaces via supramolecular interactions. The second part of the chapter deals with recent examples of recognition, selection and immobilisation of guest molecules within the cavities of the networks, which is followed in the third part with a discussion about surface assemblies that display structural features or functionality in the third dimension. The last section of the chapter is devoted to the construction of porous networks on surfaces via the interactions of biomimetic molecules… Advisors/Committee Members: FUNDP - SCHI_GCOBS (groupe de chimie organique et bioorganique supramoléculaire), FUNDP - Ecole doctorale en sciences, Bonifazi, Davide, Prato , Maurizio, Vincent, Stephane, Bonchio, Marcella, Aprile, Carmela, Madder, Annemieke.

Subjects/Keywords: PNA; Self-assembly; Chromophore; Supramolecular chemistry; Surface chemistry; Molecular recognition; Scanning probe microscopy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mohnani, G. S. (2011). Synthetic Approaches Towards Modified Peptide Nucleic Acids (PNAs) for Biomimetical Nanostructured Surfaces. (Thesis). DIAL (Belgium). Retrieved from http://hdl.handle.net/2078.2/79184

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mohnani, Gul Stefan. “Synthetic Approaches Towards Modified Peptide Nucleic Acids (PNAs) for Biomimetical Nanostructured Surfaces.” 2011. Thesis, DIAL (Belgium). Accessed July 16, 2019. http://hdl.handle.net/2078.2/79184.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mohnani, Gul Stefan. “Synthetic Approaches Towards Modified Peptide Nucleic Acids (PNAs) for Biomimetical Nanostructured Surfaces.” 2011. Web. 16 Jul 2019.

Vancouver:

Mohnani GS. Synthetic Approaches Towards Modified Peptide Nucleic Acids (PNAs) for Biomimetical Nanostructured Surfaces. [Internet] [Thesis]. DIAL (Belgium); 2011. [cited 2019 Jul 16]. Available from: http://hdl.handle.net/2078.2/79184.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mohnani GS. Synthetic Approaches Towards Modified Peptide Nucleic Acids (PNAs) for Biomimetical Nanostructured Surfaces. [Thesis]. DIAL (Belgium); 2011. Available from: http://hdl.handle.net/2078.2/79184

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Chen, Li Hua. Hierarchically micro-meso-macroporous catalysts constructed from zeolite nanocrystals: Design, Synthesis and Application.

Degree: 2011, DIAL (Belgium)

A series of novel hierarchically porous catalysts with significant micro-meso-macroporous structures constructed from zeolite nanocrystals have been successfully synthesized by a quasi solid state crystallization transformation process using a glycerin medium. These catalysts possess well-defined macropores and interconnected mesopores in the macropore walls which were constructed by selected microporous zeolitic units. A series of products, including hierarchically porous acidic aluminosilicates catalysts and hierarchically heteroatom-doped catalysts have been synthesized successfully by the quasi solid state crystallization transformation process. Hierarchical micro-meso-macroporous acidic catalysts constructed from zeolite ZSM-5 nanocrystals were synthesized using this synthetic system under the effect of a structure directing agent. The final product MMM-ZSM-5(2) presented an exceptional catalytic performance for the cracking of 1,3,5-triisopropylbenzene (TIPB). Hierarchically micro-meso-macroporous acidic catalysts constructed from zeolite Beta nanocrystals have also been synthesized. The acidity properties of the products formed after different crystallization transformation periods were investigated. Furthermore, hierarchically micro-meso-macroporous catalysts with heteroatom-doping into the zeolite architecture were also synthesized by this quasi solid state crystallization transformation process. Hierarchically micro-meso-macroporous catalysts constructed from crystalline titanium-doped silicalite-1(TS-1) were also obtained. The final product MMM-TS-1(3) presented superior catalytic performances both for the epoxidation of styrene and 2,4,6-trimethylstyrene. Finally, hierarchically micro-meso-macroporous catalysts constructed from zirconium-doped silicalite-1 (ZrS-1) nanocrystals were also synthesized successfully. The present work demonstrates that the quasi solid state crystallization transformation process is a facile and versatile method to synthesize micro-meso-macroporous catalysts with high performances in different reactions.

Une nouvelle gamme de catalyseurs à porosité hiérarchisée, constituée d’une proportion significative de structures micro-méso-macroporeuses et construits par l’assemblage de nanocristaux de zéolithes, a été mise au point avec succès par un processus de cristallisation à l’état quasi solide, et ce via l’emploi de glycérine. Ces catalyseurs sont caractérisés par un réseau de macropores bien définis, dont les parois sont constituées de mésopores interconnectés, eux-mêmes délimités par des unités zéolithiques microporeuses adaptées. Une série de produits, incluant des catalyseurs aluminosilicatés acides à porosité hiérarchisée ainsi que des catalyseurs dopés en hétéroatomes à porosité hiérarchisée, a été synthétisée avec succès par la méthode de cristallisation à l’état quasi solide. Des catalyseurs acides micro-méso-macroporeux hiérarchisés construits par des nanocristaux de zéolithes ZSM-5 furent premièrement mis au point par ce procédé, tout en y étudiant l’influence de…

Advisors/Committee Members: FUNDP - SCHI_GCNM (groupe de chimie des nanomatériaux), FUNDP - Ecole doctorale en sciences, SU, Bao-Lian, Aprile, Carmela, Qiu, Shi-Lun, Lodewyckx, peter, Bonifazi, Davide, Léonard, Alexandre.

Subjects/Keywords: Hierarchically porous catalyst; Micro-meso-macroporous; Zeolite; Quasi solid state crsytallization transformation process

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chen, L. H. (2011). Hierarchically micro-meso-macroporous catalysts constructed from zeolite nanocrystals: Design, Synthesis and Application. (Thesis). DIAL (Belgium). Retrieved from http://hdl.handle.net/2078.2/69299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Chen, Li Hua. “Hierarchically micro-meso-macroporous catalysts constructed from zeolite nanocrystals: Design, Synthesis and Application.” 2011. Thesis, DIAL (Belgium). Accessed July 16, 2019. http://hdl.handle.net/2078.2/69299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Chen, Li Hua. “Hierarchically micro-meso-macroporous catalysts constructed from zeolite nanocrystals: Design, Synthesis and Application.” 2011. Web. 16 Jul 2019.

Vancouver:

Chen LH. Hierarchically micro-meso-macroporous catalysts constructed from zeolite nanocrystals: Design, Synthesis and Application. [Internet] [Thesis]. DIAL (Belgium); 2011. [cited 2019 Jul 16]. Available from: http://hdl.handle.net/2078.2/69299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen LH. Hierarchically micro-meso-macroporous catalysts constructed from zeolite nanocrystals: Design, Synthesis and Application. [Thesis]. DIAL (Belgium); 2011. Available from: http://hdl.handle.net/2078.2/69299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.