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Colorado State University
1.
Warro, Daniel.
Effects of a single bout of exercise, with energy replacement, on plasma concentrations of TNF-α following consumption of a high-fat, high-carbohydrate mixed meal, The.
Degree: MS(M.S.), Food Science and Human Nutrition, 2011, Colorado State University
URL: http://hdl.handle.net/10217/47420 
► Background: Cardiovascular disease (CVD) is a major contributor to all-cause mortality in the United States and is a major cause of long-term disability. The risk…
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▼ Background: Cardiovascular disease (CVD) is a major
contributor to all-cause mortality in the United States and is a major cause of long-term disability. The risk for CHD typically includes a panel of fasting blood lipids including total, LDL-, and HDL-cholesterol. However, in recent years, the lipemic response to a meal and the accompanying pro-inflammatory molecules are recognized as independent risk factors for the development of CVD. Attention has focused on the vascular endothelium, where an increase in low-grade inflammatory processes leads to the development and progression of vascular insults ultimately contributing to an advanced, complicated atherosclerotic lesion. A large body of evidence suggests that improvements in postprandial lipemia, such as decreased triglycerides (TG) and improved insulin sensitivity can be achieved following an individual exercise session. However, limited data exists elucidating the effects of a prior acute bout of moderate intensity exercise on possible pro-inflammatory changes during the postprandial period. Research consistently shows that an important determinant of the acute metabolic changes associated with a single session of exercise are energy-expenditure dependent. It is of clinical importance to understand the postprandial metabolic response after an acute bout of exercise in which the caloric cost of exercise has been balanced with additional energy intake, i.e. with energy replacement. Purpose: Therefore, the purpose of this study was to determine the effects of a single bout of moderate intensity exercise, with energy replacement, on plasma tumor necrosis factor alpha (TNF-α) concentrations, measured before and after consumption of a high-fat, high-carbohydrate meal in young, non-obese, sedentary females. Methods: Eight, non-obese, sedentary women participated in two separate high-fat, high-carbohydrate meal tests after undergoing different treatments the following day. For the non-exercise condition (NoEx), the day prior to the postprandial challenge subjects refrained from exercise and consumed a prescribed diet. For the exercise condition (Ex) subjects consumed the same prescribed diet, and completed a cycle ergometer exercise bout at 65% peak heart rate, eliciting a net exercise energy expenditure of ~285 kcalories. Subjects then consumed an additional mixed-meal snack to account for the additional energy cost of the exercise. The following morning subjects reported to the laboratory in a fasted
state at which time a venous blood sample was obtained. They were then fed a high-fat, high-carbohydrate meal (0.75g fat, 1.1g CHO, and 0.35 g protein/kg body weight), and postprandial venous blood samples were obtained 2, 4, and 6 hours after consumption meal for determination of plasma TNF-α concentrations. Results: Plasma TNF-α concentrations were low in all subjects at baseline and dropped further by the second hour of the postprandial period returning toward baseline in both the Ex and NoEx conditions (time effect, p<0.05). There was not a condition by time…
Advisors/Committee Members: Melby, Christopher (advisor), Hickey, Matthew (advisor), Nelson, Tracy (committee member).
Subjects/Keywords: exercise; acute exercise; meal replacement; nutrition; TNF alpha; tumor necrosis factor alpha
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APA (6th Edition):
Warro, D. (2011). Effects of a single bout of exercise, with energy replacement, on plasma concentrations of TNF-α following consumption of a high-fat, high-carbohydrate mixed meal, The. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/47420
Chicago Manual of Style (16th Edition):
Warro, Daniel. “Effects of a single bout of exercise, with energy replacement, on plasma concentrations of TNF-α following consumption of a high-fat, high-carbohydrate mixed meal, The.” 2011. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/47420.
MLA Handbook (7th Edition):
Warro, Daniel. “Effects of a single bout of exercise, with energy replacement, on plasma concentrations of TNF-α following consumption of a high-fat, high-carbohydrate mixed meal, The.” 2011. Web. 04 Mar 2021.
Vancouver:
Warro D. Effects of a single bout of exercise, with energy replacement, on plasma concentrations of TNF-α following consumption of a high-fat, high-carbohydrate mixed meal, The. [Internet] [Masters thesis]. Colorado State University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/47420.
Council of Science Editors:
Warro D. Effects of a single bout of exercise, with energy replacement, on plasma concentrations of TNF-α following consumption of a high-fat, high-carbohydrate mixed meal, The. [Masters Thesis]. Colorado State University; 2011. Available from: http://hdl.handle.net/10217/47420
Colorado State University
2.
Giordano, Gregory Robert.
Sprint interval training: the influence of exercise modality.
Degree: MS(M.S.), Health and Exercise Science, 2013, Colorado State University
URL: http://hdl.handle.net/10217/81021
► Sprint interval training (SIT), whether performed on a cycle ergometer or non-motorized treadmill, enhances exercise capacity and evokes favorable metabolic and cardiopulmonary adaptations. However, despite…
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▼ Sprint interval training (SIT), whether performed on a cycle ergometer or non-motorized treadmill, enhances exercise capacity and evokes favorable metabolic and cardiopulmonary adaptations. However, despite known differences between cycling and running, the influence of exercise modality on the adaptive response to SIT has not been directly addressed. Additionally, the effect of SIT on the angiogenic factors, pigment epithelial-derived factor (PEDF) and vascular endothelial growth factor (VEGF), has not been well characterized. PURPOSE: To examine the influence of exercise modality on the adaptive response to SIT, we compared the effects of SIT performed on one of three different exercise machines: non-motorized treadmill, cycle ergometer, or plyometrics platform. Additionally, we sought to characterize the changes in circulating and skeletal muscle PEDF and VEGF following three weeks of SIT. METHODS: Twenty-seven healthy, sedentary or recreationally active adults (age: 23 ± 5 years; body mass index: 25.7 ± 4.7 kg m-2; VO2peak: 36.7 ± 6.1 ml kg-1 min-1 (mean ± SE)) completed nine sessions of repeated (four to eight) 30-s bouts of maximal exercise on a non-motorized treadmill (RUN), cycle ergometer (CYC), or plyometrics platform (JMP) over 21 days. Prior to and following completion of SIT, peak oxygen uptake (VO2peak) and time to exhaustion at 80% VO2peak were measured. Additionally, blood and skeletal muscle was sampled prior to and following completion of SIT to measure PEDF and VEGF. RESULTS: Three weeks of SIT increased time to exhaustion (40.0 min ± 3.2 vs.51.3 ± 5.5 min, P = 0.006). The interaction with exercise modality did not achieve statistical significance (P = 0.08), however, it appears that time to exhaustion increased in the RUN (43.2 ± 5.2 vs. 57.4 ± 9.2 min) and CYC (41.7 ± 6.1 vs. 62.3 ± 11.6 min) groups, but not the JMP group (35.5 ± 5.6 vs. 35.0 ± 4.9 min). Circulating and skeletal muscle VEGF and PEDF were not altered by three weeks of SIT (P > 0.05). DISCUSSION: Independent of exercise modality, three weeks of SIT improves endurance exercise capacity and does not alter circulating or skeletal muscle PEDF or VEGF.
Advisors/Committee Members: Bell, Christopher (advisor), Hickey, Matthew (committee member), Melby, Christopher (committee member).
Subjects/Keywords: exercise training; high intensity; oxidized low-density lipoprotein; pigment epithelium-derived factor; plyometrics platform; vascular endothelial growth factor
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APA (6th Edition):
Giordano, G. R. (2013). Sprint interval training: the influence of exercise modality. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/81021
Chicago Manual of Style (16th Edition):
Giordano, Gregory Robert. “Sprint interval training: the influence of exercise modality.” 2013. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/81021.
MLA Handbook (7th Edition):
Giordano, Gregory Robert. “Sprint interval training: the influence of exercise modality.” 2013. Web. 04 Mar 2021.
Vancouver:
Giordano GR. Sprint interval training: the influence of exercise modality. [Internet] [Masters thesis]. Colorado State University; 2013. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/81021.
Council of Science Editors:
Giordano GR. Sprint interval training: the influence of exercise modality. [Masters Thesis]. Colorado State University; 2013. Available from: http://hdl.handle.net/10217/81021
Colorado State University
3.
Paris, Hunter LouisRoss.
What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux.
