Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

Sorted by: relevance · author · university · dateNew search

You searched for +publisher:"Colorado State University" +contributor:("Avens, John S."). Showing records 1 – 2 of 2 total matches.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


Colorado State University

1. Hamm, Alison Kay. Effect of hop extract supplementation on gut microbiota and metabolic function in ovariectomized mice, The.

Degree: PhD, Food Science and Human Nutrition, 2018, Colorado State University

Estrogen decline with aging, or menopause, is associated with increased risk for cardiometabolic diseases primarily due to altered metabolism and weight gain. Standard treatment has traditionally been with 17β-estradiol (E2) prescription, although its use has declined over the last decade due to associated increase in breast and ovarian cancer risk. As a result, use of phytoestrogenic herbal supplements has increased, due to their perceived safety and effectiveness in treatment of menopausal side effects. The gut microbiota may also be important in terms of mitigating disease risk and hormone exposure during the menopause transition, as our gut microbiota are important modulators of local and systemic inflammation. Gut microbes also can metabolize hormones and dietary flavonoids, altering their bioactivity and bioavailability. In this study, we supplemented ovariectomized (OVX) or control sham-operated C57BL/6 mice, with oral E2, a flavonoid-rich extract from hops (Humulus lupulus), or placebo carrier oil, and observed differences in adiposity, inflammation, and gut bacteria composition. Hops extract (HE) did not protect against ovariectomy-associated weight gain or increased visceral adiposity, while E2-treated animals had similar body weights and fat depot sizes as Sham-operated animals. However, HE was protective against liver triglyceride accumulation, to levels similar to Sham control and OVX E2 groups. We found no evidence of OVX having a significant impact on the overall gut bacterial community structure in any of our treatment groups. We did find differences in abundance of two bacteria; Akkermansia muciniphila was lower with HE treatment in the Sham group, and Ruminococcus gnavus was higher with OVX compared to Sham control. Possible mechanisms of the interplay between gut bacteria, loss of estrogen, and hormone replacement will be discussed. Advisors/Committee Members: Weir, Tiffany L. (advisor), Cox-York, Kimberly A. (committee member), Broeckling, Corey D. (committee member), Avens, John S. (committee member), Bunning, Marisa L. (committee member).

Subjects/Keywords: Hop Extract; Menopause; Gut Health; Microbiome; Hormone Therapy

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hamm, A. K. (2018). Effect of hop extract supplementation on gut microbiota and metabolic function in ovariectomized mice, The. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/185624

Chicago Manual of Style (16th Edition):

Hamm, Alison Kay. “Effect of hop extract supplementation on gut microbiota and metabolic function in ovariectomized mice, The.” 2018. Doctoral Dissertation, Colorado State University. Accessed August 25, 2019. http://hdl.handle.net/10217/185624.

MLA Handbook (7th Edition):

Hamm, Alison Kay. “Effect of hop extract supplementation on gut microbiota and metabolic function in ovariectomized mice, The.” 2018. Web. 25 Aug 2019.

Vancouver:

Hamm AK. Effect of hop extract supplementation on gut microbiota and metabolic function in ovariectomized mice, The. [Internet] [Doctoral dissertation]. Colorado State University; 2018. [cited 2019 Aug 25]. Available from: http://hdl.handle.net/10217/185624.

Council of Science Editors:

Hamm AK. Effect of hop extract supplementation on gut microbiota and metabolic function in ovariectomized mice, The. [Doctoral Dissertation]. Colorado State University; 2018. Available from: http://hdl.handle.net/10217/185624


Colorado State University

2. Henley, Twila Jean. Effects of dark malts, dry hopping, and filtration on xanthohumol content and bioactivity of American India Pale Ales.

Degree: MS(M.S.), Food Science and Human Nutrition, 2007, Colorado State University

Xanthohumol (XN), a prenylated chalcone found in hops (Humulus lupulus L.) has been shown to possess a wide spectrum of beneficial properties including anti-oxidant, anti-proliferative, pro-apoptotic, anti-inflammatory, anti-bacterial, anti-viral, and anti-malarial activities. Efforts have been made to increase the amount of XN in beers by modifying certain brewing ingredients and procedures. However, the effects of modifications such as addition of dark malts, dry hopping, and DE filtration on XN content and the biological activity of American India Pale Ales (IPAs) are not known. In this study, different brands of IPAs with and without addition of dark/roasted malts, dry hopping, and filtration and one non IPA as a standard were analyzed for XN, isoxanthohumol, total phenolic content, and antioxidant capacity. Isolated beer compounds and selected whole beer matrixes were used to determine the synergistic effect of beer compounds on proliferation and apoptosis of HCT 116 p53 +/+ colon cancer cells. No XN was found in the standard, and the XN content in IPAs ranged from 0.00 to 12.69 mg/L. A heavily dry hopped IPA made with increased amounts of dark malt contained higher amounts of XN compared to other IPAs. The use of dark malts was protective against the removal of XN and other phenolics after diatomaceous earth (DE) filtration and dry hopping increased XN content in beer. Whole beer matrixes with greater levels of XN suppressed proliferation and elevated apoptosis in colon cancer cells compared with isolated XN and/or IX, indicating that the biological effect of XN can be bolstered in the presence of other beer compounds. Advisors/Committee Members: Stone, Martha (advisor), Vanamala, Jairam (advisor), Bunning, Marisa Lee, 1954- (committee member), Avens, John S. (committee member), Reddivari, Lavanya (committee member), Stonaker, Frank H. (committee member).

Subjects/Keywords: isoxanthohumol; xanthohumol; UPLC/MS/MS; phenolic compound; malt; beer

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Henley, T. J. (2007). Effects of dark malts, dry hopping, and filtration on xanthohumol content and bioactivity of American India Pale Ales. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/47316

Chicago Manual of Style (16th Edition):

Henley, Twila Jean. “Effects of dark malts, dry hopping, and filtration on xanthohumol content and bioactivity of American India Pale Ales.” 2007. Masters Thesis, Colorado State University. Accessed August 25, 2019. http://hdl.handle.net/10217/47316.

MLA Handbook (7th Edition):

Henley, Twila Jean. “Effects of dark malts, dry hopping, and filtration on xanthohumol content and bioactivity of American India Pale Ales.” 2007. Web. 25 Aug 2019.

Vancouver:

Henley TJ. Effects of dark malts, dry hopping, and filtration on xanthohumol content and bioactivity of American India Pale Ales. [Internet] [Masters thesis]. Colorado State University; 2007. [cited 2019 Aug 25]. Available from: http://hdl.handle.net/10217/47316.

Council of Science Editors:

Henley TJ. Effects of dark malts, dry hopping, and filtration on xanthohumol content and bioactivity of American India Pale Ales. [Masters Thesis]. Colorado State University; 2007. Available from: http://hdl.handle.net/10217/47316

.