Degree: MS(M.S.), Health and Exercise Science, 2014, Colorado State University
URL: http://hdl.handle.net/10217/84047
► INTRODUCTION: Weight regain after weight loss is the experience of most obese dieters. Metabolic adjustments characterized by decreased resting metabolic rate (RMR) and increased hunger…
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▼ INTRODUCTION: Weight regain after weight loss is the experience of most obese dieters. Metabolic adjustments characterized by decreased resting metabolic rate (RMR) and increased hunger can prevent long-term success. Possibly this energy gap could be attenuated by a high flux (HF)
state (higher expenditure coupled with higher intake). METHODS: 6 obese adults [age (mean±SE) = 42±12 y; body mass index (BMI)=35.7±3.7 kg/m2] underwent 7% diet-induced weight loss and were stabilized at this weight for 3 weeks. RMR via indirect calorimetry, and hunger via visual analog scale were then examined during two 4-day conditions of energy balance in random order – Low Flux (LF): sedentary with energy intake (EI)=RMR x1.35; and HF: daily exercise net energy cost of ~500 kcal/d and EI= RMR x1.7. RESULTS: Average 5-day weight did not differ between HF (103.4±4.7 kg) and LF (103±4.8 kg) (P>0.10). Average daily RMR was higher during HF (1926±138 kcal/day) compared to LF (1847±126 kcal/day; P = 0.05). Resting fat oxidation was also higher during HF (0.073+0.010 g/min) compared to LF (0.059+0.012 g/min; P<0.05). Average daily, perceived end-of-day hunger was lower during HF compared to LF (P<0.05). CONCLUSION: These preliminary data suggest that compared to a sedentary LF
state of energy balance, a HF energy balance
state is associated with a greater RMR, resting fat oxidation, and less hunger - all of which may attenuate the energy gap and protect against weight regain.
Advisors/Committee Members: Bell, Christopher (advisor), Melby, Christopher (committee member), Hickey, Matthew (committee member).
Subjects/Keywords: energy balance; weight loss; obesity; metabolism
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APA (6th Edition):
Paris, H. L. (2014). What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/84047
Chicago Manual of Style (16th Edition):
Paris, Hunter LouisRoss. “What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux.” 2014. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/84047.
MLA Handbook (7th Edition):
Paris, Hunter LouisRoss. “What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux.” 2014. Web. 04 Mar 2021.
Vancouver:
Paris HL. What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux. [Internet] [Masters thesis]. Colorado State University; 2014. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/84047.
Council of Science Editors:
Paris HL. What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux. [Masters Thesis]. Colorado State University; 2014. Available from: http://hdl.handle.net/10217/84047
Colorado State University
4.
Linde, Peter.
FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance.
Degree: MS(M.S.), Biomedical Sciences, 2017, Colorado State University
URL: http://hdl.handle.net/10217/185764
► Fatty Acid Desaturase 2 (FADS2) haplotypes associated with hyperactivity of its gene product, delta-6-desaturase (D6D), are associated with obesity and type-2 diabetes in humans. D6D…
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▼ Fatty Acid Desaturase 2 (FADS2) haplotypes associated with hyperactivity of its gene product, delta-6-desaturase (D6D), are associated with obesity and type-2 diabetes in humans. D6D regulates long-chain polyunsaturated fatty acid (PUFA) biosynthesis and is upregulated in several rodent models of obesity/insulin resistance, but its direct influence on diabetes is unclear. D6D activity might favor pathogenic effects of omega-6 FA linoleic acid (LA) by enhancing production of its product arachidonic acid (AA). Conversely, D6D may promote protective effects of omega-3 FA α-linolenic acid (ALA) by enhancing production of ALA to long-chain PUFAs that displace AA in cell membranes. It is hypothesized that abundant LA found in the modern western diet will be converted to AA promoting an inflammatory phenotype. The present study is to determine the interaction of heterozygous knockout (HET) or transgenic overexpression (TG) of FADS2 in mice fed high fat diets (HFD), as well as the interaction of LA:ALA content in the HFD. Adult male mice with HET (low), wild type (WT; medium), and TG (high) expression of FADS2 were fed HFD (45% w/w) containing 8% PUFA supplied by a balanced mix of LA and ALA (1:1), LA-rich (41:1), or ALA-rich (1:4) for 16 weeks. Glucose intolerance developed in WT mice, with no difference between diets. In HET mice, glucose intolerance was attenuated but this protection was removed by ALA rich diet. TG mice developed more glucose intolerance than WT. TG mice fed high LA diets were more glucose tolerant than high ALA and mixed diets. In conclusion, FADS2 expression modulates metabolic responses to high fat feeding. HET provides some protection against glucose intolerance, except when given an ALA rich diet. Transgenic overexpression increases glucose intolerance while a high LA diet attenuates this effect. This is inconsistent with current hypotheses that AA production from LA increases metabolic risk.
Advisors/Committee Members: Chicco, Adam (advisor), Melby, Christopher (committee member), Bouma, Gerrit (committee member).
Subjects/Keywords: inflammation; metabolism; lipids; diabetes
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APA (6th Edition):
Linde, P. (2017). FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/185764
Chicago Manual of Style (16th Edition):
Linde, Peter. “FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance.” 2017. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/185764.
MLA Handbook (7th Edition):
Linde, Peter. “FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance.” 2017. Web. 04 Mar 2021.
Vancouver:
Linde P. FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance. [Internet] [Masters thesis]. Colorado State University; 2017. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/185764.
Council of Science Editors:
Linde P. FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance. [Masters Thesis]. Colorado State University; 2017. Available from: http://hdl.handle.net/10217/185764
Colorado State University
5.
Swigris, Jody Lynn.
Wellness integrated mathematics.
Degree: MS(M.S.), Food Science and Human Nutrition, 2011, Colorado State University
URL: http://hdl.handle.net/10217/47462
► Wellness Integrated Mathematics (WIM) was a four-week, 8th grade mathematics curriculum that taught proportional reasoning using nutrition and fitness examples. The three objectives were to…
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▼ Wellness Integrated Mathematics (WIM) was a four-week, 8th grade mathematics curriculum that taught proportional reasoning using nutrition and fitness examples. The three objectives were to increase student knowledge of nutrition, fitness and math. WIM used a quasi-experimental, non-randomized, control/comparison design. Participants were four eighth-grade math classes in a single middle school. Two classes, totaling 47 students, were assigned to the comparison group. Two classes, totaling 48 students, were assigned to the intervention group. WIM was modeled after the successful middle school nutrition intervention, EatFit. The four-week curriculum consisted of nine lessons including a food demonstration and food tastings. To measure change in nutritional and fitness knowledge, the previously tested 21-item Wellness Integrated Mathematics Questionnaire (WIM-Q) was given to both groups before and after the intervention. Mathematical knowledge was measured by giving the Ratios and Proportions Math Exam to both groups before and after the intervention. Paired samples t-tests were performed on data from pre- and post-tests for both groups. The intervention group showed significant increases in overall (pre-test/post-test) percentage scores for: nutritional knowledge (60%/76%), p = .000; fitness knowledge (65%/80%), p = .000; and math knowledge (39%/92%), p = .000. The comparison group made only significant increases in math knowledge (22%/90%), p = .000. Results of the Wellness Integrated Mathematics Intervention indicate that a standards-based mathematics curriculum integrating nutrition and fitness can be an effective way to teach proportional reasoning while increasing nutrition and fitness knowledge.
Advisors/Committee Members: Cunningham-Sabo, Leslie (advisor), Melby, Christopher L. (committee member), Lucero, Rodrick S. (committee member).
Subjects/Keywords: education; physical education; nutrition; mathematics; fitness
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APA (6th Edition):
Swigris, J. L. (2011). Wellness integrated mathematics. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/47462
Chicago Manual of Style (16th Edition):
Swigris, Jody Lynn. “Wellness integrated mathematics.” 2011. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/47462.
MLA Handbook (7th Edition):
Swigris, Jody Lynn. “Wellness integrated mathematics.” 2011. Web. 04 Mar 2021.
Vancouver:
Swigris JL. Wellness integrated mathematics. [Internet] [Masters thesis]. Colorado State University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/47462.
Council of Science Editors:
Swigris JL. Wellness integrated mathematics. [Masters Thesis]. Colorado State University; 2011. Available from: http://hdl.handle.net/10217/47462
Colorado State University
6.
Woods, Rachel M.
Accuracy of walking metabolic prediction equations using a large diverse data set.
Degree: MS(M.S.), Health and Exercise Science, 2014, Colorado State University
URL: http://hdl.handle.net/10217/84579
► Walking metabolic rate prediction equations are commonly used to estimate oxygen consumption, exercise intensity and energy expenditure across a wide range of ages and anthropometrics.…
(more)
▼ Walking metabolic rate prediction equations are commonly used to estimate oxygen consumption, exercise intensity and energy expenditure across a wide range of ages and anthropometrics. Despite their widespread use, independent validations of these equations using metabolic data from a large number of individuals are uncommon. PURPOSE: To assess the accuracy of the commonly used ACSM and Pandolf walking metabolic rate prediction equations, along with two new walking metabolic rate predictions equations developed by Weyand et al. and Browning et al., using data from a large number of adults. METHODS: We used demographic, anthropometric, walking speed, and oxygen consumption data from several laboratories (N = 450 (164 Males, 286 females), 18-85 years old, 16.5-44 kg/m2). We estimated oxygen consumption using each prediction equation in 1,078 walking trials ranging from 0.55-2.18 m/s, and 0.5-12% grade. Comparisons between predictive methods were made for all walking trials, as well as among normal weight participants during level and gradient walking, and overweight and obese participants during level and gradient walking. We computed the mean prediction difference (MPD) as the difference between predicted vs. measured rates of oxygen consumption (ml/kg/min) for each trial, and examined the relationship between the MPD and measured oxygen consumption (ml/kg/min) using modified Bland-Altman plots. Linear regression was used to determine the intercept (fixed bias) and slope (proportional bias) for each equation. The absolute value of the mean prediction difference, and Root Mean Square Error (RMSE) values were also calculated for each equation and population. RESULTS: For level walking, all prediction equations had mean prediction differences that were statistically different from zero (P ≤ 0.05) except for the Browning et al., equation when applied to normal weight individuals and the Pandolf equation when applied to overweight and obese individuals. Most importantly, all prediction equations had significant (P ≤ 0.05) fixed and proportional bias, and demonstrated large RMSE (7.8-23.5% of mean measured metabolic rate) that were similar across equations and population. In addition, prediction error increased as measured metabolic rate increased for all equations. CONCLUSION: The metabolic prediction equations evaluated here each had considerable error when compared to measured values, regardless of the population in which the equation was created and/or validated. Improvements in prediction equations may require using approaches that aim to minimize RMSE and/or developing population/intensity specific equations.
Advisors/Committee Members: Browning, Raymond C. (advisor), Hickey, Mathew (committee member), Melby, Christopher (committee member).
Subjects/Keywords: exercise physiology; walking; prediction
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APA (6th Edition):
Woods, R. M. (2014). Accuracy of walking metabolic prediction equations using a large diverse data set. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/84579
Chicago Manual of Style (16th Edition):
Woods, Rachel M. “Accuracy of walking metabolic prediction equations using a large diverse data set.” 2014. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/84579.
MLA Handbook (7th Edition):
Woods, Rachel M. “Accuracy of walking metabolic prediction equations using a large diverse data set.” 2014. Web. 04 Mar 2021.
Vancouver:
Woods RM. Accuracy of walking metabolic prediction equations using a large diverse data set. [Internet] [Masters thesis]. Colorado State University; 2014. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/84579.
Council of Science Editors:
Woods RM. Accuracy of walking metabolic prediction equations using a large diverse data set. [Masters Thesis]. Colorado State University; 2014. Available from: http://hdl.handle.net/10217/84579
Colorado State University
7.
Ehrlicher, Sarah E.
Nrf2 activation but not vitamin C treatment promotes proteostatic maintenance during an oxidative challenge.
Degree: MS(M.S.), Health and Exercise Science, 2016, Colorado State University
URL: http://hdl.handle.net/10217/173519
► Improved proteostasis may be a mechanism of stress resistance, and it is likely that the increased protein turnover with exercise training contributes to adaptation to…
(more)
▼ Improved proteostasis may be a mechanism of stress resistance, and it is likely that the increased protein turnover with exercise training contributes to adaptation to stress. Exogenous antioxidant treatments such as vitamin C (VitC) target the detrimental effects of reactive oxygen species (ROS), but may simultaneously prevent the beneficial redox signaling associated with exercise. A possible alternative strategy to prevent oxidative damage while permitting redox-sensitive signaling is to increase endogenous antioxidants. The transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) increases the transcription of endogenous antioxidants by binding to the antioxidant response element in the promoter region of target genes. Protandim (Pro, LifeVantage), a combination of five phytochemicals, activates Nrf2 by increasing its translocation to the nucleus. We hypothesized that, compared to VitC, treatment with the Nrf2 activator Pro would not blunt ROS induced proteostatic maintenance. To mimic ROS signaling, C2C12 myoblasts were treated with H2O2. Treatment occurred alone or in combination with either VitC or Pro. Deuterium oxide labeling was used to measure protein synthesis in the mitochondrial and cytosolic cell fractions after 2, 4, 8, and 12 hours of treatment. Simultaneously cell proliferation was measured by deuterium incorporation into DNA. Compared to the untreated control, H2O2 alone increased DNA synthesis but did not increase mitochondrial protein synthesis, resulting in decreased proteostasis. Compared to H2O2 alone, Pro decreased protein synthesis in both cytosolic and mitochondrial fractions. However, Pro also decreased DNA synthesis. This resulted in a greater protein to DNA ratio suggesting maintenance of proteostasis. VitC with H2O2 increased DNA synthesis and decreased proteostasis, similar to H2O2 treatment alone. From these data, it appears that although treatment with exogenous antioxidants increases proliferation, activation of Nrf2 maintains mitochondrial protein synthesis despite a reduction in proliferation. Further study into the role of Nrf2 in improving mitochondrial proteostasis to promote stress resistance is warranted.
Advisors/Committee Members: Miller, Benjamin F. (advisor), Hamilton, Karyn L. (advisor), Melby, Christopher (committee member).
Subjects/Keywords: protein turnover; stress resistance; redox balance; hydrogen peroxide
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APA (6th Edition):
Ehrlicher, S. E. (2016). Nrf2 activation but not vitamin C treatment promotes proteostatic maintenance during an oxidative challenge. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/173519
Chicago Manual of Style (16th Edition):
Ehrlicher, Sarah E. “Nrf2 activation but not vitamin C treatment promotes proteostatic maintenance during an oxidative challenge.” 2016. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/173519.
MLA Handbook (7th Edition):
Ehrlicher, Sarah E. “Nrf2 activation but not vitamin C treatment promotes proteostatic maintenance during an oxidative challenge.” 2016. Web. 04 Mar 2021.
Vancouver:
Ehrlicher SE. Nrf2 activation but not vitamin C treatment promotes proteostatic maintenance during an oxidative challenge. [Internet] [Masters thesis]. Colorado State University; 2016. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/173519.
Council of Science Editors:
Ehrlicher SE. Nrf2 activation but not vitamin C treatment promotes proteostatic maintenance during an oxidative challenge. [Masters Thesis]. Colorado State University; 2016. Available from: http://hdl.handle.net/10217/173519
Colorado State University
8.
Minor, Brian.
Impact of timing of protein intake on nitrogen balance in exercising older individuals on a hypercaloric diet.
Degree: MS(M.S.), Health and Exercise Science, 2011, Colorado State University
URL: http://hdl.handle.net/10217/52121
► We have previously shown that in older adults, consumption of protein in the form of chocolate milk immediately after exercise enhances nitrogen balance (NBAL) when…
(more)
▼ We have previously shown that in older adults, consumption of protein in the form of chocolate milk immediately after exercise enhances nitrogen balance (NBAL) when energy balance is maintained. Since it is known that hypercaloric diets increase nitrogen (N) retention, it is important to know if the timing of protein intake after aerobic exercise provides further increases in N retention compared to the consumption of carbohydrate only post exercise. PURPOSE: To investigate if consumption of protein and carbohydrate (PRO + CHO) immediately after exercise as opposed to earlier in the day can improve NBAL in older individuals consuming a hypercaloric diet. METHODS: In a randomized cross-over design, subjects completed two separate 3-day exercise and nutrition interventions. Exercise (60 minutes of stationary cycling at 55% of VO2max) was performed daily at 4:30 PM. Diets were hypercaloric (calculated at +15% daily intake), with a PRO+CHO or carbohydrate only (CHO) drink consumed at 10 am and the opposite drink consumed after exercise (5:30 PM). Both diets (1.2 g protein/kg bodyweight, 30% fat, and balance as carbohydrate) were isonitrogenous and isocaloric with only the timing of the drinks differing. A 24 hour stay in a metabolic chamber confirmed positive energy balance while 24-hour urine collections determined NBAL. RESULTS: The 3-day mean NBAL was not significantly different (p=.0881) (n=6) between the CHO trial (.970 ± .517 g N) and the PRO + CHO trial (1.659 ± .430 g N) although a trend toward increased NBAL with PRO+CHO was apparent. The mean energy balance was not significantly different (p=.2906) between the CHO trial (+13.09 ± 1.94%) and the PRO + CHO trial (+ 14.28 ± 1.75%). Further analyses comparing the positive energy balance cohort to previously completed negative, and even energy balance cohorts distinguished the role of energy balance and timing of nutrition effects. CONCLUSION: Older individuals in positive energy balance do not maintain a significantly more positive NBAL balance by consuming protein after aerobic exercise as opposed to earlier in the day although energy balance does change the effect of protein timing on NBAL.
Advisors/Committee Members: Miller, Benjamin (advisor), Hamilton, Karyn (committee member), Melanson, Ed (committee member), Hickey, Matthew (committee member), Melby, Christopher (committee member).
Subjects/Keywords: nitrogen balance; wasting; sarcopenia; older individuals; protein timing; exercise
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APA (6th Edition):
Minor, B. (2011). Impact of timing of protein intake on nitrogen balance in exercising older individuals on a hypercaloric diet. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/52121
Chicago Manual of Style (16th Edition):
Minor, Brian. “Impact of timing of protein intake on nitrogen balance in exercising older individuals on a hypercaloric diet.” 2011. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/52121.
MLA Handbook (7th Edition):
Minor, Brian. “Impact of timing of protein intake on nitrogen balance in exercising older individuals on a hypercaloric diet.” 2011. Web. 04 Mar 2021.
Vancouver:
Minor B. Impact of timing of protein intake on nitrogen balance in exercising older individuals on a hypercaloric diet. [Internet] [Masters thesis]. Colorado State University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/52121.
Council of Science Editors:
Minor B. Impact of timing of protein intake on nitrogen balance in exercising older individuals on a hypercaloric diet. [Masters Thesis]. Colorado State University; 2011. Available from: http://hdl.handle.net/10217/52121
Colorado State University
9.
Heusinger, Daniel.
Impact of timing of milk intake on nitrogen balance in hypocaloric exercising older individuals.
Degree: MS(M.S.), Food Science and Human Nutrition, 2011, Colorado State University
URL: http://hdl.handle.net/10217/70362
► We have previously shown that in older adults, consumption of protein immediately after aerobic exercise, rather than earlier in the day, enhances nitrogen balance when…
(more)
▼ We have previously shown that in older adults, consumption of protein immediately after aerobic exercise, rather than earlier in the day, enhances nitrogen balance when energy balance is maintained. Since some older individuals consume lower calorie diets, it is important to know if these benefits also occur during hypocaloric feeding. The purpose of the study was to investigate if consumption of protein immediately after aerobic exercise rather than earlier in the day can improve nitrogen balance in older individuals consuming a hypocaloric diet. In a randomized crossover design, healthy sedentary male (n=2; age=67.0±1.0 years; BMI=27.4±0.3 kg/m²) and female (n=8; age=63.0±1.8 years; BMI=22.3±0.6 kg/m²) subjects completed two separate 3-day exercise and nutrition interventions. Exercise (60 minutes of stationary cycling at 55% of VO2max) was performed daily. Diets were hypocaloric (-15% daily intake), with a protein+carbohydrate (PRO+CHO) or carbohydrate only (CHO) drink consumed in the morning and the opposite drink consumed after exercise. Both diets (15% protein, 30% fat, and 55% carbohydrate) were isonitrogenous and isocaloric with only the timing of the drinks differing. A 24-hour stay in a metabolic chamber confirmed negative energy balance, while 24-hour urine collections determined nitrogen balance. The 3-day mean nitrogen balance was not significantly greater in the PRO+CHO trial (0.097±0.526g N) trial than the CHO trial (-0.070 ±0.520g N) (p=0.280). Thus, older individuals in negative energy balance do not maintain a significantly more positive nitrogen balance by consuming protein after aerobic exercise as opposed to earlier in the day. These results differ from our previous work and indicate that energy balance is an important determinant of the anabolic effect of protein feeding.
Advisors/Committee Members: Miller, Benjamin (advisor), Melby, Christopher (advisor), Hamilton, Karyn (committee member), Melanson, Ed (committee member), Hickey, Matthew (committee member).
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APA (6th Edition):
Heusinger, D. (2011). Impact of timing of milk intake on nitrogen balance in hypocaloric exercising older individuals. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/70362
Chicago Manual of Style (16th Edition):
Heusinger, Daniel. “Impact of timing of milk intake on nitrogen balance in hypocaloric exercising older individuals.” 2011. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/70362.
MLA Handbook (7th Edition):
Heusinger, Daniel. “Impact of timing of milk intake on nitrogen balance in hypocaloric exercising older individuals.” 2011. Web. 04 Mar 2021.
Vancouver:
Heusinger D. Impact of timing of milk intake on nitrogen balance in hypocaloric exercising older individuals. [Internet] [Masters thesis]. Colorado State University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/70362.
Council of Science Editors:
Heusinger D. Impact of timing of milk intake on nitrogen balance in hypocaloric exercising older individuals. [Masters Thesis]. Colorado State University; 2011. Available from: http://hdl.handle.net/10217/70362
10.
Matthews, Shawna Beth.
Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility.
Degree: PhD, Cell and Molecular Biology, 2015, Colorado State University
URL: http://hdl.handle.net/10217/170291
► Given the ongoing obesity epidemic, in which more women in the US are overweight or obese than are lean, the impact of obesity on the…
(more)
▼ Given the ongoing obesity epidemic, in which more women in the US are overweight or obese than are lean, the impact of obesity on the development of breast cancer is an important public health concern. Obese women with breast cancer generally have larger tumors and poorer prognosis than lean women with breast cancer. In an effort to deconstruct the biological mechanisms that link obesity and breast cancer, we have developed a novel rat model with high relevance to the polygenic development of obesity and breast cancer in humans. These rats have differing susceptibility to obesity when fed a diet of similar macronutrient composition as that consumed by the average American woman. Diet susceptible (DS) rats rapidly accumulate excess body fat and display metabolic perturbations, including resistance to insulin and leptin, which normally provide "stop eating" anorexigenic cues. In contrast, diet resistant (DR) rats remain lean despite being fed the same diet. Findings from experiments conducted in our novel rat model have provided several critical pieces of information. When DR and DS rats were treated with a chemical carcinogen, DS rats displayed markedly accelerated mammary cancer formation compared to DR rats, including higher cancer incidence, multiplicity, and tumor burden, in conjunction with reduced cancer latency. The larger tumor mass in DS rats was found to be attributable to higher growth rates in DS vs. DR tumors, due to a combination of accelerated cell cycle progression and reduced apoptotic efficiency. Importantly, DS rats tended to develop more tumors that were negative for sex hormone receptor expression, a subtype of breast cancer with high rates of breast cancer mortality. This observation was corroborated by an endocrine ablation experiment, i.e., bilateral ovariectomy. Removal of the ovaries puts a strong selection pressure on expansion of cell populations that can grow in the absence of high circulating levels of sex hormones. In addition to removal of the primary source of circulating sex hormones, several experiments failed to provide evidence in support of peripheral production of estrogen by adipose tissue. In spite of the lack of estrogen at the host systemic and local (mammary gland) level, ovariectomized DS rats displayed elevated cancer multiplicity and sum tumor weight compared to ovariectomized DR rats, indicating that obesity in DS rats promotes the growth of cancer cells in an estrogen-independent manner. Clinically, chronic inflammation in adipose tissue as a consequence of obesity has been shown to create a permissive environment for the development of breast cancer. While DS rats display evidence of heightened fat storage in the form of adipocyte hypertrophy, there was no evidence of inflammation accompanying this hypertrophy in the rat mammary gland in the current studies. Thus, peripheral production of estrogen by fat tissue and chronic inflammation in fat tissue—two of the mainstream mechanisms proposed to link excess fat and breast cancer—do not appear to be obligatory…
Advisors/Committee Members: Thompson, Henry J. (advisor), Henry, Charles (committee member), Hickey, Matthew (committee member), Melby, Christopher (committee member).
Subjects/Keywords: breast cancer; obesity; prevention; rat
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APA (6th Edition):
Matthews, S. B. (2015). Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/170291
Chicago Manual of Style (16th Edition):
Matthews, Shawna Beth. “Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility.” 2015. Doctoral Dissertation, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/170291.
MLA Handbook (7th Edition):
Matthews, Shawna Beth. “Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility.” 2015. Web. 04 Mar 2021.
Vancouver:
Matthews SB. Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility. [Internet] [Doctoral dissertation]. Colorado State University; 2015. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/170291.
Council of Science Editors:
Matthews SB. Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility. [Doctoral Dissertation]. Colorado State University; 2015. Available from: http://hdl.handle.net/10217/170291
11.
Schreck, Laura M.
1 month effect of breaking up sedentary activity on insulin sensitivity and glucose homeostasis in free-living overweight/obese adults.
Degree: MS(M.S.), Health and Exercise Science, 2019, Colorado State University
URL: http://hdl.handle.net/10217/197433
► Sedentary behavior (SB) triggers an inability to adjust substrate use to substrate availability (low metabolic flexibility, MF), which may precede glucose intolerance in the pathogenesis…
(more)
▼ Sedentary behavior (SB) triggers an inability to adjust substrate use to substrate availability (low metabolic flexibility, MF), which may precede glucose intolerance in the pathogenesis of insulin resistance. We and others have shown that frequent interruptions in SB leads to improved glycemic control, however the underlying role of MF in this process is unknown. This study examined the effects of breaking up SB on MF and glucose metabolism in free-living overweight and obese adults. To distinguish effects of breaking up SB from being physically active, we also studied a group where participants performed a single energy matched continuous bout of exercise. Physically inactive, adults (12F/9M, mean±SD, age: 33±8 yr, BMI: 29.5±3.3 kg/m2) were randomly assigned to a 4 week intervention consisting of brisk walking for 5 min each hour for 10h, 5 d/wk (MICRO, n=10), or 4 weeks of an intervention consisting of one continuous 45 min bout of exercise per day, 5d/wk (ONE, n=9). Outcomes assessed at baseline and after each intervention included: MF (waking respiratory quotient, RQ, minus sleeping RQ as measured in a whole room calorimeter), insulin sensitivity (SI, IVGTT), 24h glycemia (continuous glucose monitor), 24h glucose oxidation (U13C glucose tracer), SB, time spent standing, time spent stepping (ActivPAL) and TEE (double labeled water). Groups were similar on all outcome variables at baseline. Linear mixed models evaluated intervention and intervention-by-group effects. MICRO and ONE decreased time sitting and increased time stepping with no significant changes in TEE. Compared to ONE, MICRO decreased 24h glycemic variability (p=0.06), improved the acute whole body insulin sensitivity (p=0.08) and acute insulin response to glucose (AIRg) (p=0.02) , maintained exogenous glucose oxidation (p<0.03) and improved MF (p=0.02). Independent of time sitting and stepping, breaking up SB improves glucose homeostasis and MF. The effects of such an intervention in persons with type 2 diabetes warrants further study.
Advisors/Committee Members: Hickey, Matthew (advisor), Bergouignan, Audrey (advisor), Broussard, Josiane (committee member), Melby, Christopher (committee member).
Subjects/Keywords: frequent interruptions; metabolic flexibility; sedentary; glycemia; carbohydrate; metabolism
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APA (6th Edition):
Schreck, L. M. (2019). 1 month effect of breaking up sedentary activity on insulin sensitivity and glucose homeostasis in free-living overweight/obese adults. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/197433
Chicago Manual of Style (16th Edition):
Schreck, Laura M. “1 month effect of breaking up sedentary activity on insulin sensitivity and glucose homeostasis in free-living overweight/obese adults.” 2019. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/197433.
MLA Handbook (7th Edition):
Schreck, Laura M. “1 month effect of breaking up sedentary activity on insulin sensitivity and glucose homeostasis in free-living overweight/obese adults.” 2019. Web. 04 Mar 2021.
Vancouver:
Schreck LM. 1 month effect of breaking up sedentary activity on insulin sensitivity and glucose homeostasis in free-living overweight/obese adults. [Internet] [Masters thesis]. Colorado State University; 2019. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/197433.
Council of Science Editors:
Schreck LM. 1 month effect of breaking up sedentary activity on insulin sensitivity and glucose homeostasis in free-living overweight/obese adults. [Masters Thesis]. Colorado State University; 2019. Available from: http://hdl.handle.net/10217/197433
12.
Peth, James Anthony.
Predictors of learning outcomes among students in nutrition science courses at Colorado State University.
Degree: PhD, Food Science and Human Nutrition, 2018, Colorado State University
URL: http://hdl.handle.net/10217/191386
► Overview This dissertation is a summary of exploratory research to assess predictors of learning outcomes (academic background, conceptions of subject, motivations for studying, and approaches…
(more)
▼ Overview This dissertation is a summary of exploratory research to assess predictors of learning outcomes (academic background, conceptions of subject, motivations for studying, and approaches to learning) among students taking two undergraduate nutrition science courses at CSU—Human Nutrition (Course 1) and Integrative Nutrition & Metabolism (Course 2). It was comprised of three studies. Introduction There is a global need for experts trained in nutrition with an integrationist approach to health sciences and equipped to understand complex issues in health and disease. Yet, many students in nutrition sciences courses are not learning at a mastery level and often lack the knowledge and ability to integrate what they have learned to apply it to more advanced courses and their careers. Key factors influencing a student's approach to learning and performance outcomes in a course include their academic background, motivations for learning the subject, conceptions of the subject, and approaches to learning. Pilot data from preliminary research performed during a course re-design project at
Colorado State University (CSU) indicate many students begin nutrition science courses with inadequate prior knowledge from prerequisite courses, lack autonomous motivations, exhibit fragmented conceptions of the science of nutrition, and adopt surface, rather than deeper, more meaningful approaches to learning. Methods Exploratory mixed-methods research was performed to assess academic background, motivations for studying nutrition, conceptions of the discipline, and approaches to learning among students in Course 1 (Human Nutrition) and Course 2 (Integrative Nutrition & Metabolism). It was comprised of three studies. The first was an analysis of academic and demographic data for 1,739 students, who had completed Course 1 only (n=1,377) or both Course 1 and Course 2 (n=362) between 2010-2016, to identify and evaluate relationships with in-class exam performance. Studies 2-3 were analyses of semi-structured interviews with students who had completed Course 1 only (n=12) or both Course 1 and Course 2 (n=27) between 2012-2015. Each student reflected on their experiences before and after the course(s) they completed, including their motivations for studying nutrition, conceptions of nutrition as a discipline, and approaches to learning. Transcripts were inductively coded and discrete categories of motivations, conceptions, and approaches were developed using phenomenography. Transcripts were re-analyzed using focused coding, and each student was categorized for each domain. Statistical tests were conducted to evaluate the strength of relationships among academic background variables, motivations, conceptions, approaches, and learning outcomes. Results Pre-course GPA, grades in prerequisite courses, and scores on a prior knowledge test for Course 1 were positively correlated with in-class exam performance. Pre-course GPA was the best predictor for both courses, explaining 51.9% and 43.9% of the score variance in Course 1 and Course 2,…
Advisors/Committee Members: Melby, Christopher (advisor), Balgopal, Meena (advisor), Foster, Michelle (committee member), Gentile, Christopher (committee member), Hickey, Matthew (committee member).
Subjects/Keywords: conceptions; motivations; science; education; approaches to learning; nutrition
…3
Nutrition Science Courses at Colorado State University… …CONSENT TO PARTICIPATE IN A RESEARCH STUDY AT COLORADO
STATE UNIVERSITY… …Nutrition Science Courses at Colorado State University
Most students in Food Science and Human… …Nutrition (FSHN) at Colorado State
University (CSU) enroll with an expressed… …Health Care; April 18, 2015; Colorado State University.
14. Goldenfeld N, Woese C. Biology’s…
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APA (6th Edition):
Peth, J. A. (2018). Predictors of learning outcomes among students in nutrition science courses at Colorado State University. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/191386
Chicago Manual of Style (16th Edition):
Peth, James Anthony. “Predictors of learning outcomes among students in nutrition science courses at Colorado State University.” 2018. Doctoral Dissertation, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/191386.
MLA Handbook (7th Edition):
Peth, James Anthony. “Predictors of learning outcomes among students in nutrition science courses at Colorado State University.” 2018. Web. 04 Mar 2021.
Vancouver:
Peth JA. Predictors of learning outcomes among students in nutrition science courses at Colorado State University. [Internet] [Doctoral dissertation]. Colorado State University; 2018. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/191386.
Council of Science Editors:
Peth JA. Predictors of learning outcomes among students in nutrition science courses at Colorado State University. [Doctoral Dissertation]. Colorado State University; 2018. Available from: http://hdl.handle.net/10217/191386
Colorado State University
13.
Dadkhah, Maryam.
Development and evaluation of the America On the Move program for university students.
Degree: PhD, Food Science and Human Nutrition, 2013, Colorado State University
URL: http://hdl.handle.net/10217/80937
Subjects/Keywords: America On the Move; college; healthy eating; physical activity; small lifestyle changes; weight gain prevention
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APA (6th Edition):
Dadkhah, M. (2013). Development and evaluation of the America On the Move program for university students. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/80937
Chicago Manual of Style (16th Edition):
Dadkhah, Maryam. “Development and evaluation of the America On the Move program for university students.” 2013. Doctoral Dissertation, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/80937.
MLA Handbook (7th Edition):
Dadkhah, Maryam. “Development and evaluation of the America On the Move program for university students.” 2013. Web. 04 Mar 2021.
Vancouver:
Dadkhah M. Development and evaluation of the America On the Move program for university students. [Internet] [Doctoral dissertation]. Colorado State University; 2013. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/80937.
Council of Science Editors:
Dadkhah M. Development and evaluation of the America On the Move program for university students. [Doctoral Dissertation]. Colorado State University; 2013. Available from: http://hdl.handle.net/10217/80937
Colorado State University
14.
Krause, Molly Annamarie.
Single session of moderate exercise, without energy deficit, may reduce svcam-1 concentrations in young, sedentary females, A.
Degree: MS(M.S.), Food Science and Human Nutrition, 2010, Colorado State University
URL: http://hdl.handle.net/10217/44965
► Purpose: Cardiovascular disease remains the number one cause of death within the United States and globally [1, 2]. Postprandial lipemia and vascular adhesion molecules are…
(more)
▼ Purpose: Cardiovascular disease remains the number one cause of death within the United States and globally [1, 2]. Postprandial lipemia and vascular adhesion molecules are becoming more widely recognized as biomedical makers associated with increased risk of developing CVD [3-5]. It has been well established that moderate exercise can improve some aspects of postprandial metabolism such as decreased triglycerides and improved insulin sensitivity [6]. However, there is limited data regarding the effect of prior moderate exercise on attenuating postprandial response specific to adhesion molecules [7, 8]. The purpose of this study was to determine the effects of a single bout of acute exercise, with energy replacement, on plasma soluble vascular adhesion molecule-1 (sVCAM-1), a marker of endothelial dysfunction, measured during fasting and in response to a high-fat, high-carbohydrate meal in young, non-obese, sedentary females. Methods: Eight, non-obese (x body mass index=24.6 kg/m2), habitually sedentary females (x age= 19.6 y) participated in this study. Following preliminary testing, each subject completed two trials in random order: 1) Exercise (Ex) 2) Non-exercise (Non-Ex). Each trial took place over 2 days. On the evening of day 1, subjects either rested (Non-Ex) or completed a cycle ergometer exercise bout at 65% peak heart rate, eliciting net exercise energy expenditure of ~285kcalories. On the morning of day 2 of each trial a fasting venous blood sample was drawn for measurement of sVCAM-1, followed by the consumption of a high-fat, high-sugar meal by each participant. Postprandial venous blood samples were then taken over at 2, 4, and 6 hours following meal ingestion for measurement plasma sVCAM-1 concentrations. Results: There was no significant treatment by time interaction on sVCAM-1 concentrations, nor was there a significant main effect of time. There was a significant condition effect on circulating soluble VCAM-1 concentrations such that concentrations were lower before and following the high-fat, high-sugar meal challenge for the EX compare to the NonEx condition. Conclusions: Results from the current study suggest that a single session of moderate exercise, without an energy deficit, may reduce sVCAM-1 concentrations in young, sedentary females. However, this finding must be viewed with caution owing to possible issues with thesVCAM-1 measurements, and the assay repeated prior to drawing any conclusions about the effect of acute exercise on circulating sVCAM-1 concentrations measured the morning after exercise.
Advisors/Committee Members: Melby, Christopher (advisor), Hickey, Matthew (committee member), Nelson, Tracy (committee member).
Subjects/Keywords: sVCAM-1; females; exercise; energy deficit; adhesion molecules; Cell adhesion molecules; Sedentary women; Young women – Nutrition
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APA (6th Edition):
Krause, M. A. (2010). Single session of moderate exercise, without energy deficit, may reduce svcam-1 concentrations in young, sedentary females, A. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/44965
Chicago Manual of Style (16th Edition):
Krause, Molly Annamarie. “Single session of moderate exercise, without energy deficit, may reduce svcam-1 concentrations in young, sedentary females, A.” 2010. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/44965.
MLA Handbook (7th Edition):
Krause, Molly Annamarie. “Single session of moderate exercise, without energy deficit, may reduce svcam-1 concentrations in young, sedentary females, A.” 2010. Web. 04 Mar 2021.
Vancouver:
Krause MA. Single session of moderate exercise, without energy deficit, may reduce svcam-1 concentrations in young, sedentary females, A. [Internet] [Masters thesis]. Colorado State University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/44965.
Council of Science Editors:
Krause MA. Single session of moderate exercise, without energy deficit, may reduce svcam-1 concentrations in young, sedentary females, A. [Masters Thesis]. Colorado State University; 2010. Available from: http://hdl.handle.net/10217/44965
Colorado State University
15.
Ehlen, Kellie Amanda.
Effects of speed and grade on the biomechanics and energetics of walking in obese adults.
Degree: MS(M.S.), Health and Exercise Science, 2010, Colorado State University
URL: http://hdl.handle.net/10217/39255
► Brisk walking is a recommended form of exercise for obese individuals. However, lower extremity joint loads and the associated risk of musculoskeletal injury or pathology…
(more)
▼ Brisk walking is a recommended form of exercise for obese individuals. However, lower extremity joint loads and the associated risk of musculoskeletal injury or pathology increase with walking speed. Walking uphill at a slower speed may offer an alternative form of moderate intensity exercise that reduces joint loading. The purpose of this study was to quantify the biomechanics and energetics of level and uphill walking in obese adults. We hypothesized that compared to brisk level walking, walking slower up a moderate incline would reduce lower extremity joint loading while providing appropriate physiologic stimulus. Twelve obese adult volunteers, age = 27 (5.5) years, mass = 100.5 (15.7) kg, BMI = 33.4 (2.6) kg/m2, (mean (S.D.)), participated in this study. We measured ground reaction forces, three-dimensional lower extremity kinematics and oxygen consumption while subjects walked on a dual-belt force measuring treadmill at several speed (0.50-1.75m/s)/grade (0-9°) combinations. We calculated net muscle moments at the hip, knee and ankle and metabolic rate for each condition. Walking slower uphill significantly reduced net muscle moments at the knee compared to faster level walking (p<0.05). Peak knee extension and adduction moments were reduced by ~19% and 26%, respectively, when subjects walked at 0.75m/s, 6° vs. 1.50m/s, 0°. The greater knee moments during level walking suggests subjects had greater medial compartment knee joint loads. All walking trials were moderate intensity (48.5-59.8% of VO2max). A slower walking speed combined with a moderate incline appears to be an effective strategy for reducing knee joint loads while providing appropriate cardiovascular stimulus in obese adults.
Advisors/Committee Members: Browning, Raymond (advisor), Reiser, Raoul Frederick, II (committee member), Melby, Christopher L. (committee member).
Subjects/Keywords: Fitness walking; Overweight persons; Obesity
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APA (6th Edition):
Ehlen, K. A. (2010). Effects of speed and grade on the biomechanics and energetics of walking in obese adults. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/39255
Chicago Manual of Style (16th Edition):
Ehlen, Kellie Amanda. “Effects of speed and grade on the biomechanics and energetics of walking in obese adults.” 2010. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/39255.
MLA Handbook (7th Edition):
Ehlen, Kellie Amanda. “Effects of speed and grade on the biomechanics and energetics of walking in obese adults.” 2010. Web. 04 Mar 2021.
Vancouver:
Ehlen KA. Effects of speed and grade on the biomechanics and energetics of walking in obese adults. [Internet] [Masters thesis]. Colorado State University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/39255.
Council of Science Editors:
Ehlen KA. Effects of speed and grade on the biomechanics and energetics of walking in obese adults. [Masters Thesis]. Colorado State University; 2010. Available from: http://hdl.handle.net/10217/39255
Colorado State University
16.
Culbertson, Diana Lynn.
Mini-program ENERGY Cortez: obesity and type 2 diabetes prevention through science enrichment for elementary school children in rural southwestern Colorado.
Degree: MS(M.S.), Food Science and Human Nutrition, 2010, Colorado State University
URL: http://hdl.handle.net/10217/38507
Subjects/Keywords: Indian children – Nutrition – Colorado – Montezuma County; Indian children – Health and hygiene – Colorado – Montezuma County; Obesity in children – Colorado – Montezuma County – Prevention; Diabetes in children – Colorado – Montezuma County – Prevention
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APA (6th Edition):
Culbertson, D. L. (2010). Mini-program ENERGY Cortez: obesity and type 2 diabetes prevention through science enrichment for elementary school children in rural southwestern Colorado. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/38507
Chicago Manual of Style (16th Edition):
Culbertson, Diana Lynn. “Mini-program ENERGY Cortez: obesity and type 2 diabetes prevention through science enrichment for elementary school children in rural southwestern Colorado.” 2010. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/38507.
MLA Handbook (7th Edition):
Culbertson, Diana Lynn. “Mini-program ENERGY Cortez: obesity and type 2 diabetes prevention through science enrichment for elementary school children in rural southwestern Colorado.” 2010. Web. 04 Mar 2021.
Vancouver:
Culbertson DL. Mini-program ENERGY Cortez: obesity and type 2 diabetes prevention through science enrichment for elementary school children in rural southwestern Colorado. [Internet] [Masters thesis]. Colorado State University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/38507.
Council of Science Editors:
Culbertson DL. Mini-program ENERGY Cortez: obesity and type 2 diabetes prevention through science enrichment for elementary school children in rural southwestern Colorado. [Masters Thesis]. Colorado State University; 2010. Available from: http://hdl.handle.net/10217/38507
Colorado State University
17.
Lonac, Mark Charles.
Effect of short-term epigallocatechin-3-gallate supplementation on the thermic effect of feeding and resting metabolic rate.
Degree: MS(M.S.), Health and Exercise Science, 2009, Colorado State University
URL: http://hdl.handle.net/10217/34983
► The sympathetic nervous system (SNS) both provides tonic support of resting metabolic rate (RMR) and mediates approximately one-third of the thermic effect of feeding (TEF),…
(more)
▼ The sympathetic nervous system (SNS) both provides tonic support of resting metabolic rate (RMR) and mediates approximately one-third of the thermic effect of feeding (TEF), the latter accounting for ~10% of daily energy expenditure. Epigallocatechin-3-gallate (EGCG), the most abundant and bioactive catechin in green tea, inhibits the catecholamine-degrading action of the enzyme catechol-O-methyltransferase, thereby prolonging SNS activation. Accordingly, we hypothesized that short-term EGCG supplementation would augment RMR and TEF in healthy adult humans. METHODS: Sixteen subjects reported to our lab on two mornings (≥ 10 days apart) after 12 hours without food, caffeine, and alcohol and 24 hours without exercise. Each visit followed double-blinded, randomized EGCG or cornmeal placebo supplementation (seven pills over 48 hours, 135 mg EGCG/pill). RMR and respiratory exchange ratio (RER) were determined using the ventilated hood technique for 45 minutes prior to consumption of a liquid mixed-composition meal providing calories equivalent to 40% of RMR. Energy expenditure (EE) and RER were then measured for the first 20 of every 30 minutes for five hours. RESULTS: All subjects (n = 9 males, n =7 females; age 25 ± 2 yrs, mean ± s.e.; 22.6 ± 1.8% body fat) were weight stable and were washed out from prior green tea or EGCG use for ≥ one month. Results are reported as placebo vs. EGCG. EGCG did not affect RMR or baseline RER (RMR: 1665 ± 84 vs. 1610 ± 89 kcal/day; p = 0.10; RER: 0.82 ± 0.01 vs. 0.83 ± 0.01; p = 0.29). EGCG did not affect the area under the TEF response curve, expressed as absolute postprandial EE (441,083 ± 22,436 vs. 429,350 ± 24,209 arbitrary units, A.U.; p = 0.22) or the absolute (58,104 ± 5,297 vs. 58,949 ± 5,672 A.U.; p = 0.88) or percentage (3,508 ± 263 vs. 3,647 ± 285 A.U.; p = 0.67) difference between absolute postprandial EE and baseline RMR. No differences between placebo and EGCG were observed for RER during TEF. CONCLUSION: These results indicate that, contrary to our hypothesis, short-term EGCG supplementation does not influence RMR or TEF in healthy adults. This suggests that reported positive benefits of green tea on energy balance are the result of increased physical activity EE and/or decreased energy intake.
Advisors/Committee Members: Bell, Christopher (advisor), Hickey, Matthew S. (committee member), Nelson-Ceschin, Tracy L. (committee member), Melby, Christopher L. (committee member).
Subjects/Keywords: TEF; EGCG; sympathetic nervous system; SNS; resting metabolic rate; RMR; thermic effect of feeding; Epigallocatechin gallate; Sympathetic nervous system; Epigallocatechin-3-gallate
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APA (6th Edition):
Lonac, M. C. (2009). Effect of short-term epigallocatechin-3-gallate supplementation on the thermic effect of feeding and resting metabolic rate. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/34983
Chicago Manual of Style (16th Edition):
Lonac, Mark Charles. “Effect of short-term epigallocatechin-3-gallate supplementation on the thermic effect of feeding and resting metabolic rate.” 2009. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/34983.
MLA Handbook (7th Edition):
Lonac, Mark Charles. “Effect of short-term epigallocatechin-3-gallate supplementation on the thermic effect of feeding and resting metabolic rate.” 2009. Web. 04 Mar 2021.
Vancouver:
Lonac MC. Effect of short-term epigallocatechin-3-gallate supplementation on the thermic effect of feeding and resting metabolic rate. [Internet] [Masters thesis]. Colorado State University; 2009. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/34983.
Council of Science Editors:
Lonac MC. Effect of short-term epigallocatechin-3-gallate supplementation on the thermic effect of feeding and resting metabolic rate. [Masters Thesis]. Colorado State University; 2009. Available from: http://hdl.handle.net/10217/34983
Colorado State University
18.
Johnson, Tyler Kass.
Short-term sprint-interval training improves insulin sensitivity in young adult humans.
Degree: MS(M.S.), Health and Exercise Science, 2009, Colorado State University
URL: http://hdl.handle.net/10217/28553
► Habitual endurance exercise has been shown repeatedly to increase insulin sensitivity, one of the principal determinants of blood glucose control. Many adults however, choose not…
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▼ Habitual endurance exercise has been shown repeatedly to increase insulin sensitivity, one of the principal determinants of blood glucose control. Many adults however, choose not to participate in this type of exercise, citing insufficient time as a perceived obstacle. A recent study has described improved blood glucose control post-consumption of a glucose beverage following 2-weeks of sprint-interval training (SIT), implying that SIT may increase insulin sensitivity. PURPOSE: Using the gold standard measure, the hyperinsulinemic euglycemic clamp technique, we investigated the hypothesis that SIT will increase insulin sensitivity. METHODS: 12 healthy, sedentary or recreationally active adults (age: 27 ± 3 yr; body mass index: 26.2 ± 1.4 kg/m2; VO2peak: 36.0 ± 3.3 ml/kg/min (mean ± SE)) completed 6 sessions of repeated (4 to 7) 30-second bouts of extremely high-intensity cycle ergometer exercise (i.e. a Wingate protocol) over 14 days. Prior to and 72 hours following completion of SIT the glucose infusion rate (GIR) required to maintain a blood glucose concentration of 90 mg/dL during a standardized infusion of insulin was determined. In order to quantify the effect of the most recent SIT bout on insulin sensitivity, GIR was determined in 7 adults (25 ± 1 yr; 25.7 ± 1.4 kg/m2; 37.1 ± 4.3 ml/kg/min) prior to and 72 hours following a single bout of SIT. Finally, in order to establish the day-to-day variability in GIR, 9 adults (23 ± 2 yr; 26.8 ± 1.6 kg/m2, 33.3 ± 2.2 ml/kg/min) served as a sedentary control. RESULTS: Compared with baseline, insulin sensitivity was increased following short-term SIT (GIR: 6.2 ± 0.7 vs. 8.0 ± 0.8 mg/kg/min; P = 0.02) but was unchanged following a single bout of SIT (9.7 ± 1.3 vs. 10.7 ± 1.4; P = 0.43) or a period of inactivity (7.9 ± 0.9 vs. 8.3 ± 1.0; P = 0.38). Regardless of intervention, blood glucose concentration at the end of the hyperinsulinemic euglycemic clamp, body mass and fasting blood glucose concentration remained unchanged (all P > 0.2), with the exception of a small increase in fasting glucose following a single bout of SIT (73.6 ± 1.8 vs. 75.8 ± 1.3 mg/dL; P = 0.01). CONCLUSION: These data, collected using the gold standard hyperinsulinemic euglycemic clamp technique, suggest that short-term SIT is a viable alternative to endurance training as a strategy to improve insulin sensitivity.
Advisors/Committee Members: Bell, Christopher (advisor), Hickey, Matthew S. (advisor), Miller, Benjamin F. (committee member), Melby, Christopher L. (committee member).
Subjects/Keywords: SIT; sprint-interval training; hyperinsulinemic euglycemic clamp technique; glucose infusion rate; GIR; insulin sensitivity; Sprinting – Training; Insulin; Young adults – Exercise – Physiological aspects
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APA (6th Edition):
Johnson, T. K. (2009). Short-term sprint-interval training improves insulin sensitivity in young adult humans. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/28553
Chicago Manual of Style (16th Edition):
Johnson, Tyler Kass. “Short-term sprint-interval training improves insulin sensitivity in young adult humans.” 2009. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/28553.
MLA Handbook (7th Edition):
Johnson, Tyler Kass. “Short-term sprint-interval training improves insulin sensitivity in young adult humans.” 2009. Web. 04 Mar 2021.
Vancouver:
Johnson TK. Short-term sprint-interval training improves insulin sensitivity in young adult humans. [Internet] [Masters thesis]. Colorado State University; 2009. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/28553.
Council of Science Editors:
Johnson TK. Short-term sprint-interval training improves insulin sensitivity in young adult humans. [Masters Thesis]. Colorado State University; 2009. Available from: http://hdl.handle.net/10217/28553
Colorado State University
19.
Kuzma, Jessica Nichole.
Ingestion of wheat germ in healthy subjects does not acutely elevate plasma wheat germ agglutinin concentrations.
Degree: MS(M.S.), Health and Exercise Science, 2009, Colorado State University
URL: http://hdl.handle.net/10217/34982
► Because the fiber content (15 g/day) of the typical U.S. diet is considerably lower than recommended values (25-30 g) the public is encouraged by USDA…
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▼ Because the fiber content (15 g/day) of the typical U.S. diet is considerably lower than recommended values (25-30 g) the public is encouraged by USDA Dietary Guidelines to increase consumption of high fiber foods such as whole grains, fruits, and vegetables. Because whole grains are also a rich source of the lectin wheat germ agglutinin (WGA), those abiding by current recommendations would consequently increase their lectin intake. The WGA lectin has been poorly studied in humans, and it is unclear if it can breach the gut barrier, enter circulation, and influence physiology. Apart from animal studies, characterization of lectin behavior in humans is limited to tomato lectin (TL) and peanut lectin (PNA) feeding studies; both of which were able to detect lectin in systemic circulation within hours of ingestion of tomato juice and peanuts, respectively. Because lectin consumption has elicited adverse health effects in laboratory animals, a prudent first step in humans will be to determine if common dietary lectins such as WGA can enter circulation in quantities capable of influencing normal cell function. The purpose of this study was to determine if WGA enters the circulation of healthy subjects following ingestion of wheat germ and to determine the potential time course and concentration of this lectin in venous plasma. Fourteen normal males and females between 17 and 40 yrs completed preliminary screening and reported to the lab after an overnight fast. Following baseline blood measurements, subjects consumed 50 g wheat germ within a 60 min interval. Blood samples were obtained at 30, 60, 90, 120, 240 min, and at 24 hrs post ingestion. Venous plasma concentrations of WGA were determined via WGA-specific Enzyme-Linked Immunosorbent Assay (ELISA) at the six time intervals, including baseline. According to the protocol utilized, WGA was not detected in venous plasma samples from any of the subjects following consumption of 50 g of wheat germ, thereby indicating that the available WGA in wheat germ either did not breach the gut barrier, or preferentially bound tissues other than plasma proteins. These data represent an important first step in determining the safety of WGA found in common whole-wheat food products. Further research will be required to determine if WGA enters the bloodstream and binds formed elements such as erythrocytes, platelets, and leukocytes in addition to other tissues and organs.
Advisors/Committee Members: Nelson-Ceschin, Tracy L. (advisor), Cordain, Loren, 1950- (advisor), Melby, Christopher L. (committee member), Hickey, Matthew S. (committee member).
Subjects/Keywords: human subjects; wheat germ agglutinin lectin; WGA lectin; venous plasma; Lectins; Agglutinins; Blood plasma; Wheat germ
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APA (6th Edition):
Kuzma, J. N. (2009). Ingestion of wheat germ in healthy subjects does not acutely elevate plasma wheat germ agglutinin concentrations. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/34982
Chicago Manual of Style (16th Edition):
Kuzma, Jessica Nichole. “Ingestion of wheat germ in healthy subjects does not acutely elevate plasma wheat germ agglutinin concentrations.” 2009. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/34982.
MLA Handbook (7th Edition):
Kuzma, Jessica Nichole. “Ingestion of wheat germ in healthy subjects does not acutely elevate plasma wheat germ agglutinin concentrations.” 2009. Web. 04 Mar 2021.
Vancouver:
Kuzma JN. Ingestion of wheat germ in healthy subjects does not acutely elevate plasma wheat germ agglutinin concentrations. [Internet] [Masters thesis]. Colorado State University; 2009. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/34982.
Council of Science Editors:
Kuzma JN. Ingestion of wheat germ in healthy subjects does not acutely elevate plasma wheat germ agglutinin concentrations. [Masters Thesis]. Colorado State University; 2009. Available from: http://hdl.handle.net/10217/34982
Colorado State University
20.
Jordan, Leora Y.
Milk consumption after moderate intensity aerobic exercise improves Nitrogen balance in older adults.
Degree: MS(M.S.), Health and Exercise Science, 2010, Colorado State University
URL: http://hdl.handle.net/10217/37799
► Sarcopenia is the progressive decline in muscle mass that happens with age and can lead to falls, fractures, and inability to maintain activities of daily…
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▼ Sarcopenia is the progressive decline in muscle mass that happens with age and can lead to falls, fractures, and inability to maintain activities of daily living. Simplistically, sarcopenia results from a disequilibrium in the rates of muscle protein synthesis (MPS) and muscle protein breakdown (MPB), with a net negative protein and nitrogen balance over time. This study was designed to determine whether subjects in energy balance can increase nitrogen balance by timing milk intake immediately after exercise. In a randomized cross-over design, ten older individuals (64.5±2.0 y) completed two 3-day trials that were isocaloric and isonitrogenous. During the two trials, subjects consumed either chocolate milk (PRO+CHO) or a Kool-Aid type beverage (CHO) following a daily bout of cycling exercise (60 minutes at 55% of VO2max). Study diet was repeated across trials and controlled for protein/nitrogen content (1.2 g/kg and 14% of total kcal) and energy balance (within 200 kcal). For all trial days, 24-hour urine collections were completed and analyzed for nitrogen content. Mean energy balance (CHO+PRO: 202±36 kcal; CHO: 191±44 kcal; p=0.68) and mean physical activity level (PAL) (CHO+PRO: 1.61±0.04; CHO: 1.60±0.04; p=0.60) did not differ between trials, but mean nitrogen balance was significantly more positive in the PRO+CHO (1.2 g N±0.32) trial than the CHO trial (0.8 g N ±0.45) (p<0.05). Thus, under conditions of energy balance, nitrogen/protein balance becomes more positive when chocolate milk is consumed immediately after moderate intensity aerobic exercise compared to a CHO-only beverage.
Advisors/Committee Members: Miller, Benjamin F. (advisor), Hickey, Matthew S. (committee member), Melanson, Ed (committee member), Melby, Christopher L. (committee member).
Subjects/Keywords: Older people – Exercise; Milk consumption; Nitrogen in the body
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APA ·
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APA (6th Edition):
Jordan, L. Y. (2010). Milk consumption after moderate intensity aerobic exercise improves Nitrogen balance in older adults. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/37799
Chicago Manual of Style (16th Edition):
Jordan, Leora Y. “Milk consumption after moderate intensity aerobic exercise improves Nitrogen balance in older adults.” 2010. Masters Thesis, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/37799.
MLA Handbook (7th Edition):
Jordan, Leora Y. “Milk consumption after moderate intensity aerobic exercise improves Nitrogen balance in older adults.” 2010. Web. 04 Mar 2021.
Vancouver:
Jordan LY. Milk consumption after moderate intensity aerobic exercise improves Nitrogen balance in older adults. [Internet] [Masters thesis]. Colorado State University; 2010. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/37799.
Council of Science Editors:
Jordan LY. Milk consumption after moderate intensity aerobic exercise improves Nitrogen balance in older adults. [Masters Thesis]. Colorado State University; 2010. Available from: http://hdl.handle.net/10217/37799
Colorado State University
21.
Radhakrishnan, Sridhar.
Potato and grape polyphenols, respectively, suppress high-fat diet-elevated oxidative stress/innate inflammation markers in porcine model and induce apoptosis in HCT-116 p53 +/+ and p53 -/- human colon cancer cell lines in vitro.
Degree: PhD, Food Science and Human Nutrition, 2014, Colorado State University
URL: http://hdl.handle.net/10217/83808
To view the abstract, please see the full text of the document.
Advisors/Committee Members: Vanamala, Jairam (advisor), Kim, Sung Woo (committee member), Melby, Christopher (committee member), Pagliassotti, Michael (committee member), Veeramachaneni, DN Rao (committee member).Subjects/Keywords: colon inflammation and cancer; pig model; potato; resveratrol; grape seed extract; high-fat diet
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APA (6th Edition):
Radhakrishnan, S. (2014). Potato and grape polyphenols, respectively, suppress high-fat diet-elevated oxidative stress/innate inflammation markers in porcine model and induce apoptosis in HCT-116 p53 +/+ and p53 -/- human colon cancer cell lines in vitro. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/83808
Chicago Manual of Style (16th Edition):
Radhakrishnan, Sridhar. “Potato and grape polyphenols, respectively, suppress high-fat diet-elevated oxidative stress/innate inflammation markers in porcine model and induce apoptosis in HCT-116 p53 +/+ and p53 -/- human colon cancer cell lines in vitro.” 2014. Doctoral Dissertation, Colorado State University. Accessed March 04, 2021.
http://hdl.handle.net/10217/83808.
MLA Handbook (7th Edition):
Radhakrishnan, Sridhar. “Potato and grape polyphenols, respectively, suppress high-fat diet-elevated oxidative stress/innate inflammation markers in porcine model and induce apoptosis in HCT-116 p53 +/+ and p53 -/- human colon cancer cell lines in vitro.” 2014. Web. 04 Mar 2021.
Vancouver:
Radhakrishnan S. Potato and grape polyphenols, respectively, suppress high-fat diet-elevated oxidative stress/innate inflammation markers in porcine model and induce apoptosis in HCT-116 p53 +/+ and p53 -/- human colon cancer cell lines in vitro. [Internet] [Doctoral dissertation]. Colorado State University; 2014. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10217/83808.
Council of Science Editors:
Radhakrishnan S. Potato and grape polyphenols, respectively, suppress high-fat diet-elevated oxidative stress/innate inflammation markers in porcine model and induce apoptosis in HCT-116 p53 +/+ and p53 -/- human colon cancer cell lines in vitro. [Doctoral Dissertation]. Colorado State University; 2014. Available from: http://hdl.handle.net/10217/83808
. 
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